Perspectives in Diabetes:

Microvascular Complications of Impaired Glucose Tolerance

J. Robinson Singleton, A. Gordon Smith, James W. Russell, and Eva L. Feldman
Diabetes 2003 52: 2867 -2873. [Abstract] [Full Text] [PDF]  

Metabolism:

Endurance Training in Humans Leads to Fiber Type-Specific Increases in Levels of Peroxisome Proliferator-Activated Receptor- Coactivator-1 and Peroxisome Proliferator-Activated Receptor- in Skeletal Muscle

Aaron P. Russell, Jonas Feilchenfeldt, Sylvia Schreiber, Manu Praz, Antoinette Crettenand, Charles Gobelet, Christoph A. Meier, David R. Bell, Anastasia Kralli, Jean-Paul Giacobino, and Olivier Dériaz
Diabetes 2003 52: 2874 -2881. [Abstract] [Full Text] [PDF]  

Elevation of Free Fatty Acids Induces Inflammation and Impairs Vascular Reactivity in Healthy Subjects

Devjit Tripathy, Priya Mohanty, Sandeep Dhindsa, Tufail Syed, Husam Ghanim, Ahmad Aljada, and Paresh Dandona
Diabetes 2003 52: 2882 -2887. [Abstract] [Full Text] [PDF]  

A Mammalian Protein Homologous to Fructosamine-3-Kinase Is a Ketosamine-3-Kinase Acting on Psicosamines and Ribulosamines but not on Fructosamines

François Collard, Ghislain Delpierre, Vincent Stroobant, Gert Matthijs, and Emile Van Schaftingen
Diabetes 2003 52: 2888 -2895. [Abstract] [Full Text] [PDF]  

Signal Transduction:

Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH₂-terminal Kinase

Dan Kawamori, Yoshitaka Kajimoto, Hideaki Kaneto, Yutaka Umayahara, Yoshio Fujitani, Takeshi Miyatsuka, Hirotaka Watada, Ingo B. Leibiger, Yoshimitsu Yamasaki, and Masatsugu Hori
Diabetes 2003 52: 2896 -2904. [Abstract] [Full Text] [PDF]  

Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement

Hiraku Ono, Hitoshi Shimano, Hideki Katagiri, Naoya Yahagi, Hideyuki Sakoda, Yukiko Onishi, Motonobu Anai, Takehide Ogihara, Midori Fujishiro, Amelia Y.I. Viana, Yasushi Fukushima, Miho Abe, Nobuhiro Shojima, Masatoshi Kikuchi, Nobuhiro Yamada, Yoshitomo Oka, and Tomoichiro Asano
Diabetes 2003 52: 2905 -2913. [Abstract] [Full Text] [PDF]  

Obesity Study:

Agouti Expression in Human Adipose Tissue: Functional Consequences and Increased Expression in Type 2 Diabetes

Steven R. Smith, Barbara Gawronska-Kozak, Lenka Janderová, Taylor Nguyen, Angela Murrell, Jacqueline M. Stephens, and Randall L. Mynatt
Diabetes 2003 52: 2914 -2922. [Abstract] [Full Text] [PDF]  

Insulin is Required for Prandial Ghrelin Suppression in Humans

Giuseppe Murdolo, Paola Lucidi, Chiara Di Loreto, Natascia Parlanti, Arianna De Cicco, Cristina Fatone, Carmine G. Fanelli, Geremia B. Bolli, Fausto Santeusanio, and Pierpaolo De Feo
Diabetes 2003 52: 2923 -2927. [Abstract] [Full Text] [PDF]  

Adrenalectomy Alters the Sensitivity of the Central Nervous System Melanocortin System

Deborah L. Drazen, Matthew D. Wortman, Michael W. Schwartz, Deborah J. Clegg, Gertjan van Dijk, Stephen C. Woods, and Randy J. Seeley
Diabetes 2003 52: 2928 -2934. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Brain Death Significantly Reduces Isolated Pancreatic Islet Yields and Functionality In Vitro and In Vivo After Transplantation in Rats

Juan L. Contreras, Christopher Eckstein, Cheryl A. Smyth, Marty T. Sellers, Mario Vilatoba, Guadalupe Bilbao, Firoz G. Rahemtulla, Carlton J. Young, J. Anthony Thompson, Irshad H. Chaudry, and Devin E. Eckhoff
Diabetes 2003 52: 2935 -2942. [Abstract] [Full Text] [PDF]  

Islet Study:

On-Line Monitoring of Apoptosis in Insulin-Secreting Cells

Martin Köhler, Sergei V. Zaitsev, Irina I. Zaitseva, Barbara Leibiger, Ingo B. Leibiger, Mikael Turunen, Iouri L. Kapelioukh, Linda Bakkman, Ioulia B. Appelskog, Jacques Boutet de Monvel, Gabriela Imreh, and Per-Olof Berggren
Diabetes 2003 52: 2943 -2950. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Gestational Diabetes Induces Placental Genes for Chronic Stress and Inflammatory Pathways

Tatjana Radaelli, Ali Varastehpour, Patrick Catalano, and Sylvie Hauguel-de Mouzon
Diabetes 2003 52: 2951 -2958. [Abstract] [Full Text] [PDF]  

Complications:

Activation of Vascular Endothelial Growth Factor Receptor-1 Sustains Angiogenesis and Bcl-2 Expression Via the Phosphatidylinositol 3-Kinase Pathway in Endothelial Cells

Jun Cai, Shakil Ahmad, Wen G. Jiang, Jianhua Huang, Christopher D. Kontos, Mike Boulton, and Asif Ahmed
Diabetes 2003 52: 2959 -2968. [Abstract] [Full Text] [PDF]  

Nephrinuria in Diabetic Nephropathy of Type 1 Diabetes

Anu Pätäri, Carol Forsblom, Marika Havana, Heidi Taipale, Per-Henrik Groop, and Harry Holthöfer
Diabetes 2003 52: 2969 -2974. [Abstract] [Full Text] [PDF]  

Connective Tissue Growth Factor and IGF-I Are Produced by Human Renal Fibroblasts and Cooperate in the Induction of Collagen Production by High Glucose

Suzanne Lam, Reinier N. van der Geest, Nicole A.M. Verhagen, Frans A. van Nieuwenhoven, Ingrid E. Blom, Jan Aten, Roel Goldschmeding, Mohamed R. Daha, and Cees van Kooten
Diabetes 2003 52: 2975 -2983. [Abstract] [Full Text] [PDF]  

Genetics:

Autosomal-Dominant Mode of Inheritance of a Melanocortin-4 Receptor Mutation in a Patient with Severe Early-Onset Obesity Is Due to a Dominant-Negative Effect Caused by Receptor Dimerization

Heike Biebermann, Heiko Krude, Andrea Elsner, Vladimir Chubanov, Thomas Gudermann, and Annette Grüters
Diabetes 2003 52: 2984 -2988. [Abstract] [Full Text] [PDF]  

Regulation of Apolipoprotein M Gene Expression by MODY3 Gene Hepatocyte Nuclear Factor-1: Haploinsufficiency Is Associated With Reduced Serum Apolipoprotein M Levels

Symi Richter, David Q. Shih, Ewan R. Pearson, Christian Wolfrum, Stefan S. Fajans, Andrew T. Hattersley, and Markus Stoffel
Diabetes 2003 52: 2989 -2995. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

The Human MC4R Promoter: Characterization and Role in Obesity

Cecile Lubrano-Berthelier, Martha Cavazos, Catherine Le Stunff, Kurt Haas, Astrid Shapiro, Sumei Zhang, Pierre Bougneres, and Christian Vaisse
Diabetes 2003 52: 2996 -3000. [Abstract] [Full Text] [PDF]  

A Genome-Wide Search for Genes Involved in Type 2 Diabetes in a Recently Genetically Isolated Population From the Netherlands

Yurii S. Aulchenko, Norbert Vaessen, Peter Heutink, Jan Pullen, Pieter J.L.M. Snijders, Albert Hofman, Lodewijk A. Sandkuijl, Jeanine J. Houwing-Duistermaat, Mark Edwards, Simon Bennett, Ben A. Oostra, and Cornelia M. van Duijn
Diabetes 2003 52: 3001 -3004. [Abstract] [Full Text] [PDF]  

The Role of Insulin Receptor Substrate-1 Gene (IRS1) in Type 2 Diabetes in Pima Indians

Peter Kovacs, Robert L. Hanson, Yong-Ho Lee, Xiaolin Yang, Sayuko Kobes, Paska A. Permana, Clifton Bogardus, and Leslie J. Baier
Diabetes 2003 52: 3005 -3009. [Abstract] [Full Text] [PDF]  

The Human Peroxisome Proliferator-Activated Receptor 2 (PPAR2) Pro12Ala Polymorphism Is Associated With Decreased Risk of Diabetic Nephropathy in Patients With Type 2 Diabetes

Maria Luiza Caramori, Luis Henrique Canani, Luciana A. Costa, and Jorge Luiz Gross
Diabetes 2003 52: 3010 -3013. [Abstract] [Full Text] [PDF]  

Errata:

Errata

Diabetes 2003 52: 3014 . [Extract] [Full Text] [PDF]  

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