Perspectives in Diabetes:

Genetic Studies of Late Diabetic Complications: The Overlooked Importance of Diabetes Duration Before Complication Onset

John J. Rogus, James H. Warram, and Andrzej S. Krolewski
Diabetes 2002 51: 1655 -1662. [Abstract] [Full Text] [PDF]  

Metabolism:

Direct and Indirect Effects of Insulin on Glucose Uptake and Storage by the Liver

Shosuke Satake, Mary Courtney Moore, Kayano Igawa, Margaret Converse, Benjamin Farmer, Doss W. Neal, and Alan D. Cherrington
Diabetes 2002 51: 1663 -1671. [Abstract] [Full Text] [PDF]  

Role of the Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase Signaling Pathway in Insulin-Induced Expression of Sterol Regulatory Element Binding Protein 1c and Glucokinase Genes in Rat Hepatocytes

Michihiro Matsumoto, Wataru Ogawa, Kiyoshi Teshigawara, Hiroshi Inoue, Kazuaki Miyake, Hiroshi Sakaue, and Masato Kasuga
Diabetes 2002 51: 1672 -1680. [Abstract] [Full Text] [PDF]  

Diabetes Impairs Hypothalamo-Pituitary-Adrenal (HPA) Responses to Hypoglycemia, and Insulin Treatment Normalizes HPA but not Epinephrine Responses

Owen Chan, Stephen Chan, Karen Inouye, Kathy Shum, Stephen G. Matthews, and Mladen Vranic
Diabetes 2002 51: 1681 -1689. [Abstract] [Full Text] [PDF]  

Amino Acid Kinetics During the Anhepatic Phase of Liver Transplantation

Alberto Battezzati, Andrea Caumo, Annalisa Fattorini, Lucia Piceni Sereni, Jorgelina Coppa, Raffaele Romito, Mario Ammatuna, Enrico Regalia, Vincenzo Mazzaferro, and Livio Luzi
Diabetes 2002 51: 1690 -1698. [Abstract] [Full Text] [PDF]  

Mature Adipocytes Inhibit In Vitro Differentiation of Human Preadipocytes via Angiotensin Type 1 Receptors

Jürgen Janke, Stefan Engeli, Kerstin Gorzelniak, Friedrich C. Luft, and Arya M. Sharma
Diabetes 2002 51: 1699 -1707. [Abstract] [Full Text] [PDF]  

Differential Effects of Fenofibrate or Simvastatin Treatment of Rats on Hepatic Microsomal Overt and Latent Diacylglycerol Acyltransferase Activities

Ian J. Waterman and Victor A. Zammit
Diabetes 2002 51: 1708 -1713. [Abstract] [Full Text] [PDF]  

A Nuclear Magnetic Resonance-Based Demonstration of Substantial Oxidative L-Alanine Metabolism and L-Alanine-Enhanced Glucose Metabolism in a Clonal Pancreatic ß-Cell Line : Metabolism of L-Alanine Is Important to the Regulation of Insulin Secretion

Lorraine Brennan, Aine Shine, Chandralal Hewage, J. Paul G. Malthouse, Kevin M. Brindle, Neville McClenaghan, Peter R. Flatt, and Philip Newsholme
Diabetes 2002 51: 1714 -1721. [Abstract] [Full Text] [PDF]  

Sterol Regulatory Element Binding Protein-1c Expression and Action in Rat Muscles: Insulin-Like Effects on the Control of Glycolytic and Lipogenic Enzymes and UCP3 Gene Expression

Isabelle Guillet-Deniau, Virginie Mieulet, Soazig Le Lay, Younes Achouri, Denis Carré, Jean Girard, Fabienne Foufelle, and Pascal Ferré
Diabetes 2002 51: 1722 -1728. [Abstract] [Full Text] [PDF]  

Obesity:

Central Leptin Gene Therapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemia, and Hyperinsulinemia : Increase in Serum Ghrelin Levels

Michael G. Dube, Elena Beretta, Harveen Dhillon, Naohiko Ueno, Pushpa S. Kalra, and Satya P. Kalra
Diabetes 2002 51: 1729 -1736. [Abstract] [Full Text] [PDF]  

Humoral Regulation of Resistin Expression in 3T3-L1 and Mouse Adipose Cells

Nobuhiro Shojima, Hideyuki Sakoda, Takehide Ogihara, Midori Fujishiro, Hideki Katagiri, Motonobu Anai, Yukiko Onishi, Hiraku Ono, Kouichi Inukai, Miho Abe, Yasushi Fukushima, Masatoshi Kikuchi, Yoshitomo Oka, and Tomoichiro Asano
Diabetes 2002 51: 1737 -1744. [Abstract] [Full Text] [PDF]  

Immunology:

Characterization of the T-Cell Response to Coxsackievirus B4: Evidence That Effector Memory Cells Predominate in Patients With Type 1 Diabetes

Ruben Varela-Calvino, Richard Ellis, Gianluca Sgarbi, Colin M. Dayan, and Mark Peakman
Diabetes 2002 51: 1745 -1753. [Abstract] [Full Text] [PDF]  

A 12-Year Prospective Study of the Relationship Between Islet Antibodies and ß-Cell Function At and After the Diagnosis in Patients With Adult-Onset Diabetes

Henrik Borg, Anders Gottsäter, Per Fernlund, and Göran Sundkvist
Diabetes 2002 51: 1754 -1762. [Abstract] [Full Text] [PDF]  

Islet:

Expression of the Vesicular Inhibitory Amino Acid Transporter in Pancreatic Islet Cells : Distribution of the Transporter Within Rat Islets

Steven D. Chessler, William T. Simonson, Ian R. Sweet, and Lisa P. Hammerle
Diabetes 2002 51: 1763 -1771. [Abstract] [Full Text] [PDF]  

Inhibition of Interleukin-1ß-Induced COX-2 and EP3 Gene Expression by Sodium Salicylate Enhances Pancreatic Islet ß-Cell Function

Phuong Oanh T. Tran, Catherine E. Gleason, and R. Paul Robertson
Diabetes 2002 51: 1772 -1778. [Abstract] [Full Text] [PDF]  

Inhibition of Thrombin Abrogates the Instant Blood-Mediated Inflammatory Reaction Triggered by Isolated Human Islets: Possible Application of the Thrombin Inhibitor Melagatran in Clinical Islet Transplantation

Lisa Özmen, Kristina Nilsson Ekdahl, Graciela Elgue, Rolf Larsson, Olle Korsgren, and Bo Nilsson
Diabetes 2002 51: 1779 -1784. [Abstract] [Full Text] [PDF]  

Hepatocyte Nuclear Factor-1 Modulates Pancreatic ß-Cell Growth by Regulating the Expression of Insulin-Like Growth Factor-1 in INS-1 Cells

Qin Yang, Kazuya Yamagata, Kenji Fukui, Yang Cao, Takao Nammo, Hiromi Iwahashi, Haiyan Wang, Itaru Matsumura, Toshiaki Hanafusa, Richard Bucala, Claes B. Wollheim, Jun-ichiro Miyagawa, and Yuji Matsuzawa
Diabetes 2002 51: 1785 -1792. [Abstract] [Full Text] [PDF]  

Overexpression of c-Myc in ß-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes

D. Ross Laybutt, Gordon C. Weir, Hideaki Kaneto, Judith Lebet, Richard D. Palmiter, Arun Sharma, and Susan Bonner-Weir
Diabetes 2002 51: 1793 -1804. [Abstract] [Full Text] [PDF]  

cFLIP Protein Prevents Tumor Necrosis Factor-–Mediated Induction of Caspase-8–Dependent Apoptosis in Insulin-Secreting ßTc-Tet Cells

Sandra Cottet, Philippe Dupraz, Fabienne Hamburger, Wanda Dolci, Muriel Jaquet, and Bernard Thorens
Diabetes 2002 51: 1805 -1814. [Abstract] [Full Text] [PDF]  

Na/Ca Exchanger Overexpression Induces Endoplasmic Reticulum–Related Apoptosis and Caspase-12 Activation in Insulin-Releasing BRIN-BD11 Cells

Oscar Diaz-Horta, Adama Kamagate, André Herchuelz, and Françoise Van Eylen
Diabetes 2002 51: 1815 -1824. [Abstract] [Full Text] [PDF]  

The Composition of Dietary Fat Directly Influences Glucose-Stimulated Insulin Secretion in Rats

Robert L. Dobbins, Lidia S. Szczepaniak, Jeff Myhill, Yoshifumi Tamura, Hiroshi Uchino, Adria Giacca, and J. Denis McGarry
Diabetes 2002 51: 1825 -1833. [Abstract] [Full Text] [PDF]  

ß-Cell Neogenesis During Prolonged Hyperglycemia in Rats

Mark Lipsett and Diane T. Finegood
Diabetes 2002 51: 1834 -1841. [Abstract] [Full Text] [PDF]  

Targeted Disruption of the Protein Tyrosine Phosphatase-Like Molecule IA-2 Results in Alterations in Glucose Tolerance Tests and Insulin Secretion

Keiichi Saeki, Min Zhu, Atsutaka Kubosaki, Jingping Xie, Michael S. Lan, and Abner Louis Notkins
Diabetes 2002 51: 1842 -1850. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Antidiabetic Effects of Panax ginseng Berry Extract and the Identification of an Effective Component

Anoja S. Attele, Yun-Ping Zhou, Jing-Tian Xie, Ji An Wu, Liu Zhang, Lucy Dey, William Pugh, Paul A. Rue, Kenneth S. Polonsky, and Chun-Su Yuan
Diabetes 2002 51: 1851 -1858. [Abstract] [Full Text] [PDF]  

Tanis: A Link Between Type 2 Diabetes and Inflammation?

Ken Walder, Lakshmi Kantham, Janine S. McMillan, James Trevaskis, Lyndal Kerr, Andrea de Silva, Terry Sunderland, Nathan Godde, Yuan Gao, Natalie Bishara, Kelly Windmill, Janette Tenne-Brown, Guy Augert, Paul Z. Zimmet, and Greg R. Collier
Diabetes 2002 51: 1859 -1866. [Abstract] [Full Text] [PDF]  

Sensitivity to Acute Insulin-Mediated Suppression of Plasma Free Fatty Acids Is Not a Determinant of Fasting VLDL Triglyceride Secretion in Healthy Humans

André Carpentier, Bruce W. Patterson, Nathalie Leung, and Gary F. Lewis
Diabetes 2002 51: 1867 -1875. [Abstract] [Full Text] [PDF]  

Altered Tumor Necrosis Factor- (TNF-) Processing in Adipocytes and Increased Expression of Transmembrane TNF- in Obesity

Haiyan Xu, K. Teoman Uysal, J. David Becherer, Peter Arner, and Gökhan S. Hotamisligil
Diabetes 2002 51: 1876 -1883. [Abstract] [Full Text] [PDF]  

Plasma Adiponectin Concentration Is Associated With Skeletal Muscle Insulin Receptor Tyrosine Phosphorylation, and Low Plasma Concentration Precedes a Decrease in Whole-Body Insulin Sensitivity in Humans

Norbert Stefan, Barbora Vozarova, Tohru Funahashi, Yuji Matsuzawa, Christian Weyer, Robert S. Lindsay, Jack F. Youngren, Peter J. Havel, Richard E. Pratley, Clifton Bogardus, and P. Antonio Tataranni
Diabetes 2002 51: 1884 -1888. [Abstract] [Full Text] [PDF]  

High Alanine Aminotransferase Is Associated With Decreased Hepatic Insulin Sensitivity and Predicts the Development of Type 2 Diabetes

Barbora Vozarova, Norbert Stefan, Robert S. Lindsay, Aramesh Saremi, Richard E. Pratley, Clifton Bogardus, and P. Antonio Tataranni
Diabetes 2002 51: 1889 -1895. [Abstract] [Full Text] [PDF]  

The Novel Diazoxide Analog 3-Isopropylamino-7-Methoxy-4H-1,2,4-Benzothiadiazine 1,1-Dioxide Is a Selective Kir6.2/SUR1 Channel Opener

Michael Dabrowski, Frances M. Ashcroft, Rebecca Ashfield, Philippe Lebrun, Bernard Pirotte, Jan Egebjerg, John Bondo Hansen, and Philip Wahl
Diabetes 2002 51: 1896 -1906. [Abstract] [Full Text] [PDF]  

Female Rats Do Not Exhibit Free Fatty Acid–Induced Insulin Resistance

Andrea Hevener, Donna Reichart, Andrej Janez, and Jerrold Olefsky
Diabetes 2002 51: 1907 -1912. [Abstract] [Full Text] [PDF]  

Gene Expression Profile in Skeletal Muscle of Type 2 Diabetes and the Effect of Insulin Treatment

Raghavakaimal Sreekumar, Panagiotis Halvatsiotis, Jill Coenen Schimke, and K. Sreekumaran Nair
Diabetes 2002 51: 1913 -1920. [Abstract] [Full Text] [PDF]  

Differential Effects of Tumor Necrosis Factor- on Protein Kinase C Isoforms and Mediate Inhibition of Insulin Receptor Signaling

Tovit Rosenzweig, Liora Braiman, Asia Bak, Addy Alt, Toshio Kuroki, and Sanford R. Sampson
Diabetes 2002 51: 1921 -1930. [Abstract] [Full Text] [PDF]  

Complications:

Interleukin-10 Protects Nitric Oxide–Dependent Relaxation During Diabetes: Role of Superoxide

Carol A. Gunnett, Donald D. Heistad, and Frank M. Faraci
Diabetes 2002 51: 1931 -1937. [Abstract] [Full Text] [PDF]  

Hyperglycemia-Induced Apoptosis in Mouse Myocardium: Mitochondrial Cytochrome c–Mediated Caspase-3 Activation Pathway

Lu Cai, Wei Li, Guangwu Wang, Luping Guo, Youchun Jiang, and Y. James Kang
Diabetes 2002 51: 1938 -1948. [Abstract] [Full Text] [PDF]  

Lipoprotein Subclasses and Particle Sizes and Their Relationship With Coronary Artery Calcification in Men and Women With and Without Type 1 Diabetes

Helen M. Colhoun, James D. Otvos, Mike B. Rubens, M. R. Taskinen, S. Richard Underwood, and John H. Fuller
Diabetes 2002 51: 1949 -1956. [Abstract] [Full Text] [PDF]  

Thrombomodulin Deficiency in Human Diabetic Nerve Microvasculature

Charlene E. Hafer-Macko, Frederick M. Ivey, Kymberly A. Gyure, John D. Sorkin, and Richard F. Macko
Diabetes 2002 51: 1957 -1963. [Abstract] [Full Text] [PDF]  

Genetics:

Enterovirus RNA Is Found in Peripheral Blood Mononuclear Cells in a Majority of Type 1 Diabetic Children at Onset

Hong Yin, Anna-Karin Berg, Torsten Tuvemo, and Gun Frisk
Diabetes 2002 51: 1964 -1971. [Abstract] [Full Text] [PDF]  

The Diabetes-Prone BB Rat Carries a Frameshift Mutation in Ian4, a Positional Candidate of Iddm1

Lars Hornum, John Rømer, and Helle Markholst
Diabetes 2002 51: 1972 -1979. [Abstract] [Full Text] [PDF]  

Mutations in the Human Leptin and Leptin Receptor Genes as Models of Serum Leptin Receptor Regulation

Najiba Lahlou, Tarik Issad, Yves Lebouc, Jean-Claude Carel, Luc Camoin, Marc Roger, and Jean Girard
Diabetes 2002 51: 1980 -1985. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

Insertion/Deletion Polymorphism of the ACE Gene Is Associated With Type 2 Diabetes

Yan Feng, Tianhua Niu, Xin Xu, Changzhong Chen, Qiongfang Li, Rongli Qian, Guoying Wang, and Xiping Xu
Diabetes 2002 51: 1986 -1988. [Abstract] [Full Text] [PDF]  

An X-Chromosome Scan Reveals a Locus for Fat Distribution in Chromosome Region Xp21–22

R. Arlen Price, Wei-Dong Li, and Robin Kilker
Diabetes 2002 51: 1989 -1991. [Abstract] [Full Text] [PDF]  

Errata:

Erratum

Diabetes 2002 51: 1992 . [Extract] [Full Text] [PDF]  

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