Diabetes -- Table of Contents (March 2003, 52 [3])

Perspectives in Diabetes:

Glucose Toxicity in ß-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection: R. Paul Robertson, Jamie Harmon, Phuong Oanh Tran, Yoshito Tanaka, and Hiroki Takahashi
Diabetes 2003 52: 581 -587. [Abstract] [Full Text] [PDF]

Metabolism and Signal Transduction:

Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo: David B. Ring, Kirk W. Johnson, Erik J. Henriksen, John M. Nuss, Dane Goff, Tyson R. Kinnick, Sylvia T. Ma, John W. Reeder, Isa Samuels, Trina Slabiak, Allan S. Wagman, Mary-Ellen Wernette Hammond, and Stephen D. Harrison
Diabetes 2003 52: 588 -595. [Abstract] [Full Text] [PDF]

Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance: Mirela Delibegovic, Christopher G. Armstrong, Lorraine Dobbie, Peter W. Watt, Andrew J.H. Smith, and Patricia T.W. Cohen
Diabetes 2003 52: 596 -604. [Abstract] [Full Text] [PDF]

Role of Corticotrophin-Releasing Hormone in the Impairment of Counterregulatory Responses to Hypoglycemia: Daniel E. Flanagan, Tara Keshavarz, Mark L. Evans, Sally Flanagan, Xiaoning Fan, Ralph J. Jacob, and Robert S. Sherwin
Diabetes 2003 52: 605 -613. [Abstract] [Full Text] [PDF]

Contribution of Fatty Acids Released From Lipolysis of Plasma Triglycerides to Total Plasma Fatty Acid Flux and Tissue-Specific Fatty Acid Uptake: Bas Teusink, Peter J. Voshol, Vivian E.H. Dahlmans, Patrick C.N. Rensen, Hanno Pijl, Johannes A. Romijn, and Louis M. Havekes
Diabetes 2003 52: 614 -620. [Abstract] [Full Text] [PDF]

Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor ${kappa}$ B in PBMCs: Stephan Schiekofer, Martin Andrassy, Jiang Chen, Gottfried Rudofsky, Jochen Schneider, Thoralf Wendt, Norbert Stefan, Per Humpert, Andreas Fritsche, Michael Stumvoll, Erwin Schleicher, Hans-Ulrich Häring, Peter P. Nawroth, and Angelika Bierhaus
Diabetes 2003 52: 621 -633. [Abstract] [Full Text] [PDF]

Enhanced Basal Activation of Mitogen-Activated Protein Kinases in Adipocytes From Type 2 Diabetes: Potential Role of p38 in the Downregulation of GLUT4 Expression: Christian J. Carlson, Sandra Koterski, Richard J. Sciotti, German Braillard Poccard, and Cristina M. Rondinone
Diabetes 2003 52: 634 -641. [Abstract] [Full Text] [PDF]

Regulation of PGC-1 Promoter Activity by Protein Kinase B and the Forkhead Transcription Factor FKHR: Hiroaki Daitoku, Kazuyuki Yamagata, Hitomi Matsuzaki, Mitsutoki Hatta, and Akiyoshi Fukamizu
Diabetes 2003 52: 642 -649. [Abstract] [Full Text] [PDF]

Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase: Cora Weigert, Karsten Klopfer, Christiana Kausch, Katrin Brodbeck, Michael Stumvoll, Hans U. Häring, and Erwin D. Schleicher
Diabetes 2003 52: 650 -656. [Abstract] [Full Text] [PDF]

Effect of Short-Term Fasting and Refeeding on Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle: Henriette Pilegaard, Bengt Saltin, and P. Darrell Neufer
Diabetes 2003 52: 657 -662. [Abstract] [Full Text] [PDF]

Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation: Monica A. Borg, William V. Tamborlane, Gerald I. Shulman, and Robert S. Sherwin
Diabetes 2003 52: 663 -666. [Abstract] [Full Text] [PDF]

Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy: Susan A. Phillips, Theodore P. Ciaraldi, Alice P.S. Kong, Rahil Bandukwala, Vanita Aroda, Leslie Carter, Sunita Baxi, Sunder R. Mudaliar, and Robert R. Henry
Diabetes 2003 52: 667 -674. [Abstract] [Full Text] [PDF]

Nocturnal and Postprandial Free Fatty Acid Kinetics in Normal and Type 2 Diabetic Subjects: Effects of Insulin Sensitization Therapy: John M. Miles, David Wooldridge, Wayne J. Grellner, Sheryl Windsor, William L. Isley, Samuel Klein, and William S. Harris
Diabetes 2003 52: 675 -681. [Abstract] [Full Text] [PDF]

Obesity Studies:

Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats: Deborah J. Clegg, Christine A. Riedy, Kathleen A. Blake Smith, Stephen C. Benoit, and Stephen C. Woods
Diabetes 2003 52: 682 -687. [Abstract] [Full Text] [PDF]

Gene Expression Profiles of Nondiabetic and Diabetic Obese Mice Suggest a Role of Hepatic Lipogenic Capacity in Diabetes Susceptibility: Hong Lan, Mary E. Rabaglia, Jonathan P. Stoehr, Samuel T. Nadler, Kathryn L. Schueler, Fei Zou, Brian S. Yandell, and Alan D. Attie
Diabetes 2003 52: 688 -700. [Abstract] [Full Text] [PDF] Data Supplement

Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content: Mirja Tiikkainen, Robert Bergholm, Satu Vehkavaara, Aila Rissanen, Anna-Maija Häkkinen, Marjo Tamminen, Kari Teramo, and Hannele Yki-Järvinen
Diabetes 2003 52: 701 -707. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice: Y. Clare Zhang, Antonello Pileggi, Anupam Agarwal, R. Damaris Molano, Matthew Powers, Todd Brusko, Clive Wasserfall, Kevin Goudy, Elsie Zahr, Raffaella Poggioli, Marda Scott-Jorgensen, Martha Campbell-Thompson, James M. Crawford, Harry Nick, Terence Flotte, Tamir M. Ellis, Camillo Ricordi, Luca Inverardi, and Mark A. Atkinson
Diabetes 2003 52: 708 -716. [Abstract] [Full Text] [PDF]

Processing and Presentation of the Islet Autoantigen GAD by Vascular Endothelial Cells Promotes Transmigration of Autoreactive T-Cells: James E. Greening, Timothy I.M. Tree, Karolena T. Kotowicz, Astrid G. van Halteren, Bart O. Roep, Nigel J. Klein, and Mark Peakman
Diabetes 2003 52: 717 -725. [Abstract] [Full Text] [PDF]

Islet Studies:

Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic ß-Cell Turnover and Function: Kathrin Maedler, José Oberholzer, Pascal Bucher, Giatgen A. Spinas, and Marc Y. Donath
Diabetes 2003 52: 726 -733. [Abstract] [Full Text] [PDF]

Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat: Doris A. Stoffers, Biva M. Desai, Diva D. DeLeon, and Rebecca A. Simmons
Diabetes 2003 52: 734 -740. [Abstract] [Full Text] [PDF]

Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates ß-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats: J. Andrew Pospisilik, Jennifer Martin, Timothy Doty, Jan A. Ehses, Nathalie Pamir, Francis C. Lynn, Shalea Piteau, Hans-Ulrich Demuth, Christopher H.S. McIntosh, and Raymond A. Pederson
Diabetes 2003 52: 741 -750. [Abstract] [Full Text] [PDF]

Development and Characterization of a Glucagon-Like Peptide 1-Albumin Conjugate: The Ability to Activate the Glucagon-Like Peptide 1 Receptor In Vivo: Jung-Guk Kim, Laurie L. Baggio, Dominique P. Bridon, Jean-Paul Castaigne, Martin F. Robitaille, Lucie Jetté, Corinne Benquet, and Daniel J. Drucker
Diabetes 2003 52: 751 -759. [Abstract] [Full Text] [PDF]

Role of H1-Calponin in Pancreatic AR42J Cell Differentiation Into Insulin-Producing Cells: Tomoaki Morioka, Hidenori Koyama, Hisako Yamamura, Shinji Tanaka, Shinya Fukumoto, Masanori Emoto, Hiroyuki Mizuguchi, Takao Hayakawa, Itaru Kojima, Katsuhito Takahashi, and Yoshiki Nishizawa
Diabetes 2003 52: 760 -766. [Abstract] [Full Text] [PDF]

The Insulin Secretory Granule Is the Major Site of K_ATP Channels of the Endocrine Pancreas: Xuehui Geng, Lehong Li, Simon Watkins, Paul D. Robbins, and Peter Drain
Diabetes 2003 52: 767 -776. [Abstract] [Full Text] [PDF]

Pathophysiology:

Metallothionein Prevents Diabetes-Induced Deficits in Cardiomyocytes by Inhibiting Reactive Oxygen Species Production: Gang Ye, Naira S. Metreveli, Jun Ren, and Paul N. Epstein
Diabetes 2003 52: 777 -783. [Abstract] [Full Text] [PDF]

The Focal Form of Persistent Hyperinsulinemic Hypoglycemia of Infancy: Morphological and Molecular Studies Show Structural and Functional Differences With Insulinoma: Christine Sempoux, Yves Guiot, Karin Dahan, Pierre Moulin, Martine Stevens, Virginie Lambot, Pascale de Lonlay, Jean-Christophe Fournet, Claudine Junien, Francis Jaubert, Claire Nihoul-Fekete, Jean-Marie Saudubray, and Jacques Rahier
Diabetes 2003 52: 784 -794. [Abstract] [Full Text] [PDF]

L-Arginine-Nitric Oxide Kinetics in Normal and Type 2 Diabetic Subjects: A Stable-Labelled ¹⁵N Arginine Approach: Angelo Avogaro, Gianna Toffolo, Edward Kiwanuka, Saula Vigili de Kreutzenberg, Paolo Tessari, and Claudio Cobelli
Diabetes 2003 52: 795 -802. [Abstract] [Full Text] [PDF] Data Supplement

Differential Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate in Subjects With the Metabolic Syndrome: Gerald F. Watts, P. Hugh R. Barrett, Juying Ji, Adrian P. Serone, Dick C. Chan, Kevin D. Croft, Franziska Loehrer, and Anthony G. Johnson
Diabetes 2003 52: 803 -811. [Abstract] [Full Text] [PDF]

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study: Joachim Spranger, Anja Kroke, Matthias Möhlig, Kurt Hoffmann, Manuela M. Bergmann, Michael Ristow, Heiner Boeing, and Andreas F.H. Pfeiffer
Diabetes 2003 52: 812 -817. [Abstract] [Full Text] [PDF]

Complications:

Effect of Reinstitution of Good Glycemic Control on Retinal Oxidative Stress and Nitrative Stress in Diabetic Rats: Renu A. Kowluru
Diabetes 2003 52: 818 -823. [Abstract] [Full Text] [PDF]

Latent Transforming Growth Factor-ß Binding Protein-1, a Component of Latent Transforming Growth Factor-ß Complex, Accelerates the Migration of Aortic Smooth Muscle Cells in Diabetic Rats Through Integrin-ß₃: Tetsuto Kanzaki and Masako Otabe
Diabetes 2003 52: 824 -828. [Abstract] [Full Text] [PDF]

Characterization of Retinal Leukostasis and Hemodynamics in Insulin Resistance and Diabetes: Role of Oxidants and Protein Kinase-C Activation: Toru Abiko, Atsuko Abiko, Allen C. Clermont, Brett Shoelson, Naoichi Horio, Junichi Takahashi, Anthony P. Adamis, George L. King, and Sven-Erik Bursell
Diabetes 2003 52: 829 -837. [Abstract] [Full Text] [PDF]

Role of Protein Kinase C on the Expression of Platelet-Derived Growth Factor and Endothelin-1 in the Retina of Diabetic Rats and Cultured Retinal Capillary Pericytes: Tamotsu Yokota, Ronald C. Ma, Joong-Yeol Park, Keiji Isshiki, Konstantinos B. Sotiropoulos, Ravi K. Rauniyar, Karin E. Bornfeldt, and George L. King
Diabetes 2003 52: 838 -845. [Abstract] [Full Text] [PDF]

The Response of Antioxidant Genes to Hyperglycemia Is Abnormal in Patients With Type 1 Diabetes and Diabetic Nephropathy: Andrea D. Hodgkinson, Tracey Bartlett, Peter J. Oates, Beverley A. Millward, and Andrew G. Demaine
Diabetes 2003 52: 846 -851. [Abstract] [Full Text] [PDF]

Increased Serum IGF-I During Pregnancy Is Associated With Progression of Diabetic Retinopathy: Finn F. Lauszus, Joachim G. Klebe, Toke Bek, and Allan Flyvbjerg
Diabetes 2003 52: 852 -856. [Abstract] [Full Text] [PDF]

Enhanced Recombinant Adeno-Associated Virus-Mediated Vascular Endothelial Growth Factor Expression in the Adult Mouse Retina: A Potential Model for Diabetic Retinopathy: P. Elizabeth Rakoczy, Meliha Brankov, Angela Fonceca, Tammy Zaknich, Ben C. Rae, and Chooi-May Lai
Diabetes 2003 52: 857 -863. [Abstract] [Full Text] [PDF]

Aldose Reductase Inhibitor Fidarestat Prevents Retinal Oxidative Stress and Vascular Endothelial Growth Factor Overexpression in Streptozotocin-Diabetic Rats: Irina G. Obrosova, Alexander G. Minchenko, Rukmini Vasupuram, Lauren White, Omorodola I. Abatan, Arno K. Kumagai, Robert N. Frank, and Martin J. Stevens
Diabetes 2003 52: 864 -871. [Abstract] [Full Text] [PDF]

Genetics:

A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity: Timothy M. Frayling, Cecilia M. Lindgren, Jean Claude Chevre, Stephan Menzel, Marie Wishart, Yamina Benmezroua, Alison Brown, Julie C. Evans, Pamidghantam Subba Rao, Christian Dina, Cécile Lecoeur, Timo Kanninen, Peter Almgren, Michael P. Bulman, Youxiang Wang, James Mills, Rosemarie Wright-Pascoe, Melanie M. Mahtani, Francesco Prisco, Angels Costa, Ignacio Cognet, Torben Hansen, Oluf Pedersen, Sian Ellard, Tiinamaija Tuomi, Leif C. Groop, Philippe Froguel, Andrew T. Hattersley, and Martine Vaxillaire
Diabetes 2003 52: 872 -881. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

Insulin Autoantibodies Are Associated With Islet Inflammation But Not Always Related to Diabetes Progression in NOD Congenic Mice: David T. Robles, George S. Eisenbarth, Natalie J.M. Dailey, Laurence B. Peterson, and Linda S. Wicker
Diabetes 2003 52: 882 -886. [Abstract] [Full Text] [PDF]

The Gly⁹⁷² $->$ Arg IRS-1 Variant Is Associated With Type 1 Diabetes in Continental Italy: Massimo Federici, Antonio Petrone, Ottavia Porzio, Carla Bizzarri, Davide Lauro, Rossella D’Alfonso, Ippolita Patera, Marco Cappa, Lorenza Nisticò, Marco Baroni, Giorgio Sesti, Umberto di Mario, Renato Lauro, and Raffaella Buzzetti
Diabetes 2003 52: 887 -890. [Abstract] [Full Text] [PDF]

The Functional -374 T/A RAGE Gene Polymorphism Is Associated With Proteinuria and Cardiovascular Disease in Type 1 Diabetic Patients: Kim Pettersson-Fernholm, Carol Forsblom, Barry I. Hudson, Markus Perola, Peter J. Grant, and Per-Henrik Groop
Diabetes 2003 52: 891 -894. [Abstract] [Full Text] [PDF]

A Gly482Ser Missense Mutation in the Peroxisome Proliferator-Activated Receptor ${gamma}$ Coactivator-1 Is Associated With Altered Lipid Oxidation and Early Insulin Secretion in Pima Indians: Yunhua Li Muller, Clifton Bogardus, Oluf Pedersen, and Leslie Baier
Diabetes 2003 52: 895 -898. [Abstract] [Full Text] [PDF]