Diabetes -- Table of Contents (January 2002, 51 [1])

Rapid Publications:

A P387L Variant in Protein Tyrosine Phosphatase-1B (PTP-1B) Is Associated With Type 2 Diabetes and Impaired Serine Phosphorylation of PTP-1B In Vitro: Søren M. Echwald, Helle Bach, Henrik Vestergaard, Bjørn Richelsen, Kurt Kristensen, Thomas Drivsholm, Knut Borch-Johnsen, Torben Hansen, and Oluf Pedersen
Diabetes 2002 51: 1 -6. First published on December 11, 2001 as 10.2337/diabetes.51.1.1 [Abstract] [Full Text] [PDF]

Banting Lecture 2001:

Banting Lecture 2001: Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes: J. Denis McGarry
Diabetes 2002 51: 7 -18. [Extract] [Full Text] [PDF]

Metabolism and Signal Transduction:

Phosphatidylinositol 3-Kinase Redistribution Is Associated With Skeletal Muscle Insulin Resistance in Gestational Diabetes Mellitus: Jianhua Shao, Hiroshi Yamashita, Liping Qiao, Boris Draznin, and Jacob E. Friedman
Diabetes 2002 51: 19 -29. [Abstract] [Full Text] [PDF]

Regulation of Glucose Transport and Insulin Signaling by Troglitazone or Metformin in Adipose Tissue of Type 2 Diabetic Subjects: Theodore P. Ciaraldi, Alice P.S. Kong, Neelima V. Chu, Dennis D. Kim, Sunita Baxi, Mattias Loviscach, Ray Plodkowski, Richard Reitz, Michael Caulfield, Sunder Mudaliar, and Robert R. Henry
Diabetes 2002 51: 30 -36. [Abstract] [Full Text] [PDF]

Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity: Interaction With Family History of Type 2 Diabetes: Michael Stumvoll, Otto Tschritter, Andreas Fritsche, Harald Staiger, Walter Renn, Melanie Weisser, Fausto Machicao, and Hans Häring
Diabetes 2002 51: 37 -41. [Abstract] [Full Text] [PDF]

Skeletal Muscle Microvascular Recruitment by Physiological Hyperinsulinemia Precedes Increases in Total Blood Flow: M.A. Vincent, D. Dawson, A.D.H. Clark, J.R. Lindner, S. Rattigan, M.G. Clark, and E.J. Barrett
Diabetes 2002 51: 42 -48. [Abstract] [Full Text] [PDF]

Hepatic Glycogen Metabolism in Type 1 Diabetes After Long-Term Near Normoglycemia: Martin G. Bischof, Elisabeth Bernroider, Martin Krssak, Michael Krebs, Harald Stingl, Peter Nowotny, Chunlin Yu, Gerald I. Shulman, Werner Waldhäusl, and Michael Roden
Diabetes 2002 51: 49 -54. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation: Lorenzo Piemonti, Biagio Eugenio Leone, Rita Nano, Alessandra Saccani, Paolo Monti, Paola Maffi, Giancarlo Bianchi, Antonio Sica, Giuseppe Peri, Raffaella Melzi, Luca Aldrighetti, Antonio Secchi, Valerio Di Carlo, Paola Allavena, and Federico Bertuzzi
Diabetes 2002 51: 55 -65. [Abstract] [Full Text] [PDF]

ß-Cell Death and Mass in Syngeneically Transplanted Islets Exposed to Short- and Long-Term Hyperglycemia: Montserrat Biarnés, Marta Montolio, Victor Nacher, Mercè Raurell, Joan Soler, and Eduard Montanya
Diabetes 2002 51: 66 -72. [Abstract] [Full Text] [PDF]

Oral Exposure to Diabetes-Promoting Food or Immunomodulators in Neonates Alters Gut Cytokines and Diabetes: Fraser W. Scott, Paul Rowsell, Gen-Sheng Wang, Karolina Burghardt, Hubert Kolb, and Stefanie Flohé
Diabetes 2002 51: 73 -78. [Abstract] [Full Text] [PDF]

A Distinct Th1 Immune Response Precedes the Described Th2 Response in Islet Xenograft Rejection: Henrik Krook, Anette Hagberg, Zhenshun Song, Ulf Landegren, Lars Wennberg, and Olle Korsgren
Diabetes 2002 51: 79 -86. [Abstract] [Full Text] [PDF]

Islet Studies:

Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca²⁺] Elevation Signals: Kazuhiro Eto, Tokuyuki Yamashita, Yoshiharu Tsubamoto, Yasuo Terauchi, Kenzo Hirose, Naoto Kubota, Shigeo Yamashita, Junko Taka, Shinobu Satoh, Hisahiko Sekihara, Kazuyuki Tobe, Masamitsu Iino, Mitsuhiko Noda, Satoshi Kimura, and Takashi Kadowaki
Diabetes 2002 51: 87 -97. [Abstract] [Full Text] [PDF]

A Key Role for ß-Cell Cytosolic Phospholipase A₂ in the Maintenance of Insulin Stores But Not in the Initiation of Insulin Secretion: Shanta J. Persaud, Helen M. Roderigo-Milne, Paul E. Squires, David Sugden, Caroline P.D. Wheeler-Jones, Phil J. Marsh, Véronique D. Belin, Melanie J. Luther, and Peter M. Jones
Diabetes 2002 51: 98 -104. [Abstract] [Full Text] [PDF]

Intracellular pH Plays a Critical Role in Glucose-Induced Time-Dependent Potentiation of Insulin Release in Rat Islets: Subhadra C. Gunawardana and Geoffrey W.G. Sharp
Diabetes 2002 51: 105 -113. [Abstract] [Full Text] [PDF]

Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1 ${alpha}$ in Pancreatic ß-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced ß-cell Proliferation, and Diabetes: Kazuya Yamagata, Takao Nammo, Makoto Moriwaki, Arisa Ihara, Katsumi Iizuka, Qin Yang, Tomomi Satoh, Ming Li, Rikako Uenaka, Kohei Okita, Hiromi Iwahashi, Qian Zhu, Yang Cao, Akihisa Imagawa, Yoshihiro Tochino, Toshiaki Hanafusa, Jun-ichiro Miyagawa, and Yuji Matsuzawa
Diabetes 2002 51: 114 -123. [Abstract] [Full Text] [PDF]

Ghrelin Is Present in Pancreatic ${alpha}$ -Cells of Humans and Rats and Stimulates Insulin Secretion: Yukari Date, Masamitsu Nakazato, Suzuko Hashiguchi, Katsuya Dezaki, Muhtashan S. Mondal, Hiroshi Hosoda, Masayasu Kojima, Kenji Kangawa, Terukatsu Arima, Hisayuki Matsuo, Toshihiko Yada, and Shigeru Matsukura
Diabetes 2002 51: 124 -129. [Abstract] [Full Text] [PDF]

Pathophysiology:

Basal Insulin Gene Expression Significantly Improves Conventional Insulin Therapy in Type 1 Diabetic Rats: Hengjiang Dong, Jennifer Altomonte, Nuria Morral, Marcia Meseck, Swan N. Thung, and Savio L.C. Woo
Diabetes 2002 51: 130 -138. [Abstract] [Full Text] [PDF]

Intrahepatic Mechanisms Underlying the Effect of Metformin in Decreasing Basal Glucose Production in Rats Fed a High-Fat Diet: Gilles Mithieux, Ludovic Guignot, Jean-Claude Bordet, and Nicolas Wiernsperger
Diabetes 2002 51: 139 -143. [Abstract] [Full Text] [PDF]

Insulin Resistance in Morbid Obesity: Reversal With Intramyocellular Fat Depletion: Aldo V. Greco, Gertrude Mingrone, Annalisa Giancaterini, Melania Manco, Manrico Morroni, Saverio Cinti, Marnie Granzotto, Roberto Vettor, Stefania Camastra, and Ele Ferrannini
Diabetes 2002 51: 144 -151. [Abstract] [Full Text] [PDF]

Chronic Central Melanocortin-4 Receptor Antagonism and Central Neuropeptide-Y Infusion in Rats Produce Increased Adiposity by Divergent Pathways: Katherine Baran, Elaine Preston, Donna Wilks, Gregory J. Cooney, Edward W. Kraegen, and Amanda Sainsbury
Diabetes 2002 51: 152 -158. [Abstract] [Full Text] [PDF]

Complications:

Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells: Inhibition by the AMP-Activated Protein Kinase Activation: Yasuo Ido, David Carling, and Neil Ruderman
Diabetes 2002 51: 159 -167. [Abstract] [Full Text] [PDF]

Leptin Effect on Endothelial Nitric Oxide Is Mediated Through Akt–Endothelial Nitric Oxide Synthase Phosphorylation Pathway: Carmine Vecchione, Angelo Maffei, Salvatore Colella, Alessandra Aretini, Roberta Poulet, Giacomo Frati, Maria Teresa Gentile, Luigi Fratta, Valentina Trimarco, Bruno Trimarco, and Giuseppe Lembo
Diabetes 2002 51: 168 -173. [Abstract] [Full Text] [PDF]

Overexpression of Metallothionein Reduces Diabetic Cardiomyopathy: Qiangrong Liang, Edward C. Carlson, Rajakumar V. Donthi, Patrica M. Kralik, Xia Shen, and Paul N. Epstein
Diabetes 2002 51: 174 -181. [Abstract] [Full Text] [PDF]

Autocrine Activation of the IGF-I Signaling Pathway in Mesangial Cells Isolated From Diabetic NOD Mice: Ivan Tack, Sharon J. Elliot, Mylene Potier, Ana Rivera, Gary E. Striker, and Liliane J. Striker
Diabetes 2002 51: 182 -188. [Abstract] [Full Text] [PDF]

The Effect of Dimethylbiguanide on Thrombin Activity, FXIII Activation, Fibrin Polymerization, and Fibrin Clot Formation: Kristina F. Standeven, Robert A.S. Ariëns, Paul Whitaker, Alison E. Ashcroft, John W. Weisel, and Peter J. Grant
Diabetes 2002 51: 189 -197. [Abstract] [Full Text] [PDF]

High Glucose via Peroxynitrite Causes Tyrosine Nitration and Inactivation of Prostacyclin Synthase That Is Associated With Thromboxane/Prostaglandin H₂ Receptor–Mediated Apoptosis and Adhesion Molecule Expression in Cultured Human Aortic Endothelial Cells: Ming-Hui Zou, Chaomei Shi, and Richard A. Cohen
Diabetes 2002 51: 198 -203. [Abstract] [Full Text] [PDF]

Epidemiology:

Predictability of Childhood Adiposity and Insulin for Developing Insulin Resistance Syndrome (Syndrome X) in Young Adulthood: The Bogalusa Heart Study: Sathanur R. Srinivasan, Leann Myers, and Gerald S. Berenson
Diabetes 2002 51: 204 -209. [Abstract] [Full Text] [PDF]

High Familial Risk and Genetic Susceptibility in Early Onset Childhood Diabetes: Kathleen M. Gillespie, Edwin A.M. Gale, and Polly J. Bingley
Diabetes 2002 51: 210 -214. [Abstract] [Full Text] [PDF]

Congenic Mapping of the Diabetogenic Locus Idd4 to a 5.2-cM Region of Chromosome 11 in NOD Mice: Identification of Two Potential Candidate Subloci: Marsha Grattan, Qing-Sheng Mi, Craig Meagher, and Terry L. Delovitch
Diabetes 2002 51: 215 -223. [Abstract] [Full Text] [PDF]

PAX6 Mutation as a Genetic Factor Common to Aniridia and Glucose Intolerance: Tetsuyuki Yasuda, Yoshitaka Kajimoto, Yoshio Fujitani, Hirotaka Watada, Shuji Yamamoto, Takao Watarai, Yutaka Umayahara, Munehide Matsuhisa, Shin-ichi Gorogawa, Yasuaki Kuwayama, Yasuo Tano, Yoshimitsu Yamasaki, and Masatsugu Hori
Diabetes 2002 51: 224 -230. [Abstract] [Full Text] [PDF]

SNP43 of CAPN10 and the Risk of Type 2 Diabetes in African-Americans: The Atherosclerosis Risk in Communities Study: Michael J. Garant, W.H. Linda Kao, Frederick Brancati, Josef Coresh, Tejal M. Rami, Craig L. Hanis, Eric Boerwinkle, and Alan R. Shuldiner
Diabetes 2002 51: 231 -237. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

Chemokine Receptor Genotype Is Associated With Diabetic Nephropathy in Japanese With Type 2 Diabetes: Kunihiro Nakajima, Yasushi Tanaka, Takashi Nomiyama, Takeshi Ogihara, Lianshan Piao, Ken Sakai, Tomio Onuma, and Ryuzo Kawamori
Diabetes 2002 51: 238 -242. [Abstract] [Full Text] [PDF]

A Novel Homozygous Missense Mutation of Melanocortin-4 Receptor (MC4R) in a Japanese Woman With Severe Obesity: Hiromasa Kobayashi, Yoshihiro Ogawa, Mitsuyo Shintani, Ken Ebihara, Makiko Shimodahira, Toshio Iwakura, Megumu Hino, Takashi Ishihara, Katsuji Ikekubo, Hiroyuki Kurahachi, and Kazuwa Nakao
Diabetes 2002 51: 243 -246. [Abstract] [Full Text] [PDF]

Variation in the Calpain-10 Gene Affects Blood Glucose Levels in the British Population: Stephen Lynn, Julie C. Evans, Christopher White, Timothy M. Frayling, Andrew T. Hattersley, Doug M. Turnbull, Yukio Horikawa, Nancy J. Cox, Graeme I. Bell, and Mark Walker
Diabetes 2002 51: 247 -250. [Abstract] [Full Text] [PDF] Online Appendix

The Angiotensin-Converting Enzyme DD Genotype Is Associated With Glomerulopathy Lesions in Type 2 Diabetes: Anna Solini, Michele Dalla Vestra, Alois Saller, Romano Nosadini, Gaetano Crepaldi, and Paola Fioretto
Diabetes 2002 51: 251 -255. [Abstract] [Full Text] [PDF]

Errata:

Erratum: Diabetes 2002 51: 256 . [Extract] [Full Text] [PDF]