Rapid Publications:

Functional Genomics of the Endocrine Pancreas: The Pancreas Clone Set and PancChip, New Resources for Diabetes Research

L. Marie Scearce, John E. Brestelli, Shannon K. McWeeney, Catherine S. Lee, Joan Mazzarelli, Deborah F. Pinney, Angel Pizarro, Christian J. Stoeckert, Jr., Sandra W. Clifton, M. Alan Permutt, Juliana Brown, Douglas A. Melton, and Klaus H. Kaestner
Diabetes 2002 51: 1997 -2004. First published on June 6, 2002 as 10.2337/diabetes.51.7.1997 [Abstract] [Full Text] [PDF]  

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IB-

Samar I. Itani, Neil B. Ruderman, Frank Schmieder, and Guenther Boden
Diabetes 2002 51: 2005 -2011. First published on June 6, 2002 as 10.2337/diabetes.51.7.2005 [Abstract] [Full Text] [PDF]  

The Gene INPPL1, Encoding the Lipid Phosphatase SHIP2, Is a Candidate for Type 2 Diabetes In Rat and Man

Evelyne Marion, Pamela Jane Kaisaki, Valérie Pouillon, Cyril Gueydan, Jonathan C. Levy, André Bodson, Georges Krzentowski, Jean-Claude Daubresse, Jean Mockel, Jens Behrends, Geneviève Servais, Claude Szpirer, Véronique Kruys, Dominique Gauguier, and Stéphane Schurmans
Diabetes 2002 51: 2012 -2017. First published on June 6, 2002 as 10.2337/diabetes.51.7.2012 [Abstract] [Full Text] [PDF]  

Critical Role for Cataplerosis via Citrate in Glucose-Regulated Insulin Release

Daisy Flamez, Veerle Berger, Mogens Kruhøffer, Torben Orntoft, Daniel Pipeleers, and Frans C. Schuit
Diabetes 2002 51: 2018 -2024. First published on June 6, 2002 as 10.2337/diabetes.51.7.2018 [Abstract] [Full Text] [PDF]  

Perspectives in Diabetes:

Renal Perfusion and the Renal Hemodynamic Response to Blocking the Renin System in Diabetes: Are the Forces Leading to Vasodilation and Vasoconstriction Linked?

M. Cecilia Lansang and Norman K. Hollenberg
Diabetes 2002 51: 2025 -2028. [Abstract] [Full Text] [PDF]  

Metabolism and Signal Transduction:

Increased Lipolysis and Decreased Leptin Production by Human Omental as Compared With Subcutaneous Preadipocytes

Vanessa van Harmelen, Andrea Dicker, Mikael Rydén, Hans Hauner, Fredrik Lönnqvist, Erik Näslund, and Peter Arner
Diabetes 2002 51: 2029 -2036. [Abstract] [Full Text] [PDF]  

Isomer-Dependent Metabolic Effects of Conjugated Linoleic Acid: Insights From Molecular Markers Sterol Regulatory Element-Binding Protein-1c and LXR

Helen M. Roche, Enda Noone, Ciaran Sewter, Siobhan Mc Bennett, David Savage, Michael J. Gibney, Stephen O’Rahilly, and Antonio J. Vidal-Puig
Diabetes 2002 51: 2037 -2044. [Abstract] [Full Text] [PDF]  

Role of Peroxisome Proliferator-Activated Receptor- in Maintenance of the Characteristics of Mature 3T3-L1 Adipocytes

Yoshikazu Tamori, Jiro Masugi, Naonobu Nishino, and Masato Kasuga
Diabetes 2002 51: 2045 -2055. [Abstract] [Full Text] [PDF]  

Glucokinase Is the Likely Mediator of Glucosensing in Both Glucose-Excited and Glucose-Inhibited Central Neurons

Ambrose A. Dunn-Meynell, Vanessa H. Routh, Ling Kang, Larry Gaspers, and Barry E. Levin
Diabetes 2002 51: 2056 -2065. [Abstract] [Full Text] [PDF]  

Normalization of Skeletal Muscle Glycogen Synthesis and Glycolysis in Rosiglitazone-Treated Zucker Fatty Rats: An In Vivo Nuclear Magnetic Resonance Study

Beat M. Jucker, Thomas R. Schaeffer, Robin E. Haimbach, Thomas S. McIntosh, Daniel Chun, Matthew Mayer, Derek H. Ohlstein, Hugh M. Davis, Stephen A. Smith, Alexander R. Cobitz, and Susanta K. Sarkar
Diabetes 2002 51: 2066 -2073. [Abstract] [Full Text] [PDF]  

Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

Nicolas Musi, Michael F. Hirshman, Jonas Nygren, Monika Svanfeldt, Peter Bavenholm, Olav Rooyackers, Gaochao Zhou, Joanne M. Williamson, Olle Ljunqvist, Suad Efendic, David E. Moller, Anders Thorell, and Laurie J. Goodyear
Diabetes 2002 51: 2074 -2081. [Abstract] [Full Text] [PDF]  

Improved Insulin Sensitivity Is Associated With Restricted Intake of Dietary Glycoxidation Products in the db/db Mouse

Susanna M. Hofmann, Heng-Jiang Dong, Zhu Li, Weijing Cai, Jennifer Altomonte, Swan N. Thung, Feng Zeng, Edward A. Fisher, and Helen Vlassara
Diabetes 2002 51: 2082 -2089. [Abstract] [Full Text] [PDF]  

Sustained Exposure of L6 Myotubes to High Glucose and Insulin Decreases Insulin-Stimulated GLUT4 Translocation but Upregulates GLUT4 Activity

Carol Huang, Romel Somwar, Nish Patel, Wenyan Niu, Dóra Török, and Amira Klip
Diabetes 2002 51: 2090 -2098. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Appetite Suppression and Weight Reduction by a Centrally Active Aminosterol

Rexford S. Ahima, Hiralben R. Patel, Nobuhiko Takahashi, Yong Qi, Stanley M. Hileman, and Michael A. Zasloff
Diabetes 2002 51: 2099 -2104. [Abstract] [Full Text] [PDF]  

Regulation of Circulating Soluble Leptin Receptor Levels By Gender, Adiposity, Sex Steroids, and Leptin : Observational and Interventional Studies in Humans

Jean L. Chan, Susann Blüher, Nikos Yiannakouris, Marc A. Suchard, Jurgen Kratzsch, and Christos S. Mantzoros
Diabetes 2002 51: 2105 -2112. [Abstract] [Full Text] [PDF]  

Adrenalectomy Improves Diabetes in A-ZIP/F-1 Lipoatrophic Mice by Increasing Both Liver and Muscle Insulin Sensitivity

Martin Haluzik, Kelly R. Dietz, Jason K. Kim, Bernice Marcus-Samuels, Gerald I. Shulman, Oksana Gavrilova, and Marc L. Reitman
Diabetes 2002 51: 2113 -2118. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Redirection of Human Autoreactive T-Cells Upon Interaction With Dendritic Cells Modulated by TX527, an Analog of 1,25 Dihydroxyvitamin D₃

Astrid G.S. van Halteren, Evelyne van Etten, Esther C. de Jong, Roger Bouillon, Bart O. Roep, and Chantal Mathieu
Diabetes 2002 51: 2119 -2125. [Abstract] [Full Text] [PDF]  

Immunological Characterization and Therapeutic Activity of an Altered-Peptide Ligand, NBI-6024, Based on the Immunodominant Type 1 Diabetes Autoantigen Insulin B-Chain (9–23) Peptide

David G. Alleva, Amitabh Gaur, Liping Jin, Dale Wegmann, Peter A. Gottlieb, Anil Pahuja, Eric B. Johnson, Theresa Motheral, Amy Putnam, Paul D. Crowe, Nicholas Ling, Stefen A. Boehme, and Paul J. Conlon
Diabetes 2002 51: 2126 -2134. [Abstract] [Full Text] [PDF]  

Pancreatic Islet Transplantation Using the Nonhuman Primate (Rhesus) Model Predicts That the Portal Vein Is Superior to the Celiac Artery as the Islet Infusion Site

Boaz Hirshberg, Sean Montgomery, Michael G. Wysoki, He Xu, Doug Tadaki, Janet Lee, Kenneth Hines, Jason Gaglia, Noelle Patterson, John Leconte, Douglas Hale, Richard Chang, Alan D. Kirk, and David M. Harlan
Diabetes 2002 51: 2135 -2140. [Abstract] [Full Text] [PDF]  

An Interval Tightly Linked to but Distinct From the H2 Complex Controls Both Overt Diabetes (Idd16) and Chronic Experimental Autoimmune Thyroiditis (Ceat1) in Nonobese Diabetic Mice

Olivier Boulard, Diane Damotte, Nathalie Deruytter, Guy Fluteau, Claude Carnaud, and Henri-Jean Garchon
Diabetes 2002 51: 2141 -2147. [Abstract] [Full Text] [PDF] Online Appendix  

Islet Studies:

Successful Islet Transplantation: Continued Insulin Reserve Provides Long-Term Glycemic Control

Edmond A. Ryan, Jonathan R.T. Lakey, Breay W. Paty, Sharleen Imes, Gregory S. Korbutt, Norman M. Kneteman, David Bigam, Ray V. Rajotte, and A.M. James Shapiro
Diabetes 2002 51: 2148 -2157. [Abstract] [Full Text] [PDF]  

Estrogen Can Prevent or Reverse Obesity and Diabetes in Mice Expressing Human Islet Amyloid Polypeptide

John G. Geisler, Walter Zawalich, Kathleen Zawalich, Jonathan R.T. Lakey, Hans Stukenbrok, Anthony J. Milici, and Walter C. Soeller
Diabetes 2002 51: 2158 -2169. [Abstract] [Full Text] [PDF]  

Pathophysiology:

ß-Cell Function Is a Major Contributor to Oral Glucose Tolerance in High-Risk Relatives of Four Ethnic Groups in the U.S.

Christine C. Jensen, Miriam Cnop, Rebecca L. Hull, Wilfred Y. Fujimoto, Steven E. Kahn, and the American Diabetes Association GENNID Study Group
Diabetes 2002 51: 2170 -2178. [Abstract] [Full Text] [PDF]  

Glycemic Control Determines Hepatic and Peripheral Glucose Effectiveness in Type 2 Diabetic Subjects

Meredith Hawkins, Ilan Gabriely, Robert Wozniak, Kalpana Reddy, Luciano Rossetti, and Harry Shamoon
Diabetes 2002 51: 2179 -2189. [Abstract] [Full Text] [PDF]  

Inhibition of Glycogen Synthase Kinase 3 Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle

Svetlana E. Nikoulina, Theodore P. Ciaraldi, Sunder Mudaliar, Leslie Carter, Kirk Johnson, and Robert R. Henry
Diabetes 2002 51: 2190 -2198. [Abstract] [Full Text] [PDF]  

Long-Term AICAR Administration Reduces Metabolic Disturbances and Lowers Blood Pressure in Rats Displaying Features of the Insulin Resistance Syndrome

Esben S. Buhl, Niels Jessen, Rasmus Pold, Thomas Ledet, Allan Flyvbjerg, Steen B. Pedersen, Oluf Pedersen, Ole Schmitz, and Sten Lund
Diabetes 2002 51: 2199 -2206. [Abstract] [Full Text] [PDF]  

TNF- Is a Predictor of Insulin Resistance in Human Pregnancy

John P. Kirwan, Sylvie Hauguel-De Mouzon, Jacques Lepercq, Jean-Claude Challier, Larraine Huston-Presley, Jacob E. Friedman, Satish C. Kalhan, and Patrick M. Catalano
Diabetes 2002 51: 2207 -2213. [Abstract] [Full Text] [PDF]  

Alterations in the Activity of Placental Amino Acid Transporters in Pregnancies Complicated by Diabetes

Thomas Jansson, Ylva Ekstrand, Caroline Björn, Margareta Wennergren, and Theresa L. Powell
Diabetes 2002 51: 2214 -2219. [Abstract] [Full Text] [PDF]  

The Effect of a 3-Month Low-Intensity Endurance Training Program on Fat Oxidation and Acetyl-CoA Carboxylase-2 Expression

Patrick Schrauwen, Dorien P.C. van Aggel-Leijssen, Gabby Hul, Anton J.M. Wagenmakers, Hubert Vidal, Wim H.M. Saris, and Marleen A. van Baak
Diabetes 2002 51: 2220 -2226. [Abstract] [Full Text] [PDF]  

Complications:

Herpes Simplex-Mediated Gene Transfer of Nerve Growth Factor Protects Against Peripheral Neuropathy in Streptozotocin-Induced Diabetes in the Mouse

James R. Goss, William F. Goins, David Lacomis, Marina Mata, Joseph C. Glorioso, and David J. Fink
Diabetes 2002 51: 2227 -2232. [Abstract] [Full Text] [PDF]  

Influence of Experimental Diabetes on the Microcirculation of Injured Peripheral Nerve: Functional and Morphological Aspects

James M. Kennedy and Douglas W. Zochodne
Diabetes 2002 51: 2233 -2240. [Abstract] [Full Text] [PDF]  

Activation of Nuclear Factor-B Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes

Giulio Romeo, Wei-Hua Liu, Veronica Asnaghi, Timothy S. Kern, and Mara Lorenzi
Diabetes 2002 51: 2241 -2248. [Abstract] [Full Text] [PDF]  

Elevated Spinal Cyclooxygenase and Prostaglandin Release During Hyperalgesia in Diabetic Rats

Jason D. Freshwater, Camilla I. Svensson, Annika B. Malmberg, and Nigel A. Calcutt
Diabetes 2002 51: 2249 -2255. [Abstract] [Full Text] [PDF]  

Negative Regulation of Rho Signaling by Insulin and Its Impact on Actin Cytoskeleton Organization in Vascular Smooth Muscle Cells: Role of Nitric Oxide and Cyclic Guanosine Monophosphate Signaling Pathways

Najma Begum, Oana A. Sandu, and Noreen Duddy
Diabetes 2002 51: 2256 -2263. [Abstract] [Full Text] [PDF]  

Minor Effect of GLUT1 Polymorphisms on Susceptibility to Diabetic Nephropathy in Type 1 Diabetes

Daniel P.K. Ng, Luis Canani, Shin-ichi Araki, Adam Smiles, Dariusz Moczulski, James H. Warram, and Andrzej S. Krolewski
Diabetes 2002 51: 2264 -2269. [Abstract] [Full Text] [PDF] Online AppendixOnline Appendix  

Modulation of Growth Hormone Signal Transduction in Kidneys of Streptozotocin-Induced Diabetic Animals: Effect of a Growth Hormone Receptor Antagonist

Ana C.P. Thirone, John A. Scarlett, Alessandra L. Gasparetti, Eliana P. Araujo, Maria H.L. Lima, Carla R.O. Carvalho, Lício A. Velloso, and Mario J.A. Saad
Diabetes 2002 51: 2270 -2281. [Abstract] [Full Text] [PDF]  

Endothelial Dysfunction Relates to Folate Status in Children and Adolescents With Type 1 Diabetes

Esko J. Wiltshire, Roger Gent, Craig Hirte, Alexia Pena, David W. Thomas, and Jennifer J. Couper
Diabetes 2002 51: 2282 -2286. [Abstract] [Full Text] [PDF]  

Hyperketonemia Increases Tumor Necrosis Factor- Secretion in Cultured U937 Monocytes and Type 1 Diabetic Patients and Is Apparently Mediated by Oxidative Stress and cAMP Deficiency

Sushil K. Jain, Krishnaswamy Kannan, Gideon Lim, Robert McVie, and Joseph A. Bocchini, Jr.
Diabetes 2002 51: 2287 -2293. [Abstract] [Full Text] [PDF]  

Epidemiology:

Vitamin D Receptor (VDR) mRNA and VDR Protein Levels in Relation to Vitamin D Status, Insulin Secretory Capacity, and VDR Genotype in Bangladeshi Asians

Babatunji-William Ogunkolade, Barbara J. Boucher, Jean M. Prahl, Stephen A. Bustin, Jacky M. Burrin, Kate Noonan, Bernard V. North, Nassima Mannan, Michael F. McDermott, Hector F. DeLuca, and Graham A. Hitman
Diabetes 2002 51: 2294 -2300. [Abstract] [Full Text] [PDF]  

Genetics:

Loss of Kinase Activity in a Patient With Wolcott-Rallison Syndrome Caused By a Novel Mutation in the EIF2AK3 Gene

Anna Biason-Lauber, Mariarosaria Lang-Muritano, Tindara Vaccaro, and Eugen J. Schoenle
Diabetes 2002 51: 2301 -2305. [Abstract] [Full Text] [PDF]  

A Haplotype at the Adiponectin Locus Is Associated With Obesity and Other Features of the Insulin Resistance Syndrome

Claudia Menzaghi, Tonino Ercolino, Rosa Di Paola, Anders H. Berg, James H. Warram, Philipp E. Scherer, Vincenzo Trischitta, and Alessandro Doria
Diabetes 2002 51: 2306 -2312. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

A Putative Functional Polymorphism in the IGF-I Gene: Association Studies With Type 2 Diabetes, Adult Height, Glucose Tolerance, and Fetal Growth in U.K. Populations

Timothy M. Frayling, Andrew T. Hattersley, Anne McCarthy, Jeff Holly, Simon M.S. Mitchell, Anna L. Gloyn, Katharine Owen, David Davies, George Davey Smith, and Yoav Ben-Shlomo
Diabetes 2002 51: 2313 -2316. [Abstract] [Full Text] [PDF]  

Defining the Importance of Mitochondrial Gene Defects in Maternally Inherited Diabetes by Sequencing the Entire Mitochondrial Genome

Alan T.W. Choo-Kang, Stephen Lynn, Geoffrey A. Taylor, Mark E. Daly, Sarbpreet S. Sihota, Teressa M. Wardell, Patrick F. Chinnery, Douglass M. Turnbull, and Mark Walker
Diabetes 2002 51: 2317 -2320. [Abstract] [Full Text] [PDF] Online AppendixOnline appendix  

The Effects of the Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor-2 Gene on Insulin Sensitivity and Insulin Metabolism Interact With Size at Birth

Johan G. Eriksson, Virpi Lindi, Matti Uusitupa, Tom J. Forsén, Markku Laakso, Clive Osmond, and David J.P. Barker
Diabetes 2002 51: 2321 -2324. [Abstract] [Full Text] [PDF]  

Association of Adiponectin Mutation With Type 2 Diabetes : A Candidate Gene for the Insulin Resistance Syndrome

Hidehiko Kondo, Iichiro Shimomura, Yuko Matsukawa, Masahiro Kumada, Masahiko Takahashi, Morihiro Matsuda, Noriyuki Ouchi, Shinji Kihara, Toshiharu Kawamoto, Satoru Sumitsuji, Tohru Funahashi, and Yuji Matsuzawa
Diabetes 2002 51: 2325 -2328. [Abstract] [Full Text] [PDF]  

Maturity-Onset Diabetes of the Young Caused by a Balanced Translocation Where the 20q12 Break Point Results in Disruption Upstream of the Coding Region of Hepatocyte Nuclear Factor-4 (HNF4A) Gene

Anna L. Gloyn, Sian Ellard, Maggie Shepherd, Rodney T. Howell, Elizabeth M. Parry, Andrew Jefferson, Elaine R. Levy, and Andrew T. Hattersley
Diabetes 2002 51: 2329 -2333. [Abstract] [Full Text] [PDF]  

IL-12p40 Is Associated With Type 1 Diabetes in Caucasian-American Families

Abdoreza Davoodi-Semiromi, James J. Yang, and Jin-Xiong She
Diabetes 2002 51: 2334 -2336. [Abstract] [Full Text] [PDF]  

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