Diabetes -- Table of Contents (February 2001, 50 [2])

Perspectives in Diabetes:

The Discovery of Type 1 Diabetes: Edwin A.M. Gale
Diabetes 2001 50: 217 -226. [Abstract] [Full Text] [PDF]

Rapid Publications:

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway: Mitsuyo Shintani, Yoshihiro Ogawa, Ken Ebihara, Megumi Aizawa-Abe, Fumiko Miyanaga, Kazuhiko Takaya, Tatsuya Hayashi, Gen Inoue, Kiminori Hosoda, Masayasu Kojima, Kenji Kangawa, and Kazuwa Nakao
Diabetes 2001 50: 227 -232. [Abstract] [Full Text] [PDF]

Metabolism and Signal Transduction:

Overexpression of 1-Acyl-Glycerol-3-Phosphate Acyltransferase- ${alpha}$ Enhances Lipid Storage in Cellular Models of Adipose Tissue and Skeletal Muscle: Hong Ruan and Henry J. Pownall
Diabetes 2001 50: 233 -240. [Abstract] [Full Text] [PDF]

Nitric Oxide Increases Glucose Uptake Through a Mechanism That Is Distinct From the Insulin and Contraction Pathways in Rat Skeletal Muscle: Yasuki Higaki, Michael F. Hirshman, Nobuharu Fujii, and Laurie J. Goodyear
Diabetes 2001 50: 241 -247. [Abstract] [Full Text] [PDF]

Effects of Chronic Central Nervous System Administration of Agouti-Related Protein in Pair-Fed Animals: Caroline J. Small, Min S. Kim, Sarah A. Stanley, John R.D. Mitchell, Kevin Murphy, David G.A. Morgan, Mohammad A. Ghatei, and Stephen R. Bloom
Diabetes 2001 50: 248 -254. [Abstract] [Full Text] [PDF]

PKC ${delta}$ Activation: A Divergence Point in the Signaling of Insulin and IGF-1—Induced Proliferation of Skin Keratinocytes: Shlomzion Shen, Addy Alt, Efrat Wertheimer, Marina Gartsbein, Toshio Kuroki, Motoi Ohba, Liora Braiman, Sanford R. Sampson, and Tamar Tennenbaum
Diabetes 2001 50: 255 -264. [Abstract] [Full Text] [PDF]

Regulation of Glycogen Synthase Kinase-3 in Human Skeletal Muscle: Effects of Food Intake and Bicycle Exercise: Jørgen F.P. Wojtaszewski, Pernille Nielsen, Bente Kiens, and Erik A. Richter
Diabetes 2001 50: 265 -269. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Prolonged Islet Graft Survival in NOD Mice by Blockade of the CD40-CD154 Pathway of T-Cell Costimulation: R. Damaris Molano, Thierry Berney, Hua Li, Pierre Cattan, Antonello Pileggi, Caterina Vizzardelli, Norma S. Kenyon, Camillo Ricordi, Linda C. Burkly, and Luca Inverardi
Diabetes 2001 50: 270 -276. [Abstract] [Full Text] [PDF]

Metabolic Effects of Restoring Partial ß-Cell Function After Islet Allotransplantation in Type 1 Diabetic Patients: Livio Luzi, Gianluca Perseghin, Mathias D. Brendel, Ileana Terruzzi, Alberto Battezzati, Michael Eckhard, Daniel Brandhorst, Heide Brandhorst, Schirin Friemann, Carlo Socci, Valerio Di Carlo, Lucia Piceni Sereni, Stefano Benedini, Antonio Secchi, Guido Pozza, and Reinhard G. Bretzel
Diabetes 2001 50: 277 -282. [Abstract] [Full Text] [PDF]

Islet Studies:

Double-Stranded RNA—Dependent Protein Kinase Is Not Required for Double-Stranded RNA—Induced Nitric Oxide Synthase Expression or Nuclear Factor- ${kappa}$ B Activation by Islets: Libby A. Blair, Monique R. Heitmeier, Anna L. Scarim, Leonard B. Maggi, Jr., and John A. Corbett
Diabetes 2001 50: 283 -290. [Abstract] [Full Text] [PDF]

Effects of Glucose and Amino Acids on Free ADP in ßHC9 Insulin-Secreting Cells: Peter Ronner, C. Maik Naumann, and Edward Friel
Diabetes 2001 50: 291 -300. [Abstract] [Full Text] [PDF]

Stimulated Endocrine Cell Proliferation and Differentiation in Transplanted Human Pancreatic Islets: Effects of the ob Gene and Compensatory Growth of the Implantation Organ: Björn Tyrberg, Jarkko Ustinov, Timo Otonkoski, and Arne Andersson
Diabetes 2001 50: 301 -307. [Abstract] [Full Text] [PDF]

Defective Stimulus-Secretion Coupling in Islets of Psammomys obesus, an Animal Model for Type 2 Diabetes: Rafael Nesher, Nasim Warwar, Akhtar Khan, Suad Efendic, Erol Cerasi, and Nurit Kaiser
Diabetes 2001 50: 308 -314. [Abstract] [Full Text] [PDF]

Lipotoxicity of the Pancreatic ß-Cell Is Associated With Glucose-Dependent Esterification of Fatty Acids Into Neutral Lipids: Isabelle Briaud, Jamie S. Harmon, Cynthia L. Kelpe, Venkatesh Babu G. Segu, and Vincent Poitout
Diabetes 2001 50: 315 -321. [Abstract] [Full Text] [PDF]

Dysregulation of Insulin Secretion in Children With Congenital Hyperinsulinism due to Sulfonylurea Receptor Mutations: A. Grimberg, R.J. Ferry, Jr., A. Kelly, S. Koo-McCoy, K. Polonsky, B. Glaser, M.A. Permutt, L. Aguilar-Bryan, D. Stafford, P.S. Thornton, L. Baker, and Charles A. Stanley
Diabetes 2001 50: 322 -328. [Abstract] [Full Text] [PDF]

Hyperinsulinism of Infancy: The Regulated Release of Insulin by K_ATP Channel—Independent Pathways: Susanne G. Straub, Karen E. Cosgrove, Carina Ämmälä, Ruth M. Shepherd, Rachel E. O'Brien, Philippa D. Barnes, Na'ama Kuchinski, Joanna C. Chapman, Michela Schaeppi, Benjamin Glaser, Keith J. Lindley, Geoffrey W.G. Sharp, Albert Aynsley-Green, and Mark J. Dunne
Diabetes 2001 50: 329 -339. [Abstract] [Full Text] [PDF]

Characterization of a K_ATP Channel—Independent Pathway Involved in Potentiation of Insulin Secretion by Efaroxan: Sue L.F. Chan, Mirna Mourtada, and Noel G. Morgan
Diabetes 2001 50: 340 -347. [Abstract] [Full Text] [PDF]

Physiological Increase in Plasma Leptin Markedly Inhibits Insulin Secretion In Vivo: Jane A. Cases, Ilan Gabriely, Xiao Hui Ma, Xiao Man Yang, Tamar Michaeli, Norman Fleischer, Luciano Rossetti, and Nir Barzilai
Diabetes 2001 50: 348 -352. [Abstract] [Full Text] [PDF]

Metabolic Regulation by Leucine of Translation Initiation Through the mTOR-Signaling Pathway by Pancreatic ß-Cells: Guang Xu, Guim Kwon, Wilhelm S. Cruz, Connie A. Marshall, and Michael L. McDaniel
Diabetes 2001 50: 353 -360. [Abstract] [Full Text] [PDF]

Expression and Distribution of Lactate/Monocarboxylate Transporter Isoforms in Pancreatic Islets and the Exocrine Pancreas: Chao Zhao, Marieangela C. Wilson, Franz Schuit, Andrew P. Halestrap, and Guy A. Rutter
Diabetes 2001 50: 361 -366. [Abstract] [Full Text] [PDF]

Pathophysiology:

${alpha}$ - and ß-Cell Responses to Small Changes in Plasma Glucose in the Conscious Dog: Nancy Flattem, Kayano Igawa, Masakazu Shiota, Maya G. Emshwiller, Doss W. Neal, and Alan D. Cherrington
Diabetes 2001 50: 367 -375. [Abstract] [Full Text] [PDF]

Central Infusion of Histamine Reduces Fat Accumulation and Upregulates UCP Family in Leptin-Resistant Obese Mice: Takayuki Masaki, Hironobu Yoshimatsu, Seiichi Chiba, Takeshi Watanabe, and Toshiie Sakata
Diabetes 2001 50: 376 -384. [Abstract] [Full Text] [PDF]

Targeted Disruption of Histamine H₁-Receptor Attenuates Regulatory Effects of Leptin on Feeding, Adiposity, and UCP Family in Mice: Takayuki Masaki, Hironobu Yoshimatsu, Seiichi Chiba, Takeshi Watanabe, and Toshiie Sakata
Diabetes 2001 50: 385 -391. [Abstract] [Full Text] [PDF]

Effects of Short-Term Improvement of Insulin Treatment and Glycemia on Hepatic Glycogen Metabolism in Type 1 Diabetes: Martin G. Bischof, Martin Krssak, Michael Krebs, Elisabeth Bernroider, Harald Stingl, Werner Waldhäusl, and Michael Roden
Diabetes 2001 50: 392 -398. [Abstract] [Full Text] [PDF]

Hypoglycemic Detection Does Not Occur in the Hepatic Artery or Liver: Findings Consistent With a Portal Vein Glucosensor Locus: Andrea L. Hevener, Richard N. Bergman, and Casey M. Donovan
Diabetes 2001 50: 399 -403. [Abstract] [Full Text] [PDF]

Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of ${alpha}$ -Lipoic Acid: Betty A. Maddux, Wendy See, John C. Lawrence, Jr., Amy L. Goldfine, Ira D. Goldfine, and Joseph L. Evans
Diabetes 2001 50: 404 -410. [Abstract] [Full Text] [PDF]

Peroxisome Proliferator—Activated Receptor (PPAR)- ${alpha}$ Activation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats: Comparison With PPAR- ${gamma}$ Activation: Ji-Ming Ye, Patrick J. Doyle, Miguel A. Iglesias, David G. Watson, Gregory J. Cooney, and Edward W. Kraegen
Diabetes 2001 50: 411 -417. [Abstract] [Full Text] [PDF]

Free Fatty Acids Induce Peripheral Insulin Resistance Without Increasing Muscle Hexosamine Pathway Product Levels in Rats: Cheol S. Choi, Felix N. Lee, and Jang H. Youn
Diabetes 2001 50: 418 -424. [Abstract] [Full Text] [PDF]

Transgenic Complementation of Leptin-Receptor Deficiency: I. Rescue of the Obesity/Diabetes Phenotype of LEPR-Null Mice Expressing a LEPR-B Transgene: Timothy J. Kowalski, Shun-Mei Liu, Rudolph L. Leibel, and Streamson C. Chua, Jr.
Diabetes 2001 50: 425 -435. [Abstract] [Full Text] [PDF]

Complications:

Redistribution of Sudomotor Responses Is an Early Sign of Sympathetic Dysfunction in Type 1 Diabetes: Robert D. Hoeldtke, Kimberly D. Bryner, Gabriella G. Horvath, Robert W. Phares, Lance F. Broy, and Gerald R. Hobbs
Diabetes 2001 50: 436 -443. [Abstract] [Full Text] [PDF]

Cyclic Stretch and Hypertension Induce Retinal Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor—2: Potential Mechanisms for Exacerbation of Diabetic Retinopathy by Hypertension: Izumi Suzuma, Yasuaki Hata, Allen Clermont, Frank Pokras, Susan L. Rook, Kiyoshi Suzuma, Edward P. Feener, and Lloyd Paul Aiello
Diabetes 2001 50: 444 -454. [Abstract] [Full Text] [PDF]

The Effect of Diabetes on Expression of ß₁-, ß₂-, and ß₃-Adrenoreceptors in Rat Hearts: Ü. Deniz Dinçer, Keshore R. Bidasee, Sahika Güner, Ayin Tay, A. Tanju Özçelikay, and V. Melih Altan
Diabetes 2001 50: 455 -461. [Abstract] [Full Text] [PDF]

Acute Hyperinsulinism Modulates Plasma Apolipoprotein B-48 Triglyceride—Rich Lipoproteins in Healthy Subjects During the Postprandial Period: Amandine Harbis, Catherine Defoort, Hervé Narbonne, Christine Juhel, Michèle Senft, Christian Latgé, Blandine Delenne, Henri Portugal, Catherine Atlan-Gepner, Bernard Vialettes, and Denis Lairon
Diabetes 2001 50: 462 -469. [Abstract] [Full Text] [PDF]

Epidemiology:

Type 1 Diabetes Manifested Solely by 2-h Oral Glucose Tolerance Test Criteria: Carla J. Greenbaum, David Cuthbertson, and Jeffrey P. Krischer
Diabetes 2001 50: 470 -476. [Abstract] [Full Text] [PDF]

Errata:

Erratum: Diabetes 2001 50: 477 . [Extract] [Full Text] [PDF]

Erratum: Diabetes 2001 50: 478 . [Extract] [Full Text] [PDF]