Diabetes -- Table of Contents (August 2002, 51 [8])

Perspectives in Diabetes:

The Peroxisome Proliferator-Activated Receptor- ${gamma}$ 2 Pro12Ala Polymorphism: Michael Stumvoll and Hans Häring
Diabetes 2002 51: 2341 -2347. [Abstract] [Full Text] [PDF]

Cross-Talk Between Iron Metabolism and Diabetes: José Manuel Fernández-Real, Abel López-Bermejo, and Wifredo Ricart
Diabetes 2002 51: 2348 -2354. [Abstract] [Full Text] [PDF]

A Genetic Switch in Pancreatic ß-Cells: Implications for Differentiation and Haploinsufficiency: Jorge Ferrer
Diabetes 2002 51: 2355 -2362. [Abstract] [Full Text] [PDF]

Metabolism and Signal Transduction:

Effects of Benfluorex on Fatty Acid and Glucose Metabolism in Isolated Rat Hepatocytes: From Metabolic Fluxes to Gene Expression: Claude Kohl, Denis Ravel, Jean Girard, and Jean-Paul Pégorier
Diabetes 2002 51: 2363 -2368. [Abstract] [Full Text] [PDF]

Impairment of Insulin Signaling in Human Skeletal Muscle Cells by Co-Culture With Human Adipocytes: Daniela Dietze, Marlis Koenen, Karin Röhrig, Hiroyoshi Horikoshi, Hans Hauner, and Jürgen Eckel
Diabetes 2002 51: 2369 -2376. [Abstract] [Full Text] [PDF]

Regulatory Effects of HMG CoA Reductase Inhibitor and Fish Oils on Apolipoprotein B-100 Kinetics in Insulin-Resistant Obese Male Subjects With Dyslipidemia: Dick C. Chan, Gerald F. Watts, P. Hugh R. Barrett, Lawrence J. Beilin, Trevor G. Redgrave, and Trevor A. Mori
Diabetes 2002 51: 2377 -2386. [Abstract] [Full Text] [PDF]

Association of SH2-Containing Inositol Phosphatase 2 With the Insulin Resistance of Diabetic db/db Mice: Hiroyuki Hori, Toshiyasu Sasaoka, Hajime Ishihara, Tsutomu Wada, Shihou Murakami, Manabu Ishiki, and Masashi Kobayashi
Diabetes 2002 51: 2387 -2394. [Abstract] [Full Text] [PDF]

Synthesis Rate of Muscle Proteins, Muscle Functions, and Amino Acid Kinetics in Type 2 Diabetes: Panagiotis Halvatsiotis, Kevin R. Short, Maureen Bigelow, and K. Sreekumaran Nair
Diabetes 2002 51: 2395 -2404. [Abstract] [Full Text] [PDF]

Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis: Cristina M. Rondinone, James M. Trevillyan, Jill Clampit, Rebecca J. Gum, Cathy Berg, Paul Kroeger, Leigh Frost, Bradley A. Zinker, Regina Reilly, Roger Ulrich, Madeline Butler, Brett P. Monia, Michael R. Jirousek, and Jeffrey F. Waring
Diabetes 2002 51: 2405 -2411. [Abstract] [Full Text] [PDF]

Potentiation of Insulin Signaling in Tissues of Zucker Obese Rats After Acute and Long-Term Treatment With PPAR ${gamma}$ Agonists: Guoqiang Jiang, Qing Dallas-Yang, Zhihua Li, Deborah Szalkowski, Franklin Liu, Xiaolan Shen, Margaret Wu, Gaochao Zhou, Thomas Doebber, Joel Berger, David E. Moller, and Bei B. Zhang
Diabetes 2002 51: 2412 -2419. [Abstract] [Full Text] [PDF]

The Antidiabetic Drug Metformin Activates the AMP-Activated Protein Kinase Cascade via an Adenine Nucleotide-Independent Mechanism: Simon A. Hawley, Anne E. Gadalla, Grith Skytte Olsen, and D. Grahame Hardie
Diabetes 2002 51: 2420 -2425. [Abstract] [Full Text] [PDF]

Liver X Receptors Downregulate 11ß-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity: Thomas M. Stulnig, Udo Oppermann, Knut R. Steffensen, Gertrud U. Schuster, and Jan-Åke Gustafsson
Diabetes 2002 51: 2426 -2433. [Abstract] [Full Text] [PDF]

Obesity Studies:

Leptin Potentiates Thermogenic Sympathetic Responses to Hypothermia: A Receptor-Mediated Effect: Martin Hausberg, Donald A. Morgan, Jennifer L. Mitchell, William I. Sivitz, Allyn L. Mark, and William G. Haynes
Diabetes 2002 51: 2434 -2440. [Abstract] [Full Text] [PDF]

Selective Antagonism of the NPY Y5 Receptor Does Not Have a Major Effect on Feeding in Rats: Andrew V. Turnbull, Laraine Ellershaw, Dave J. Masters, Susan Birtles, Scott Boyer, Debbie Carroll, Paul Clarkson, Sue J.G. Loxham, Pat McAulay, Joanne L. Teague, Kevin M. Foote, J. Elizabeth Pease, and Michael H. Block
Diabetes 2002 51: 2441 -2449. [Abstract] [Full Text] [PDF]

Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene: Suresh T. Mathews, Gurmant P. Singh, Mollie Ranalletta, Vivian J. Cintron, Xiaoling Qiang, Anton Scott Goustin, Kai-Lin Catherine Jen, Maureen J. Charron, Willi Jahnen-Dechent, and George Grunberger
Diabetes 2002 51: 2450 -2458. [Abstract] [Full Text] [PDF]

Decreased Mitochondrial Proton Leak and Reduced Expression of Uncoupling Protein 3 in Skeletal Muscle of Obese Diet-Resistant Women: Mary-Ellen Harper, Robert Dent, Shadi Monemdjou, Véronic Bézaire, Lloyd Van Wyck, George Wells, Gul Nihan Kavaslar, Andre Gauthier, Frédérique Tesson, and Ruth McPherson
Diabetes 2002 51: 2459 -2466. [Abstract] [Full Text] [PDF]

Impaired Postprandial Adipose Tissue Blood Flow Response Is Related to Aspects of Insulin Sensitivity: Fredrik Karpe, Barbara A. Fielding, Vera Ilic, Ian A. Macdonald, Lucinda K.M. Summers, and Keith N. Frayn
Diabetes 2002 51: 2467 -2473. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Reduced Expression of Th1-Associated Chemokine Receptors on Peripheral Blood Lymphocytes at Diagnosis of Type 1 Diabetes: T. Lohmann, S. Laue, U. Nietzschmann, T.M. Kapellen, I. Lehmann, S. Schroeder, R. Paschke, and W. Kiess
Diabetes 2002 51: 2474 -2480. [Abstract] [Full Text] [PDF]

Phagocytosis of Apoptotic Cells by Macrophages From NOD Mice Is Reduced: Bronwyn A. O’Brien, Yongqian Huang, Xuan Geng, Jan P. Dutz, and Diane T. Finegood
Diabetes 2002 51: 2481 -2488. [Abstract] [Full Text] [PDF]

The Role of CC Chemokine Receptor 5 (CCR5) in Islet Allograft Rejection: Reza Abdi, R. Neal Smith, Leila Makhlouf, Nader Najafian, Andrew D. Luster, Hugh Auchincloss, Jr., and Mohamed H. Sayegh
Diabetes 2002 51: 2489 -2495. [Abstract] [Full Text] [PDF]

Islet Studies:

Succinate Is a Preferential Metabolic Stimulus-Coupling Signal for Glucose-Induced Proinsulin Biosynthesis Translation: Cristina Alarcon, Barton Wicksteed, Marc Prentki, Barbara E. Corkey, and Christopher J. Rhodes
Diabetes 2002 51: 2496 -2504. [Abstract] [Full Text] [PDF]

PDX-1 Induces Differentiation of Intestinal Epithelioid IEC-6 Into Insulin-Producing Cells: Shigeru Yoshida, Yoshitaka Kajimoto, Tetsuyuki Yasuda, Hirotaka Watada, Yoshio Fujitani, Hiroshi Kosaka, Takahiro Gotow, Takeshi Miyatsuka, Yutaka Umayahara, Yoshimitsu Yamasaki, and Masatsugu Hori
Diabetes 2002 51: 2505 -2513. [Abstract] [Full Text] [PDF]

Sulfatide Controls Insulin Secretion by Modulation of ATP-sensitive K⁺-Channel Activity and Ca²⁺-Dependent Exocytosis in Rat Pancreatic ß-Cells: Karsten Buschard, Marianne Høy, Krister Bokvist, Hervør L. Olsen, Sten Madsbad, Pam Fredman, and Jesper Gromada
Diabetes 2002 51: 2514 -2521. [Abstract] [Full Text] [PDF]

Ouabain Suppresses Glucose-Induced Mitochondrial ATP Production and Insulin Release by Generating Reactive Oxygen Species in Pancreatic Islets: Mariko Kajikawa, Shimpei Fujimoto, Yoshiyuki Tsuura, Eri Mukai, Tomomi Takeda, Yoshiyuki Hamamoto, Mihoko Takehiro, Jun Fujita, Yuichiro Yamada, and Yutaka Seino
Diabetes 2002 51: 2522 -2529. [Abstract] [Full Text] [PDF]

Islet Hyperperfusion During Prediabetic Phase in OLETF Rats, a Model of Type 2 Diabetes: Masanori Iwase, Yuji Uchizono, Kenji Tashiro, Daisuke Goto, and Mitsuo Iida
Diabetes 2002 51: 2530 -2535. [Abstract] [Full Text] [PDF]

Stimulation of Acetyl-CoA Carboxylase Gene Expression by Glucose Requires Insulin Release and Sterol Regulatory Element Binding Protein 1c in Pancreatic MIN6 ß-Cells: Chrysovalantis Andreolas, Gabriela da Silva Xavier, Frederique Diraison, Chao Zhao, Aniko Varadi, Fernando Lopez-Casillas, Pascal Ferré, Fabienne Foufelle, and Guy A. Rutter
Diabetes 2002 51: 2536 -2545. [Abstract] [Full Text] [PDF]

Foxa2 Controls Pdx1 Gene Expression in Pancreatic ß-Cells In Vivo: Catherine S. Lee, Newman J. Sund, Marko Z. Vatamaniuk, Franz M. Matschinsky, Doris A. Stoffers, and Klaus H. Kaestner
Diabetes 2002 51: 2546 -2551. [Abstract] [Full Text] [PDF]

Increased Glucose Sensitivity of Stimulus-Secretion Coupling in Islets From Psammomys obesus After Diet Induction of Diabetes: Jose A.G. Pertusa, Rafael Nesher, Nurit Kaiser, Erol Cerasi, Jean-Claude Henquin, and Jean-Christophe Jonas
Diabetes 2002 51: 2552 -2560. [Abstract] [Full Text] [PDF]

Preservation of Human Islet Cell Functional Mass by Anti-Oxidative Action of a Novel SOD Mimic Compound: Rita Bottino, A.N. Balamurugan, Suzanne Bertera, Massimo Pietropaolo, Massimo Trucco, and Jon D. Piganelli
Diabetes 2002 51: 2561 -2567. [Abstract] [Full Text] [PDF]

Pathophysiology:

Maternal First-Trimester Enterovirus Infection and Future Risk of Type 1 Diabetes in the Exposed Fetus: Hanna R. Viskari, Merja Roivainen, Antti Reunanen, Janne Pitkäniemi, Karita Sadeharju, Pentti Koskela, Tapani Hovi, Pauli Leinikki, Pekka Vilja, Jaakko Tuomilehto, and Heikki Hyöty
Diabetes 2002 51: 2568 -2571. [Abstract] [Full Text] [PDF]

Nitric Oxide Synthase Inhibition Reduces Glucose Uptake During Exercise in Individuals With Type 2 Diabetes More Than in Control Subjects: Bronwyn A. Kingwell, Melissa Formosa, Michael Muhlmann, Scott J. Bradley, and Glenn K. McConell
Diabetes 2002 51: 2572 -2580. [Abstract] [Full Text] [PDF]

Association of the Pro12Ala Polymorphism in the PPAR- ${gamma}$ 2 Gene With 3-Year Incidence of Type 2 Diabetes and Body Weight Change in the Finnish Diabetes Prevention Study: Virpi I. Lindi, Matti I.J. Uusitupa, Jaana Lindström, Anne Louheranta, Johan G. Eriksson, Timo T. Valle, Helena Hämäläinen, Pirjo Ilanne-Parikka, Sirkka Keinänen-Kiukaanniemi, Markku Laakso, and Jaakko Tuomilehto
Diabetes 2002 51: 2581 -2586. [Abstract] [Full Text] [PDF]

Impaired Long-Chain Fatty Acid Oxidation and Contractile Dysfunction in the Obese Zucker Rat Heart: Martin E. Young, Patrick H. Guthrie, Peter Razeghi, Brendan Leighton, Shahrzad Abbasi, Sarita Patil, Keith A. Youker, and Heinrich Taegtmeyer
Diabetes 2002 51: 2587 -2595. [Abstract] [Full Text] [PDF]

Cerivastatin Improves Insulin Sensitivity and Insulin Secretion in Early-State Obese Type 2 Diabetes: J.A. Paniagua, J. López-Miranda, A. Escribano, F.J. Berral, C. Marín, D. Bravo, E. Paz-Rojas, P. Gómez, M. Barcos, J.A. Moreno, and F. Pérez-Jiménez
Diabetes 2002 51: 2596 -2603. [Abstract] [Full Text] [PDF]

Complications:

Hepatocyte Growth Factor Prevents Endothelial Cell Death Through Inhibition of bax Translocation From Cytosol to Mitochondrial Membrane: Hironori Nakagami, Ryuichi Morishita, Kei Yamamoto, Yoshiaki Taniyama, Motokuni Aoki, Keita Yamasaki, Kunio Matsumoto, Toshikazu Nakamura, Yasufumi Kaneda, and Toshio Ogihara
Diabetes 2002 51: 2604 -2611. [Abstract] [Full Text] [PDF]

Effects of Mesangium Glycation on Matrix Metalloproteinase Activities: Possible Role in Diabetic Nephropathy: S.V. McLennan, S.K.Y. Martell, and D.K. Yue
Diabetes 2002 51: 2612 -2618. [Abstract] [Full Text] [PDF]

Dissection of Metabolic, Vascular, and Nerve Conduction Interrelationships in Experimental Diabetic Neuropathy by Cyclooxygenase Inhibition and Acetyl-L-Carnitine Administration: Rodica Pop-Busui, Victor Marinescu, Carol Van Huysen, Fei Li, Kelli Sullivan, Douglas A. Greene, Dennis Larkin, and Martin J. Stevens
Diabetes 2002 51: 2619 -2628. [Abstract] [Full Text] [PDF]

Low Circulating Levels of Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1) Are Closely Associated With the Presence of Macrovascular Disease and Hypertension in Type 2 Diabetes: Adrian H. Heald, K.W. Siddals, William Fraser, William Taylor, Kalpana Kaushal, Julie Morris, Robert J. Young, Anne White, and J. Martin Gibson
Diabetes 2002 51: 2629 -2636. [Abstract] [Full Text] [PDF]

Silent Coronary Atheromatosis in Type 1 Diabetic Patients and Its Relation to Long-Term Glycemic Control: Jakob Larsen, Magne Brekke, Leiv Sandvik, Harald Arnesen, Kristian F. Hanssen, and Knut Dahl-Jorgensen
Diabetes 2002 51: 2637 -2641. [Abstract] [Full Text] [PDF]

Factor Analysis of Metabolic Syndrome Using Directly Measured Insulin Sensitivity: The Insulin Resistance Atherosclerosis Study: Anthony J.G. Hanley, Andrew J. Karter, Andreas Festa, Ralph D’Agostino, Jr., Lynne E. Wagenknecht, Peter Savage, Russell P. Tracy, Mohammed F. Saad, and Steven Haffner
Diabetes 2002 51: 2642 -2647. [Abstract] [Full Text] [PDF]

Glucose Increases Endothelial-Dependent Superoxide Formation in Coronary Arteries by NAD(P)H Oxidase Activation: Attenuation by the 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor Atorvastatin: Michael Christ, Johann Bauersachs, Claudia Liebetrau, Marina Heck, Andreas Günther, and Martin Wehling
Diabetes 2002 51: 2648 -2652. [Abstract] [Full Text] [PDF]

Genetics:

Peroxisome Proliferator-Activated Receptor- ${gamma}$ 2 Polymorphism Pro12Ala Is Associated With Nephropathy in Type 2 Diabetes: The Berlin Diabetes Mellitus (BeDiaM) Study: Stefan-Martin Herrmann, Jens Ringel, Ji-Guang Wang, Jan A. Staessen, and Eva Brand
Diabetes 2002 51: 2653 -2657. [Abstract] [Full Text] [PDF]

Variants in the Calpain-10 Gene Predispose to Insulin Resistance and Elevated Free Fatty Acid Levels: Marju Orho-Melander, Mia Klannemark, Malin K. Svensson, Martin Ridderstråle, Cecilia M. Lindgren, and Leif Groop
Diabetes 2002 51: 2658 -2664. [Abstract] [Full Text] [PDF]

Errata:

Errata: Diabetes 2002 51: 2665 . [Extract] [Full Text] [PDF]

Errata: Diabetes 2002 51: 2665 . [Extract] [Full Text] [PDF]