Editorials:

Insulin Secretion: Movement at All Levels

Jean-Claude Henquin, Christian Boitard, Suad Efendic, Ele Ferrannini, Donald F. Steiner, and Erol Cerasi
Diabetes 2002 51: S S1 -S2. [Extract] [Full Text] [PDF]  

Section 1: Insulin Release: Some Molecular Requisites:

Molecular Determinants of Regulated Exocytosis

Stefan H. Gerber and Thomas C. Südhof
Diabetes 2002 51: S S3 -S11. [Abstract] [Full Text] [PDF]  

Role of Electrostatic and Hydrophobic Interactions in Ca²⁺-Dependent Phospholipid Binding by the C₂A-Domain From Synaptotagmin I

Stefan H. Gerber, Josep Rizo, and Thomas C. Südhof
Diabetes 2002 51: S S12 -S18. [Abstract] [Full Text] [PDF]  

Fast and cAMP-Sensitive Mode of Ca²⁺-Dependent Exocytosis in Pancreatic ß-Cells

Haruo Kasai, Tomoyuki Suzuki, Ting-Ting Liu, Takuya Kishimoto, and Noriko Takahashi
Diabetes 2002 51: S S19 -S24. [Abstract] [Full Text] [PDF]  

Two-Photon Excitation Imaging of Pancreatic Islets With Various Fluorescent Probes

Noriko Takahashi, Tomomi Nemoto, Ryoichi Kimura, Akira Tachikawa, Akiko Miwa, Haruo Okado, Yasushi Miyashita, Masamitsu Iino, Takashi Kadowaki, and Haruo Kasai
Diabetes 2002 51: S S25 -S28. [Abstract] [Full Text] [PDF]  

Triggering of Insulin Release by a Combination of cAMP Signal and Nutrients : An ATP-Sensitive K⁺ Channel–Independent Phenomenon

Mitsuhisa Komatsu, Yoshihiko Sato, Satoko Yamada, Keishi Yamauchi, Kiyoshi Hashizume, and Toru Aizawa
Diabetes 2002 51: S S29 -S32. [Abstract] [Full Text] [PDF]  

Sulfonylurea-Mediated Stimulation of Insulin Exocytosis via an ATP-Sensitive K⁺ Channel–Independent Action

Erik Renström, Sebastian Barg, Frank Thévenod, and Patrik Rorsman
Diabetes 2002 51: S S33 -S36. [Abstract] [Full Text] [PDF]  

ß-Cell Mitochondria and Insulin Secretion: Messenger Role of Nucleotides and Metabolites

Claes B. Wollheim and Pierre Maechler
Diabetes 2002 51: S S37 -S42. [Abstract] [Full Text] [PDF]  

Effect of the Insulin Mimetic L-783,281 on Intracellular [Ca²⁺] and Insulin Secretion From Pancreatic ß-Cells

Michael G. Roper, Wei-jun Qian, Bei B. Zhang, Rohit N. Kulkarni, C. Ronald Kahn, and Robert T. Kennedy
Diabetes 2002 51: S S43 -S49. [Abstract] [Full Text] [PDF]  

Glucose-Dependent Promotion of Insulin Release From Mouse Pancreatic Islets by the Insulin-Mimetic Compound L-783,281

Johanna Westerlund, Bryan A. Wolf, and Peter Bergsten
Diabetes 2002 51: S S50 -S52. [Abstract] [Full Text] [PDF]  

Section 2: Biphasic Insulin Release: Pools and Signal Modulation:

Modeling Phasic Insulin Release: Immediate and Time-Dependent Effects of Glucose

Rafael Nesher and Erol Cerasi
Diabetes 2002 51: S S53 -S59. [Abstract] [Full Text] [PDF]  

Signals and Pools Underlying Biphasic Insulin Secretion

Jean-Claude Henquin, Nobuyoshi Ishiyama, Myriam Nenquin, Magalie A. Ravier, and Jean-Christophe Jonas
Diabetes 2002 51: S S60 -S67. [Abstract] [Full Text] [PDF]  

ß-Cell Protein Kinases and the Dynamics of the Insulin Response to Glucose

Rafael Nesher, Eyal Anteby, Michael Yedovizky, Nasim Warwar, Nurit Kaiser, and Erol Cerasi
Diabetes 2002 51: S S68 -S73. [Abstract] [Full Text] [PDF]  

A Subset of 50 Secretory Granules in Close Contact With L-Type Ca²⁺ Channels Accounts for First-Phase Insulin Secretion in Mouse ß-Cells

Sebastian Barg, Lena Eliasson, Erik Renström, and Patrik Rorsman
Diabetes 2002 51: S S74 -S82. [Abstract] [Full Text] [PDF]  

Triggering and Augmentation Mechanisms, Granule Pools, and Biphasic Insulin Secretion

Troitza K. Bratanova-Tochkova, Haiying Cheng, Samira Daniel, Subhadra Gunawardana, Yi-Jia Liu, Jennifer Mulvaney-Musa, Thomas Schermerhorn, Susanne G. Straub, Hiroki Yajima, and Geoffrey W.G. Sharp
Diabetes 2002 51: S S83 -S90. [Abstract] [Full Text] [PDF]  

The Effects of Cerulenin, an Inhibitor of Protein Acylation, on the Two Phases of Glucose-Stimulated Insulin Secretion

Susanne G. Straub, Hiroki Yajima, Mitsuhisa Komatsu, Toru Aizawa, and Geoffrey W.G. Sharp
Diabetes 2002 51: S S91 -S95. [Abstract] [Full Text] [PDF]  

Importance of Nonionic Signals for Glucose-Induced Biphasic Insulin Secretion

Toru Aizawa, Yoshihiko Sato, and Mitsuhisa Komatsu
Diabetes 2002 51: S S96 -S98. [Abstract] [Full Text] [PDF]  

Implication of Glutamate in the Kinetics of Insulin Secretion in Rat and Mouse Perfused Pancreas

Pierre Maechler, Asllan Gjinovci, and Claes B. Wollheim
Diabetes 2002 51: S S99 -S102. [Abstract] [Full Text] [PDF]  

Section 3: Phasic Insulin Release and Metabolic Control:

Physiological Consequences of Phasic Insulin Release in the Normal Animal

Alan D. Cherrington, Dana Sindelar, Dale Edgerton, Kurt Steiner, and Owen P. McGuinness
Diabetes 2002 51: S S103 -S108. [Abstract] [Full Text] [PDF]  

Phasic Insulin Release and Metabolic Regulation in Type 2 Diabetes

Stefano Del Prato, Piero Marchetti, and Riccardo C. Bonadonna
Diabetes 2002 51: S S109 -S116. [Abstract] [Full Text] [PDF]  

Is Reduced First-Phase Insulin Release the Earliest Detectable Abnormality in Individuals Destined to Develop Type 2 Diabetes?

John E. Gerich
Diabetes 2002 51: S S117 -S121. [Abstract] [Full Text] [PDF]  

Clinical Characterization of Insulin Secretion as the Basis for Genetic Analyses

Michael Stumvoll, Andreas Fritsche, and Hans-Ulrich Häring
Diabetes 2002 51: S S122 -S129. [Abstract] [Full Text] [PDF]  

Effect of Acute Hyperglycemia on Insulin Secretion in Humans

Elena Toschi, Stefania Camastra, Anna Maria Sironi, Antonio Masoni, Amalia Gastaldelli, Andrea Mari, Ele Ferrannini, and Andrea Natali
Diabetes 2002 51: S S130 -S133. [Abstract] [Full Text] [PDF]  

Lipotoxicity in Human Pancreatic Islets and the Protective Effect of Metformin

Roberto Lupi, Silvia Del Guerra, Vanna Fierabracci, Lorella Marselli, Michela Novelli, Giovanni Patanè, Ugo Boggi, Franco Mosca, Salvatore Piro, Stefano Del Prato, and Piero Marchetti
Diabetes 2002 51: S S134 -S137. [Abstract] [Full Text] [PDF]  

Altered ß-Cell Distribution of pdx-1 and GLUT-2 After a Short-Term Challenge With a High-Fat Diet in C57BL/6J Mice

Martina Kvist Reimer and Bo Ahrén
Diabetes 2002 51: S S138 -S143. [Abstract] [Full Text] [PDF]  

Section 4: Oscillations in beta-Cells:

Control Mechanisms of the Oscillations of Insulin Secretion In Vitro and In Vivo

Patrick Gilon, Magalie A. Ravier, Jean-Christophe Jonas, and Jean-Claude Henquin
Diabetes 2002 51: S S144 -S151. [Abstract] [Full Text] [PDF]  

Metabolic Oscillations in ß-Cells

Robert T. Kennedy, Lisa M. Kauri, Gabriella M. Dahlgren, and Sung-Kwon Jung
Diabetes 2002 51: S S152 -S161. [Abstract] [Full Text] [PDF]  

Glucose-Stimulated Oscillations in Free Cytosolic ATP Concentration Imaged in Single Islet ß-Cells: Evidence for a Ca²⁺-Dependent Mechanism

Edward K. Ainscow and Guy A. Rutter
Diabetes 2002 51: S S162 -S170. [Abstract] [Full Text] [PDF]  

Role of Oscillations in Membrane Potential, Cytoplasmic Ca²⁺, and Metabolism for Plasma Insulin Oscillations

Peter Bergsten
Diabetes 2002 51: S S171 -S176. [Abstract] [Full Text] [PDF]  

Do Oscillations of Insulin Secretion Occur in the Absence of Cytoplasmic Ca²⁺ Oscillations in ß-Cells?

Lise L. Kjems, Magalie A. Ravier, Jean-Christophe Jonas, and Jean-Claude Henquin
Diabetes 2002 51: S S177 -S182. [Abstract] [Full Text] [PDF]  

TRP Genes: Candidates for Nonselective Cation Channels and Store-Operated Channels in Insulin-Secreting Cells

Feng Qian, Ping Huang, Li Ma, Andrey Kuznetsov, Natalia Tamarina, and Louis H. Philipson
Diabetes 2002 51: S S183 -S189. [Abstract] [Full Text] [PDF]  

Dynamic Imaging of Endoplasmic Reticulum Ca²⁺ Concentration in Insulin-Secreting MIN6 Cells Using Recombinant Targeted Cameleons: Roles of Sarco(endo)plasmic Reticulum Ca²⁺-ATPase (SERCA)-2 and Ryanodine Receptors

Aniko Varadi and Guy A. Rutter
Diabetes 2002 51: S S190 -S201. [Abstract] [Full Text] [PDF]  

Section 5: Methodology for Quantifying Insulin Release in Man:

Quantification of Insulin Secretion in Relation to Insulin Sensitivity in Nondiabetic Postmenopausal Women

Bo Ahrén and Hillevi Larsson
Diabetes 2002 51: S S202 -S211. [Abstract] [Full Text] [PDF]  

Accurate Assessment of ß-Cell Function: The Hyperbolic Correction

Richard N. Bergman, Marilyn Ader, Katrin Huecking, and Gregg Van Citters
Diabetes 2002 51: S S212 -S220. [Abstract] [Full Text] [PDF]  

Assessing Insulin Secretion by Modeling in Multiple-Meal Tests: Role of Potentiation

Andrea Mari, Andrea Tura, Amalia Gastaldelli, and Ele Ferrannini
Diabetes 2002 51: S S221 -S226. [Abstract] [Full Text] [PDF]  

Insulin Release in Impaired Glucose Tolerance: Oral Minimal Model Predicts Normal Sensitivity to Glucose but Defective Response Times

Elena Breda, Gianna Toffolo, Kenneth S. Polonsky, and Claudio Cobelli
Diabetes 2002 51: S S227 -S233. [Abstract] [Full Text] [PDF]  

Relationships Among Age, Proinsulin Conversion, and ß-Cell Function in Nondiabetic Humans

Andreas Fritsche, Alexander Madaus, Norbert Stefan, Otto Tschritter, Elke Maerker, Anna Teigeler, Hans Häring, and Michael Stumvoll
Diabetes 2002 51: S S234 -S239. [Abstract] [Full Text] [PDF]  

Rationale and Methods for the Estimation of Insulin Secretion in a Given Patient: From Research to Clinical Practice

Philippe Vague and Loan Nguyen
Diabetes 2002 51: S S240 -S244. [Abstract] [Full Text] [PDF]  

Section 6: Pusatile and Phasic Insulin Release in Normal and Diabetic Men:

Pulsatile Insulin Secretion: Detection, Regulation, and Role in Diabetes

Niels Pørksen, Malene Hollingdal, Claus Juhl, Peter Butler, Johannes D. Veldhuis, and Ole Schmitz
Diabetes 2002 51: S S245 -S254. [Abstract] [Full Text] [PDF]  

Effects of Fasting on Physiologically Pulsatile Insulin Release in Healthy Humans

Claus Juhl, Thorbjørn Grøfte, Peter C. Butler, Johannes D. Veldhuis, Ole Schmitz, and Niels Pørksen
Diabetes 2002 51: S S255 -S257. [Abstract] [Full Text] [PDF]  

Ultradian Oscillations of Insulin Secretion in Humans

Chantal Simon and Gabrielle Brandenberger
Diabetes 2002 51: S S258 -S261. [Abstract] [Full Text] [PDF]  

Reduced Early Insulin Secretion in the Etiology of Type 2 Diabetes Mellitus in Pima Indians

Clifton Bogardus and P. Antonio Tataranni
Diabetes 2002 51: S S262 -S264. [Abstract] [Full Text] [PDF]  

Disturbances in ß-Cell Function in Impaired Fasting Glycemia

Timon W. van Haeften, Walkyria Pimenta, Asimina Mitrakou, Mary Korytkowski, Trond Jenssen, Hannele Yki-Jarvinen, and John E. Gerich
Diabetes 2002 51: S S265 -S270. [Abstract] [Full Text] [PDF]  

Intense Exercise Has Unique Effects on Both Insulin Release and Its Roles in Glucoregulation: Implications for Diabetes

Errol B. Marliss and Mladen Vranic
Diabetes 2002 51: S S271 -S283. [Abstract] [Full Text] [PDF]  

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