Metabolism and Signal Transduction:

Differential Effects of Rosiglitazone on Skeletal Muscle and Liver Insulin Resistance in A-ZIP/F-1 Fatless Mice

Jason K. Kim, Jonathan J. Fillmore, Oksana Gavrilova, Lily Chao, Takamasa Higashimori, Hyejeong Choi, Hyo-Jeong Kim, Chunli Yu, Yan Chen, Xianqin Qu, Martin Haluzik, Marc L. Reitman, and Gerald I. Shulman
Diabetes 2003 52: 1311 -1318. [Abstract] [Full Text] [PDF]  

Reduced Activation of Phosphatidylinositol-3 Kinase and Increased Serine 636 Phosphorylation of Insulin Receptor Substrate-1 in Primary Culture of Skeletal Muscle Cells From Patients With Type 2 Diabetes

Karim Bouzakri, Marina Roques, Philippe Gual, Sophie Espinosa, Fitsum Guebre-Egziabher, Jean-Paul Riou, Martine Laville, Yannick Le Marchand-Brustel, Jean-François Tanti, and Hubert Vidal
Diabetes 2003 52: 1319 -1325. [Abstract] [Full Text] [PDF]  

Fetal Programming of Perivenous Glucose Uptake Reveals a Regulatory Mechanism Governing Hepatic Glucose Output During Refeeding

Helena C. Murphy, Gemma Regan, Irina G. Bogdarina, Adrian J.L. Clark, Richard A. Iles, Robert D. Cohen, Graham A. Hitman, Colin L. Berry, Zoe Coade, Clive J. Petry, and Shamus P. Burns
Diabetes 2003 52: 1326 -1332. [Abstract] [Full Text] [PDF]  

Glucose 6-Phosphate Regulates Hepatic Glycogenolysis Through Inactivation of Phosphorylase

Susan Aiston, Birgitte Andersen, and Loranne Agius
Diabetes 2003 52: 1333 -1339. [Abstract] [Full Text] [PDF]  

Insulin Resistance and Lipodystrophy in Mice Lacking Ribosomal S6 Kinase 2

Karim El-Haschimi, Scott D. Dufresne, Michael F. Hirshman, Jeffrey S. Flier, Laurie J. Goodyear, and Christian Bjørbæk
Diabetes 2003 52: 1340 -1346. [Abstract] [Full Text] [PDF]  

Combined Infusion of Epinephrine and Norepinephrine During Moderate Exercise Reproduces the Glucoregulatory Response of Intense Exercise

Stuart H. Kreisman, Jeffrey B. Halter, Mladen Vranic, and Errol B. Marliss
Diabetes 2003 52: 1347 -1354. [Abstract] [Full Text] [PDF]  

Involvement of AMP-Activated Protein Kinase in Glucose Uptake Stimulated by the Globular Domain of Adiponectin in Primary Rat Adipocytes

Xiangdong Wu, Hiroyuki Motoshima, Kalyankar Mahadev, Timothy J. Stalker, Rosario Scalia, and Barry J. Goldstein
Diabetes 2003 52: 1355 -1363. [Abstract] [Full Text] [PDF]  

Pioglitazone Reduces Hepatic Fat Content and Augments Splanchnic Glucose Uptake in Patients With Type 2 Diabetes

Mandeep Bajaj, Swangjit Suraamornkul, Thongchai Pratipanawatr, Lou J. Hardies, Wilailak Pratipanawatr, Leonard Glass, Eugenio Cersosimo, Yoshinori Miyazaki, and Ralph A. DeFronzo
Diabetes 2003 52: 1364 -1370. [Abstract] [Full Text] [PDF]  

Starvation and Diabetes Reduce the Amount of Pyruvate Dehydrogenase Phosphatase in Rat Heart and Kidney

Boli Huang, Pengfei Wu, Kirill M. Popov, and Robert A. Harris
Diabetes 2003 52: 1371 -1376. [Abstract] [Full Text] [PDF]  

Differential Regulation of Protein Dynamics in Splanchnic and Skeletal Muscle Beds by Insulin and Amino Acids in Healthy Human Subjects

Jonas Nygren and K. Sreekumaran Nair
Diabetes 2003 52: 1377 -1385. [Abstract] [Full Text] [PDF]  

Renal Compensation for Impaired Hepatic Glucose Release During Hypoglycemia in Type 2 Diabetes: Further Evidence for Hepatorenal Reciprocity

Hans J. Woerle, Christian Meyer, Emilia M. Popa, Philip E. Cryer, and John E. Gerich
Diabetes 2003 52: 1386 -1392. [Abstract] [Full Text] [PDF]  

Increased Phosphorylation of Skeletal Muscle Glycogen Synthase at NH₂-Terminal Sites During Physiological Hyperinsulinemia in Type 2 Diabetes

Kurt Højlund, Peter Stæhr, Bo Falck Hansen, Kevin A. Green, D. Grahame Hardie, Erik A. Richter, Henning Beck-Nielsen, and Jørgen F.P. Wojtaszewski
Diabetes 2003 52: 1393 -1402. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Low Circulating IGF-II Concentrations Predict Weight Gain and Obesity in Humans

Manjinder S. Sandhu, J. Martin Gibson, Adrian H. Heald, David B. Dunger, and Nicholas J. Wareham
Diabetes 2003 52: 1403 -1408. [Abstract] [Full Text] [PDF]  

Leptin Activation of Corticosterone Production in Hepatocytes May Contribute to the Reversal of Obesity and Hyperglycemia in Leptin-Deficient ob/ob Mice

Yanjun Liu, Yuichi Nakagawa, Ying Wang, Renshan Li, Xiaojun Li, Takehiko Ohzeki, and Theodore C. Friedman
Diabetes 2003 52: 1409 -1416. [Abstract] [Full Text] [PDF]  

The Presence of a Catalytically Inactive Form of Hormone-Sensitive Lipase Is Associated With Decreased Lipolysis in Abdominal Subcutaneous Adipose Tissue of Obese Subjects

Hind Ray, Michel Beylot, Peter Arner, Dominique Larrouy, Dominique Langin, Cecilia Holm, and Valérie Large
Diabetes 2003 52: 1417 -1422. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Discrete and Complementary Mechanisms of Protection of ß-Cells Against Cytokine-Induced and Oxidative Damage Achieved by bcl-2 Overexpression and a Cytokine Selection Strategy

Veronique Vien Tran, Guoxun Chen, Christopher B. Newgard, and Hans E. Hohmeier
Diabetes 2003 52: 1423 -1432. [Abstract] [Full Text] [PDF]  

The Degree of Phylogenetic Disparity of Islet Grafts Dictates the Reliance on Indirect CD4 T-Cell Antigen Recognition for Rejection

Gina R. Rayat, Zachary A. Johnson, Joshua N. Beilke, Gregory S. Korbutt, Ray V. Rajotte, and Ronald G. Gill
Diabetes 2003 52: 1433 -1440. [Abstract] [Full Text] [PDF]  

Fetal or Neonatal Low-Glycotoxin Environment Prevents Autoimmune Diabetes in NOD Mice

Melpomeni Peppa, Cijiang He, Masakazu Hattori, Robert McEvoy, Feng Zheng, and Helen Vlassara
Diabetes 2003 52: 1441 -1448. [Abstract] [Full Text] [PDF]  

Islet Studies:

Increased Vulnerability of Brain Mitochondria in Diabetic (Goto-Kakizaki) Rats With Aging and Amyloid-ß Exposure

Paula I. Moreira, Maria S. Santos, António M. Moreno, Raquel Seiça, and Catarina R. Oliveira
Diabetes 2003 52: 1449 -1456. [Abstract] [Full Text] [PDF]  

Pancreatic ß-Cells Express Phagocyte-Like NAD(P)H Oxidase

Henriette R. Oliveira, Rozangela Verlengia, Carla R.O. Carvalho, Luiz R.G. Britto, Rui Curi, and Angelo R. Carpinelli
Diabetes 2003 52: 1457 -1463. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Circadian Variation in the Onset of Myocardial Infarction: Effect of Duration of Diabetes

Jamal S. Rana, Kenneth J. Mukamal, James P. Morgan, James E. Muller, and Murray A. Mittleman
Diabetes 2003 52: 1464 -1468. [Abstract] [Full Text] [PDF]  

Mechanisms of Abnormal Cardiac Repolarization During Insulin-Induced Hypoglycemia

Robert T.C.E. Robinson, Nigel D. Harris, Robert H. Ireland, Stuart Lee, Christopher Newman, and Simon R. Heller
Diabetes 2003 52: 1469 -1474. [Abstract] [Full Text] [PDF]  

The Natural History of Progression From Normal Glucose Tolerance to Type 2 Diabetes in the Baltimore Longitudinal Study of Aging

James B. Meigs, Denis C. Muller, David M. Nathan, Deirdre R. Blake, and Reubin Andres
Diabetes 2003 52: 1475 -1484. [Abstract] [Full Text] [PDF]  

Free Fatty Acid-Mediated Impairment of Glucose-Stimulated Insulin Secretion in Nondiabetic Oji-Cree Individuals From the Sandy Lake Community of Ontario, Canada: A Population at Very High Risk for Developing Type 2 Diabetes

André Carpentier, Bernard Zinman, Nathalie Leung, Adria Giacca, Anthony J.G. Hanley, Stewart B. Harris, Robert A. Hegele, and Gary F. Lewis
Diabetes 2003 52: 1485 -1495. [Abstract] [Full Text] [PDF]  

Complications:

Differential Effects of Diabetes on Rat Choroid Plexus Ion Transporter Expression

Richard D. Egleton, Christopher C. Campos, Jason D. Huber, Rachel C. Brown, and Thomas P. Davis
Diabetes 2003 52: 1496 -1501. [Abstract] [Full Text] [PDF]  

A Role for Advanced Glycation End Products in Diminished Bone Healing in Type 1 Diabetes

Ronaldo B. Santana, Lei Xu, Hermik Babakhanlou Chase, Salomon Amar, Dana T. Graves, and Philip C. Trackman
Diabetes 2003 52: 1502 -1510. [Abstract] [Full Text] [PDF]  

Alternative Splicing of NHE-1 Mediates Na-Li Countertransport and Associates With Activity Rate

Gianpaolo Zerbini, Anna Maestroni, Diego Breviario, Ruggero Mangili, and Giorgio Casari
Diabetes 2003 52: 1511 -1518. [Abstract] [Full Text] [PDF]  

Protein Kinase C ß2-Dependent Phosphorylation of Core 2 GlcNAc-T Promotes Leukocyte-Endothelial Cell Adhesion: A Mechanism Underlying Capillary Occlusion in Diabetic Retinopathy

Rakesh Chibber, Bahaedin M. Ben-Mahmud, Giovanni E. Mann, Jin J. Zhang, and Eva M. Kohner
Diabetes 2003 52: 1519 -1527. [Abstract] [Full Text] [PDF]  

Genetics:

Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice

Rohit N. Kulkarni, Katrine Almind, H. Joseph Goren, Jonathon N. Winnay, Kohjiro Ueki, Terumasa Okada, and C. Ronald Kahn
Diabetes 2003 52: 1528 -1534. [Abstract] [Full Text] [PDF]  

Identification of Interactive Loci Linked to Insulin and Leptin in Mice With Genetic Insulin Resistance

Katrine Almind, Rohit N. Kulkarni, Scott M. Lannon, and C. Ronald Kahn
Diabetes 2003 52: 1535 -1543. [Abstract] [Full Text] [PDF]  

Metabolic Effects of the Gly1057Asp Polymorphism in IRS-2 and Interactions With Obesity

Norbert Stefan, Peter Kovacs, Michael Stumvoll, Robert L. Hanson, Angela Lehn-Stefan, Paska A. Permana, Leslie J. Baier, P. Antonio Tataranni, Kristi Silver, and Clifton Bogardus
Diabetes 2003 52: 1544 -1550. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

Identification of a Structurally Distinct CD101 Molecule Encoded in the 950-kb Idd10 Region of NOD Mice

Carlos Penha-Gonçalves, Carolyn Moule, Luc J. Smink, Joanna Howson, Simon Gregory, Jane Rogers, Paul A. Lyons, Joseph J. Suttie, Christopher J. Lord, Laurence B. Peterson, John A. Todd, and Linda S. Wicker
Diabetes 2003 52: 1551 -1556. [Abstract] [Full Text] [PDF]  

Linkage and Linkage Disequilibrium Mapping of Genes Influencing Human Obesity in Chromosome Region 7q22.1–7q35

Wei-Dong Li, Ding Li, Shuang Wang, Shuanglin Zhang, Hongyu Zhao, and R. Arlen Price
Diabetes 2003 52: 1557 -1561. [Abstract] [Full Text] [PDF]  

Polymorphisms in the Insulin-Degrading Enzyme Gene Are Associated With Type 2 Diabetes in Men From the NHLBI Framingham Heart Study

Samer Karamohamed, Serkalem Demissie, Jeannine Volcjak, Chunyu Liu, Nancy Heard-Costa, Jun Liu, Christina M. Shoemaker, Carolien I. Panhuysen, James B. Meigs, Peter Wilson, Larry D. Atwood, L. Adrienne Cupples, and Alan Herbert
Diabetes 2003 52: 1562 -1567. [Abstract] [Full Text] [PDF]  

Pro12Ala of the Peroxisome Proliferator–Activated Receptor-2 Gene Is Associated With Lower Serum Insulin Levels in Nonobese African Americans: The Atherosclerosis Risk in Communities Study

W.H. Linda Kao, Josef Coresh, Alan R. Shuldiner, Eric Boerwinkle, Molly S. Bray, and Frederick L. Brancati
Diabetes 2003 52: 1568 -1572. [Abstract] [Full Text] [PDF]  

Prevalence of Mutations in AGPAT2 Among Human Lipodystrophies

Jocelyne Magré, Marc Delépine, Lionel Van Maldergem, Jean-Jacques Robert, J. Antonie Maassen, Muriel Meier, Vanessa R. Panz, Chong Ae Kim, Nadia Tubiana-Rufi, Paul Czernichow, Eva Seemanova, Charles R. Buchanan, Didier Lacombe, Corinne Vigouroux, Olivier Lascols, C. Ronald Kahn, Jacqueline Capeau, and Mark Lathrop
Diabetes 2003 52: 1573 -1578. [Abstract] [Full Text] [PDF]  

A Polymorphism in the TCF7 Gene, C883A, Is Associated With Type 1 Diabetes

Janelle A. Noble, Amy M. White, Laura C. Lazzeroni, Ana M. Valdes, Daniel B. Mirel, Rebecca Reynolds, Andrew Grupe, Dee Aud, Gary Peltz, and Henry A. Erlich
Diabetes 2003 52: 1579 -1582. [Abstract] [Full Text] [PDF]  

A Quantitative Trait Locus on 7q31 for the Changes in Plasma Insulin in Response to Exercise Training: The HERITAGE Family Study

Timo A. Lakka, Tuomo Rankinen, S. John Weisnagel, Yvon C. Chagnon, Treva Rice, Arthur S. Leon, James S. Skinner, Jack H. Wilmore, D.C. Rao, and Claude Bouchard
Diabetes 2003 52: 1583 -1587. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Status of Research Funded by the American Diabetes Association—Year 4

Mayer B. Davidson
Diabetes 2003 52: 1588 . [Extract] [Full Text] [PDF]  

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