Editorials:

The islet in type 2 diabetes: back to center stage

E Cerasi, C Boitard, S Efendic, E Ferrannini, JC Henquin, and DF Steiner
Diabetes 2001 50: S S1 -S3. [PDF]  

Section 1:

Developmental biology of the pancreas

H Edlund
Diabetes 2001 50: S S5 -S9. [PDF]  

Changes in the expression of transcription factors in pancreatic AR42J cells during differentiation into insulin-producing cells

Y Zhang, H Mashima, and I Kojima
Diabetes 2001 50: S S10 -S14. [PDF]  

Online monitoring of stimulus-induced gene expression in pancreatic beta-cells

T Moede, B Leibiger, P Berggren, and IB Leibiger
Diabetes 2001 50: S S15 -S19. [PDF]  

Beta-cell turnover: its assessment and implications

S Bonner-Weir
Diabetes 2001 50: S S20 -S24. [PDF]  

Regulation of beta-cell mass by hormones and growth factors

JH Nielsen, ED Galsgaard, A Møldrup, B Nissen Friedrichsen, N Billestrup, JA Hansen, YC Lee, and C Carlsson
Diabetes 2001 50: S S25 -S29. [PDF]  

Endocrine pancreas plasticity under physiological and pathological conditions

C Bernard-Kargar and A Ktorza
Diabetes 2001 50: S S30 -S35. [PDF]  

Insulin promoter factor-1 controls several aspects of beta-cell identity

N Baeza, A Hart, U Ahlgren, and H Edlund
Diabetes 2001 50: S S36 . [PDF]  

Regulatory elements involved in human pdx-1 gene expression

S Marshak, E Ben-Shushan, M Shoshkes, L Havin, E Cerasi, and D Melloul
Diabetes 2001 50: S S37 -S38. [PDF]  

Na-Pi cotransporter expressed during the differentiation of pancreatic AR42J cells

H Mashima, Y Zhang, T Tajima, J Takeda, and I Kojima
Diabetes 2001 50: S S39 . [PDF]  

Expression of dominant-negative STAT5 inhibits growth hormone- and prolactin-induced proliferation of insulin-producing cells

E Douglas Galsgaard, B Nissen Friedrichsen, JH Nielsen, and A Møldrup
Diabetes 2001 50: S S40 -S41. [PDF]  

Novel pancreatic precursor cell lines for studying beta-cell differentiation

A Sharma, M Taneja, P Rietz, J Weitekamp, and S Bonner-Weir
Diabetes 2001 50: S S42 -S43. [PDF]  

Section 2:

Role of apoptosis in pancreatic beta-cell death in diabetes

J Chandra, B Zhivotovsky, S Zaitsev, L Juntti-Berggren, P Berggren, and S Orrenius
Diabetes 2001 50: S S44 -S47. [PDF]  

Roles of ATP-sensitive K+ channels in cell survival and differentiation in the endocrine pancreas

T Miki, T Iwanaga, K Nagashima, Y Ihara, and S Seino
Diabetes 2001 50: S S48 -S51. [PDF]  

Role of pancreatic beta-cells in the process of beta-cell death

D Pipeleers, A Hoorens, M Marchial-Pipeleers, M Van de Casteele, L Bouwens, and Z Ling
Diabetes 2001 50: S S52 -S57. [PDF]  

Beta-cell apoptosis: stimuli and signaling

T Mandrup-Poulsen
Diabetes 2001 50: S S58 -S63. [PDF]  

Beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes

DL Eizirik and MI Darville
Diabetes 2001 50: S S64 -S69. [PDF]  

Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis

SV Zaitsev, IB Appelskog, IL Kapelioukh, S Yang, M Köhler, S Efendic, and P Berggren
Diabetes 2001 50: S S70 -S76. [PDF]  

Effects of serum from patients with type 1 diabetes on primary cerebellar granule cells

J Chandra, S Yang, M Köhler, S Zaitsev, L Juntti-Berggren, P Berggren, B Zhivotovsky, and S Orrenius
Diabetes 2001 50: S S77 -S81. [PDF]  

Cytokine-mediated apoptosis in rat beta-cells is preceded by downregulation of Bcl-2 and Bax-omega expression

M Van de Casteele, H Heimberg, Z Ling, and DG Pipeleers
Diabetes 2001 50: S S82 . [PDF]  

Molecular regulation of Fas expression in beta-cells

MI Darville, D Liu, M Chen, and DL Eizirik
Diabetes 2001 50: S S83 . [PDF]  

Section 3:

Early development of beta-cells is impaired in the GK rat model of type 2 diabetes

F Miralles and B Portha
Diabetes 2001 50: S S84 -S88. [PDF]  

beta-Cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colony

B Portha, M Giroix, P Serradas, M Gangernau, J Movassat, F Rajas, D Bailbe, and C Plachot
Diabetes 2001 50: S S89 -S93. [PDF]  

Beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors

TM Frayling, JC Evans, MP Bulman, E Pearson, L Allen, K Owen, C Bingham, M Hannemann, M Shepherd, S Ellard, and AT Hattersley
Diabetes 2001 50: S S94 -S100. [PDF]  

Beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations

ER Pearson, G Velho, P Clark, A Stride, M Shepherd, TM Frayling, MP Bulman, S Ellard, P Froguel, and AT Hattersley
Diabetes 2001 50: S S101 -S107. [PDF]  

Hyperglycemia contributes to impaired insulin response in GK rat islets

Z Ling, C Hong-Lie, C Östenson, S Efendic, and A Khan
Diabetes 2001 50: S S108 -S112. [PDF]  

Beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes

G Leibowitz, M Yuli, MY Donath, R Nesher, D Melloul, E Cerasi, DJ Gross, and N Kaiser
Diabetes 2001 50: S S113 -S117. [PDF]  

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

RH Unger and Y Zhou
Diabetes 2001 50: S S118 -S121. [PDF]  

Overstimulation and beta-cell function

V Grill and A Björklund
Diabetes 2001 50: S S122 -S124. [PDF]  

Sialylated form of the neural cell adhesion molecule (NCAM): a new tool for the identification and sorting of beta-cell subpopulations with different functional activity

C Bernard-Kargar, N Kassis, M Berthault, W Pralong, and A Ktorza
Diabetes 2001 50: S S125 -S130. [PDF]  

Beta-cell-specific expression of insulin and PDX-1 genes

S Marshak, E Benshushan, M Shoshkes, G Leibovitz, N Kaiser, D Gross, F Bertuzzi, E Cerasi, and D Melloul
Diabetes 2001 50: S S131 -S132. [PDF]  

Establishment of a Tet-On gene expression system in glucose-responsive and -unresponsive MIN6 cells

Y Kashima, T Miki, K Minami, and S Seino
Diabetes 2001 50: S S133 . [PDF]  

Identification of genes involved in glucose-stimulated insulin secretion

PB Jensen, FK Knop, G Chen, HE Hohmeier, H Mulder, and CB Newgard
Diabetes 2001 50: S S134 . [PDF]  

Expression profiling of pancreatic beta-cells: glucose regulation of secretory and metabolic pathway genes

GC Webb, MS Akbar, C Zhao, and DF Steiner
Diabetes 2001 50: S S135 -S136. [PDF]  

Potential role of the early response gene c-myc in beta-cell adaptation to changes in glucose concentration

J Jonas, R Laybutt, GM Steil, N Trivedi, GC Weir, and J Henquin
Diabetes 2001 50: S S137 . [PDF]  

Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of type 2 diabetes

G Leibowitz, D Melloul, M Yuli, DJ Gross, Å Apelqvist, H Edlund, E Cerasi, and N Kaiser
Diabetes 2001 50: S S138 -S139. [PDF]  

Section 4:

IRS proteins and beta-cell function

DJ Burks and MF White
Diabetes 2001 50: S S140 -S145. [PDF]  

Endocrine pancreas in insulin receptor-deficient mouse pups

M Jackerott, A Baudry, B Lamothe, D Bucchini, J Jami, and RL Joshi
Diabetes 2001 50: S S146 -S149. [PDF]  

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2

L Leroux, P Desbois, L Lamotte, B Duvillié, N Cordonnier, M Jackerott, J Jami, D Bucchini, and RJ Joshi
Diabetes 2001 50: S S150 -S153. [PDF]  

Beta-cell adaptation and decompensation during the progression of diabetes

GC Weir, DR Laybutt, H Kaneto, S Bonner-Weir, and A Sharma
Diabetes 2001 50: S S154 -S159. [PDF]  

Beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms

D Porte, Jr and SE Kahn
Diabetes 2001 50: S S160 -S163. [PDF]  

A model for glucose control of insulin secretion during 24 h of free living

A Mari, S Camastra, E Toschi, A Giancaterini, A Gastaldelli, G Mingrone, and E Ferrannini
Diabetes 2001 50: S S164 -S168. [PDF]  

Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?

A Clark, L Jones, E de Koning, BC Hansen, and DR Matthews
Diabetes 2001 50: S S169 -S171. [PDF]  

Human type 2 diabetes: morphological evidence for abnormal beta-cell function

C Sempoux, Y Guiot, D Dubois, P Moulin, and J Rahier
Diabetes 2001 50: S S172 -S177. [PDF]  

A model for assessing insulin secretion and its control under free-living conditions

E Toschi, S Camastra, A Mari, A Gastaldelli, S Baldi, A Masoni, and E Ferrannini
Diabetes 2001 50: S S178 -S179. [PDF]  

Beta-cell adaptation to hyperglycemia

R Laybutt, W Hasenkamp, A Groff, S Grey, J Jonas, H Kaneto, A Sharma, S Bonner-Weir, and G Weir
Diabetes 2001 50: S S180 -S181. [PDF]  

The focal form of persistent hyperinsulinemic hypoglycemia of infancy

C Sempoux, Y Guiot, and J Rahier
Diabetes 2001 50: S S182 -S183. [PDF]  

Oophorectomy promotes islet amyloid formation in human islet amyloid polypeptide transgenic mice

RL Hull, B Verchere, S Andrikopoulos, F Wang, J Vidal, and SE Kahn
Diabetes 2001 50: S S184 -S185. [PDF]  

Beta-cell neogenesis in type 2 diabetes

LC Jones and A Clark
Diabetes 2001 50: S S186 -S187. [PDF]  

No decrease of the beta-cell mass in type 2 diabetic patients

Y Guiot, C Sempoux, P Moulin, and J Rahier
Diabetes 2001 50: S S188 . [PDF]  

Prospects for treatment of type 2 diabetes by expansion of the beta-cell mass

S Efrat
Diabetes 2001 50: S S189 -S190. [PDF]  

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