Rapid Publications:

Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus: A Key Mediator of Insulin-Induced Anorexia

Kevin D. Niswender, Christopher D. Morrison, Deborah J. Clegg, Ryan Olson, Denis G. Baskin, Martin G. Myers, Jr., Randy J. Seeley, and Michael W. Schwartz
Diabetes 2003 52: 227 -231. First published on December 6, 2002 as 10.2337/diabetes.52.2.227 [Abstract] [Full Text] [PDF]  

Perspectives in Diabetes:

Is the Energy Homeostasis System Inherently Biased Toward Weight Gain?

Michael W. Schwartz, Stephen C. Woods, Randy J. Seeley, Gregory S. Barsh, Denis G. Baskin, and Rudolph L. Leibel
Diabetes 2003 52: 232 -238. [Abstract] [Full Text] [PDF]  

Metabolism and Signal Transduction:

Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism

Otto Tschritter, Andreas Fritsche, Claus Thamer, Michael Haap, Fatemeh Shirkavand, Stefanie Rahe, Harald Staiger, Elke Maerker, Hans Häring, and Michael Stumvoll
Diabetes 2003 52: 239 -243. [Abstract] [Full Text] [PDF]  

Increased Intramyocellular Lipid Concentration Identifies Impaired Glucose Metabolism in Women With Previous Gestational Diabetes

Alexandra Kautzky-Willer, Martin Krssak, Christine Winzer, Giovanni Pacini, Andrea Tura, Serdar Farhan, Oswald Wagner, Georg Brabant, Rüdiger Horn, Harald Stingl, Barbara Schneider, Werner Waldhäusl, and Michael Roden
Diabetes 2003 52: 244 -251. [Abstract] [Full Text] [PDF]  

Role of Leptin in the Regulation of Glucagon-Like Peptide-1 Secretion

Younes Anini and Patricia L. Brubaker
Diabetes 2003 52: 252 -259. [Abstract] [Full Text] [PDF]  

Effects of Free Fatty Acids Per Se on Glucose Production, Gluconeogenesis, and Glycogenolysis

Peter Staehr, Ole Hother-Nielsen, Bernard R. Landau, Visvanathan Chandramouli, Jens Juul Holst, and Henning Beck-Nielsen
Diabetes 2003 52: 260 -267. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Sexual Differentiation, Pregnancy, Calorie Restriction, and Aging Affect the Adipocyte-Specific Secretory Protein Adiponectin

Terry P. Combs, Anders H. Berg, Michael W. Rajala, Simon Klebanov, Puneeth Iyengar, José C. Jimenez-Chillaron, Mary Elizabeth Patti, Sabra L. Klein, Robert S. Weinstein, and Philipp E. Scherer
Diabetes 2003 52: 268 -276. [Abstract] [Full Text] [PDF]  

Leptin Receptor-Deficient Obese Zucker Rats Reduce Their Food Intake in Response to a Systemic Supply of Calories From Glucose

Marc Gilbert, Christophe Magnan, Sophie Turban, Jocelyne André, and Michèle Guerre-Millo
Diabetes 2003 52: 277 -282. [Abstract] [Full Text] [PDF]  

Differential Effects of Rosiglitazone and Metformin on Adipose Tissue Distribution and Glucose Uptake in Type 2 Diabetic Subjects

Kirsi A. Virtanen, Kirsti Hällsten, Riitta Parkkola, Tuula Janatuinen, Fredrik Lönnqvist, Tapio Viljanen, Tapani Rönnemaa, Juhani Knuuti, Risto Huupponen, Peter Lönnroth, and Pirjo Nuutila
Diabetes 2003 52: 283 -290. [Abstract] [Full Text] [PDF]  

PPAR- Activation Mediates Adipose Depot-Specific Effects on Gene Expression and Lipoprotein Lipase Activity: Mechanisms for Modulation of Postprandial Lipemia and Differential Adipose Accretion

Mathieu Laplante, Henrike Sell, Karen L. MacNaul, Denis Richard, Joel P. Berger, and Yves Deshaies
Diabetes 2003 52: 291 -299. [Abstract] [Full Text] [PDF]  

Role of the Fatty Acid Binding Protein mal1 in Obesity and Insulin Resistance

Kazuhisa Maeda, K. Teoman Uysal, Liza Makowski, Cem Z. Görgün, Genichi Atsumi, Rex A. Parker, Jens Brüning, Ann Vogel Hertzel, David A. Bernlohr, and Gökhan S. Hotamisligil
Diabetes 2003 52: 300 -307. [Abstract] [Full Text] [PDF]  

STAT5A Promotes Adipogenesis in Nonprecursor Cells and Associates With the Glucocorticoid Receptor During Adipocyte Differentiation

Z. Elizabeth Floyd and Jacqueline M. Stephens
Diabetes 2003 52: 308 -314. [Abstract] [Full Text] [PDF]  

Hyperactivity and Reduced Energy Cost of Physical Activity in Serotonin 5-HT_2C Receptor Mutant Mice

Katsunori Nonogaki, Luna Abdallah, Evan H. Goulding, Stephen J. Bonasera, and Laurence H. Tecott
Diabetes 2003 52: 315 -320. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

NOD Congenic Mice Genetically Protected From Autoimmune Diabetes Remain Resistant to Transplantation Tolerance Induction

Todd Pearson, Thomas G. Markees, Linda S. Wicker, David V. Serreze, Laurence B. Peterson, John P. Mordes, Aldo A. Rossini, and Dale L. Greiner
Diabetes 2003 52: 321 -326. [Abstract] [Full Text] [PDF]  

T-Cell Compartments of Prediabetic NOD Mice

Stuart P. Berzins, Emily S. Venanzi, Christophe Benoist, and Diane Mathis
Diabetes 2003 52: 327 -334. [Abstract] [Full Text] [PDF]  

Acute Shock Induced by Antigen Vaccination in NOD Mice

Lut Overbergh, Brigitte Decallonne, Dumitru D. Branisteanu, Dirk Valckx, Ahmad Kasran, Roger Bouillon, and Chantal Mathieu
Diabetes 2003 52: 335 -341. [Abstract] [Full Text] [PDF]  

Accelerated Diabetes in Rat Insulin Promoter-Tumor Necrosis Factor- Transgenic Nonobese Diabetic Mice Lacking Major Histocompatibility Class II Molecules

Govindarajan Rajagopalan, Yogish C. Kudva, Richard A. Flavell, and Chella S. David
Diabetes 2003 52: 342 -347. [Abstract] [Full Text] [PDF]  

Molecular Regulation of Monocyte Chemoattractant Protein-1 Expression in Pancreatic ß-Cells

Burak Kutlu, Martine I. Darville, Alessandra K. Cardozo, and Décio L. Eizirik
Diabetes 2003 52: 348 -355. [Abstract] [Full Text] [PDF]  

Islet Studies:

Stimulation of Insulin Secretion by Denatonium, One of the Most Bitter-Tasting Substances Known

Susanne G. Straub, Jennifer Mulvaney-Musa, Hiroki Yajima, Gregory A. Weiland, and Geoffrey W.G. Sharp
Diabetes 2003 52: 356 -364. [Abstract] [Full Text] [PDF]  

Role of Endogenous Glucagon-Like Peptide-1 in Islet Regeneration After Partial Pancreatectomy

Diva D. De León, Shaoping Deng, Reza Madani, Rexford S. Ahima, Daniel J. Drucker, and Doris A. Stoffers
Diabetes 2003 52: 365 -371. [Abstract] [Full Text] [PDF]  

Increased Dietary Fat Promotes Islet Amyloid Formation and ß-Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid

Rebecca L. Hull, Sofianos Andrikopoulos, C. Bruce Verchere, Josep Vidal, Feng Wang, Miriam Cnop, Ronald L. Prigeon, and Steven E. Kahn
Diabetes 2003 52: 372 -379. [Abstract] [Full Text] [PDF]  

The Influence of GLP-1 on Glucose-Stimulated Insulin Secretion: Effects on ß-Cell Sensitivity in Type 2 and Nondiabetic Subjects

Lise L. Kjems, Jens J. Holst, Aage Vølund, and Sten Madsbad
Diabetes 2003 52: 380 -386. [Abstract] [Full Text] [PDF]  

Gene Transfer of Manganese Superoxide Dismutase Extends Islet Graft Function in a Mouse Model of Autoimmune Diabetes

Suzanne Bertera, Megan L. Crawford, Angela M. Alexander, Glenn D. Papworth, Simon C. Watkins, Paul D. Robbins, and Massimo Trucco
Diabetes 2003 52: 387 -393. [Abstract] [Full Text] [PDF]  

Differential Effects of Glucose and Glyburide on Energetics and Na⁺ Levels of ßHC9 Cells: Nuclear Magnetic Resonance Spectroscopy and Respirometry Studies

Nicolai M. Doliba, Marko Z. Vatamaniuk, Carol W. Buettger, Wei Qin, Heather W. Collins, Suzanne L. Wehrli, Richard D. Carr, and Franz M. Matschinsky
Diabetes 2003 52: 394 -402. [Abstract] [Full Text] [PDF]  

BETA2 Activates Transcription From the Upstream Glucokinase Gene Promoter in Islet ß-Cells and Gut Endocrine Cells

J. Michael Moates, Sarmistha Nanda, Michelle A. Cissell, Ming-Jer Tsai, and Roland Stein
Diabetes 2003 52: 403 -408. [Abstract] [Full Text] [PDF]  

Dominant Negative Pathogenesis by Mutant Proinsulin in the Akita Diabetic Mouse

Tetsuro Izumi, Hiromi Yokota-Hashimoto, Shengli Zhao, Jie Wang, Philippe A. Halban, and Toshiyuki Takeuchi
Diabetes 2003 52: 409 -416. [Abstract] [Full Text] [PDF]  

Connexin 36 Controls Synchronization of Ca²⁺ Oscillations and Insulin Secretion in MIN6 Cells

Alessandra Calabrese, Min Zhang, Véronique Serre-Beinier, David Caton, Christophe Mas, Leslie S. Satin, and Paolo Meda
Diabetes 2003 52: 417 -424. [Abstract] [Full Text] [PDF]  

Pax-6 Activates Endogenous Proglucagon Gene Expression in the Rodent Gastrointestinal Epithelium

Denny K.Y. Trinh, Kai Zhang, Moazzem Hossain, Patricia L. Brubaker, and Daniel J. Drucker
Diabetes 2003 52: 425 -433. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Age-Dependent Changes in Metabolism, Contractile Function, and Ischemic Sensitivity in Hearts From db/db Mice

Ellen Aasum, Anne D. Hafstad, David L. Severson, and Terje S. Larsen
Diabetes 2003 52: 434 -441. [Abstract] [Full Text] [PDF]  

Inflammation-Sensitive Plasma Proteins, Diabetes, and Mortality and Incidence of Myocardial Infarction and Stroke: A Population-Based Study

Gunnar Engström, Lars Stavenow, Bo Hedblad, Peter Lind, Karl-Fredrik Eriksson, Lars Janzon, and Folke Lindgärde
Diabetes 2003 52: 442 -447. [Abstract] [Full Text] [PDF]  

Preferential Stiffening of Central Over Peripheral Arteries in Type 2 Diabetes

Eiji Kimoto, Tetsuo Shoji, Kayo Shinohara, Masaaki Inaba, Yasuhisa Okuno, Takami Miki, Hidenori Koyama, Masanori Emoto, and Yoshiki Nishizawa
Diabetes 2003 52: 448 -452. [Abstract] [Full Text] [PDF]  

Effects of Insulin Resistance and Type 2 Diabetes on Lipoprotein Subclass Particle Size and Concentration Determined by Nuclear Magnetic Resonance

W. Timothy Garvey, Soonho Kwon, Deyi Zheng, Sara Shaughnessy, Penny Wallace, Amy Hutto, Kimberly Pugh, Alicia J. Jenkins, Richard L. Klein, and Youlian Liao
Diabetes 2003 52: 453 -462. [Abstract] [Full Text] [PDF]  

Prediction of Type 2 Diabetes Using Simple Measures of Insulin Resistance: Combined Results From the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study

Anthony J.G. Hanley, Ken Williams, Clicerio Gonzalez, Ralph B. D’Agostino, Jr, Lynne E. Wagenknecht, Michael P. Stern, and Steven M. Haffner
Diabetes 2003 52: 463 -469. [Abstract] [Full Text] [PDF]  

Altered Homeostatic Adaptation of First- and Second-Phase ß-Cell Secretion in the Offspring of Patients With Type 2 Diabetes: Studies With a Minimal Model to Assess ß-Cell Function

Riccardo C. Bonadonna, Michael Stumvoll, Andreas Fritsche, Michele Muggeo, Hans Häring, Enzo Bonora, and Timon W. van Haeften
Diabetes 2003 52: 470 -480. [Abstract] [Full Text] [PDF]  

Diabetes Activates Cell Death Pathway After Transient Focal Cerebral Ischemia

Marianna Muranyi, Masayuki Fujioka, QingPing He, Angela Han, Gregory Yong, Katalin Csiszar, and Ping-An Li
Diabetes 2003 52: 481 -486. [Abstract] [Full Text] [PDF]  

Effects of Free Fatty Acids on Glucose Uptake and Utilization in Healthy Women

Carol J. Homko, Peter Cheung, and Guenther Boden
Diabetes 2003 52: 487 -491. [Abstract] [Full Text] [PDF]  

Demonstration of Glycated Insulin in Human Diabetic Plasma and Decreased Biological Activity Assessed by Euglycemic-Hyperinsulinemic Clamp Technique in Humans

Steven J. Hunter, Alison C. Boyd, Finbarr P.M. O’Harte, Aine M. McKillop, M. Ivan Wiggam, Mark H. Mooney, Jane T. McCluskey, John R. Lindsay, Cieran N. Ennis, Raymond Gamble, Brian Sheridan, Christopher R. Barnett, Helene McNulty, Patrick M. Bell, and Peter R. Flatt
Diabetes 2003 52: 492 -498. [Abstract] [Full Text] [PDF]  

Complications:

Comparative Trial of N-Acetyl-Cysteine, Taurine, and Oxerutin on Skin and Kidney Damage in Long-Term Experimental Diabetes

Patrizio Odetti, Carlo Pesce, Nicola Traverso, Stefano Menini, Elena Pesce Maineri, Luana Cosso, Sabina Valentini, Stefania Patriarca, Damiano Cottalasso, Umberto M. Marinari, and Maria Adelaide Pronzato
Diabetes 2003 52: 499 -505. [Abstract] [Full Text] [PDF]  

A Role for the Polyol Pathway in the Early Neuroretinal Apoptosis and Glial Changes Induced by Diabetes in the Rat

Veronica Asnaghi, Chiara Gerhardinger, Todd Hoehn, Abidemi Adeboje, and Mara Lorenzi
Diabetes 2003 52: 506 -511. [Abstract] [Full Text] [PDF]  

Protein Kinase C ß Inhibition Attenuates the Progression of Experimental Diabetic Nephropathy in the Presence of Continued Hypertension

Darren J. Kelly, Yuan Zhang, Claire Hepper, Renae M. Gow, Kassie Jaworski, Bruce E. Kemp, Jennifer L. Wilkinson-Berka, and Richard E. Gilbert
Diabetes 2003 52: 512 -518. [Abstract] [Full Text] [PDF]  

Glucose-Induced Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase-Dependent Upregulation of the Platelet-Derived Growth Factor-ß Receptor Potentiates Vascular Smooth Muscle Cell Chemotaxis

Malcolm Campbell, William E. Allen, Jonathan A. Silversides, and Elisabeth R. Trimble
Diabetes 2003 52: 519 -526. [Abstract] [Full Text] [PDF]  

Evidence for a Novel TGF-ß1-Independent Mechanism of Fibronectin Production in Mesangial Cells Overexpressing Glucose Transporters

Cora Weigert, Katrin Brodbeck, Frank C. Brosius III, Matthias Huber, Rainer Lehmann, Ulrich Friess, Sonia Facchin, Steffen Aulwurm, Hans U. Häring, Erwin D. Schleicher, and Charles W. Heilig
Diabetes 2003 52: 527 -535. [Abstract] [Full Text] [PDF]  

Amelioration of Sensory Nerve Dysfunction by C-Peptide in Patients With Type 1 Diabetes

Karin Ekberg, Tom Brismar, Bo-Lennart Johansson, Björn Jonsson, Per Lindström, and John Wahren
Diabetes 2003 52: 536 -541. [Abstract] [Full Text] [PDF]  

Microvascular Alterations in Diabetic Mice Correlate With Level of Hyperglycemia

Petra Algenstaedt, Christian Schaefer, Tanja Biermann, Andreas Hamann, Britta Schwarzloh, Heiner Greten, Wolfgang Rüther, and Nils Hansen-Algenstaedt
Diabetes 2003 52: 542 -549. [Abstract] [Full Text] [PDF] Video Clips  

Genetics:

Genome-Wide and Fine-Mapping Linkage Studies of Type 2 Diabetes and Glucose Traits in the Old Order Amish: Evidence for a New Diabetes Locus on Chromosome 14q11 and Confirmation of a Locus on Chromosome 1q21-q24

Wen-Chi Hsueh, Pamela L. St. Jean, Braxton D. Mitchell, Toni I. Pollin, William C. Knowler, Margaret G. Ehm, Callum J. Bell, Hakan Sakul, Michael J. Wagner, Daniel K. Burns, and Alan R. Shuldiner
Diabetes 2003 52: 550 -557. [Abstract] [Full Text] [PDF] Full Genome Scan  

Brief Genetics Reports:

The C-174G Promoter Polymorphism of the IL-6 Gene Affects Energy Expenditure and Insulin Sensitivity

Agata Kubaszek, Jussi Pihlajamäki, Kari Punnonen, Pauli Karhapää, Ilkka Vauhkonen, and Markku Laakso
Diabetes 2003 52: 558 -561. [Abstract] [Full Text] [PDF]  

Systematic Search for Single Nucleotide Polymorphisms in the FOXC2 Gene: The Absence of Evidence for the Association of Three Frequent Single Nucleotide Polymorphisms and Four Common Haplotypes With Japanese Type 2 Diabetes

Haruhiko Osawa, Hiroshi Onuma, Akiko Murakami, Masaaki Ochi, Tatsuya Nishimiya, Kenichi Kato, Ikki Shimizu, Yasuhisa Fujii, Jun Ohashi, and Hideichi Makino
Diabetes 2003 52: 562 -567. [Abstract] [Full Text] [PDF]  

Large-Scale Association Studies of Variants in Genes Encoding the Pancreatic ß-Cell K_ATP Channel Subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) Confirm That the KCNJ11 E23K Variant Is Associated With Type 2 Diabetes

Anna L. Gloyn, Michael N. Weedon, Katharine R. Owen, Martina J. Turner, Bridget A. Knight, Graham Hitman, Mark Walker, Jonathan C. Levy, Mike Sampson, Stephanie Halford, Mark I. McCarthy, Andrew T. Hattersley, and Timothy M. Frayling
Diabetes 2003 52: 568 -572. [Abstract] [Full Text] [PDF]  

The E23K Variant of Kir6.2 Associates With Impaired Post-OGTT Serum Insulin Response and Increased Risk of Type 2 Diabetes

Eva-Maria D. Nielsen, Lars Hansen, Bendix Carstensen, Søren M. Echwald, Thomas Drivsholm, Charlotte Glümer, Birger Thorsteinsson, Knut Borch-Johnsen, Torben Hansen, and Oluf Pedersen
Diabetes 2003 52: 573 -577. [Abstract] [Full Text] [PDF]  

Errata:

Errata

Diabetes 2003 52: 578 . [Extract] [Full Text] [PDF]  

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