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May 14, 2013

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Original Research:

Leen M. ‘t Hart,
Andreas Fritsche,
Giel Nijpels,
Nienke van Leeuwen,
Louise A. Donnelly,
Jacqueline M. Dekker,
Marjan Alssema,
Joao Fadista,
Françoise Carlotti,
Anette P. Gjesing,
Colin N.A. Palmer,
Timon W. van Haeften,
Silke A. Herzberg-Schäfer,
Annemarie M.C. Simonis-Bik,
Jeanine J. Houwing-Duistermaat,
Quinta Helmer,
Joris Deelen,
Bruno Guigas,
Torben Hansen,
Fausto Machicao,
Gonneke Willemsen,
Robert J. Heine,
Mark H.H. Kramer,
Jens J. Holst,
Eelco J.P. de Koning,
Hans-Ulrich Häring,
Oluf Pedersen,
Leif Groop,
Eco J.C. de Geus,
P. Eline Slagboom,
Dorret I. Boomsma,
Elisabeth M.W. Eekhoff,
Ewan R Pearson,
and Michaela Diamant

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway Diabetes published ahead of print May 14, 2013, doi:10.2337/db13-0227

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Original Research:

Léonie Egli,
Virgile Lecoultre,
Fanny Theytaz,
Vanessa Campos,
Leanne Hodson,
Philippe Schneiter,
Bettina Mittendorfer,
Bruce W. Patterson,
Barbara A. Fielding,
Philipp A. Gerber,
Vittorio Giusti,
Kaspar Berneis,
and Luc Tappy

Exercise Prevents Fructose-Induced Hypertriglyceridemia in Healthy Young Subjects Diabetes published ahead of print May 14, 2013, doi:10.2337/db12-1651

May 13, 2013

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Original Research:

Birgitte Lindegaard,
Vance B. Matthews,
Claus Brandt,
Pernille Hojman,
Tamara L. Allen,
Emma Estevez,
Matthew J. Watt,
Clinton R. Bruce,
Ole Mortensen,
Susanne Syberg,
Caroline Rudnicka,
Julie Abildgaard,
Henriette Pilegaard,
Juan Hidalgo,
Susanne Ditlevsen,
Thomas J. Alsted,
Andreas N. Madsen,
Bente K. Pedersen,
and Mark A. Febbraio

Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice Diabetes published ahead of print May 13, 2013, doi:10.2337/db12-1095

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Original Research:

Rica Tanaka,
Max Vaynrub,
Haruchika Masuda,
Rie Ito,
Michiru Kobori,
Muneo Miyasaka,
Hiroshi Mizuno,
Stephen M. Warren,
and Takayuki Asahara

Quality Control Culture System Restores Diabetic Endothelial Progenitor Cell Vasculogenesis and Accelerates Wound Closure Diabetes published ahead of print May 13, 2013, doi:10.2337/db12-1621

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Original Research:

Scott M. Blackman,
Clayton W. Commander,
Christopher Watson,
Kristin M. Arcara,
Lisa J. Strug,
Jaclyn R. Stonebraker,
Fred A. Wright,
Johanna M. Rommens,
Lei Sun,
Rhonda G. Pace,
Sarah A. Norris,
Peter R. Durie,
Mitchell L. Drumm,
Michael R. Knowles,
and Garry R. Cutting

Genetic modifiers of cystic fibrosis-related diabetes Diabetes published ahead of print May 13, 2013, doi:10.2337/db13-0510

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Original Research:

Nurit Hadad,
Olga Burgazliev,
Vered Elgazar-Carmon,
Yulia Solomonov,
Stephan Wueest,
Flurin Item,
Daniel Konrad,
Assaf Rudich,
and Rachel Levy

Induction of cytosolic phospholipase A₂α is required for adipose neutrophil infiltration and hepatic insulin resistance early in the course of high fat feeding Diabetes published ahead of print May 13, 2013, doi:10.2337/db12-1300

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Original Research:

Audrey Baeyens,
Louis Pérol,
Gwladys Fourcade,
Nicolas Cagnard,
Wassila Carpentier,
Janine Woytschak,
Onur Boyman,
Agnès Hartemann,
and Eliane Piaggio

Limitations of IL-2 and rapamycin in immunotherapy of type 1 diabetes Diabetes published ahead of print May 13, 2013, doi:10.2337/db13-0214

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Original Research:

Brigitte I Frohnert,
David R Jacobs, Jr.,
Julia Steinberger,
Antoinette Moran,
Lyn M Steffen,
and Alan R Sinaiko

Relation between Serum Free Fatty Acids and Adiposity, Insulin Resistance and Cardiovascular Risk Factors from Adolescence to Adulthood Diabetes published ahead of print May 13, 2013, doi:10.2337/db12-1122

May 8, 2013

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Original Research:

Paul V. Sabatini,
Nicole A.J. Krentz,
Bader Zarrouki,
Clara Y. Westwell-Roper,
Cuilan Nian,
Ryan A. Uy,
A.M. James Shapiro,
Vincent Poitout,
and Francis C. Lynn

Npas4 Is a Novel Activity-Regulated Cytoprotective Factor in Pancreatic β-Cells Diabetes published ahead of print May 8, 2013, doi:10.2337/db12-1527

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Original Research:

Heather C. Denroche,
Whitney L. Quong,
Jennifer E. Bruin,
Eva Tudurí,
Ali Asadi,
Maria M. Glavas,
Jessica K. Fox,
and Timothy J. Kieffer

Leptin administration enhances islet transplant performance in diabetic mice Diabetes published ahead of print May 8, 2013, doi:10.2337/db12-1684

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Original Research:

Chunling Huang,
Sylvie Shen,
Qing Ma,
Jason Chen,
Anthony Gill,
Carol A. Pollock,
and Xin-Ming Chen

Blockade of KCa3.1 Ameliorates Renal Fibrosis Through the TGF-β1/Smad Pathway in Diabetic Mice Diabetes published ahead of print May 8, 2013, doi:10.2337/db13-0135

May 6, 2013

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Original Research:

Abulizi Abudukadier,
Yoshihito Fujita,
Akio Obara,
Akiko Ohashi,
Toru Fukushima,
Yuichi Sato,
Masahito Ogura,
Yasuhiko Nakamura,
Shimpei Fujimoto,
Masaya Hosokawa,
Hiroyuki Hasegawa,
and Nobuya Inagaki

Tetrahydrobiopterin has a glucose-lowering effect by suppressing hepatic gluconeogenesis in an endothelial nitric oxide synthase-dependent manner in diabetic mice Diabetes published ahead of print May 6, 2013, doi:10.2337/db12-1242

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Original Research:

Nils B Jørgensen,
Carsten Dirksen,
Kirstine N Bojsen-møller,
Siv H Jacobsen,
Dorte Worm,
Dorte L Hansen,
Viggo B Kristiansen,
Lars Naver,
Sten Madsbad,
and Jens J Holst

The exaggerated glucagon-like peptide-1 response is important for the improved β-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes Diabetes published ahead of print May 6, 2013, doi:10.2337/db13-0022

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Original Research:

Supriya D. Deshpande,
Sumanth Putta,
Mei Wang,
Jennifer Y. Lai,
Markus Bitzer,
Robert G. Nelson,
Linda L. Lanting,
Mitsuo Kato,
and Rama Natarajan

Transforming Growth Factor-β induced cross talk between p53 and a microRNA in the pathogenesis of Diabetic Nephropathy Diabetes published ahead of print May 6, 2013, doi:10.2337/db13-0305

April 30, 2013

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Original Research:

Kim S. Bell-Anderson,
Alister P. Funnell,
Helen Williams,
Hanapi Mat Jusoh,
Tiffany Scully,
Wooi F. Lim,
Jon G. Burdach,
Ka Sin Mak,
Alexander J. Knights,
Andrew J. Hoy,
Hannah R. Nicholas,
Amanda Sainsbury,
Nigel Turner,
Richard C. Pearson,
and Merlin Crossley

Loss of Krüppel-like Factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2). Diabetes published ahead of print April 30, 2013, doi:10.2337/db12-1745

April 29, 2013

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Original Research:

Robert L Hanson,
Tingwei Guo,
Yunhua Li Muller,
Jamie Fleming,
William C Knowler,
Sayuko Kobes,
Clifton Bogardus,
and Leslie J Baier

Strong Parent-of-Origin Effects in the Association of KCNQ1 Variants with Type 2 Diabetes Mellitus in American Indians Diabetes published ahead of print April 29, 2013, doi:10.2337/db12-1767

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Original Research:

Chunhua Dai,
Marcela Brissova,
Rachel B. Reinert,
Lara Nyman,
Eric H. Liu,
Courtney Thompson,
Alena Shostak,
Masakazu Shiota,
Takamune Takahashi,
and Alvin C. Powers

Pancreatic Islet Vasculature Adapts to Insulin Resistance through Dilation and Not Angiogenesis Diabetes published ahead of print April 29, 2013, doi:10.2337/db12-1657

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Original Research:

Rachel E. Jennings,
Andrew A. Berry,
Rebecca Kirkwood-Wilson,
Neil A. Roberts,
Thomas Hearn,
Rachel J. Salisbury,
Jennifer Blaylock,
Karen Piper Hanley,
and Neil A. Hanley

Development of the human pancreas from foregut to endocrine commitment Diabetes published ahead of print April 29, 2013, doi:10.2337/db12-1479

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Original Research:

Yusuke Kaida,
Kei Fukami,
Takanori Matsui,
Yuichiro Higashimoto,
Yuri Nishino,
Nana Obara,
Yosuke Nakayama,
Ryotaro Ando,
Maki Toyonaga,
Seiji Ueda,
Masayoshi Takeuchi,
Hiroyoshi Inoue,
Seiya Okuda,
and Sho-ichi Yamagishi

DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy Diabetes published ahead of print April 29, 2013, doi:10.2337/db12-1608

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Original Research:

Matej Orešič,
Peddinti Gopalacharyulu,
Juha Mykkänen,
Niina Lietzen,
Marjaana Mäkinen,
Heli Nygren,
Satu Simell,
Ville Simell,
Heikki Hyöty,
Riitta Veijola,
Jorma Ilonen,
Marko Sysi-Aho,
Mikael Knip,
Tuulia Hyötyläinen,
and Olli Simell

Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes Diabetes published ahead of print April 29, 2013, doi:10.2337/db13-0159

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Original Research:

Seth J. Salpeter,
Abed Khalaileh,
Noa Weinberg-Corem,
Oren Ziv,
Ben Glaser,
and Yuval Dor

Systemic regulation of the age-related decline of pancreatic beta-cell replication Diabetes published ahead of print April 29, 2013, doi:10.2337/db13-0160

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Original Research:

Negar Karimian,
Tairan Qin,
Tao Liang,
Mayowa Osundiji,
Yachi Huang,
Trevor Teich,
Michael C. Riddell,
Mark S. Cattral,
David H. Coy,
Mladen Vranic,
and Herbert Y. Gaisano

Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counter-regulation In BioBreeding Diabetic Rats Diabetes published ahead of print April 29, 2013, doi:10.2337/db13-0164

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Original Research:

Michael R. Rickels,
Chengyang Liu,
Richard D. Shlansky-Goldberg,
Scott A. Soleimanpour,
Kumar Vivek,
Malek Kamoun,
Zaw Min,
Eileen Markmann,
Maral Palangian,
Cornelia Dalton-Bakes,
Carissa Fuller,
Allen J. Chiou,
Clyde F. Barker,
Eline T. Luning Prak,
and Ali Naji

Improvement in β-Cell Secretory Capacity Following Human Islet Transplantation According to the CIT07 Protocol Diabetes published ahead of print April 29, 2013, doi:10.2337/db12-1802

April 22, 2013

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Original Research:

Sarah J. Lessard,
Donato A. Rivas,
Ana B. Alves-Wagner,
Michael F. Hirshman,
Iain J. Gallagher,
Dumitru Constantin-Teodosiu,
Ryan Atkins,
Paul Greenhaff,
Nathan R. Qi,
Thomas Gustafsson,
Roger A. Fielding,
James A. Timmons,
Steven L. Britton,
Lauren G. Koch,
and Laurie J. Goodyear

Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks Diabetes published ahead of print April 22, 2013, doi:10.2337/db13-0062

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Original research:

Maria João Lima,
Kenneth R Muir,
Hilary M Docherty,
Robert Drummond,
Neil WA McGowan,
Shareen Forbes,
Yves Heremans,
Isabelle Houbracken,
James A Ross,
Stuart J. Forbes,
Philippe Ravassard,
Harry Heimberg,
John Casey,
and Kevin Docherty

Suppression of Epithelial to Mesenchymal Transitioning (EMT) Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue towards Functional Insulin Producing β-Like Cells* Diabetes published ahead of print April 22, 2013, doi:10.2337/db12-1256

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Original Research:

Faidon Magkos,
David Bradley,
George G. Schweitzer,
Brian N. Finck,
J. Christopher Eagon,
Olga Ilkayeva,
Christopher B. Newgard,
and Samuel Klein

Effect of roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism Diabetes published ahead of print April 22, 2013, doi:10.2337/db13-0185

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Original Research:

Clifton Jackness,
Wahida Karmally,
Gerardo Febres,
Irene M. Conwell,
Leaque Ahmed,
Marc Bessler,
Donald J. McMahon,
and Judith Korner

Very Low Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and Beta-Cell Function in Type 2 Diabetic Patients Diabetes published ahead of print April 22, 2013, doi:10.2337/db12-1762

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Original Research:

Magdalena A. Mazur,
Marcus Winkler,
Elvira Ganić,
Jesper K. Colberg,
Jenny Johansson,
Hedvig Bennet,
Malin Fex,
Ulrike A. Nuber,
and Isabella Artner

Microphtalmia transcription factor (Mitf) regulates pancreatic β cell function Diabetes published ahead of print April 22, 2013, doi:10.2337/db12-1464

April 17, 2013

Commentary:

Steven E. Kahn

Incretin Therapy and Islet Pathology – A Time for Caution Diabetes published ahead of print April 17, 2013, doi:10.2337/db13-0520

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April 11, 2013

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Original Research:

Woo-Jin Song,
Prosenjit Mondal,
Yuanyuan Li,
Suh Eun Lee,
and Mehboob A. Hussain

Pancreatic beta-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A Diabetes published ahead of print April 11, 2013, doi:10.2337/db12-1394

April 8, 2013

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Original Research:

Aimee J. Varewijck,
Hannele Yki-Järvinen,
Ronald Schmidt,
Norbert Tennagels,
and Joseph A.M.J.L. Janssen

Concentrations of Insulin Glargine and Its Metabolites During Long-Term Insulin Therapy in Type 2 Diabetic Patients and Comparison of Effects of Insulin Glargine, Its Metabolites, IGF-I, and Human Insulin on Insulin and IGF-I Receptor Signaling Diabetes published ahead of print April 8, 2013, doi:10.2337/db12-1773

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Original Research:

H. Siebe Spijker,
Raimond B.G. Ravelli,
A. Mieke Mommaas-Kienhuis,
Aart A. van Apeldoorn,
Marten A. Engelse,
Arnaud Zaldumbide,
Susan Bonner-Weir,
Ton J. Rabelink,
Rob C. Hoeben,
Hans Clevers,
Christine L. Mummery,
Françoise Carlotti,
and Eelco J.P. de Koning

Conversion of mature human β-cells into glucagon-producing α-cells Diabetes published ahead of print April 8, 2013, doi:10.2337/db12-1001

April 4, 2013

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Original Research:

Yuvaraj Mahendran,
Jagadish Vangipurapu,
Henna Cederberg,
Alena Stančáková,
Jussi Pihlajamäki,
Pasi Soininen,
Antti J. Kangas,
Jussi Paananen,
Mete Civelek,
Niyas K. Saleem,
Päivi Pajukanta,
Aldons J. Lusis,
Lori L. Bonnycastle,
Mario A. Morken,
Francis S. Collins,
Karen L. Mohlke,
Michael Boehnke,
Mika Ala-Korpela,
Johanna Kuusisto,
and Markku Laakso

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men Diabetes published ahead of print April 4, 2013, doi:10.2337/db12-1363

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Original Research:

Farah Lizotte,
Martin Paré,
Benoit Denhez,
Michael Leitges,
Andréanne Guay,
and Pedro Geraldes

PKCδ impaired vessel formation and angiogenic factor expression in diabetic ischemic limb Diabetes published ahead of print April 4, 2013, doi:10.2337/db12-1432

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Original Research:

Anna Jonsson,
Claes Ladenvall,
Tarunveer Singh Ahluwalia,
Jasmina Kravic,
Ulrika Krus,
Jalal Taneera,
Bo Isomaa,
Tiinamaija Tuomi,
Erik Renström,
Leif Groop,
and Valeriya Lyssenko

Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on α- and β-cell Function and Insulin Action in Man Diabetes published ahead of print April 4, 2013, doi:10.2337/db12-1627

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Original Research:

Sara F. Michaliszyn,
Riccardo C. Bonadonna,
Lindsey A. Sjaarda,
SoJung Lee,
Lama Farchoukh,
and Silva A. Arslanian

β-cell Lipotoxicity in Response to Free Fatty Acid Elevation in Youth: African American versus Caucasian Contrast Diabetes published ahead of print April 4, 2013, doi:10.2337/db12-1664

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Original Research:

Genevieve Marcelin,
Shun-Mei Liu,
Gary J. Schwartz,
and Streamson Chua

Identification of a loss-of-function mutation in Ube2l6 associated with obesity resistance Diabetes published ahead of print April 4, 2013, doi:10.2337/db12-1054

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Original Research:

Assaad A. Eid,
Bridget M. Ford,
Basant Bhandary,
Rita Cavagliery,
Karen Block,
Jeffrey L. Barnes,
Yves Gorin,
Goutam Ghosh Choudhury,
and Hanna E. Abboud

mTOR Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury Diabetes published ahead of print April 4, 2013, doi:10.2337/db12-1504

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Original Research:

Kristen E. Pauken,
Marc K. Jenkins,
Miyuki Azuma,
and Brian T. Fife

PD-1, but not PD-L1, expressed by islet-reactive CD4⁺ T cells suppresses infiltration of the pancreas during Type 1 Diabetes Diabetes published ahead of print April 4, 2013, doi:10.2337/db12-1475

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Original Research:

Christelle Le Foll,
Ambrose Dunn-Meynell,
Sergei Musatov,
Christophe Magnan,
and Barry E Levin

FAT/CD36: A major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice Diabetes published ahead of print April 4, 2013, doi:10.2337/db12-1689

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Original Research:

Lei Jiang,
Benedicte Brackeva,
Zhidong Ling,
Gertjan Kramer,
Johannes M Aerts,
Frans Schuit,
Bart Keymeulen,
Daniel Pipeleers,
Frans Gorus,
and Geert A. Martens

Potential of Protein Phosphatase Inhibitor 1 as Biomarker of pancreatic beta cell injury in vitro and in vivo Diabetes published ahead of print April 4, 2013, doi:10.2337/db12-1507

April 1, 2013

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Original Research:

Ge Li,
John J. Kohorst,
Wenjuan Zhang,
Eleonora Laritsky,
Govindarajan Kunde-Ramamoorthy,
Maria S. Baker,
Marta L. Fiorotto,
and Robert A. Waterland

Early Postnatal Nutrition Determines Adult Physical Activity and Energy Expenditure in Female Mice Diabetes published ahead of print April 1, 2013, doi:10.2337/db12-1306

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Original Research:

E. Jennifer Weil,
Gudeta Fufaa,
Lois I. Jones,
Tracy Lovato,
Kevin V. Lemley,
Robert L. Hanson,
William C. Knowler,
Peter H. Bennett,
Berne Yee,
Bryan D. Myers,
and Robert G. Nelson

Effect of Losartan on Prevention and Progression of Early Diabetic Nephropathy in American Indians With Type 2 Diabetes Diabetes published ahead of print April 1, 2013, doi:10.2337/db12-1512

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Original Research:

Matheni Sathananthan,
Luca P. Farrugia,
John M. Miles,
Francesca Piccinini,
Chiara Dalla Man,
Alan R. Zinsmeister,
Claudio Cobelli,
Robert A. Rizza,
and Adrian Vella

Direct Effects of Exendin-(9,39) and GLP-1-(9,36)amide on Insulin Action, β-Cell Function and Glucose Metabolism in Non-Diabetic Subjects Diabetes published ahead of print April 1, 2013, doi:10.2337/db13-0140

March 25, 2013

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Original Research:

Maria J. Ribeiro,
Joana F. Sacramento,
Constancio Gonzalez,
Maria P. Guarino,
Emília C Monteiro,
and Sílvia V. Conde

Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets Diabetes published ahead of print March 25, 2013, doi:10.2337/db12-1463

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Original Research:

Larissa W. van Golen,
Marc C. Huisman,
Richard G. Ijzerman,
Nikie J. Hoetjes,
Lothar A. Schwarte,
Adriaan A. Lammertsma,
and Michaela Diamant

Positron emission tomography measured cerebral blood flow and glucose metabolism are decreased in human type 1 diabetes Diabetes published ahead of print March 25, 2013, doi:10.2337/db12-1159

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Original Research:

Chitoku Toda,
Tetsuya Shiuchi,
Haruaki Kageyama,
Shiki Okamoto,
Eulalia A. Coutinho,
Tatsuya Sato,
Yuko Okamatsu-Ogura,
Shigefumi Yokota,
Kazuyo Takagi,
Lijun Tang,
Kumiko Saito,
Seiji Shioda,
and Yasuhiko Minokoshi

Extracellular Signal–Regulated Kinase in the Ventromedial Hypothalamus Mediates Leptin-Induced Glucose Uptake in Red-Type Skeletal Muscle Diabetes published ahead of print March 25, 2013, doi:10.2337/db12-1629

March 22, 2013

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Original Research:

Alexandra E Butler,
Martha Campbell-Thompson,
Tatyana Gurlo,
David W Dawson,
Mark Atkinson,
and Peter C Butler

Marked Expansion of Exocrine and Endocrine Pancreas with Incretin Therapy in Humans with increased Exocrine Pancreas Dysplasia and the potential for Glucagon-producing Neuroendocrine Tumors Diabetes published ahead of print March 22, 2013, doi:10.2337/db12-1686

March 21, 2013

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Original Research:

Yujie Li,
Yaohui Nie,
Ynes Helou,
Guoxian Ding,
Bin Feng,
Gang Xu,
Arthur Salomon,
and Haiyan Xu

Identification of sucrose non-fermenting related kinase (SNRK) as a suppressor of adipocyte inflammation Diabetes published ahead of print March 21, 2013, doi:10.2337/db12-1081

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Original Research:

Saul Genuth,
Jye-Yu C. Backlund,
Margaret Bayless,
David A. Bluemke,
Patricia A. Cleary,
Jill Crandall,
John M. Lachin,
Joao A.C. Lima,
Cuilian Miao,
and Evrim B. Turkbey

Effects of Prior Intensive versus Conventional Therapy and History of Glycemia on Cardiac Function in Type 1 Diabetes in the DCCT/EDIC Diabetes published ahead of print March 21, 2013, doi:10.2337/db12-0546

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Original Research:

Larbi Dridi,
Volkan Seyrantepe,
Anne Fougerat,
Xuefang Pan,
Éric Bonneil,
Pierre Thibault,
Allain Moreau,
Grant A. Mitchell,
Nikolaus Heveker,
Christopher W. Cairo,
Tarik Issad,
Alexander Hinek,
and Alexey V. Pshezhetsky

Positive Regulation of Insulin Signaling by Neuraminidase 1 Diabetes published ahead of print March 21, 2013, doi:10.2337/db12-1825

March 14, 2013

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Original Research:

Anne D Hafstad,
Jim Lund,
Elin Hadler-Olsen,
Anje C Höper,
Terje S Larsen,
and Ellen Aasum

High and moderate intensity training normalizes ventricular function and mechanoenergetics in diet-induced obese mice Diabetes published ahead of print March 14, 2013, doi:10.2337/db12-1580

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Original Research:

Yen-Hao Chen,
Saleh Heneidi,
Jung-Min Lee,
Lawrence C. Layman,
David W. Stepp,
Gloria Mabel Gamboa,
Bo-Shiun Chen,
Gregorio Chazenbalk,
and Ricardo Azziz

miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of Polycystic Ovary Syndrome patients and women with insulin resistance Diabetes published ahead of print March 14, 2013, doi:10.2337/db12-0963

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Original Research:

Jetro J. Tuulari,
Henry K. Karlsson,
Jussi Hirvonen,
Jarna C. Hannukainen,
Marco Bucci,
Mika Helmiö,
Jari Ovaska,
Minna Soinio,
Paulina Salminen,
Nina Savisto,
Lauri Nummenmaa,
and Pirjo Nuutila

Weight loss after bariatric surgery reverses insulin-induced increases in brain glucose metabolism of the morbidly obese Diabetes published ahead of print March 14, 2013, doi:10.2337/db12-1460

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Original Research:

Rita E. Mirza,
Milie M. Fang,
William J. Ennis,
and Timothy J. Koh

Blocking IL-1β Induces a Healing-associated Wound Macrophage Phenotype and Improves Healing in Type-2 Diabetes Diabetes published ahead of print March 14, 2013, doi:10.2337/db12-1450

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Original Research:

Nathalie M. Fiaschi-Taesch,
Jeffrey W. Kleinberger,
Fatimah Salim,
Ronnie Troxell,
Rachel Wills,
Mansoor Tanwir,
Gabriella Casinelli,
Amy E. Cox,
Karen K. Takane,
Donald K. Scott,
and Andrew F. Stewart

A Human Pancreatic Beta Cell G1/S Molecule Cell Cycle Atlas Diabetes published ahead of print March 14, 2013, doi:10.2337/db12-0777

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Original Research:

Nathalie M. Fiaschi-Taesch,
Jeffrey W. Kleinberger,
Fatimah Salim,
Ronnie Troxell,
Rachel Wills,
Mansoor Tanwir,
Gabriella Casinelli,
Amy E. Cox,
Karen K. Takane,
Harish Srinivas,
Donald K. Scott,
and Andrew F. Stewart

Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human Beta Cell Replication: A Revised Model of Human Beta Cell G1/S Control Diabetes published ahead of print March 14, 2013, doi:10.2337/db12-0778

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Original Research:

Sara Ramírez,
Luís Martins,
Jordi Jacas,
Patricia Carrasco,
Macarena Pozo,
Josep Clotet,
Dolors Serra,
Fausto G. Hegardt,
Carlos Diéguez,
Miguel López,
and Núria Casals

Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin Diabetes published ahead of print March 14, 2013, doi:10.2337/db12-1451

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Original Research:

David L. Morris,
Kae Won Cho,
Jennifer L. DelProposto,
Kelsie E. Oatmen,
Lynn M. Geletka,
Gabriel Martinez-Santibanez,
Kanakadurga Singer,
and Carey N. Lumeng

Adipose Tissue Macrophages Function as Antigen Presenting Cells and Regulate Adipose Tissue CD4+ T Cells in Mice Diabetes published ahead of print March 14, 2013, doi:10.2337/db12-1404

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Original Research:

Masaru Akiyama,
Chong Wee Liew,
Shusheng Lu,
Jiang Hu,
Rachael Martinez,
Ben Hambro,
Robert T. Kennedy,
and Rohit N. Kulkarni

X-box binding protein 1 is essential for insulin regulation of pancreatic alpha cell function Diabetes published ahead of print March 14, 2013, doi:10.2337/db12-1747

March 8, 2013

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Original Research:

Paolo Tessari,
Diego Cecchet,
Carlo Artusi,
Monica Vettore,
Renato Millioni,
Mario Plebani,
Lucia Puricelli,
and Monica Vedovato

Roles of insulin, age, and asymmetric dimethylarginine, on nitric oxide synthesis in vivo Diabetes published ahead of print March 8, 2013, doi:10.2337/db12-1127

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Original Research:

Brittanie J. Atkinson,
Beth A. Griesel,
Caleb D. King,
Miranda A. Josey,
and Ann Louise Olson

Moderate GLUT4 overexpression improves insulin sensitivity and fasting triglyceridemia in high fat fed transgenic mice Diabetes published ahead of print March 8, 2013, doi:10.2337/db12-1146

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Original Research:

Omid Tavana,
Nahum Puebla-Osorio,
Jiseong Kim,
Mei Sang,
Stella Jang,
and Chengming Zhu

Ku70 functions in addition to nonhomologous end joining in pancreatic beta-cells: A connection to beta-catenin regulation Diabetes published ahead of print March 8, 2013, doi:10.2337/db12-1218

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Original Research:

Kumi Kimura,
Yusuke Nakamura,
Yuka Inaba,
Michihiro Matsumoto,
Yoshiaki Kido,
Shun-ichiro Asahara,
Tomokazu Matsuda,
Hiroshi Watanabe,
Akifumi Maeda,
Fuyuhiko Inagaki,
Chisato Mukai,
Kiyoshi Takeda,
Shizuo Akira,
Tsuguhito Ota,
Hajime Nakabayashi,
Shuichi Kaneko,
Masato Kasuga,
and Hiroshi Inoue

Histidine augments the suppression of hepatic glucose production by central insulin action Diabetes published ahead of print March 8, 2013, doi:10.2337/db12-1701

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Original Research:

Shaoqing Lei,
Haobo Li,
Jinjin Xu,
Yanan Liu,
Xia Gao,
Junwen Wang,
Kwok F.J. Ng,
Wayne Bond Lau,
Xin-liang Ma,
Brian Rodrigues,
Michael G. Irwin,
and Zhengyuan Xia

Hyperglycemia-induced PKCβ₂ Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling Diabetes published ahead of print March 8, 2013, doi:10.2337/db12-1391

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Original Research:

Cristina Hernández,
Marta García-Ramírez,
Lidia Corraliza,
Jimena Fernández-Carneado,
Josep Farrera-Sinfreu,
Berta Ponsati,
Águeda González-Rodríguez,
Ángela Martínez-Valverde,
and Rafael Simó

Topical administration of somatostatin prevents retinal neurodegeneration in experimental diabetes Diabetes published ahead of print March 8, 2013, doi:10.2337/db12-0926

March 5, 2013

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Original Research:

Henry A. Erlich,
Ana Maria Valdes,
Shana McDevitt,
Birgitte B. Simen,
Lisbeth A. Blake,
Kim R. McGowan,
John A. Todd,
Stephen S. Rich,
and Janelle Noble

Next Generation Sequencing Reveals the Association of DRB3*02:02 with Type I Diabetes Diabetes published ahead of print March 5, 2013, doi:10.2337/db12-1387

March 1, 2013

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Original Research:

Paolo Monti,
Cristina Brigatti,
Miriam Krasmann,
Anette G Ziegler,
and Ezio Bonifacio

Concentration and activity of the soluble form of the Interleukin-7 Receptor alpha in type I diabetes identifies an interplay between hyperglycemia and immune function Diabetes published ahead of print March 1, 2013, doi:10.2337/db12-1726

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Original Research:

Qian Zhang,
Junjie Yu,
Bin Liu,
Ziquan Lv,
Tingting Xia,
Fei Xiao,
Shanghai Chen,
and Feifan Guo

Central activating transcription factor (ATF4) regulates hepatic insulin resistance in mice via S6K1 signaling and the vagus nerve Diabetes published ahead of print March 1, 2013, doi:10.2337/db12-1050

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Original Research:

Bettina Nowotny,
Lejla Zahiragic,
Dorothea Krog,
Peter J. Nowotny,
Christian Herder,
Maren Carstensen,
Toru Yoshimura,
Julia Szendroedi,
Esther Phielix,
Peter Schadewaldt,
Nanette C. Schloot,
Gerald I. Shulman,
and Michael Roden

Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans Diabetes published ahead of print March 1, 2013, doi:10.2337/db12-1179

February 27, 2013

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Original Research:

Changyun Hu,
Heyuan Ding,
Xiaojun Zhang,
F Susan Wong,
and Li Wen

Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes Diabetes published ahead of print February 27, 2013, doi:10.2337/db12-1175

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Original Research:

Ling Hinshaw,
Chiara Dalla Man,
Debashis K. Nandy,
Ahmed Saad,
Adil E. Bharucha,
James A. Levine,
Robert A. Rizza,
Rita Basu,
Rickey E Carter,
Claudio Cobelli,
Yogish C. Kudva,
and Ananda Basu

Diurnal Pattern of Insulin Action in Type 1 diabetes: Implications for a Closed Loop System Diabetes published ahead of print February 27, 2013, doi:10.2337/db12-1759

February 22, 2013

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Original Research:

Sebastian Martini,
Viji Nair,
Sanjeevkumar R. Patel,
Felix Eichinger,
Robert G. Nelson,
E. Jennifer Weil,
Marcus G. Pezzolesi,
Andrzej S. Krolewski,
Ann Randolph,
Benjamin J. Keller,
Thomas Werner,
and Matthias Kretzler

From SNP to Transcriptional Mechanism: A Model for FRMD3 in Diabetic Nephropathy Diabetes published ahead of print February 22, 2013, doi:10.2337/db12-1416

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Original Research:

Christina Koutsari,
Manpreet S. Mundi,
Asem H. Ali,
Bruce W. Patterson,
and Michael D. Jensen

Systemic Free Fatty Acid Disposal into Very-Low-Density Lipoprotein Triglycerides Diabetes published ahead of print February 22, 2013, doi:10.2337/db12-1557

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Original Research:

Hilary E Wilson-Pérez,
Adam P Chambers,
Karen K Ryan,
Bailing Li,
Darleen A Sandoval,
Doris Stoffers,
Daniel J Drucker,
Diego Pérez-Tilve,
and Randy J Seeley

Vertical Sleeve Gastrectomy is Effective in Two Genetic Mouse Models of Glucagon-like Peptide-1 Receptor Deficiency Diabetes published ahead of print February 22, 2013, doi:10.2337/db12-1498

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Original Research:

Jessica T.Y. Yue,
Michael C. Riddell,
Elena Burdett,
David H. Coy,
Suad Efendic,
and Mladen Vranic

Amelioration of Hypoglycemia via Somatostatin Receptor Type 2 Antagonism in Recurrently Hypoglycemic Diabetic Rats Diabetes published ahead of print February 22, 2013, doi:10.2337/db12-1523

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Original Research:

Ken T. Coppieters,
Natalie Amirian,
Philippe P. Pagni,
Carmen Baca Jones,
Anna Wiberg,
Stanley Lasch,
Edith Hintermann,
Urs Christen,
and Matthias G. von Herrath

Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic CTL to pancreatic islets in a virally induced autoimmune diabetes model Diabetes published ahead of print February 22, 2013, doi:10.2337/db12-1370

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Original Research:

Jing Luo,
Ling Zhao,
Aaron Yun Chen,
Xiaohui Zhang,
Jin Zhu,
Jiagang Zhao,
Hong Ouyang,
Hongrong Luo,
Yaojun Song,
Janet Lee,
Shrena Patel,
Peter X. Shaw,
SriniVas Sadda,
Yehong Zhuo,
Michael G. Rosenfeld,
and Kang Zhang

TCF7L2 Variation and Proliferative Diabetic Retinopathy Diabetes published ahead of print February 22, 2013, doi:10.2337/db12-1093

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Original Research:

Michael D. Dennis,
Jeffrey S. Shenberger,
Bruce A. Stanley,
Scot R. Kimball,
and Leonard S. Jefferson

Hyperglycemia Mediates a Shift from Cap-Dependent to Cap-Independent Translation via a 4E-BP1 Dependent Mechanism Diabetes published ahead of print February 22, 2013, doi:10.2337/db12-1453

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Original Research:

Anton Shostak,
Judit Meyer-Kovac,
and Henrik Oster

Circadian regulation of lipid mobilization in white adipose tissues Diabetes published ahead of print February 22, 2013, doi:10.2337/db12-1449

February 19, 2013

February 8, 2013

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Original Research:

Wencheng Zhang,
Qilong Wang,
Ping Song,
and Minghui Zou

Liver Kinase B1 Is Required for White Adipose Tissue Growth and Differentiation Diabetes published ahead of print February 8, 2013, doi:10.2337/db12-1229

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Original Research:

Mario Galgani,
Rosa Nugnes,
Dario Bruzzese,
Francesco Perna,
Veronica De Rosa,
Claudio Procaccini,
Enza Mozzillo,
Corrado M Cilio,
Ake Lernmark,
Helena Elding Larsson,
Antonio La Cava,
Adriana Franzese,
and Giuseppe Matarese

Meta-immunological profiling of children with type 1 diabetes identifies new biomarkers to monitor disease progression Diabetes published ahead of print February 8, 2013, doi:10.2337/db12-1273

February 4, 2013

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Original Article:

Jennifer E. Ho,
Martin G. Larson,
Ramachandran S. Vasan,
Anahita Ghorbani,
Susan Cheng,
Eugene P. Rhee,
Jose C. Florez,
Clary B. Clish,
Robert E. Gerszten,
and Thomas J. Wang

Metabolite Profiles During Oral Glucose Challenge Diabetes published ahead of print February 4, 2013, doi:10.2337/db12-0754

January 24, 2013

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Original Research:

Jordi Lanuza-Masdeu,
M. Isabel Arévalo,
Cristina Vila,
Albert Barberà,
Ramon Gomis,
and Carme Caelles

In vivo JNK activation in pancreatic β-cells leads to glucose intolerance caused by insulin resistance in pancreas Diabetes published ahead of print January 24, 2013, doi:10.2337/db12-1097

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