Perspectives in Diabetes:

Are Oxidative Stress-Activated Signaling Pathways Mediators of Insulin Resistance and ß-Cell Dysfunction?

Joseph L. Evans, Ira D. Goldfine, Betty A. Maddux, and Gerold M. Grodsky
Diabetes 2003 52: 1 -8. [Abstract] [Full Text] [PDF]  

Metabolism and Signal Transduction:

Regulation of Glycogen Synthase by Glucose and Glycogen: A Possible Role for AMP-Activated Protein Kinase

Reza Halse, Lee G.D. Fryer, James G. McCormack, David Carling, and Stephen J. Yeaman
Diabetes 2003 52: 9 -15. [Abstract] [Full Text] [PDF]  

Plasma Ghrelin Concentrations Are Not Regulated by Glucose or Insulin: A Double-Blind, Placebo-Controlled Crossover Clamp Study

Georg Schaller, Adele Schmidt, Johannes Pleiner, Wolfgang Woloszczuk, Michael Wolzt, and Anton Luger
Diabetes 2003 52: 16 -20. [Abstract] [Full Text] [PDF]  

Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice

Rebecca J. Gum, Lori L. Gaede, Sandra L. Koterski, Matthew Heindel, Jill E. Clampit, Bradley A. Zinker, James M. Trevillyan, Roger G. Ulrich, Michael R. Jirousek, and Cristina M. Rondinone
Diabetes 2003 52: 21 -28. [Abstract] [Full Text] [PDF]  

Dietary Cod Protein Restores Insulin-Induced Activation of Phosphatidylinositol 3-Kinase/Akt and GLUT4 Translocation to the T-Tubules in Skeletal Muscle of High-Fat-Fed Obese Rats

Frédéric Tremblay, Charles Lavigne, Hélène Jacques, and André Marette
Diabetes 2003 52: 29 -37. [Abstract] [Full Text] [PDF]  

Elevated Free Fatty Acids Impair Glucose Metabolism in Women: Decreased Stimulation of Muscle Glucose Uptake and Suppression of Splanchnic Glucose Production During Combined Hyperinsulinemia and Hyperglycemia

Pankaj Shah, Adrian Vella, Ananda Basu, Rita Basu, Aron Adkins, W. Frederick Schwenk, C. Michael Johnson, K. Sreekumaran Nair, Michael D. Jensen, and Robert A. Rizza
Diabetes 2003 52: 38 -42. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Differential Regulation of Lipogenesis and Leptin Production by Independent Signaling Pathways and Rosiglitazone During Human Adipocyte Differentiation

Nayan G. Patel, Julie C. Holder, Stephen A. Smith, Sudesh Kumar, and Margaret C. Eggo
Diabetes 2003 52: 43 -50. [Abstract] [Full Text] [PDF]  

Diabetes-Induced, Progressive Endometrial Involution Characterization of Periluminal Epithelial Lipoatrophy

David R. Garris and Bryan L. Garris
Diabetes 2003 52: 51 -58. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Purified Allogeneic Hematopoietic Stem Cell Transplantation Blocks Diabetes Pathogenesis in NOD Mice

Georg F. Beilhack, Yolanda C. Scheffold, Irving L. Weissman, Cariel Taylor, Libuse Jerabek, Matthew J. Burge, Marilyn A. Masek, and Judith A. Shizuru
Diabetes 2003 52: 59 -68. [Abstract] [Full Text] [PDF]  

Survival and Maturation of Microencapsulated Porcine Neonatal Pancreatic Cell Clusters Transplanted into Immunocompetent Diabetic Mice

Abdulkadir Omer, Valérie F. Duvivier-Kali, Nitin Trivedi, Karen Wilmot, Susan Bonner-Weir, and Gordon C. Weir
Diabetes 2003 52: 69 -75. [Abstract] [Full Text] [PDF]  

Islet Studies:

All-Trans Retinoic Acid Induces Differentiation of Ducts and Endocrine Cells by Mesenchymal/Epithelial Interactions in Embryonic Pancreas

Sidhartha Singh Tulachan, Ryuichiro Doi, Yoshiya Kawaguchi, Shoichiro Tsuji, Sanae Nakajima, Toshihiko Masui, Masayuki Koizumi, Eiji Toyoda, Tomohiko Mori, Daisuke Ito, Kazuhiro Kami, Koji Fujimoto, and Masayuki Imamura
Diabetes 2003 52: 76 -84. [Abstract] [Full Text] [PDF]  

Role for VPAC2 Receptor-Mediated Signals in Pancreas Development

Latif Rachdi, Jean-Claude Marie, and Raphael Scharfmann
Diabetes 2003 52: 85 -92. [Abstract] [Full Text] [PDF]  

Improvement of the Mitochondrial Antioxidant Defense Status Prevents Cytokine-Induced Nuclear Factor-B Activation in Insulin-Producing Cells

Anna Karenina Azevedo-Martins, Stephan Lortz, Sigurd Lenzen, Rui Curi, Decio L. Eizirik, and Markus Tiedge
Diabetes 2003 52: 93 -101. [Abstract] [Full Text] [PDF]  

ß-Cell Deficit and Increased ß-Cell Apoptosis in Humans With Type 2 Diabetes

Alexandra E. Butler, Juliette Janson, Susan Bonner-Weir, Robert Ritzel, Robert A. Rizza, and Peter C. Butler
Diabetes 2003 52: 102 -110. [Abstract] [Full Text] [PDF]  

Glucose Regulates the Release of Orexin-A From the Endocrine Pancreas

Raogo Ouedraogo, Erik Näslund, and Annette L. Kirchgessner
Diabetes 2003 52: 111 -117. [Abstract] [Full Text] [PDF]  

Measurements of Insulin Secretory Capacity and Glucose Tolerance to Predict Pancreatic ß-Cell Mass In Vivo in the Nicotinamide/Streptozotocin Göttingen Minipig, a Model of Moderate Insulin Deficiency and Diabetes

Marianne O. Larsen, Bidda Rolin, Michael Wilken, Richard D. Carr, and Carsten F. Gotfredsen
Diabetes 2003 52: 118 -123. [Abstract] [Full Text] [PDF]  

Glucagon-Like Peptide 1 Induces Pancreatic ß-Cell Proliferation Via Transactivation of the Epidermal Growth Factor Receptor

Jean Buteau, Sylvain Foisy, Erik Joly, and Marc Prentki
Diabetes 2003 52: 124 -132. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Effects of Acute Insulin Excess and Deficiency on Gluconeogenesis and Glycogenolysis in Type 1 Diabetes

Guenther Boden, Peter Cheung, and Carol Homko
Diabetes 2003 52: 133 -137. [Abstract] [Full Text] [PDF]  

Intramyocellular Lipid and Insulin Resistance: A Longitudinal In Vivo ¹H-Spectroscopic Study in Zucker Diabetic Fatty Rats

Johanna Kuhlmann, Claudia Neumann-Haefelin, Ulrich Belz, Jürgen Kalisch, Hans-Paul Juretschke, Marion Stein, Elke Kleinschmidt, Werner Kramer, and Andreas W. Herling
Diabetes 2003 52: 138 -144. [Abstract] [Full Text] [PDF]  

Apolipoprotein-E Influences Aspects of Intellectual Ability in Type 1 Diabetes

Stewart C. Ferguson, Ian J. Deary, Julie C. Evans, Sian Ellard, Andrew T. Hattersley, and Brian M. Frier
Diabetes 2003 52: 145 -148. [Abstract] [Full Text] [PDF]  

Cognitive Ability and Brain Structure in Type 1 Diabetes: Relation to Microangiopathy and Preceding Severe Hypoglycemia

Stewart C. Ferguson, Annette Blane, Petros Perros, Rory J. McCrimmon, Jonathan J.K. Best, Joanna Wardlaw, Ian J. Deary, and Brian M. Frier
Diabetes 2003 52: 149 -156. [Abstract] [Full Text] [PDF]  

Complications:

The Effectiveness of Treatments of Diabetic Autonomic Neuropathy Is Not the Same in Autonomic Nerves Supplying Different Organs

Hannah R. Shotton, Simon Clarke, and Jill Lincoln
Diabetes 2003 52: 157 -164. [Abstract] [Full Text] [PDF]  

Oxidative Injury and Apoptosis of Dorsal Root Ganglion Neurons in Chronic Experimental Diabetic Neuropathy

Ann M. Schmeichel, James D. Schmelzer, and Phillip A. Low
Diabetes 2003 52: 165 -171. [Abstract] [Full Text] [PDF]  

The Atherogenic Lipoprotein Profile Associated With Obesity and Insulin Resistance Is Largely Attributable to Intra-Abdominal Fat

Delma J. Nieves, Miriam Cnop, Barbara Retzlaff, Carolyn E. Walden, John D. Brunzell, Robert H. Knopp, and Steven E. Kahn
Diabetes 2003 52: 172 -179. [Abstract] [Full Text] [PDF]  

Genetics:

Combinations of Nondiabetic Parental Genomes Elicit Impaired Glucose Tolerance in Mouse SMXA Recombinant Inbred Strains

Misato Kobayashi, Tamio Ohno, Atsushi Tsuji, Masahiko Nishimura, and Fumihiko Horio
Diabetes 2003 52: 180 -186. [Abstract] [Full Text] [PDF]  

The Insulin Gene Variable Number Tandem Repeat Class I/III Polymorphism Is in Linkage Disequilibrium With Birth Weight but Not Type 2 Diabetes in the Pima Population

Robert S. Lindsay, Robert L. Hanson, Chris Wiedrich, William C. Knowler, Peter H. Bennett, and Leslie J. Baier
Diabetes 2003 52: 187 -193. [Abstract] [Full Text] [PDF]  

Impact of Two Common Polymorphisms in the PPAR Gene on Glucose Tolerance and Plasma Insulin Profiles in Monozygotic and Dizygotic Twins: Thrifty Genotype, Thrifty Phenotype, or Both?

Pernille Poulsen, Gitte Andersen, Mogens Fenger, Torben Hansen, Søren M. Echwald, Aage Vølund, Henning Beck-Nielsen, Oluf Pedersen, and Allan Vaag
Diabetes 2003 52: 194 -198. [Abstract] [Full Text] [PDF]  

Physical Exercise-Induced Hyperinsulinemic Hypoglycemia Is an Autosomal-Dominant Trait Characterized by Abnormal Pyruvate-Induced Insulin Release

Timo Otonkoski, Nina Kaminen, Jarkko Ustinov, Risto Lapatto, Thomas Meissner, Ertan Mayatepek, Juha Kere, and Ilkka Sipilä
Diabetes 2003 52: 199 -204. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived Genome

Frances A. Brook, Edward P. Evans, Christopher J. Lord, Paul A. Lyons, Daniel B. Rainbow, Sarah K. Howlett, Linda S. Wicker, John A. Todd, and Richard L. Gardner
Diabetes 2003 52: 205 -208. [Abstract] [Full Text] [PDF]  

Mapping Genes Influencing Type 2 Diabetes Risk and BMI in Japanese Subjects

Naoko Iwasaki, Nancy J. Cox, Yan-Qing Wang, Peter E.H. Schwarz, Graeme I. Bell, Masashi Honda, Mitsuo Imura, Makiko Ogata, Masayuki Saito, Naoyuki Kamatani, and Yasuhiko Iwamoto
Diabetes 2003 52: 209 -213. [Abstract] [Full Text] [PDF] Online Appendix  

Variation in Resistin Gene Promoter Not Associated With Polycystic Ovary Syndrome

Margrit Urbanek, Yangzhu Du, Kaisa Silander, Francis S. Collins, Claire M. Steppan, Jerome F. Strauss, III, Andrea Dunaif, Richard S. Spielman, and Richard S. Legro
Diabetes 2003 52: 214 -217. [Abstract] [Full Text] [PDF]  

A Susceptibility Allele From a Non-Diabetes-Prone Mouse Strain Accelerates Diabetes in NOD Congenic Mice

Thomas C. Brodnicki, Fiona Quirk, and Grant Morahan
Diabetes 2003 52: 218 -222. [Abstract] [Full Text] [PDF]  

Errata:

Errata

Diabetes 2003 52: 223 -224. [Extract] [Full Text] [PDF]  

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