Metabolism:

Primacy of Hepatic Insulin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog

Stella P. Kim, Martin Ellmerer, Gregg W. Van Citters, and Richard N. Bergman
Diabetes 2003 52: 2453 -2460. [Abstract] [Full Text] [PDF]  

A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes

Sangeeta Kashyap, Renata Belfort, Amalia Gastaldelli, Thongchai Pratipanawatr, Rachele Berria, Wilailak Pratipanawatr, Mandeep Bajaj, Lawrence Mandarino, Ralph DeFronzo, and Kenneth Cusi
Diabetes 2003 52: 2461 -2474. [Abstract] [Full Text] [PDF]  

Measurement of Fractional Whole-Body Gluconeogenesis in Humans From Blood Samples Using ²H Nuclear Magnetic Resonance Spectroscopy

O. Kunert, H. Stingl, E. Rosian, M. Krssák, E. Bernroider, W. Seebacher, K. Zangger, P. Staehr, V. Chandramouli, B.R. Landau, P. Nowotny, W. Waldhäusl, E. Haslinger, and M. Roden
Diabetes 2003 52: 2475 -2482. [Abstract] [Full Text] [PDF]  

Signal Transduction:

Insulin Resistance in the Liver-Specific IGF-1 Gene-Deleted Mouse Is Abrogated by Deletion of the Acid-Labile Subunit of the IGF-Binding Protein-3 Complex: Relative Roles of Growth Hormone and IGF-1 in Insulin Resistance

Martin Haluzik, Shoshana Yakar, Oksana Gavrilova, Jennifer Setser, Yves Boisclair, and Derek LeRoith
Diabetes 2003 52: 2483 -2489. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Insulin Sensitivity, Insulin Secretion, and Abdominal Fat: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

Lynne E. Wagenknecht, Carl D. Langefeld, Ann L. Scherzinger, Jill M. Norris, Steven M. Haffner, Mohammed F. Saad, and Richard N. Bergman
Diabetes 2003 52: 2490 -2496. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Variations in IB1/JIP1 Expression Regulate Susceptibility of ß-Cells to Cytokine-Induced Apoptosis Irrespective of C-Jun NH₂-Terminal Kinase Signaling

Zhidong Ling, Mark Van de Casteele, Jing Dong, Harry Heimberg, Jacques-Antoine Haefliger, Gérard Waeber, Frans Schuit, and Daniel Pipeleers
Diabetes 2003 52: 2497 -2502. [Abstract] [Full Text] [PDF]  

Islet Studies:

Nestin-Lineage Cells Contribute to the Microvasculature but Not Endocrine Cells of the Islet

Mary Kay Treutelaar, Jennifer M. Skidmore, Claudia L. Dias-Leme, Manami Hara, Lizhi Zhang, Diane Simeone, Donna M. Martin, and Charles F. Burant
Diabetes 2003 52: 2503 -2512. [Abstract] [Full Text] [PDF]  

NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat

Richard D. Carr, Christian L. Brand, Thora B. Bodvarsdottir, John B. Hansen, and Jeppe Sturis
Diabetes 2003 52: 2513 -2518. [Abstract] [Full Text] [PDF]  

Characterization and Isolation of Promoter-Defined Nestin-Positive Cells from the Human Fetal Pancreas

Rohan K. Humphrey, Nathan Bucay, Gillian M. Beattie, Ana Lopez, Conrad A. Messam, Vincenzo Cirulli, and Alberto Hayek
Diabetes 2003 52: 2519 -2525. [Abstract] [Full Text] [PDF]  

Sulfonylureas Rapidly Cross Phospholipid Bilayer Membranes by a Free-Diffusion Mechanism

Frits Kamp, Nadeem Kizilbash, Barbara E. Corkey, Per-Olof Berggren, and James A. Hamilton
Diabetes 2003 52: 2526 -2531. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Long-Term Improvement in Insulin Sensitivity by Changing Lifestyles of People with Impaired Glucose Tolerance: 4-Year Results From the Finnish Diabetes Prevention Study

Matti Uusitupa, Virpi Lindi, Anne Louheranta, Titta Salopuro, Jaana Lindström, and Jaakko Tuomilehto
Diabetes 2003 52: 2532 -2538. [Abstract] [Full Text] [PDF]  

Cellular Aspects of Intestinal Lipoprotein Assembly in Psammomys Obesus: A Model of Insulin Resistance and Type 2 Diabetes

Monika Zoltowska, Ehud Ziv, Edgard Delvin, Daniel Sinnett, Ronny Kalman, Carole Garofalo, Ernest Seidman, and Emile Levy
Diabetes 2003 52: 2539 -2545. [Abstract] [Full Text] [PDF]  

Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes

Seppo M. Pöykkö, Eija Kellokoski, Sohvi Hörkkö, Heikki Kauma, Y. Antero Kesäniemi, and Olavi Ukkola
Diabetes 2003 52: 2546 -2553. [Abstract] [Full Text] [PDF]  

Complications:

Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation

Nica M. Borradaile, Linda E. de Dreu, and Murray W. Huff
Diabetes 2003 52: 2554 -2561. [Abstract] [Full Text] [PDF]  

Insulin Affects Vascular Smooth Muscle Cell Phenotype and Migration Via Distinct Signaling Pathways

Cecilia C. Low Wang, Inga Gurevich, and Boris Draznin
Diabetes 2003 52: 2562 -2569. [Abstract] [Full Text] [PDF]  

Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells: Potential Role in Diabetic Nephropathy

Shinsuke Kiritoshi, Takeshi Nishikawa, Kazuhiro Sonoda, Daisuke Kukidome, Takahumi Senokuchi, Tomoko Matsuo, Takeshi Matsumura, Hiroshi Tokunaga, Michael Brownlee, and Eiichi Araki
Diabetes 2003 52: 2570 -2577. [Abstract] [Full Text] [PDF]  

Neuroprotective Effect of Docosahexaenoic Acid-Enriched Phospholipids in Experimental Diabetic Neuropathy

Thierry C. Coste, Alain Gerbi, Philippe Vague, Gérard Pieroni, and Denis Raccah
Diabetes 2003 52: 2578 -2585. [Abstract] [Full Text] [PDF]  

Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes

Shinichi Okada, Kenichi Shikata, Mitsuhiro Matsuda, Daisuke Ogawa, Hitomi Usui, Yuichi Kido, Ryo Nagase, Jun Wada, Yasushi Shikata, and Hirofumi Makino
Diabetes 2003 52: 2586 -2593. [Abstract] [Full Text] [PDF]  

Glucose Induces Clonal Selection and Reversible Dinucleotide Repeat Expansion in Mesangial Cells Isolated from Glomerulosclerosis-Prone Mice

Alessia Fornoni, Oliver Lenz, Liliane J. Striker, and Gary E. Striker
Diabetes 2003 52: 2594 -2602. [Abstract] [Full Text] [PDF]  

Translocation of Glomerular p47phox and p67phox by Protein Kinase C-ß Activation Is Required for Oxidative Stress in Diabetic Nephropathy

Munehiro Kitada, Daisuke Koya, Toshiro Sugimoto, Motohide Isono, Shin-ichi Araki, Atsunori Kashiwagi, and Masakazu Haneda
Diabetes 2003 52: 2603 -2614. [Abstract] [Full Text] [PDF]  

Endoneurial Capillary Abnormalities Presage Deterioration of Glucose Tolerance and Accompany Peripheral Neuropathy in Man

Soley Thrainsdottir, Rayez A. Malik, Lars B. Dahlin, Peter Wiksell, Karl F. Eriksson, Ingmar Rosén, Jesper Petersson, Douglas A. Greene, and Göran Sundkvist
Diabetes 2003 52: 2615 -2622. [Abstract] [Full Text] [PDF]  

Relationship of Family History of Type 2 Diabetes, Hypoglycemia, and Autoantibodies to Weight Gain and Lipids With Intensive and Conventional Therapy in the Diabetes Control and Complications Trial

Jonathan Q. Purnell, Raj K. Dev, Michael W. Steffes, Patricia A. Cleary, Jerry P. Palmer, Irl B. Hirsch, John E. Hokanson, and John D. Brunzell
Diabetes 2003 52: 2623 -2629. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

Kir6.2 Polymorphisms Sensitize ß-Cell ATP-Sensitive Potassium Channels to Activation by Acyl CoAs: A Possible Cellular Mechanism for Increased Susceptibility to Type 2 Diabetes?

Michael J. Riedel, Parveen Boora, Diana Steckley, Gerda de Vries, and Peter E. Light
Diabetes 2003 52: 2630 -2635. [Abstract] [Full Text] [PDF]  

A Novel Gene for Neonatal Diabetes Maps to Chromosome 10p12.1-p13

Gabrielle S. Sellick, Christine Garrett, and Richard S. Houlston
Diabetes 2003 52: 2636 -2638. [Abstract] [Full Text] [PDF]  

KIR in Type 1 Diabetes: Disparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus HLA-Matched Control Subjects

Arno R. van der Slik, Bobby P.C. Koeleman, Willem Verduijn, G. Jan Bruining, Bart O. Roep, and Marius J. Giphart
Diabetes 2003 52: 2639 -2642. [Abstract] [Full Text] [PDF] Appendix  

Errata:

Erratum

Diabetes 2003 52: 2643 . [Extract] [Full Text] [PDF]  

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