Perspectives in Diabetes:

Gene and Cell-Replacement Therapy in the Treatment of Type 1 Diabetes: How High Must the Standards Be Set?

Philippe A. Halban, Steven E. Kahn, Åke Lernmark, and Christopher J. Rhodes
Diabetes 2001 50: 2181 -2191. [Abstract] [Full Text] [PDF]  

Rapid Publications:

Insulin Activates ATP-Sensitive K⁺ Channels in Pancreatic ß-Cells Through a Phosphatidylinositol 3-Kinase–Dependent Pathway

Farrukh A. Khan, Paulette B. Goforth, Min Zhang, and Leslie S. Satin
Diabetes 2001 50: 2192 -2198. [Abstract] [Full Text] [PDF]  

Resistin / Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator–Activated Receptor- Action in Humans

David B. Savage, Ciaran P. Sewter, Ellen S. Klenk, David G. Segal, Antonio Vidal-Puig, Robert V. Considine, and Stephen O’Rahilly
Diabetes 2001 50: 2199 -2202. [Abstract] [Full Text] [PDF]  

Metabolism and Signal Transduction:

The Effect of Insulin on In Vivo Cerebral Glucose Concentrations and Rates of Glucose Transport/Metabolism in Humans

Elizabeth R. Seaquist, Gregory S. Damberg, Ivan Tkac, and Rolf Gruetter
Diabetes 2001 50: 2203 -2209. [Abstract] [Full Text] [PDF]  

A Role for Protein Phosphatase 2A–Like Activity, but Not Atypical Protein Kinase C, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate

Rosanna Cazzolli, Lee Carpenter, Trevor J. Biden, and Carsten Schmitz-Peiffer
Diabetes 2001 50: 2210 -2218. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Inhibition of Cytokine-Induced NF-B Activation by Adenovirus-Mediated Expression of a NF-B Super-Repressor Prevents ß-Cell Apoptosis

Harry Heimberg, Yves Heremans, Christian Jobin, Ruth Leemans, Alessandra K. Cardozo, Martine Darville, and Décio L. Eizirik
Diabetes 2001 50: 2219 -2224. [Abstract] [Full Text] [PDF]  

Islet Studies:

The Expression of Hormone-Sensitive Lipase in Clonal ß-Cells and Rat Islets Is Induced by Long-Term Exposure to High Glucose

Maria Sörhede Winzell, Håkan Svensson, Peter Arner, Bo Ahrén, and Cecilia Holm
Diabetes 2001 50: 2225 -2230. [Abstract] [Full Text] [PDF]  

Noninvasive In Vivo Measurement of ß-Cell Mass in Mouse Model of Diabetes

Anna Moore, Susan Bonner-Weir, and Ralph Weissleder
Diabetes 2001 50: 2231 -2236. [Abstract] [Full Text] [PDF]  

Protein Kinase C Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic ß-Cell Proliferation

Jean Buteau, Sylvain Foisy, Christopher J. Rhodes, Lee Carpenter, Trevor J. Biden, and Marc Prentki
Diabetes 2001 50: 2237 -2243. [Abstract] [Full Text] [PDF]  

Phosphorylation-Dependent Nucleocytoplasmic Shuttling of Pancreatic Duodenal Homeobox-1

Lucy J. Elrick and Kevin Docherty
Diabetes 2001 50: 2244 -2252. [Abstract] [Full Text] [PDF]  

Structural Basis for the Interference Between Nicorandil and Sulfonylurea Action

Frank Reimann, Frances M. Ashcroft, and Fiona M. Gribble
Diabetes 2001 50: 2253 -2259. [Abstract] [Full Text] [PDF]  

Inducible and Reversible ß-Cell Autoimmunity and Hyperplasia in Transgenic Mice Expressing a Conditional Oncogene

Irina Berkovich and Shimon Efrat
Diabetes 2001 50: 2260 -2267. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Effects of Leptin Deficiency and Short-Term Repletion on Hepatic Gene Expression in Genetically Obese Mice

Anthony W. Ferrante, Marie Thearle, Ted Liao, and Rudolph L. Leibel
Diabetes 2001 50: 2268 -2278. [Abstract] [Full Text] [PDF]  

Intrauterine Growth Retardation Leads to the Development of Type 2 Diabetes in the Rat

Rebecca A. Simmons, Lori J. Templeton, and Shira J. Gertz
Diabetes 2001 50: 2279 -2286. [Abstract] [Full Text] [PDF]  

Phenotypic Correction of Diabetic Mice by Adenovirus-Mediated Glucokinase Expression

Urvi J. Desai, Eric D. Slosberg, Brian R. Boettcher, Shari L. Caplan, Barbara Fanelli, Zouhair Stephan, Vicky J. Gunther, Michael Kaleko, and Sheila Connelly
Diabetes 2001 50: 2287 -2295. [Abstract] [Full Text] [PDF]  

Troglitazone Not Only Increases GLUT4 but Also Induces Its Translocation in Rat Adipocytes

Mitsuyo Shintani, Haruo Nishimura, Shin Yonemitsu, Yoshihiro Ogawa, Tatsuya Hayashi, Kiminori Hosoda, Gen Inoue, and Kazuwa Nakao
Diabetes 2001 50: 2296 -2300. [Abstract] [Full Text] [PDF]  

Pharmacological Antilipolysis Restores Insulin Sensitivity During Growth Hormone Exposure

Steen Nielsen, Niels Møller, Jens S. Christiansen, and Jens O.L. Jørgensen
Diabetes 2001 50: 2301 -2308. [Abstract] [Full Text] [PDF]  

Direct Thiazolidinedione Action on Isolated Rat Skeletal Muscle Fuel Handling Is Independent of Peroxisome Proliferator–Activated Receptor--Mediated Changes in Gene Expression

Barbara Brunmair, Florian Gras, Susanne Neschen, Michael Roden, Ludwig Wagner, Werner Waldhäusl, and Clemens Fürnsinn
Diabetes 2001 50: 2309 -2315. [Abstract] [Full Text] [PDF]  

Thiazolidinedione Treatment Prevents Free Fatty Acid–Induced Insulin Resistance in Male Wistar Rats

Andrea L. Hevener, Donna Reichart, Andrej Janez, and Jerrold Olefsky
Diabetes 2001 50: 2316 -2322. [Abstract] [Full Text] [PDF]  

Small Molecule Insulin Receptor Activators Potentiate Insulin Action in Insulin-Resistant Cells

Ming Li, Jack F. Youngren, Vara Prasad Manchem, Michael Kozlowski, Bei B. Zhang, Betty A. Maddux, and Ira D. Goldfine
Diabetes 2001 50: 2323 -2328. [Abstract] [Full Text] [PDF]  

Changes in Regional Brain ¹⁸F-Fluorodeoxyglucose Uptake at Hypoglycemia in Type 1 Diabetic Men Associated With Hypoglycemia Unawareness and Counter-Regulatory Failure

Iain Cranston, Laurence J. Reed, Paul K. Marsden, and Stephanie A. Amiel
Diabetes 2001 50: 2329 -2366. [Abstract] [Full Text] [PDF]  

Intramyocellular Lipid Is Associated With Resistance to In Vivo Insulin Actions on Glucose Uptake, Antilipolysis, and Early Insulin Signaling Pathways in Human Skeletal Muscle

Antti Virkamäki, Elena Korsheninnikova, Anneli Seppälä-Lindroos, Satu Vehkavaara, Takashi Goto, Juha Halavaara, Anna-Maija Häkkinen, and Hannele Yki-Järvinen
Diabetes 2001 50: 2337 -2343. [Abstract] [Full Text] [PDF]  

Increased Lactate Release per Fat Cell in Normoglycemic First-Degree Relatives of Individuals With Type 2 Diabetes

Madeléne M. Sandqvist, Jan W. Eriksson, and Per-Anders E. Jansson
Diabetes 2001 50: 2344 -2348. [Abstract] [Full Text] [PDF]  

Caffeine Ingestion Decreases Glucose Disposal During a Hyperinsulinemic-Euglycemic Clamp in Sedentary Humans

Felicia Greer, Robert Hudson, Robert Ross, and Terry Graham
Diabetes 2001 50: 2349 -2354. [Abstract] [Full Text] [PDF]  

Complications:

Hexosamine-Induced Fibronectin Protein Synthesis in Mesangial Cells Is Associated With Increases in cAMP Responsive Element Binding (CREB) Phosphorylation and Nuclear CREB: The Involvement of Protein Kinases A and C

Lalit P. Singh, Jack Andy, Vivian Anyamale, Kennieth Greene, Michelle Alexander, and Errol D. Crook
Diabetes 2001 50: 2355 -2362. [Abstract] [Full Text] [PDF]  

Hyperglycemia Activates p53 and p53-Regulated Genes Leading to Myocyte Cell Death

Fabio Fiordaliso, Annarosa Leri, Daniela Cesselli, Federica Limana, Bijan Safai, Bernardo Nadal-Ginard, Piero Anversa, and Jan Kajstura
Diabetes 2001 50: 2363 -2375. [Abstract] [Full Text] [PDF]  

High Glucose–Enhanced Mesangial Cell Extracellular Signal–Regulated Protein Kinase Activation and 1(IV) Collagen Expression in Response to Endothelin-1: Role of Specific Protein Kinase C Isozymes

Hong Hua, Howard J. Goldberg, I.G. Fantus, and Catharine I. Whiteside
Diabetes 2001 50: 2376 -2383. [Abstract] [Full Text] [PDF]  

Epidemiology:

The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly: The Cardiovascular Health Study

Joshua I. Barzilay, Linn Abraham, Susan R. Heckbert, Mary Cushman, Lewis H. Kuller, Helaine E. Resnick, and Russell P. Tracy
Diabetes 2001 50: 2384 -2389. [Abstract] [Full Text] [PDF]  

A Prospective Study of Drinking Patterns in Relation to Risk of Type 2 Diabetes Among Men

Katherine M. Conigrave, B. Frank Hu, Carlos A. Camargo, Meir J. Stampfer, Walter C. Willett, and Eric B. Rimm
Diabetes 2001 50: 2390 -2395. [Abstract] [Full Text] [PDF]  

Genetics:

A Major Gene Effect on Fasting Insulin and Insulin Sensitivity in Familial Combined Hyperlipidemia

Jussi Pihlajamäki, Melissa Austin, Karen Edwards, and Markku Laakso
Diabetes 2001 50: 2396 -2401. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

Characterization of the Annexin I Gene and Evaluation of Its Role in Type 2 Diabetes

Cecilia M. Lindgren, Anita Nilsson, Marju Orho-Melander, Peter Almgren, and Leif C. Groop
Diabetes 2001 50: 2402 -2405. [Abstract] [Full Text] [PDF] Online Appendix  

Analysis of the Coding and Promoter Regions of the Autoantigen IA-2 in Subjects With and Without Autoantibodies to IA-2

Tao Cai, Jingping Xie, Jin-Xiong She, and Abner Louis Notkins
Diabetes 2001 50: 2406 -2409. [Abstract] [Full Text] [PDF]  

A Common Hormone-Sensitive Lipase i6 Gene Polymorphism Is Associated With Decreased Human Adipocyte Lipolytic Function

Johan Hoffstedt, Peter Arner, Martin Schalling, Nancy L. Pedersen, Selim Sengul, Susanne Ahlberg, Anastasia Iliadou, and Catharina Lavebratt
Diabetes 2001 50: 2410 -2413. [Abstract] [Full Text] [PDF]  

Errata:

Erratum

Diabetes 2001 50: 2414 -2415. [Extract] [Full Text] [PDF]  

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