Genetic evidence for a normal-weight “metabolically obese” phenotype linking insulin resistance, hypertension, coronary artery disease and type 2 diabetes
HaniehYaghootkar, Robert A.Scott, Charles C.White, WeihuaZhang, ElizabethSpeliotes, Patricia B.Munroe, Georg B.Ehret, Joshua C.Bis, Caroline S.Fox, MarkWalker, Ingrid B.Borecki, Joshua W.Knowles, LauraYerges-Armstrong, ClaesOhlsson, John R. B.Perry, John CChambers, Jaspal SKooner, NoraFranceschini, ClaudiaLangenberg, Marie-FranceHivert, ZariDastani, J. BrentRichards, Robert K.Semple, Timothy M.Frayling
DOI: 10.2337/db14-0318 Published 18 July 2014
1Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
3Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Framingham, Massachusetts, USA.4Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
3Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Framingham, Massachusetts, USA.11Center for Population Studies, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Framingham, Massachusetts, USA.12Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
20Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.21Department of Epidemiology and Public Health, University College London, London, UK.
27The National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, UK.28The University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, UK.