Editorial:

Regulation of Insulin Production: In Search of Therapeutic Targets

Suad Efendic, Christian Boitard, Erol Cerasi, Ele Ferrannini, Jean-Claude Henquin, and Donald F. Steiner
Diabetes 2002 51: S285-287. [Extract] [Full Text] [PDF]  

Section 1: In Search of Diabetes Genes:

Challenges and Strategies for Investigating the Genetic Complexity of Common Human Diseases

Stephen S. Rich and Patrick Concannon
Diabetes 2002 51: S288-294. [Abstract] [Full Text] [PDF]  

Genetics of Obesity and Type 2 Diabetes: Tracking Pathogenic Traits During the Predisease Period

Pierre Bougnères
Diabetes 2002 51: S295-303. [Abstract] [Full Text] [PDF]  

Increased Insulin Resistance in Obese Children Who Have Both 972 IRS-1 and 1057 IRS-2 Polymorphisms

Sophie Le Fur, Catherine Le Stunff, and Pierre Bougnères
Diabetes 2002 51: S304-307. [Abstract] [Full Text] [PDF]  

Searching for Type 2 Diabetes Genes on Chromosome 20

Marshall Alan Permutt, Jonathan Wasson, Latisha Love-Gregory, Jiyan Ma, Gary Skolnick, Brian Suarez, Jennifer Lin, and Benjamin Glaser
Diabetes 2002 51: S308-315. [Abstract] [Full Text] [PDF]  

Evidence for a Novel Type 1 Diabetes Susceptibility Locus on Chromosome 8

Michèle M. Sale, Liesel M. FitzGerald, Jacinta C. Charlesworth, Donald W. Bowden, and Stephen S. Rich
Diabetes 2002 51: S316-319. [Abstract] [Full Text] [PDF]  

Section 2: Beta-Cell Genes: Functional Aspects:

Regulation of pdx-1 Gene Expression

Danielle Melloul, Sonya Marshak, and Erol Cerasi
Diabetes 2002 51: S320-325. [Abstract] [Full Text] [PDF]  

Glucose-Regulated Gene Expression Maintaining the Glucose-Responsive State of ß-Cells

Frans Schuit, Daisy Flamez, Anick De Vos, and Daniel Pipeleers
Diabetes 2002 51: S326-332. [Abstract] [Full Text] [PDF]  

Experimental Models of Transcription Factor-Associated Maturity-Onset Diabetes of the Young

Haiyan Wang, Kerstin Hagenfeldt-Johansson, Luc A. Otten, Benoit R. Gauthier, Pedro L. Herrera, and Claes B. Wollheim
Diabetes 2002 51: S333-342. [Abstract] [Full Text] [PDF]  

Decreased Glibenclamide Uptake in Hepatocytes of Hepatocyte Nuclear Factor-1-Deficient Mice: A Mechanism for Hypersensitivity to Sulfonylurea Therapy in Patients With Maturity-Onset Diabetes of the Young, Type 3 (MODY3)

Pascal Boileau, Christian Wolfrum, David Q. Shih, Tien-An Yang, Allan W. Wolkoff, and Markus Stoffel
Diabetes 2002 51: S343-348. [Abstract] [Full Text] [PDF]  

Section 3: Beta-Cell Stimulus-Secretion Coupling: K+ ATP Channels and CA2+:

Regulation of Intracellular Ca²⁺ Stores by Multiple Ca²⁺-Releasing Messengers

Jose M. Cancela and Ole H. Petersen
Diabetes 2002 51: S349-357. [Abstract] [Full Text] [PDF]  

Nucleotide Sensitivity of Pancreatic ATP-Sensitive Potassium Channels and Type 2 Diabetes

Christina Schwanstecher and Mathias Schwanstecher
Diabetes 2002 51: S358-362. [Abstract] [Full Text] [PDF]  

The Common Single Nucleotide Polymorphism E23K in K_IR6.2 Sensitizes Pancreatic ß-Cell ATP-Sensitive Potassium Channels Toward Activation Through Nucleoside Diphosphates

Christina Schwanstecher, Bettina Neugebauer, Miriam Schulz, and Mathias Schwanstecher
Diabetes 2002 51: S363-367. [Abstract] [Full Text] [PDF]  

Sulfonylurea Stimulation of Insulin Secretion

Peter Proks, Frank Reimann, Nick Green, Fiona Gribble, and Frances Ashcroft
Diabetes 2002 51: S368-376. [Abstract] [Full Text] [PDF]  

Interaction of the Cytosolic Domains of the Kir6.2 Subunit of the K_ATP Channel Is Modulated by Sulfonylureas

Jonathan D. Lippiat, Sophie L. Albinson, and Frances M. Ashcroft
Diabetes 2002 51: S377-380. [Abstract] [Full Text] [PDF]  

Gliclazide Directly Inhibits Arginine-Induced Glucagon Release

Kenan Cejvan, David H. Coy, Jens Juul Holst, Erol Cerasi, and Suad Efendic
Diabetes 2002 51: S381-384. [Abstract] [Full Text] [PDF]  

Section 4: Beta-Cell Stimulus-Secretion Coupling: Metabolic Factors:

Intracellular Targeting of Protein Kinases and Phosphatases

Neal Alto, Jennifer J. Carlisle Michel, Kimberly L. Dodge, Lorene K. Langeberg, and John D. Scott
Diabetes 2002 51: S385-388. [Abstract] [Full Text] [PDF]  

Stimulus/Secretion Coupling Factors in Glucose-Stimulated Insulin Secretion: Insights Gained From a Multidisciplinary Approach

Christopher B. Newgard, Danhong Lu, Mette Valentin Jensen, Jonathan Schissler, Anne Boucher, Shawn Burgess, and A. Dean Sherry
Diabetes 2002 51: S389-393. [Abstract] [Full Text] [PDF]  

Regulation of Pancreatic ß-Cell Glucokinase: From Basics to Therapeutics

Franz M. Matschinsky
Diabetes 2002 51: S394-404. [Abstract] [Full Text] [PDF]  

Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity: Role in ß-Cell Adaptation and Failure in the Etiology of Diabetes

Marc Prentki, Erik Joly, Wissal El-Assaad, and Raphaël Roduit
Diabetes 2002 51: S405-413. [Abstract] [Full Text] [PDF]  

Genetic Manipulations of Fatty Acid Metabolism in ß-Cells Are Associated With Dysregulated Insulin Secretion

Kazuhiro Eto, Tokuyuki Yamashita, Junji Matsui, Yasuo Terauchi, Mitsuhiko Noda, and Takashi Kadowaki
Diabetes 2002 51: S414-420. [Abstract] [Full Text] [PDF]  

Glutaminolysis and Insulin Secretion: From Bedside to Bench and Back

Andrea Kelly, Changhong Li, Zhiyong Gao, Charles A. Stanley, and Franz M. Matschinsky
Diabetes 2002 51: S421-426. [Abstract] [Full Text] [PDF]  

Section 5: Beta-Cell Stimulus-Secretion Coupling: Hormonal and Pharmacological Modulators:

Insulin Receptor Signaling and Sarco/Endoplasmic Reticulum Calcium ATPase in ß-Cells

Prabakhar D. Borge, Jacob Moibi, Scott R. Greene, Matteo Trucco, Robert A. Young, Zhiyong Gao, and Bryan A. Wolf
Diabetes 2002 51: S427-433. [Abstract] [Full Text] [PDF]  

The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion

Patrick E. MacDonald, Wasim El-kholy, Michael J. Riedel, Anne Marie F. Salapatek, Peter E. Light, and Michael B. Wheeler
Diabetes 2002 51: S434-442. [Abstract] [Full Text] [PDF]  

Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent Repolarizing K⁺ Currents in ß-Cells: A Possible Glucose-Dependent Insulinotropic Mechanism

Patrick E. MacDonald, Anne Marie F. Salapatek, and Michael B. Wheeler
Diabetes 2002 51: S443-447. [Abstract] [Full Text] [PDF]  

Two Generations of Insulinotropic Imidazoline Compounds

Suad Efendic, Alexander M. Efanov, Per-Olof Berggren, and Sergei V. Zaitsev
Diabetes 2002 51: S448-454. [Abstract] [Full Text] [PDF]  

Section 6: Beta-Cell Survival:

Endoplasmic Reticulum Stress and the Development of Diabetes: A Review

Heather P. Harding and David Ron
Diabetes 2002 51: S455-461. [Abstract] [Full Text] [PDF]  

Recent Advances in the Okamoto Model: The CD38-Cyclic ADP-Ribose Signal System and the Regenerating Gene Protein (Reg)-Reg Receptor System in ß-Cells

Hiroshi Okamoto and Shin Takasawa
Diabetes 2002 51: S462-473. [Abstract] [Full Text] [PDF]  

Prolonged In Vitro Exposure to Autoantibodies Against CD38 Impairs the Function and Survival of Human Pancreatic Islets

Piero Marchetti, Alessandro Antonelli, Roberto Lupi, Lorella Marselli, Poupak Fallahi, Claudia Nesti, Germano Baj, and Ele Ferrannini
Diabetes 2002 51: S474-477. [Abstract] [Full Text] [PDF]  

Production and Characterization of Reg Knockout Mice: Reduced Proliferation of Pancreatic ß-Cells in Reg Knockout Mice

Michiaki Unno, Koji Nata, Naoya Noguchi, Yoichi Narushima, Takako Akiyama, Takayuki Ikeda, Kei Nakagawa, Shin Takasawa, and Hiroshi Okamoto
Diabetes 2002 51: S478-483. [Abstract] [Full Text] [PDF]  

Activation of Nuclear Factor-B by Depolarization and Ca²⁺ Influx in MIN6 Insulinoma Cells

Ernesto Bernal-Mizrachi, Wu Wen, Michael Shornick, and M. Alan Permutt
Diabetes 2002 51: S484-488. [Abstract] [Full Text] [PDF]  

Proinsulin 2 Knockout NOD Mice: A Model for Genetic Variation of Insulin Gene Expression in Type 1 Diabetes

Danièle Dubois-Lafforgue, Laurent Mogenet, Karine Thébault, Jacques Jami, Patricia Krief, and Christian Boitard
Diabetes 2002 51: S489-493. [Abstract] [Full Text] [PDF]  

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