Immunology and Transplantation:

Defective Function of Fas in Patients With Type 1 Diabetes Associated With Other Autoimmune Diseases

Simona DeFranco, Sara Bonissoni, Franco Cerutti, Gianni Bona, Flavia Bottarel, Francesco Cadario, Alfredo Brusco, Giuseppe Loffredo, Ivana Rabbone, Andrea Corrias, Claudio Pignata, Ugo Ramenghi, and Umberto Dianzani
Diabetes 2001 50: 483 -488. [Abstract] [Full Text] [PDF]  

Markedly Decreased Oxygen Tension in Transplanted Rat Pancreatic Islets Irrespective of the Implantation Site

Per-Ola Carlsson, Fredrik Palm, Arne Andersson, and Per Liss
Diabetes 2001 50: 489 -495. [Abstract] [Full Text] [PDF]  

Effects of Kidney-Pancreas Transplantation on Atherosclerotic Risk Factors and Endothelial Function in Patients With Uremia and Type 1 Diabetes

Paolo Fiorina, Ennio La Rocca, Massimo Venturini, Fabio Minicucci, Isabella Fermo, Rita Paroni, Armando D’Angelo, Marisa Sblendido, Valerio Di Carlo, Marco Cristallo, Alessandro Del Maschio, Guido Pozza, and Antonio Secchi
Diabetes 2001 50: 496 -501. [Abstract] [Full Text] [PDF]  

Characterization of the Mouse Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Gene Promoter by In Situ Footprinting: Correlation With Fusion Gene Expression in the Islet-Derived ßTC-3 and Hamster Insulinoma Tumor Cell Lines

Larry J. Bischof, Cyrus C. Martin, Christina A. Svitek, Beth T. Stadelmaier, Lauri A. Hornbuckle, Joshua K. Goldman, James K. Oeser, John C. Hutton, and Richard M. O’Brien
Diabetes 2001 50: 502 -514. [Abstract] [Full Text] [PDF]  

Efficient Ex Vivo Transduction of Pancreatic Islet Cells With Recombinant Adeno-Associated Virus Vectors

Terence Flotte, Anupam Agarwal, Jianming Wang, Sihong Song, Elizabeth S. Fenjves, Luca Inverardi, Kye Chesnut, Sandra Afione, Scott Loiler, Clive Wasserfall, Matthias Kapturczak, Tamir Ellis, Harry Nick, and Mark Atkinson
Diabetes 2001 50: 515 -520. [Abstract] [Full Text] [PDF]  

Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

Henryk Zulewski, Elizabeth J. Abraham, Melissa J. Gerlach, Philip B. Daniel, Wolfgang Moritz, Beat Müller, Mario Vallejo, Melissa K. Thomas, and Joel F. Habener
Diabetes 2001 50: 521 -533. [Abstract] [Full Text] [PDF]  

The Prohormone Convertase Enzyme 2 (PC2) Is Essential for Processing Pro-Islet Amyloid Polypeptide at the NH₂-Terminal Cleavage Site

Jing Wang, Jun Xu, Jennifer Finnerty, Machi Furuta, Donald F. Steiner, and C. Bruce Verchere
Diabetes 2001 50: 534 -539. [Abstract] [Full Text] [PDF]  

Measurements of Cytoplasmic Ca²⁺ in Islet Cell Clusters Show That Glucose Rapidly Recruits ß-Cells and Gradually Increases the Individual Cell Response

Françoise C. Jonkers and Jean-Claude Henquin
Diabetes 2001 50: 540 -550. [Abstract] [Full Text] [PDF]  

Distinction Between Interleukin-1–Induced Necrosis and Apoptosis of Islet Cells

Anne Hoorens, Geert Stangé, Dejan Pavlovic, and Daniel Pipeleers
Diabetes 2001 50: 551 -557. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Effect of Vagal Cooling on the Counterregulatory Response to Hypoglycemia Induced by a Low Dose of Insulin in the Conscious Dog

Sylvain Cardin, Patricia A. Jackson, Dale S. Edgerton, Doss W. Neal, Christopher S. Coffey, and Alan D. Cherrington
Diabetes 2001 50: 558 -564. [Abstract] [Full Text] [PDF]  

Effect of Glucagon-Like Peptide-1(7-36)-Amide on Initial Splanchnic Glucose Uptake and Insulin Action in Humans With Type 1 Diabetes

Adrian Vella, Pankaj Shah, Rita Basu, Ananda Basu, Michael Camilleri, Frederick W. Schwenk, Jens J. Holst, and Robert A. Rizza
Diabetes 2001 50: 565 -572. [Abstract] [Full Text] [PDF]  

Insulin Resistance With Enhanced Insulin Signaling in High-Salt Diet–Fed Rats

Takehide Ogihara, Tomoichiro Asano, Katsuyuki Ando, Yuko Chiba, Nobuo Sekine, Hideyuki Sakoda, Motonobu Anai, Yukiko Onishi, Midori Fujishiro, Hiraku Ono, Nobuhiro Shojima, Kouichi Inukai, Yasushi Fukushima, Masatoshi Kikuchi, and Toshiro Fujita
Diabetes 2001 50: 573 -583. [Abstract] [Full Text] [PDF]  

Cellular Mechanism of Nutritionally Induced Insulin Resistance in Psammomys Obesus: Overexpression of Protein Kinase C in Skeletal Muscle Precedes the Onset of Hyperinsulinemia and Hyperglycemia

Yukio Ikeda, Grith S. Olsen, Ehud Ziv, Lone L. Hansen, Anna K. Busch, Bo F. Hansen, Eleazar Shafrir, and Luitgard Mosthaf-Seedorf
Diabetes 2001 50: 584 -592. [Abstract] [Full Text] [PDF]  

GLUT4 Overexpression in db/db Mice Dose-Dependently Ameliorates Diabetes But Is Not a Lifelong Cure

Joseph T. Brozinick, Jr., Scott C. McCoid, Thomas H. Reynolds, Nancy A. Nardone, Diane M. Hargrove, Ralph W. Stevenson, Samuel W. Cushman, and E. Michael Gibbs
Diabetes 2001 50: 593 -600. [Abstract] [Full Text] [PDF]  

Preferential Channeling of Energy Fuels Toward Fat Rather Than Muscle During High Free Fatty Acid Availability in Rats

Roberto Fabris, Enzo Nisoli, Anna Maria Lombardi, Cristina Tonello, Roberto Serra, Marnie Granzotto, Isabelle Cusin, Françoise Rohner-Jeanrenaud, Giovanni Federspil, Michele O. Carruba, and Roberto Vettor
Diabetes 2001 50: 601 -608. [Abstract] [Full Text] [PDF]  

Reduced Postprandial Concentrations of Intact Biologically Active Glucagon-Like Peptide 1 in Type 2 Diabetic Patients

Tina Vilsbøll, Thure Krarup, Carolyn F. Deacon, Sten Madsbad, and Jens J. Holst
Diabetes 2001 50: 609 -613. [Abstract] [Full Text] [PDF]  

A Genome-Wide Scan for Abdominal Fat Assessed by Computed Tomography in the Québec Family Study

Louis Pérusse, Treva Rice, Yvon C. Chagnon, Jean-Pierre Després, Simone Lemieux, Sonia Roy, Michel Lacaille, My-Ann Ho-Kim, Monique Chagnon, Michael A. Province, D.C. Rao, and Claude Bouchard
Diabetes 2001 50: 614 -621. [Abstract] [Full Text] [PDF]  

Glucokinase Gene Locus Transgenic Mice Are Resistant to the Development of Obesity-Induced Type 2 Diabetes

Masakazu Shiota, Catherine Postic, Yuka Fujimoto, Thomas L. Jetton, Kathryn Dixon, Danhua Pan, Joseph Grimsby, Joseph F. Grippo, Mark A. Magnuson, and Alan D. Cherrington
Diabetes 2001 50: 622 -629. [Abstract] [Full Text] [PDF]  

Complications:

Autonomic Neuropathy in Nondiabetic Offspring of Type 2 Diabetic Subjects Is Associated With Urinary Albumin Excretion Rate and 24-h Ambulatory Blood Pressure: The Fredericia Study

C. Hauerslev Foss, E. Vestbo, A. Frøland, H.J. Gjessing, C.E. Mogensen, and E.M. Damsgaard
Diabetes 2001 50: 630 -636. [Abstract] [Full Text] [PDF]  

A Polymorphism in the Gene for IGF-I: Functional Properties and Risk for Type 2 Diabetes and Myocardial Infarction

Norbert Vaessen, Peter Heutink, Joop A. Janssen, Jacqueline C. M. Witteman, Leon Testers, Albert Hofman, Steven W. J. Lamberts, Ben A. Oostra, Huibert A. P. Pols, and Cornelia M. van Duijn
Diabetes 2001 50: 637 -642. [Abstract] [Full Text] [PDF]  

Studies With Apolipoprotein A-II Transgenic Mice Indicate a Role for HDLs in Adiposity and Insulin Resistance

Lawrence W. Castellani, Aimie M. Goto, and Aldons J. Lusis
Diabetes 2001 50: 643 -651. [Abstract] [Full Text] [PDF]  

Lipid Transfer Protein Activities in Type 1 Diabetic Patients Without Renal Failure and Nondiabetic Control Subjects and Their Association With Coronary Artery Calcification

Helen M. Colhoun, Leo M. Scheek, Michael B. Rubens, Teus Van Gent, S. Richard Underwood, John H. Fuller, and Arie Van Tol
Diabetes 2001 50: 652 -659. [Abstract] [Full Text] [PDF]  

Direct Regulatory Effect of Fatty Acids on Macrophage Lipoprotein Lipase: Potential Role of PPARs

Sophie Élise Michaud and Geneviève Renier
Diabetes 2001 50: 660 -666. [Abstract] [Full Text] [PDF]  

Inhibition of Lipid Peroxidation Restores Impaired Vascular Endothelial Growth Factor Expression and Stimulates Wound Healing and Angiogenesis in the Genetically Diabetic Mouse

Domenica Altavilla, Antonino Saitta, Domenico Cucinotta, Mariarosaria Galeano, Barbara Deodato, Michele Colonna, Valerio Torre, Giuseppina Russo, Aurora Sardella, Giuseppe Urna, Giuseppe M. Campo, Vittorio Cavallari, Giovanni Squadrito, and Francesco Squadrito
Diabetes 2001 50: 667 -674. [Abstract] [Full Text] [PDF]  

Genetics:

A Gene Conferring Susceptibility to Type 2 Diabetes in Conjunction With Obesity Is Located on Chromosome 18p11

Alex Parker, Joanne Meyer, Steve Lewitzky, Jean S. Rennich, Gayun Chan, Jeffrey D. Thomas, Marju Orho-Melander, Mikko Lehtovirta, Carol Forsblom, Auli Hyrkkö, Martin Carlsson, Cecilia Lindgren, and Leif C. Groop
Diabetes 2001 50: 675 -680. [Abstract] [Full Text] [PDF]  

A Genome Scan for Type 2 Diabetes Susceptibility Loci in a Genetically Isolated Population

Marshall A. Permutt, Jonathon C. Wasson, Brian K. Suarez, Jennifer Lin, Jeffrey Thomas, Joanne Meyer, Steve Lewitzky, Jean S. Rennich, Alex Parker, Laura DuPrat, Sanchit Maruti, Susan Chayen, and Benjamin Glaser
Diabetes 2001 50: 681 -685. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

Evidence for Gene-Nutrient Interaction at the PPAR Locus

Jian’an Luan, Paul O. Browne, Anne-Helen Harding, David J. Halsall, Stephen O’Rahilly, V.K. Krishna Chatterjee, and Nicholas J. Wareham
Diabetes 2001 50: 686 -689. [Abstract] [Full Text] [PDF]  

In Vitro and In Vivo Studies of a Naturally Occurring Variant of the Human p85 Regulatory Subunit of the Phosphoinositide 3-Kinase: Inhibition of Protein Kinase B and Relationships With Type 2 Diabetes, Insulin Secretion, Glucose Disappearance Constant, and Insulin Sensitivity

Lars Hansen, Björn Zethelius, Lars Berglund, Richard Reneland, Torben Hansen, Christian Berne, Hans Lithell, Brian A. Hemmings, and Oluf Pedersen
Diabetes 2001 50: 690 -693. [Abstract] [Full Text] [PDF]  

Mutations in the Coding Region of the Neurogenin 3 Gene (NEUROG3) Are Not a Common Cause of Maturity-Onset Diabetes of the Young in Japanese Subjects

Laura del Bosque-Plata, Joseph Lin, Yukio Horikawa, Peter E.H. Schwarz, Nancy J. Cox, Naoko Iwasaki, Makiko Ogata, Yasuhiko Iwamoto, Michael S. German, and Graeme I. Bell
Diabetes 2001 50: 694 -696. [Abstract] [Full Text] [PDF]  

Decreased Fasting and Oral Glucose Stimulated C-peptide in Nondiabetic Subjects With Sequence Variants in the Sulfonylurea Receptor 1 Gene

S. John Weisnagel, Tuomo Rankinen, André Nadeau, D.C. Rao, Yvon C. Chagnon, Louis Pérusse, and Claude Bouchard
Diabetes 2001 50: 697 -702. [Abstract] [Full Text] [PDF]  

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