Perspectives in Diabetes:

The Succinate Mechanism of Insulin Release

Leonard A. Fahien and Michael J. MacDonald
Diabetes 2002 51: 2669 -2676. [Abstract] [Full Text] [PDF]  

Metabolism and Signal Transduction:

Long-Term Treatment With Dipeptidyl Peptidase IV Inhibitor Improves Hepatic and Peripheral Insulin Sensitivity in the VDF Zucker Rat: A Euglycemic-Hyperinsulinemic Clamp Study

John A. Pospisilik, Sara G. Stafford, Hans-Ulrich Demuth, Christopher H.S. McIntosh, and Raymond A. Pederson
Diabetes 2002 51: 2677 -2683. [Abstract] [Full Text] [PDF]  

Regulation of Dietary Fatty Acid Entrapment in Subcutaneous Adipose Tissue and Skeletal Muscle

Kevin Evans, Graham C. Burdge, Stephen A. Wootton, Mo L. Clark, and Keith N. Frayn
Diabetes 2002 51: 2684 -2690. [Abstract] [Full Text] [PDF]  

Troglitazone Treatment Increases Protein Kinase B Phosphorylation in Skeletal Muscle of Normoglycemic Subjects at Risk for the Development of Type 2 Diabetes

Marco M. Meyer, Klaus Levin, Thomas Grimmsmann, Nina Perwitz, Alexandra Eirich, Henning Beck-Nielsen, and Harald H. Klein
Diabetes 2002 51: 2691 -2697. [Abstract] [Full Text] [PDF]  

Muscle Glucose Uptake Does Not Increase When Only Local Arterial Glucose Concentration Is Increased

Kenneth Zierler and Reubin Andres
Diabetes 2002 51: 2698 -2702. [Abstract] [Full Text] [PDF]  

Isoform-Specific Regulation of 5' AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (fa/fa) Rats in Response to Contraction

Brian R. Barnes, Jeffrey W. Ryder, Tatiana L. Steiler, Lee G.D. Fryer, David Carling, and Juleen R. Zierath
Diabetes 2002 51: 2703 -2708. [Abstract] [Full Text] [PDF]  

Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C ß2 Activation and Diabetes

Kerrie J. Way, Keiji Isshiki, Kiyoshi Suzuma, Tamotsu Yokota, Dmitriy Zvagelsky, Frederick J. Schoen, George E. Sandusky, Penelope A. Pechous, Chris J. Vlahos, Hisao Wakasaki, and George L. King
Diabetes 2002 51: 2709 -2718. [Abstract] [Full Text] [PDF]  

Need for GLUT4 Activation to Reach Maximum Effect of Insulin-Mediated Glucose Uptake in Brown Adipocytes Isolated From GLUT4myc-Expressing Mice

Daniel Konrad, Philip J. Bilan, Zafar Nawaz, Gary Sweeney, Wenyan Niu, Zhi Liu, Costin N. Antonescu, Assaf Rudich, and Amira Klip
Diabetes 2002 51: 2719 -2726. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy

Carlo Colombo, Jaime J. Cutson, Toshimasa Yamauchi, Charles Vinson, Takashi Kadowaki, Oksana Gavrilova, and Marc L. Reitman
Diabetes 2002 51: 2727 -2733. [Abstract] [Full Text] [PDF]  

Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein

Hitoshi Nishizawa, Iichiro Shimomura, Ken Kishida, Norikazu Maeda, Hiroshi Kuriyama, Hiroyuki Nagaretani, Morihiro Matsuda, Hidehiko Kondo, Naoki Furuyama, Shinji Kihara, Tadashi Nakamura, Yoshihiro Tochino, Tohru Funahashi, and Yuji Matsuzawa
Diabetes 2002 51: 2734 -2741. [Abstract] [Full Text] [PDF]  

Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects

Mikaela Sjöstrand, Soffia Gudbjörnsdottir, Agneta Holmäng, Lars Lönn, Lena Strindberg, and Peter Lönnroth
Diabetes 2002 51: 2742 -2748. [Abstract] [Full Text] [PDF]  

Islet Studies:

Role of ATP Production and Uncoupling Protein-2 in the Insulin Secretory Defect Induced by Chronic Exposure to High Glucose or Free Fatty Acids and Effects of Peroxisome Proliferator-Activated Receptor- Inhibition

Giovanni Patanè, Marcello Anello, Salvatore Piro, Riccardo Vigneri, Francesco Purrello, and Agata Maria Rabuazzo
Diabetes 2002 51: 2749 -2756. [Abstract] [Full Text] [PDF]  

Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells

Frank Reimann and Fiona M. Gribble
Diabetes 2002 51: 2757 -2763. [Abstract] [Full Text] [PDF]  

Modulation of Glucocorticoid-Induced GAD Expression in Pancreatic ß-Cells by Transcriptional Activation of the GAD67 Promoter and Its Possible Effect on the Development of Diabetes

Kyung Soo Kim, Yup Kang, Sung E. Choi, Ju Hee Kim, Hyeon Man Kim, Beichen Sun, Hee-Sook Jun, and Ji-Won Yoon
Diabetes 2002 51: 2764 -2772. [Abstract] [Full Text] [PDF]  

Plasma Membrane Ca²⁺-ATPase Overexpression Reduces Ca²⁺ Oscillations and Increases Insulin Release Induced by Glucose in Insulin-Secreting BRIN-BD11 Cells

Adama Kamagate, André Herchuelz, and Françoise Van Eylen
Diabetes 2002 51: 2773 -2788. [Abstract] [Full Text] [PDF]  

Differential Interactions of Nateglinide and Repaglinide on the Human ß-Cell Sulphonylurea Receptor 1

Ann Maria K. Hansen, Inge T. Christensen, John Bondo Hansen, Richard D. Carr, Frances M. Ashcroft, and Philip Wahl
Diabetes 2002 51: 2789 -2795. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Preservation of Pancreatic ß-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women

Thomas A. Buchanan, Anny H. Xiang, Ruth K. Peters, Siri L. Kjos, Aura Marroquin, Jose Goico, Cesar Ochoa, Sylvia Tan, Kathleen Berkowitz, Howard N. Hodis, and Stanley P. Azen
Diabetes 2002 51: 2796 -2803. [Abstract] [Full Text] [PDF]  

Complications:

Diacylglycerol Production and Protein Kinase C Activity Are Increased in a Mouse Model of Diabetic Embryopathy

Yuji Hiramatsu, Naotaka Sekiguchi, Michio Hayashi, Keiji Isshiki, Tamotsu Yokota, George L. King, and Mary R. Loeken
Diabetes 2002 51: 2804 -2810. [Abstract] [Full Text] [PDF]  

Maternal Diabetes Increases the Risk of Caudal Regression Caused by Retinoic Acid

Billy W.H. Chan, Kwok-siu Chan, Tsuyoshi Koide, Sau-man Yeung, Maran B.W. Leung, Andrew J. Copp, Mary R. Loeken, Toshihiko Shiroishi, and Alisa S.W. Shum
Diabetes 2002 51: 2811 -2816. [Abstract] [Full Text] [PDF]  

Nitrosative Stress, Uric Acid, and Peripheral Nerve Function in Early Type 1 Diabetes

Robert D. Hoeldtke, Kimberly D. Bryner, Daniel R. McNeill, Gerald R. Hobbs, Jack E. Riggs, Sarah S. Warehime, Ian Christie, Gary Ganser, and Knox Van Dyke
Diabetes 2002 51: 2817 -2825. [Abstract] [Full Text] [PDF]  

The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes

Alan Stitt, Thomas A. Gardiner, Nathan L. Anderson, Paul Canning, Norma Frizzell, Noel Duffy, Cliona Boyle, Andrzej S. Januszewski, Mark Chachich, John W. Baynes, and Suzanne R. Thorpe
Diabetes 2002 51: 2826 -2832. [Abstract] [Full Text] [PDF]  

Peroxynitrite Induces Formation of N-(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From Glucose: Novel Pathways for Protein Modification by Peroxynitrite

Ryoji Nagai, Yuka Unno, Miki Cristina Hayashi, Shuichi Masuda, Fumitaka Hayase, Naohide Kinae, and Seikoh Horiuchi
Diabetes 2002 51: 2833 -2839. [Abstract] [Full Text] [PDF]  

Type 1 And Type 2 Diabetic Patients Display Different Patterns of Cellular Microparticles

Florence Sabatier, Patrice Darmon, Benedicte Hugel, Valery Combes, Marielle Sanmarco, Jean-Gabriel Velut, Dominique Arnoux, Phillipe Charpiot, Jean-Marie Freyssinet, Charles Oliver, Jose Sampol, and Francoise Dignat-George
Diabetes 2002 51: 2840 -2845. [Abstract] [Full Text] [PDF]  

Augmentation of the Neutrophil Respiratory Burst Through the Action of Advanced Glycation End Products: A Potential Contributor to Vascular Oxidant Stress

Richard K.M. Wong, Andrew I. Pettit, Joan E. Davies, and Leong L. Ng
Diabetes 2002 51: 2846 -2853. [Abstract] [Full Text] [PDF]  

Genetics:

The Prevalent Glu23Lys Polymorphism in the Potassium Inward Rectifier 6.2 (KIR6.2) Gene Is Associated With Impaired Glucagon Suppression in Response to Hyperglycemia

Otto Tschritter, Michael Stumvoll, Fausto Machicao, Martin Holzwarth, Melanie Weisser, Elke Maerker, Anna Teigeler, Hans Häring, and Andreas Fritsche
Diabetes 2002 51: 2854 -2860. [Abstract] [Full Text] [PDF]  

Liver Pyruvate Kinase Polymorphisms Are Associated With Type 2 Diabetes in Northern European Caucasians

Hua Wang, Winston Chu, Swapan K. Das, Qianfang Ren, Sandra J. Hasstedt, and Steven C. Elbein
Diabetes 2002 51: 2861 -2865. [Abstract] [Full Text] [PDF] Online Tables 3-5  

Brief Genetics Reports:

A Comprehensive, Statistically Powered Analysis of GAD2 in Type 1 Diabetes

Gillian C.L. Johnson, Felicity Payne, Sarah Nutland, Helen Stevens, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, and John A. Todd
Diabetes 2002 51: 2866 -2870. [Abstract] [Full Text] [PDF]  

Polymorphic Susceptibility to the Molecular Causes of Neural Tube Defects During Diabetic Embryopathy

Lydie Pani, Melissa Horal, and Mary R. Loeken
Diabetes 2002 51: 2871 -2874. [Abstract] [Full Text] [PDF] Online Protocol  

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