Files in this Data Supplement:
- Supplementary Figures and Tables
- Supplementary Video 1 - Dog exercise test. Fasted dogs (24 h) were subjected to 37- minute exercise under increasing speed and slope in a variable speed belt treadmill.
- Supplementary Video 2 - Dog2 before and after combined AAV1-Ins and AAV1-Gck treatment. One month after development of hyperglycemia and without exogenous insulin treatment, Dog2 showed apathetic behavior and significant cachexia. Seven months after treatment with AAV1-Ins and AAV1-Gck, Dog2 restored normoglycemia and recovered weight. Accordingly, the dog behaved more actively, like healthy control dogs.