Perspectives in Diabetes:

Neuronal Glucosensing: What Do We Know After 50 Years?

Barry E. Levin, Vanessa H. Routh, Ling Kang, Nicole M. Sanders, and Ambrose A. Dunn-Meynell
Diabetes 2004 53: 2521 -2528. [Abstract] [Full Text] [PDF]  

Signal Transduction:

Intracerebroventricular Neuropeptide Y Infusion Precludes Inhibition of Glucose and VLDL Production by Insulin

Anita M. van den Hoek, Peter J. Voshol, Barbara N. Karnekamp, Ruud M. Buijs, Johannes A. Romijn, Louis M. Havekes, and Hanno Pijl
Diabetes 2004 53: 2529 -2534. [Abstract] [Full Text] [PDF]  

Transferrin and Iron Contribute to the Lipolytic Effect of Serum in Isolated Adipocytes

John M. Rumberger, Theodore Peters, Jr, Christine Burrington, and Allan Green
Diabetes 2004 53: 2535 -2541. [Abstract] [Full Text] [PDF]  

Hypothalamic ATP-sensitive K ⁺ Channels Play a Key Role in Sensing Hypoglycemia and Triggering Counterregulatory Epinephrine and Glucagon Responses

Mark L. Evans, Rory J. McCrimmon, Daniel E. Flanagan, Tara Keshavarz, Xiaoning Fan, Ewan C. McNay, Ralph J. Jacob, and Robert S. Sherwin
Diabetes 2004 53: 2542 -2551. [Abstract] [Full Text] [PDF]  

Obesity Study:

Regulation of Growth Hormone Secretagogue Receptor Gene Expression in the Arcuate Nuclei of the Rat by Leptin and Ghrelin

Ruben Nogueiras, Sulay Tovar, Sharon E. Mitchell, D. Vernon Rayner, Zoe A. Archer, Carlos Dieguez, and Lynda M. Williams
Diabetes 2004 53: 2552 -2558. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Response of Human Islets to Isolation Stress and the Effect of Antioxidant Treatment

Rita Bottino, A.N. Balamurugan, Hubert Tse, C. Thirunavukkarasu, Xinhui Ge, Jennifer Profozich, Martha Milton, Audra Ziegenfuss, Massimo Trucco, and Jon D. Piganelli
Diabetes 2004 53: 2559 -2568. [Abstract] [Full Text] [PDF]  

Elevated C-Reactive Protein Levels in the Development of Type 1 Diabetes

H. Peter Chase, Sonia Cooper, Iris Osberg, Lars C. Stene, Katherine Barriga, Jill Norris, George S. Eisenbarth, and Marian Rewers
Diabetes 2004 53: 2569 -2573. [Abstract] [Full Text] [PDF]  

A Salen-Manganese Catalytic Free Radical Scavenger Inhibits Type 1 Diabetes and Islet Allograft Rejection

Angelica P. Olcott, Georges Tocco, Jide Tian, Dan Zekzer, Jon Fukuto, Louis Ignarro, and Daniel L. Kaufman
Diabetes 2004 53: 2574 -2580. [Abstract] [Full Text] [PDF]  

Investigation of the Role of B-Cells in Type 1 Diabetes in the NOD Mouse

F. Susan Wong, Li Wen, Michelle Tang, Murugappan Ramanathan, Irene Visintin, Joanne Daugherty, Lynn G. Hannum, Charles A. Janeway, Jr, and Mark J. Shlomchik
Diabetes 2004 53: 2581 -2587. [Abstract] [Full Text] [PDF]  

Local Activation of Dendritic Cells Leads to Insulitis and Development of Insulin-Dependent Diabetes in Transgenic Mice Expressing CD154 on the Pancreatic ß-Cells

Claus Haase, Kresten Skak, Birgitte K. Michelsen, and Helle Markholst
Diabetes 2004 53: 2588 -2595. [Abstract] [Full Text] [PDF]  

Islet Study:

Promotion of ß-Cell Differentiation by Conophylline in Fetal and Neonatal Rat Pancreas

Takeki Ogata, Lei Li, Satoko Yamada, Yoritsuna Yamamoto, Yuji Tanaka, Izumi Takei, Kazuo Umezawa, and Itaru Kojima
Diabetes 2004 53: 2596 -2602. [Abstract] [Full Text] [PDF]  

Artifactual Insulin Release From Differentiated Embryonic Stem Cells

Mattias Hansson, Anna Tonning, Ulrik Frandsen, Andreas Petri, Jayaraj Rajagopal, Mikael C.O. Englund, R. Scott Heller, Joakim Håkansson, Jan Fleckner, Helen Nilsson Sköld, Douglas Melton, Henrik Semb, and Palle Serup
Diabetes 2004 53: 2603 -2609. [Abstract] [Full Text] [PDF]  

Evidence Against the Involvement of Oxidative Stress in Fatty Acid Inhibition of Insulin Secretion

Patrick C. Moore, Marco A. Ugas, Derek K. Hagman, Susan D. Parazzoli, and Vincent Poitout
Diabetes 2004 53: 2610 -2616. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Hepatic Insulin Resistance Precedes the Development of Diabetes in a Model of Intrauterine Growth Retardation

Patricia Vuguin, Elisabeth Raab, Bing Liu, Nir Barzilai, and Rebecca Simmons
Diabetes 2004 53: 2617 -2622. [Abstract] [Full Text] [PDF]  

Elevations in Markers of Liver Injury and Risk of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study

Anthony J.G. Hanley, Ken Williams, Andreas Festa, Lynne E. Wagenknecht, Ralph B. D’Agostino, Jr., Judy Kempf, Bernard Zinman, and Steven M. Haffner
Diabetes 2004 53: 2623 -2632. [Abstract] [Full Text] [PDF] Appendix  

Alterations in Plasma Vitamin E Distribution in Type 2 Diabetic Patients With Elevated Plasma Phospholipid Transfer Protein Activity

Martina Schneider, Bruno Vergès, Alexis Klein, Elizabeth R. Miller, Valérie Deckert, Catherine Desrumaux, David Masson, Philippe Gambert, Jean-Marcel Brun, Jamila Fruchart-Najib, Denis Blache, Joseph L. Witztum, and Laurent Lagrost
Diabetes 2004 53: 2633 -2639. [Abstract] [Full Text] [PDF]  

Complications:

Nitric Oxide–Sensitive Soluble Guanylyl Cyclase Activity Is Preserved in Internal Mammary Artery of Type 2 Diabetic Patients

Klaus Witte, Jochen Hachenberger, Maria F. Castell, Christian F. Vahl, and Christlieb Haller
Diabetes 2004 53: 2640 -2644. [Abstract] [Full Text] [PDF]  

Preserved Glucoregulation but Attenuation of the Vascular Actions of Insulin in Mice Heterozygous for Knockout of the Insulin Receptor

Stephen B. Wheatcroft, Ajay M. Shah, Jian-Mei Li, Edward Duncan, Brian T. Noronha, Paul A. Crossey, and Mark T. Kearney
Diabetes 2004 53: 2645 -2652. [Abstract] [Full Text] [PDF]  

Glycation Inactivation of the Complement Regulatory Protein CD59: A Possible Role in the Pathogenesis of the Vascular Complications of Human Diabetes

Xuebin Qin, Allison Goldfine, Nicole Krumrei, Luciano Grubissich, Juan Acosta, Michael Chorev, Arthur P. Hays, and Jose A. Halperin
Diabetes 2004 53: 2653 -2661. [Abstract] [Full Text] [PDF]  

Thiazolidinediones Reduce Endothelial Expression of Receptors for Advanced Glycation End Products

Nikolaus Marx, Daniel Walcher, Nina Ivanova, Kirstin Rautzenberg, Annelie Jung, Reinhard Friedl, Vinzenz Hombach, Raffaele de Caterina, Giuseppina Basta, Marie-Paule Wautier, and Jean-Luc Wautiers
Diabetes 2004 53: 2662 -2668. [Abstract] [Full Text] [PDF]  

Selective Loss of Calcitonin Gene-Related Peptide-Expressing Primary Sensory Neurons of the A-Cell Phenotype in Early Experimental Diabetes

Yun Jiang, Jens Randel Nyengaard, Jin Song Zhang, and Johannes Jakobsen
Diabetes 2004 53: 2669 -2675. [Abstract] [Full Text] [PDF]  

Genetics:

Genome-wide Scan for Metabolic Syndrome and Related Quantitative Traits in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25

Maggie C.Y. Ng, Wing-Yee So, Vincent K.L. Lam, Clive S. Cockram, Graeme I. Bell, Nancy J. Cox, and Juliana C.N. Chan
Diabetes 2004 53: 2676 -2683. [Abstract] [Full Text] [PDF]  

Differences in the Contribution of HLA-DR and -DQ Haplotypes to Susceptibility to Adult- and Childhood-Onset Type 1 Diabetes in Japanese Patients

Satoshi Murao, Hideichi Makino, Yukikazu Kaino, Etsushi Konoue, Jun Ohashi, Kaichi Kida, Yasuhisa Fujii, Ikki Shimizu, Eiji Kawasaki, Masao Fujiyama, Shiori Kondo, Kiyonobu Tanaka, Yoshinao Tarumi, Isamu Seto, Kenichi Kato, Keizo Ohno, Yukiko Kusunoki, Osamu Ebisui, Yasuharu Takada, Katsuya Tanabe, Koji Takemoto, Hiroshi Onuma, Tatsuya Nishimiya, and Haruhiko Osawa
Diabetes 2004 53: 2684 -2690. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

Intercellular Adhesion Molecule-1 Concentration Is Genetically Correlated With Insulin Resistance, Obesity, and HDL Concentration in Mexican Americans

Jack W. Kent, Jr, Anthony G. Comuzzie, Michael C. Mahaney, Laura Almasy, David L. Rainwater, John L. VandeBerg, Jean W. MacCluer, and John Blangero
Diabetes 2004 53: 2691 -2695. [Abstract] [Full Text] [PDF] Appendix  

Melanocortin 4 Receptor Gene Variation Is Associated With Severe Obesity in Pima Indians

Lijun Ma, P. Antonio Tataranni, Clifton Bogardus, and Leslie J. Baier
Diabetes 2004 53: 2696 -2699. [Abstract] [Full Text] [PDF]  

Genetic Evidence for Discordance Between Obesity- and Diabetes-Related Traits in the LGXSM Recombinant Inbred Mouse Strains

James M. Cheverud, Thomas H. Ehrich, Jane P. Kenney, L. Susan Pletscher, and Clay F. Semenkovich
Diabetes 2004 53: 2700 -2708. [Abstract] [Full Text] [PDF] Appendix  

Analysis of the Vitamin D Receptor Gene Sequence Variants in Type 1 Diabetes

Sergey Nejentsev, Jason D. Cooper, Lisa Godfrey, Joanna M.M. Howson, Helen Rance, Sarah Nutland, Neil M. Walker, Cristian Guja, Constantin Ionescu-Tirgoviste, David A. Savage, Dag E. Undlien, Kjersti S. Rønningen, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Kathleen M. Gillespie, Susan M. Ring, David P. Strachan, Barry Widmer, David Dunger, and John A. Todd
Diabetes 2004 53: 2709 -2712. [Abstract] [Full Text] [PDF] Appendix  

Permanent Neonatal Diabetes due to Mutations in KCNJ11 Encoding Kir6.2: Patient Characteristics and Initial Response to Sulfonylurea Therapy

Jørn V. Sagen, Helge Ræder, Eba Hathout, Naim Shehadeh, Kolbeinn Gudmundsson, Halvor Bævre, Dianne Abuelo, Chanika Phornphutkul, Janne Molnes, Graeme I. Bell, Anna L. Gloyn, Andrew T. Hattersley, Anders Molven, Oddmund Søvik, and Pål R. Njølstad
Diabetes 2004 53: 2713 -2718. [Abstract] [Full Text] [PDF] Appendix  

Kir6.2 Mutations Are a Common Cause of Permanent Neonatal Diabetes in a Large Cohort of French Patients

Martine Vaxillaire, Céline Populaire, Kanetee Busiah, Hélène Cavé, Anna L. Gloyn, Andrew T. Hattersley, Paul Czernichow, Philippe Froguel, and Michel Polak
Diabetes 2004 53: 2719 -2722. [Abstract] [Full Text] [PDF]  

Pharmacology and Therapeutics:

Gene Therapy Using Replication-Defective Herpes Simplex Virus Vectors Expressing Nerve Growth Factor in a Rat Model of Diabetic Cystopathy

Katsumi Sasaki, Michael B. Chancellor, William F. Goins, Michael W. Phelan, Joseph C. Glorioso, William C. de Groat, and Naoki Yoshimura
Diabetes 2004 53: 2723 -2730. [Abstract] [Full Text] [PDF]  

Errata:

Erratum

Diabetes 2004 53: 2731 . [Extract] [Full Text] [PDF]  

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