Perspectives in Diabetes:

The Ryanodine Receptor Calcium Channel of ß-Cells: Molecular Regulation and Physiological Significance

M. Shahidul Islam
Diabetes 2002 51: 1299 -1309. [Abstract] [Full Text] [PDF]  

Metabolism and Signal Transduction:

Prevention of Overt Hypoglycemia During Exercise: Stimulation of Endogenous Glucose Production Independent of Hepatic Catecholamine Action and Changes in Pancreatic Hormone Concentration

Robert H. Coker, Yoshiharu Koyama, Joshua C. Denny, Raul C. Camacho, D. Brooks Lacy, and David H. Wasserman
Diabetes 2002 51: 1310 -1318. [Abstract] [Full Text] [PDF]  

Tumor Necrosis Factor- Suppresses Adipocyte-Specific Genes and Activates Expression of Preadipocyte Genes in 3T3-L1 Adipocytes: Nuclear Factor-B Activation by TNF- Is Obligatory

Hong Ruan, Nir Hacohen, Todd R. Golub, Luk Van Parijs, and Harvey F. Lodish
Diabetes 2002 51: 1319 -1336. [Abstract] [Full Text] [PDF]  

Obesity:

Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity

Dominique D. Pierroz, Mary Ziotopoulou, Linda Ungsunan, Stergios Moschos, Jeffrey S. Flier, and Christos S. Mantzoros
Diabetes 2002 51: 1337 -1345. [Abstract] [Full Text] [PDF]  

Immunology:

Genetic Effects on Age-Dependent Onset and Islet Cell Autoantibody Markers in Type 1 Diabetes

Jinko Graham, William A. Hagopian, Ingrid Kockum, Lou Sheng Li, Carani B. Sanjeevi, Robert M. Lowe, Jonathan B. Schaefer, Marjan Zarghami, Heather L. Day, Mona Landin-Olsson, Jerry P. Palmer, Marta Janer-Villanueva, Leroy Hood, Göran Sundkvist, Åke Lernmark, Norman Breslow, Gisela Dahlquist, and Göran Blohmé
Diabetes 2002 51: 1346 -1355. [Abstract] [Full Text] [PDF]  

Leptin Accelerates Autoimmune Diabetes in Female NOD Mice

Giuseppe Matarese, Veronica Sanna, Robert I. Lechler, Nora Sarvetnick, Silvia Fontana, Serafino Zappacosta, and Antonio La Cava
Diabetes 2002 51: 1356 -1361. [Abstract] [Full Text] [PDF]  

Decreased Vascular Density in Mouse Pancreatic Islets After Transplantation

Göran Mattsson, Leif Jansson, and Per-Ola Carlsson
Diabetes 2002 51: 1362 -1366. [Abstract] [Full Text] [PDF]  

A 1,25-Dihydroxyvitamin D₃ Analog Enhances Regulatory T-Cells and Arrests Autoimmune Diabetes in NOD Mice

Silvia Gregori, Nadia Giarratana, Simona Smiroldo, Milan Uskokovic, and Luciano Adorini
Diabetes 2002 51: 1367 -1374. [Abstract] [Full Text] [PDF]  

Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects

Helena Reijonen, Erik J. Novak, Sharon Kochik, Anne Heninger, Andrew W. Liu, William W. Kwok, and Gerald T. Nepom
Diabetes 2002 51: 1375 -1382. [Abstract] [Full Text] [PDF]  

Insulin Expression Levels in the Thymus Modulate Insulin-Specific Autoreactive T-Cell Tolerance: The Mechanism by Which the IDDM2 Locus May Predispose to Diabetes

Aziz Alami Chentoufi and Constantin Polychronakos
Diabetes 2002 51: 1383 -1390. [Abstract] [Full Text] [PDF]  

Fas/Fas Ligand Interactions Play an Essential Role in the Initiation of Murine Autoimmune Diabetes

Maki Nakayama, Masao Nagata, Hisafumi Yasuda, Kenji Arisawa, Reiko Kotani, Katsumi Yamada, Shahead Ali Chowdhury, Sagarika Chakrabarty, Zhen Zi Jin, Hideo Yagita, Koichi Yokono, and Masato Kasuga
Diabetes 2002 51: 1391 -1397. [Abstract] [Full Text] [PDF]  

Islet Studies:

Combined Expression of Pancreatic Duodenal Homeobox 1 and Islet Factor 1 Induces Immature Enterocytes to Produce Insulin

Hideto Kojima, Takaaki Nakamura, Yukihiro Fujita, Akio Kishi, Mineko Fujimiya, Syu Yamada, Motoi Kudo, Yoshihiko Nishio, Hiroshi Maegawa, Masakazu Haneda, Hitoshi Yasuda, Itaru Kojima, Masaharu Seno, Norman C.W. Wong, Ryuichi Kikkawa, and Atsunori Kashiwagi
Diabetes 2002 51: 1398 -1408. [Abstract] [Full Text] [PDF]  

Hepatocyte Nuclear Factor-1 Recruits the Transcriptional Co-Activator p300 on the GLUT2 Gene Promoter

Nobuhiro Ban, Yuichiro Yamada, Yoshimichi Someya, Kazumasa Miyawaki, Yu Ihara, Masaya Hosokawa, Shinya Toyokuni, Kinsuke Tsuda, and Yutaka Seino
Diabetes 2002 51: 1409 -1418. [Abstract] [Full Text] [PDF]  

Modulation of L-Type Ca²⁺ Channels by Distinct Domains Within SNAP-25

Junzhi Ji, Shao-Nian Yang, Xiaohang Huang, Xidan Li, Laura Sheu, Nicholas Diamant, Per-Olof Berggren, and Herbert Y. Gaisano
Diabetes 2002 51: 1425 -1436. [Abstract] [Full Text] [PDF]  

Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets: Evidence that ß-Cell Death Is Caspase Mediated, Partially Dependent on Ceramide Pathway, and Bcl-2 Regulated

Roberto Lupi, Francesco Dotta, Lorella Marselli, Silvia Del Guerra, Matilde Masini, Carmela Santangelo, Giovanni Patané, Ugo Boggi, Salvatore Piro, Marcello Anello, Ettore Bergamini, Franco Mosca, Umberto Di Mario, Stefano Del Prato, and Piero Marchetti
Diabetes 2002 51: 1437 -1442. [Abstract] [Full Text] [PDF]  

Persistent Improvement of Type 2 Diabetes in the Goto-Kakizaki Rat Model by Expansion of the ß-Cell Mass During the Prediabetic Period With Glucagon-Like Peptide-1 or Exendin-4

Cécile Tourrel, Danielle Bailbe, Matthieu Lacorne, Marie-Jo Meile, Micheline Kergoat, and Bernard Portha
Diabetes 2002 51: 1443 -1452. [Abstract] [Full Text] [PDF]  

A Potent and Highly Selective VPAC2 Agonist Enhances Glucose-Induced Insulin Release and Glucose Disposal: A Potential Therapy for Type 2 Diabetes

Manami Tsutsumi, Thomas H. Claus, Yin Liang, Yaxin Li, Ling Yang, Jian Zhu, Fernando Dela Cruz, Xianbu Peng, Hongxing Chen, Stephanie L. Yung, Sarah Hamren, James N. Livingston, and Clark Q. Pan
Diabetes 2002 51: 1453 -1460. [Abstract] [Full Text] [PDF]  

Chronic Inhibition of Circulating Dipeptidyl Peptidase IV by FE 999011 Delays the Occurrence of Diabetes in Male Zucker Diabetic Fatty Rats

Béatrice Sudre, Pierre Broqua, Richard B. White, Doreen Ashworth, D. Michael Evans, Robert Haigh, Jean-Louis Junien, and Michel L. Aubert
Diabetes 2002 51: 1461 -1469. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

Insulin Secretory Function Is Impaired in Isolated Human Islets Carrying the Gly⁹⁷²Arg IRS-1 Polymorphism

Piero Marchetti, Roberto Lupi, Massimo Federici, Lorella Marselli, Matilde Masini, Ugo Boggi, Silvia Del Guerra, Giovanni Patanè, Salvatore Piro, Marcello Anello, Ettore Bergamini, Francesco Purrello, Renato Lauro, Franco Mosca, Giorgio Sesti, and Stefano Del Prato
Diabetes 2002 51: 1419 -1424. [Abstract] [Full Text] [PDF]  

5' Flanking Variants of Resistin Are Associated With Obesity

James C. Engert, Marie-Claude Vohl, Scott M. Williams, Pierre Lepage, J C. Loredo-Osti, Janet Faith, Carole Doré, Yannick Renaud, Noël P. Burtt, Amélie Villeneuve, Joel N. Hirschhorn, David Altshuler, Leif C. Groop, Jean-Pierre Després, Daniel Gaudet, and Thomas J. Hudson
Diabetes 2002 51: 1629 -1634. [Abstract] [Full Text] [PDF]  

A Common Polymorphism in the 5'-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes

Takuya Awata, Kiyoaki Inoue, Susumu Kurihara, Tomoko Ohkubo, Masaki Watanabe, Kouichi Inukai, Ikuo Inoue, and Shigehiro Katayama
Diabetes 2002 51: 1635 -1639. [Abstract] [Full Text] [PDF]  

Positional Candidate Gene Analysis of Lim Domain Homeobox Gene (Isl-1) on Chromosome 5q11-q13 in a French Morbidly Obese Population Suggests Indication for Association With Type 2 Diabetes

Mouna Barat-Houari, Karine Clément, Vincent Vatin, Christian Dina, Geneviève Bonhomme, Francis Vasseur, Bernard Guy-Grand, and Philippe Froguel
Diabetes 2002 51: 1640 -1643. [Abstract] [Full Text] [PDF] Online Appendix  

Variation in Three Single Nucleotide Polymorphisms in the Calpain-10 Gene Not Associated With Type 2 Diabetes in a Large Finnish Cohort

Tasha E. Fingerlin, Michael R. Erdos, Richard M. Watanabe, Kerry R Wiles, Heather M. Stringham, Karen L. Mohlke, Kaisa Silander, Timo T. Valle, Thomas A. Buchanan, Jaakko Tuomilehto, Richard N. Bergman, Michael Boehnke, and Francis S. Collins
Diabetes 2002 51: 1644 -1648. [Abstract] [Full Text] [PDF]  

IL12B Polymorphism and Type 1 Diabetes in the Italian Population: A Case-Control Study

Lorenza Nisticò, Gabriele Giorgi, Mara Giordano, Andrea Galgani, Antonio Petrone, Sandra D’Alfonso, Massimo Federici, Umberto Di Mario, Paolo Pozzilli, Raffaella Buzzetti, and Isabella Cascino
Diabetes 2002 51: 1649 -1650. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Unexpected Sensitivity of Nonobese Diabetic Mice With a Disrupted Poly(ADP-Ribose) Polymerase-1 Gene to Streptozotocin-Induced and Spontaneous Diabetes

Cristina Gonzalez, Josiane Ménissier de Murcia, Philip Janiak, Jean-Pierre Bidouard, Catherine Beauvais, Saoussen Karray, Henri-Jean Garchon, and Matthieu Lévi-Strauss
Diabetes 2002 51: 1470 -1476. [Abstract] [Full Text] [PDF]  

Increased Efficiency of Fatty Acid Uptake Contributes to Lipid Accumulation in Skeletal Muscle of High Fat-Fed Insulin-Resistant Rats

Bronwyn D. Hegarty, Gregory J. Cooney, Edward W. Kraegen, and Stuart M. Furler
Diabetes 2002 51: 1477 -1484. [Abstract] [Full Text] [PDF]  

Limited Impact of Vigorous Exercise on Defenses Against Hypoglycemia: Relevance to Hypoglycemia-Associated Autonomic Failure

Veronica P. McGregor, Jeffrey S. Greiwe, Salomon Banarer, and Philip E. Cryer
Diabetes 2002 51: 1485 -1492. [Abstract] [Full Text] [PDF]  

Insulin and Rosiglitazone Regulation of Lipolysis and Lipogenesis in Human Adipose Tissue In Vitro

Philip G. McTernan, Alison L. Harte, Leah A. Anderson, Allan Green, Stephen A. Smith, Julie C. Holder, Anthony H. Barnett, Margaret C. Eggo, and Sudhesh Kumar
Diabetes 2002 51: 1493 -1498. [Abstract] [Full Text] [PDF]  

Gestational Diabetes Leads to the Development of Diabetes in Adulthood in the Rat

Judd Boloker, Shira J. Gertz, and Rebecca A. Simmons
Diabetes 2002 51: 1499 -1506. [Abstract] [Full Text] [PDF]  

Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-, Inhibits the Jun NH₂-Terminal Kinase/Activating Protein 1 Pathway and Protects the Heart From Ischemia/Reperfusion Injury

Nassirah Khandoudi, Philippe Delerive, Isabelle Berrebi-Bertrand, Robin E. Buckingham, Bart Staels, and Antoine Bril
Diabetes 2002 51: 1507 -1514. [Abstract] [Full Text] [PDF]  

Direct Evidence for Insulin-Induced Capillary Recruitment in Skin of Healthy Subjects During Physiological Hyperinsulinemia

Erik H. Serné, Richard G. IJzerman, Reinold O.B. Gans, Robin Nijveldt, Greetje de Vries, Reinder Evertz, Ab J.M. Donker, and Coen D.A. Stehouwer
Diabetes 2002 51: 1515 -1522. [Abstract] [Full Text] [PDF]  

Complications:

The 807T Allele in 2 Integrin Is Protective Against Atherosclerotic Arterial Wall Thickening and the Occurrence of Plaque in Patients With Type 2 Diabetes

Takaaki Maeno, Hidenori Koyama, Hideki Tahara, Miyoko Komatsu, Masanori Emoto, Tetsuo Shoji, Masaaki Inaba, Takami Miki, Yasuhisa Okuno, and Yoshiki Nishizawa
Diabetes 2002 51: 1523 -1528. [Abstract] [Full Text] [PDF]  

The Genetics of Hypertension Modifies the Renal Cell Replication Response Induced by Experimental Diabetes

Lilia A. Silveira, Carlos E. Bacchi, Glauce A. Pinto, and José B. Lopes de Faria
Diabetes 2002 51: 1529 -1534. [Abstract] [Full Text] [PDF]  

Advanced Glycation End Product Precursors Impair Epidermal Growth Factor Receptor Signaling

Manuel Portero-Otín, Reinald Pamplona, Maria Josep Bellmunt, Maria Cristina Ruiz, Joan Prat, Robert Salvayre, and Anne Nègre-Salvayre
Diabetes 2002 51: 1535 -1542. [Abstract] [Full Text] [PDF]  

Associations of Insulin Levels With Left Ventricular Structure and Function in American Indians : The Strong Heart Study

Arzu Ilercil, Richard B. Devereux, Mary J. Roman, Mary Paranicas, Michael J. O’Grady, Elisa T. Lee, Thomas K. Welty, Richard R. Fabsitz, and Barbara V. Howard
Diabetes 2002 51: 1543 -1547. [Abstract] [Full Text] [PDF]  

MEDICA 16 Inhibits Hepatic Acetyl-CoA Carboxylase and Reduces Plasma Triacylglycerol Levels in Insulin-Resistant JCR: LA-cp Rats

Laura L. Atkinson, Sandra E. Kelly, James C. Russell, Jacob Bar-Tana, and Gary D. Lopaschuk
Diabetes 2002 51: 1548 -1555. [Abstract] [Full Text] [PDF]  

Mechanisms of Amelioration of Glucose-Induced Endothelial Dysfunction Following Inhibition of Protein Kinase C In Vivo

Gregory Booth, Timothy J. Stalker, Allan M. Lefer, and Rosario Scalia
Diabetes 2002 51: 1556 -1564. [Abstract] [Full Text] [PDF]  

Downregulation of Connexin 43 Expression by High Glucose Reduces Gap Junction Activity in Microvascular Endothelial Cells

Tsuyoshi Sato, Robert Haimovici, Richard Kao, An-Fei Li, and Sayon Roy
Diabetes 2002 51: 1565 -1571. [Abstract] [Full Text] [PDF]  

The Early Natural History of Nephropathy in Type 1 Diabetes: I. Study Design and Baseline Characteristics of the Study Participants

Michael Mauer and Keith Drummond
Diabetes 2002 51: 1572 -1579. [Abstract] [Full Text] [PDF]  

The Early Natural History of Nephropathy in Type 1 Diabetes: II. Early Renal Structural Changes in Type 1 Diabetes

Keith Drummond and Michael Mauer
Diabetes 2002 51: 1580 -1587. [Abstract] [Full Text] [PDF]  

Accumulation of 8-Hydroxy-2'-Deoxyguanosine and Mitochondrial DNA Deletion in Kidney of Diabetic Rats

Maiko Kakimoto, Toyoshi Inoguchi, Toshiyo Sonta, Hai Yan Yu, Minako Imamura, Takashi Etoh, Toshihiko Hashimoto, and Hajime Nawata
Diabetes 2002 51: 1588 -1595. [Abstract] [Full Text] [PDF]  

C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study

Dilys J. Freeman, John Norrie, Muriel J. Caslake, Allan Gaw, Ian Ford, Gordon D.O. Lowe, Denis St. J. O’Reilly, Chris J. Packard, and Naveed Sattar
Diabetes 2002 51: 1596 -1600. [Abstract] [Full Text] [PDF]  

Genetics:

Effect of the (C825T) Gß₃ Polymorphism on Adrenoceptor-Mediated Lipolysis in Human Fat Cells

Mikael Rydén, Gary Faulds, Johan Hoffstedt, Anders Wennlund, and Peter Arner
Diabetes 2002 51: 1601 -1608. [Abstract] [Full Text] [PDF]  

Contribution of Known and Unknown Susceptibility Genes to Early-Onset Diabetes in Scandinavia: Evidence for Heterogeneity

Cecilia M. Lindgren, Elisabeth Widén, Tiinamaija Tuomi, Haiyan Li, Peter Almgren, Timo Kanninen, Olle Melander, Jianping Weng, Markku Lehto, and Leif C. Groop
Diabetes 2002 51: 1609 -1617. [Abstract] [Full Text] [PDF] Web Appendices 1 and 2  

Polymorphisms in the Oxygen-Regulated Protein 150 Gene (ORP150) Are Associated With Insulin Resistance in Pima Indians

Peter Kovacs, Xiaolin Yang, Paska A. Permana, Clifton Bogardus, and Leslie J. Baier
Diabetes 2002 51: 1618 -1621. [Abstract] [Full Text] [PDF]  

Haplotype Combinations of Calpain 10 Gene Polymorphisms Associate With Increased Risk of Impaired Glucose Tolerance and Type 2 Diabetes in South Indians

Paul G. Cassell, Alan E. Jackson, Bernard V. North, Julie C. Evans, Denise Syndercombe-Court, Chris Phillips, Ambady Ramachandran, Chamukuttan Snehalatha, Susan V. Gelding, Shanti Vijayaravaghan, David Curtis, and Graham A. Hitman
Diabetes 2002 51: 1622 -1628. [Abstract] [Full Text] [PDF] Online Appendix  

Tribute:

John Denis McGarry, PhD

Daniel W. Foster
Diabetes 2002 51: 1651 . [Extract] [Full Text] [PDF]  

Errata:

Errata

Diabetes 2002 51: 1652 . [Extract] [Full Text] [PDF]  

Errata

Diabetes 2002 51: 1652 . [Extract] [Full Text] [PDF]  

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