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Research ArticleOriginal Research

A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans

Huaixing Li, Wei Gan, Ling Lu, Xiao Dong, Xueyao Han, Cheng Hu, Zhen Yang, Liang Sun, Wei Bao, Pengtao Li, Meian He, Liangdan Sun, Yiqin Wang, Jingwen Zhu, Qianqian Ning, Yong Tang, Rong Zhang, Jie Wen, Di Wang, Xilin Zhu, Kunquan Guo, Xianbo Zuo, Xiaohui Guo, Handong Yang, Xianghai Zhou, DIAGRAM Consortium, AGEN-T2D Consortium, Xuejun Zhang, Lu Qi, Ruth J.F. Loos, Frank B. Hu, Tangchun Wu, Ying Liu, Liegang Liu, Ze Yang, Renming Hu, Weiping Jia, Linong Ji, Yixue Li, Xu Lin
DOI: 10.2337/db12-0454 Published 31 August 2012
Huaixing Li
1Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
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Wei Gan
1Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
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Ling Lu
1Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
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Xiao Dong
2Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
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Xueyao Han
3Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China
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Cheng Hu
4Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
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Zhen Yang
5Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Liang Sun
6Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China
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Wei Bao
7Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China8Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Pengtao Li
9State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
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Meian He
8Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China10Institute of Occupational Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Liangdan Sun
11Institute of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China12Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China13State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Hefei, Anhui, China
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Yiqin Wang
1Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
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Jingwen Zhu
1Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
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Qianqian Ning
2Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
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Yong Tang
3Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China
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Rong Zhang
4Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
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Jie Wen
5Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Di Wang
7Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China8Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Xilin Zhu
9State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
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Kunquan Guo
8Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China10Institute of Occupational Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Xianbo Zuo
11Institute of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China12Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China13State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Hefei, Anhui, China
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Xiaohui Guo
14Peking University First Hospital, Beijing, China
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Handong Yang
15Dongfeng Central Hospital, Dongfeng Motor Corporation and Hubei University of Medicine, Shiyan, Hubei, China
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Xianghai Zhou
3Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China
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Xuejun Zhang
11Institute of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China12Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China13State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Hefei, Anhui, China
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Lu Qi
16Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
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Ruth J.F. Loos
17Department of Preventive Medicine, Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, New York18Department of Preventive Medicine, Child Health and Development Institute, Mount Sinai School of Medicine, New York, New York
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Frank B. Hu
16Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
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Tangchun Wu
8Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China10Institute of Occupational Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Ying Liu
9State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
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Liegang Liu
7Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China8Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Ze Yang
6Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China
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Renming Hu
5Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Weiping Jia
4Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
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Linong Ji
3Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China
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Yixue Li
2Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China19Shanghai Center for Bioinformation Technology, Shanghai, China20College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China
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Xu Lin
1Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
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