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Research ArticleOriginal Research

Skeletal Muscle Expression of Phosphofructokinase is Influenced by Genetic Variation and Associated with Insulin Sensitivity

Sarah Keildson, Joao Fadista, Claes Ladenvall, Åsa K. Hedman, Targ Elgzyri, Kerrin S. Small, Elin Grundberg, Alexandra C. Nica, Daniel Glass, J. Brent Richards, Amy Barrett, James Nisbet, Hou-Feng Zheng, Tina Rönn, Kristoffer Ström, Karl-Fredrik Eriksson, Inga Prokopenko, MAGIC consortium, DIAGRAM consortium, MuTHER consortium, Timothy D Spector, Emmanouil T. Dermitzakis, Panos Deloukas, Mark I McCarthy, Johan Rung, Leif Groop, Paul W. Franks, Cecilia M. Lindgren, Ola Hansson
DOI: 10.2337/db13-1301 Published 4 December 2013
Sarah Keildson
1 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
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Joao Fadista
2 Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital Malmö, Lund University, Malmö 20502, Sweden
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Claes Ladenvall
2 Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital Malmö, Lund University, Malmö 20502, Sweden
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Åsa K. Hedman
1 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
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Targ Elgzyri
2 Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital Malmö, Lund University, Malmö 20502, Sweden
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Kerrin S. Small
3 Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, United Kingdom4 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, United Kingdom
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Elin Grundberg
3 Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, United Kingdom4 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, United Kingdom
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Alexandra C. Nica
5 Department of Genetic Medicine and Development, University of Geneva, Medical School, 1211 Geneva 4, Switzerland
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Daniel Glass
3 Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, United Kingdom
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J. Brent Richards
3 Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, United Kingdom6 Department of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada
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Amy Barrett
7 Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, United Kingdom
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James Nisbet
4 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, United Kingdom
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Hou-Feng Zheng
6 Department of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada
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Tina Rönn
2 Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital Malmö, Lund University, Malmö 20502, Sweden
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Kristoffer Ström
2 Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital Malmö, Lund University, Malmö 20502, Sweden8 Swedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, SE-83125 Östersund, Sweden
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Karl-Fredrik Eriksson
2 Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital Malmö, Lund University, Malmö 20502, Sweden
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Inga Prokopenko
1 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
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Timothy D Spector
3 Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, United Kingdom
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Emmanouil T. Dermitzakis
5 Department of Genetic Medicine and Development, University of Geneva, Medical School, 1211 Geneva 4, Switzerland
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Panos Deloukas
4 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, United Kingdom
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Mark I McCarthy
1 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom7 Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, United Kingdom10 Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LE, United Kingdom
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Johan Rung
9 EMBL-EBI, European Molecular Biology Laboratory-European Bioinformatics Institute, Cambridge, CB10 1SD, United Kingdom
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Leif Groop
2 Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital Malmö, Lund University, Malmö 20502, Sweden
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Paul W. Franks
11 Lund University Diabetes Center, Department of Clinical Sciences, Genetic and Molecular Epidemiology, Skåne University Hospital Malmö, Lund University, Malmö 20502, Sweden
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Cecilia M. Lindgren
1 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom12 Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
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Ola Hansson
2 Lund University Diabetes Center, Department of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital Malmö, Lund University, Malmö 20502, Sweden
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  • For correspondence: ola.hansson@med.lu.se

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