Perspectives in Diabetes:

The Neuropeptide Pituitary Adenylate Cyclase–Activating Polypeptide and Islet Function

Karin Filipsson, Martina Kvist-Reimer, and Bo Ahrén
Diabetes 2001 50: 1959 -1969. [Abstract] [Full Text] [PDF]  

Rapid Publications:

A Role for Hormone-Sensitive Lipase in Glucose-Stimulated Insulin Secretion: A Study in Hormone-Sensitive Lipase-Deficient Mice

Raphaël Roduit, Pellegrino Masiello, Shu Pei Wang, Hong Li, Grant A. Mitchell, and Marc Prentki
Diabetes 2001 50: 1970 -1975. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Isolation and Functional Characterization of Recombinant GAD65 Autoantibodies Derived by IgG Repertoire Cloning From Patients With Type 1 Diabetes

Karin Jury, Petra Söhnlein, Monique Vogel, and Wiltrud Richter
Diabetes 2001 50: 1976 -1982. [Abstract] [Full Text] [PDF]  

Heme Oxygenase-1 Induction in Islet Cells Results in Protection From Apoptosis and Improved In Vivo Function After Transplantation

Antonello Pileggi, R. Damaris Molano, Thierry Berney, Pierre Cattan, Caterina Vizzardelli, Robert Oliver, Christopher Fraker, Camillo Ricordi, Ricardo L. Pastori, Fritz H. Bach, and Luca Inverardi
Diabetes 2001 50: 1983 -1991. [Abstract] [Full Text] [PDF]  

Autoreactive Diabetogenic T-Cells in NOD Mice Can Efficiently Expand From a Greatly Reduced Precursor Pool

David V. Serreze, Ellis A. Johnson, Harold D. Chapman, Robert T. Graser, Michele P. Marron, Teresa P. DiLorenzo, Pablo Silveira, Yoshitaka Yoshimura, Stanley G. Nathenson, and Sebastian Joyce
Diabetes 2001 50: 1992 -2000. [Abstract] [Full Text] [PDF]  

Islet Studies:

Decrease in ß-Cell Mass Leads to Impaired Pulsatile Insulin Secretion, Reduced Postprandial Hepatic Insulin Clearance, and Relative Hyperglucagonemia in the Minipig

Lise L. Kjems, Barbara M. Kirby, Elizabeth M. Welsh, Johannes D. Veldhuis, Marty Straume, Susan S. McIntyre, Dongchang Yang, Pierre Lefèbvre, and Peter C. Butler
Diabetes 2001 50: 2001 -2012. [Abstract] [Full Text] [PDF]  

Calpains Play a Role in Insulin Secretion and Action

Seamus K. Sreenan, Yun-Ping Zhou, Kenichi Otani, Polly A. Hansen, Kevin P.M. Currie, Chien-Yuan Pan, Jean-Pyo Lee, Diane M. Ostrega, William Pugh, Yukio Horikawa, Nancy J. Cox, Craig L. Hanis, Charles F. Burant, Aaron P. Fox, Graeme I. Bell, and Kenneth S. Polonsky
Diabetes 2001 50: 2013 -2020. [Abstract] [Full Text] [PDF]  

Expression of the Receptor Tyrosine Kinase KIT in Mature ß-Cells and in the Pancreas in Development

Latif Rachdi, Lynda El Ghazi, Florence Bernex, Jean-Jacques Panthier, Paul Czernichow, and Raphael Scharfmann
Diabetes 2001 50: 2021 -2028. [Abstract] [Full Text] [PDF]  

A Low-Affinity Ca²⁺-Dependent Association of Calmodulin With the Rab3A Effector Domain Inversely Correlates With Insulin Exocytosis

Hiroshi Kajio, Scott Olszewski, Philip J. Rosner, Matthew J. Donelan, Kieran F. Geoghegan, and Christopher J. Rhodes
Diabetes 2001 50: 2029 -2039. [Abstract] [Full Text] [PDF]  

Overexpression of Metallothionein in Pancreatic ß-Cells Reduces Streptozotocin-Induced DNA Damage and Diabetes

Hainan Chen, Edward C. Carlson, Lori Pellet, Jon T. Moritz, and Paul N. Epstein
Diabetes 2001 50: 2040 -2046. [Abstract] [Full Text] [PDF]  

Pathophysiology:

The Generalized Aminoaciduria Seen in Patients With Hepatocyte Nuclear Factor-1 Mutations Is a Feature of All Patients With Diabetes and Is Associated With Glucosuria

Coralie Bingham, Sian Ellard, Anthony J. Nicholls, Charles A. Pennock, John Allen, Alan J. James, Simon C. Satchell, Maurice B. Salzmann, and Andrew T. Hattersley
Diabetes 2001 50: 2047 -2052. [Abstract] [Full Text] [PDF]  

Use of a cDNA Array for the Identification of Genes Induced in Islets of Suckling Rats by a High-Carbohydrate Nutritional Intervention

Fei Song, Malathi Srinivasan, Ravikumar Aalinkeel, and Mulchand S. Patel
Diabetes 2001 50: 2053 -2060. [Abstract] [Full Text] [PDF]  

Combined Treatment With Benzylamine and Low Dosages of Vanadate Enhances Glucose Tolerance and Reduces Hyperglycemia in Streptozotocin-Induced Diabetic Rats

Luc Marti, Anna Abella, Christian Carpéné, Manuel Palacín, Xavier Testar, and Antonio Zorzano
Diabetes 2001 50: 2061 -2068. [Abstract] [Full Text] [PDF]  

Interactions of Impaired Glucose Transport and Phosphorylation in Skeletal Muscle Insulin Resistance: A Dose-Response Assessment Using Positron Emission Tomography

Katherine V. Williams, Julie C. Price, and David E. Kelley
Diabetes 2001 50: 2069 -2079. [Abstract] [Full Text] [PDF]  

Adipocyte Produces Matrix Metalloproteinases 2 and 9: Involvement in Adipose Differentiation

Anne Bouloumié, Coralie Sengenès, Ghyslaine Portolan, Jean Galitzky, and Max Lafontan
Diabetes 2001 50: 2080 -2086. [Abstract] [Full Text] [PDF]  

Abnormal Glucose Handling by the Kidney in Response to Hypoglycemia in Type 1 Diabetes

Eugenio Cersosimo, Peter Garlick, and John Ferretti
Diabetes 2001 50: 2087 -2093. [Abstract] [Full Text] [PDF]  

PPAR Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein

Norikazu Maeda, Masahiko Takahashi, Tohru Funahashi, Shinji Kihara, Hitoshi Nishizawa, Ken Kishida, Hiroyuki Nagaretani, Morihiro Matsuda, Ryutaro Komuro, Noriyuki Ouchi, Hiroshi Kuriyama, Kikuko Hotta, Tadashi Nakamura, Iichiro Shimomura, and Yuji Matsuzawa
Diabetes 2001 50: 2094 -2099. [Abstract] [Full Text] [PDF]  

Complications:

Reduced Oral Wound Healing in the NOD Mouse Model for Type 1 Autoimmune Diabetes and Its Reversal by Epidermal Growth Factor Supplementation

Akos Nagy, Hiroyuki Nagashima, Seunghee Cha, Gregory E. Oxford, Tivadar Zelles, Ammon B. Peck, and Michael G. Humphreys-Beher
Diabetes 2001 50: 2100 -2104. [Abstract] [Full Text] [PDF]  

Glucose and Palmitic Acid Induce Degeneration of Myofibrils and Modulate Apoptosis in Rat Adult Cardiomyocytes

Daniela Dyntar, Monika Eppenberger-Eberhardt, Kathrin Maedler, Martin Pruschy, Hans M. Eppenberger, Giatgen A. Spinas, and Marc Y. Donath
Diabetes 2001 50: 2105 -2113. [Abstract] [Full Text] [PDF]  

Overexpression of Cu²⁺/Zn²⁺ Superoxide Dismutase Protects Against Early Diabetic Glomerular Injury in Transgenic Mice

Patricia A. Craven, Mona F. Melhem, Stephen L. Phillips, and Frederick R. DeRubertis
Diabetes 2001 50: 2114 -2125. [Abstract] [Full Text] [PDF]  

Changes in Matrix Proteoglycans Induced by Insulin and Fatty Acids in Hepatic Cells May Contribute to Dyslipidemia of Insulin Resistance

Urban Olsson, Ann-Charlotte Egnell, Mariam Rodríguez Lee, Gunnel Östergren Lundén, Malin Lorentzon, Markku Salmivirta, Göran Bondjers, and Germán Camejo
Diabetes 2001 50: 2126 -2132. [Abstract] [Full Text] [PDF]  

Depressed Levels of Ca²⁺-Cycling Proteins May Underlie Sarcoplasmic Reticulum Dysfunction in the Diabetic Heart

Thomas Netticadan, Rana M. Temsah, Ardeep Kent, Vijayan Elimban, and Naranjan S. Dhalla
Diabetes 2001 50: 2133 -2138. [Abstract] [Full Text] [PDF]  

Human Fructosamine-3-Kinase: Purification, Sequencing, Substrate Specificity, and Evidence of Activity In Vivo

Benjamin S. Szwergold, Scott Howell, and Paul J. Beisswenger
Diabetes 2001 50: 2139 -2147. [Abstract] [Full Text] [PDF]  

Skeletal Muscle of Stroke-Prone Spontaneously Hypertensive Rats Exhibits Reduced Insulin-Stimulated Glucose Transport and Elevated Levels of Caveolin and Flotillin

Declan J. James, Fiona Cairns, Ian P. Salt, Gregory J. Murphy, Anna F. Dominiczak, John M.C. Connell, and Gwyn W. Gould
Diabetes 2001 50: 2148 -2156. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

Mutational Screening of the CART Gene in Obese Children: Identifying a Mutation (Leu34Phe) Associated With Reduced Resting Energy Expenditure and Cosegregating With Obesity Phenotype in a Large Family

Emanuele Miraglia del Giudice, Nicola Santoro, Grazia Cirillo, Luigi D’Urso, Rosario Di Toro, and Laura Perrone
Diabetes 2001 50: 2157 -2160. [Abstract] [Full Text] [PDF]  

Functional Significance of the UCSNP-43 Polymorphism in the CAPN10 Gene for Proinsulin Processing and Insulin Secretion in Nondiabetic Germans

Michael Stumvoll, Andreas Fritsche, Alexander Madaus, Norbert Stefan, Melanie Weisser, Fausto Machicao, and Hans Häring
Diabetes 2001 50: 2161 -2163. [Abstract] [Full Text] [PDF]  

Role of Allelic Variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in Moderate-to-Severe Insulin Resistance of Women With Polycystic Ovary Syndrome

Samira Ait El Mkadem, Corinne Lautier, Françoise Macari, Nicolas Molinari, Patrick Lefèbvre, Eric Renard, Jean Christophe Gris, Gérard Cros, Jean Pierre Daurès, Jacques Bringer, Morris F. White, and Florin Grigorescu
Diabetes 2001 50: 2164 -2168. [Abstract] [Full Text] [PDF]  

Association of a Novel Point Mutation (C159G) of the CTLA4 Gene With Type 1 Diabetes in West Africans but not in Chinese

Douglas Osei-Hyiaman, Lifang Hou, Ren Zhiyin, Zhang Zhiming, Haiquin Yu, Abena Agyeiwaa Amankwah, and Shoji Harada
Diabetes 2001 50: 2169 -2171. [Abstract] [Full Text] [PDF]  

Genetic Variation in the Peroxisome Proliferator–Activated Receptor-2 Gene (Pro12Ala) Affects Metabolic Responses to Weight Loss and Subsequent Weight Regain

Barbara J. Nicklas, Elisabeth F.C. van Rossum, Dora M. Berman, Alice S. Ryan, Karen E. Dennis, and Alan R. Shuldiner
Diabetes 2001 50: 2172 -2176. [Abstract] [Full Text] [PDF]  

Errata:

Erratum

Diabetes 2001 50: 2177 -2178. [Extract] [Full Text] [PDF]  

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