Diabetes -- Table of Contents (November 2004, 53 [11])

Perspectives in Diabetes:

Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology: Cecilia C. Low Wang, Marc L. Goalstone, and Boris Draznin
Diabetes 2004 53: 2735 -2740. [Abstract] [Full Text] [PDF]

Metabolism:

Physiological Hyperinsulinemia in Dogs Augments Access of Macromolecules to Insulin-Sensitive Tissues: Martin Ellmerer, Stella P. Kim, Marianthe Hamilton-Wessler, Katrin Hücking, Erlinda Kirkman, and Richard N. Bergman
Diabetes 2004 53: 2741 -2747. [Abstract] [Full Text] [PDF]

Signal Transduction:

Regulation of Peroxisome Proliferator–Activated Receptor- ${gamma}$ Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis: Jae Eun Kim and Jie Chen
Diabetes 2004 53: 2748 -2756. [Abstract] [Full Text] [PDF]

CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue: Sang-kyu Park, So-Young Oh, Min-Young Lee, Sarah Yoon, Kyung-Sup Kim, and Jae-woo Kim
Diabetes 2004 53: 2757 -2766. [Abstract] [Full Text] [PDF]

A New ATP-Sensitive K⁺ Channel–Independent Mechanism Is Involved in Glucose-Excited Neurons of Mouse Arcuate Nucleus: Xavier Fioramonti, Anne Lorsignol, Anne Taupignon, and Luc Pénicaud
Diabetes 2004 53: 2767 -2775. [Abstract] [Full Text] [PDF]

Platelet-Derived Growth Factor Stimulates Glucose Transport in Skeletal Muscles of Transgenic Mice Specifically Expressing Platelet-Derived Growth Factor Receptor in the Muscle, but It Does Not Affect Blood Glucose Levels: Tomoyuki Yuasa, Rei Kakuhata, Kazuhiro Kishi, Toshiyuki Obata, Yasuo Shinohara, Yoshimi Bando, Keisuke Izumi, Fumiko Kajiura, Mitsuru Matsumoto, and Yousuke Ebina
Diabetes 2004 53: 2776 -2786. [Abstract] [Full Text] [PDF]

Obesity Study:

Ciliary Neurotrophic Factor_Ax15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet-Induced Obese and UCP1-DTA Mice: Susann Blüher, Stergios Moschos, John Bullen, Jr., Efi Kokkotou, Eleftheria Maratos-Flier, Stanley J. Wiegand, Mark W. Sleeman, and Christos S. Mantzoros
Diabetes 2004 53: 2787 -2796. [Abstract] [Full Text] [PDF] Online Appendix

Immunology and Transplantation:

Fas Deficiency Prevents Type 1 Diabetes by Inducing Hyporesponsiveness in Islet ß-Cell–Reactive T-Cells: Luis Vence, Christophe Benoist, and Diane Mathis
Diabetes 2004 53: 2797 -2803. [Abstract] [Full Text] [PDF]

Islet Study:

Activated Protein C Preserves Functional Islet Mass After Intraportal Transplantation: A Novel Link Between Endothelial Cell Activation, Thrombosis, Inflammation, and Islet Cell Death: Juan L. Contreras, Christopher Eckstein, Cheryl A. Smyth, Guadalupe Bilbao, Mario Vilatoba, Sharman E. Ringland, Carlton Young, J. Anthony Thompson, José A. Fernández, John H. Griffin, and Devin E. Eckhoff
Diabetes 2004 53: 2804 -2814. [Abstract] [Full Text] [PDF]

Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure: Saida Abdelli, Jeff Ansite, Raphael Roduit, Tiziana Borsello, Ippei Matsumoto, Toshiya Sawada, Nathalie Allaman-Pillet, Hugues Henry, Jacques S. Beckmann, Bernhard J. Hering, and Christophe Bonny
Diabetes 2004 53: 2815 -2823. [Abstract] [Full Text] [PDF]

Interplay of Glucagon-Like Peptide-1 and Transforming Growth Factor-ß Signaling in Insulin-Positive Differentiation of AR42J Cells: Kok-Hooi Yew, Krishna L. Prasadan, Barry L. Preuett, Mark J. Hembree, Christopher R. McFall, Christina L. Benjes, Amanda R. Crowley, Susan L. Sharp, Zhixing Li, Sidhartha S. Tulachan, Sheilendra S. Mehta, and George K. Gittes
Diabetes 2004 53: 2824 -2835. [Abstract] [Full Text] [PDF]

Palmitate Stimulation of Glucagon Secretion in Mouse Pancreatic ${alpha}$ -Cells Results From Activation of L-Type Calcium Channels and Elevation of Cytoplasmic Calcium: Charlotta S. Olofsson, Albert Salehi, Sven O. Göpel, Cecilia Holm, and Patrik Rorsman
Diabetes 2004 53: 2836 -2843. [Abstract] [Full Text] [PDF]

Pioglitazone Reduces Islet Triglyceride Content and Restores Impaired Glucose-Stimulated Insulin Secretion in Heterozygous Peroxisome Proliferator–Activated Receptor- ${gamma}$ –Deficient Mice on a High-Fat Diet: Junji Matsui, Yasuo Terauchi, Naoto Kubota, Iseki Takamoto, Kazuhiro Eto, Tokuyuki Yamashita, Kajuro Komeda, Toshimasa Yamauchi, Junji Kamon, Shunbun Kita, Mitsuhiko Noda, and Takashi Kadowaki
Diabetes 2004 53: 2844 -2854. [Abstract] [Full Text] [PDF]

Pathophysiology:

Elevated Alanine Aminotransferase Predicts New-Onset Type 2 Diabetes Independently of Classical Risk Factors, Metabolic Syndrome, and C-Reactive Protein in the West of Scotland Coronary Prevention Study: Naveed Sattar, Olga Scherbakova, Ian Ford, Denis St. J. O’Reilly, Adrian Stanley, Ewan Forrest, Peter W. MacFarlane, Chris J. Packard, Stuart M. Cobbe, and James Shepherd
Diabetes 2004 53: 2855 -2860. [Abstract] [Full Text] [PDF]

A Possible Link Between Skeletal Muscle Mitochondrial Efficiency and Age-Induced Insulin Resistance: Susanna Iossa, Maria Pina Mollica, Lillà Lionetti, Raffaella Crescenzo, Rosaria Tasso, and Giovanna Liverini
Diabetes 2004 53: 2861 -2866. [Abstract] [Full Text] [PDF]

Impact of Intra-Abdominal Fat and Age on Insulin Sensitivity and ß-Cell Function: Kristina M. Utzschneider, Darcy B. Carr, Rebecca L. Hull, Keiichi Kodama, Jane B. Shofer, Barbara M. Retzlaff, Robert H. Knopp, and Steven E. Kahn
Diabetes 2004 53: 2867 -2872. [Abstract] [Full Text] [PDF]

Free Fatty Acid Levels Modulate Microvascular Function: Relevance for Obesity-Associated Insulin Resistance, Hypertension, and Microangiopathy: Renate T. de Jongh, Erik H. Serné, Richard G. IJzerman, Greetje de Vries, and Coen D.A. Stehouwer
Diabetes 2004 53: 2873 -2882. [Abstract] [Full Text] [PDF]

A Prospective Study of Serum Lipids and Risk of Diabetic Macular Edema in Type 1 Diabetes: Biljana Miljanovic, Robert J. Glynn, David M. Nathan, JoAnn E. Manson, and Debra A. Schaumberg
Diabetes 2004 53: 2883 -2892. [Abstract] [Full Text] [PDF]

Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone: Gary F. Lewis, Susan Murdoch, Kristine Uffelman, Mark Naples, Linda Szeto, Alegria Albers, Khosrow Adeli, and John D. Brunzell
Diabetes 2004 53: 2893 -2900. [Abstract] [Full Text] [PDF]

Phloridzin Improves Hyperglycemia But Not Hepatic Insulin Resistance in a Transgenic Mouse Model of Type 2 Diabetes: Hong Zhao, Shoshana Yakar, Oksana Gavrilova, Hui Sun, Yang Zhang, Hyunsook Kim, Jennifer Setser, William Jou, and Derek LeRoith
Diabetes 2004 53: 2901 -2909. [Abstract] [Full Text] [PDF]

Complication:

Activation of Nulcear Factor- ${kappa}$ B by Hyperglycemia in Vascular Smooth Muscle Cells Is Regulated by Aldose Reductase: Kota V. Ramana, Brian Friedrich, Sanjay Srivastava, Aruni Bhatnagar, and Satish K. Srivastava
Diabetes 2004 53: 2910 -2920. [Abstract] [Full Text] [PDF]

Attenuation of Extracellular Matrix Accumulation in Diabetic Nephropathy by the Advanced Glycation End Product Cross-Link Breaker ALT-711 via a Protein Kinase C- ${alpha}$ –Dependent Pathway: Vicki Thallas-Bonke, Carsten Lindschau, Bishoy Rizkalla, Leon A. Bach, Geoffrey Boner, Matthias Meier, Hermann Haller, Mark E. Cooper, and Josephine M. Forbes
Diabetes 2004 53: 2921 -2930. [Abstract] [Full Text] [PDF]

Interactions Between Hyperglycemia and Hypoxia: Implications for Diabetic Retinopathy: Jens R. Nyengaard, Yassuo Ido, Charles Kilo, and Joseph R. Williamson
Diabetes 2004 53: 2931 -2938. [Abstract] [Full Text] [PDF] Online Appendix

Podocyte-Derived Vascular Endothelial Growth Factor Mediates the Stimulation of ${alpha}$ 3(IV) Collagen Production by Transforming Growth Factor-ß1 in Mouse Podocytes: Sheldon Chen, Yuki Kasama, Joseph S. Lee, Belinda Jim, Maria Marin, and Fuad N. Ziyadeh
Diabetes 2004 53: 2939 -2949. [Abstract] [Full Text] [PDF]

Leukocyte-Derived Myeloperoxidase Amplifies High-Glucose—Induced Endothelial Dysfunction Through Interaction With High-Glucose—Stimulated, Vascular Non—Leukocyte-Derived Reactive Oxygen Species: Chunxiang Zhang, Jian Yang, and Lisa K. Jennings
Diabetes 2004 53: 2950 -2959. [Abstract] [Full Text] [PDF]

Poly(ADP-Ribose) Polymerase Is Involved in the Development of Diabetic Retinopathy via Regulation of Nuclear Factor- ${kappa}$ B: Ling Zheng, Csaba Szabó, and Timothy S. Kern
Diabetes 2004 53: 2960 -2967. [Abstract] [Full Text] [PDF]

Tumor Necrosis Factor- ${alpha}$ in Diabetic Plasma Increases the Activity of Core 2 GlcNAc-T and Adherence of Human Leukocytes to Retinal Endothelial Cells: Significance of Core 2 GlcNAc-T in Diabetic Retinopathy: Bahaedin M. Ben-Mahmud, Giovanni E. Mann, Alessandro Datti, Aldo Orlacchio, Eva M. Kohner, and Rakesh Chibber
Diabetes 2004 53: 2968 -2976. [Abstract] [Full Text] [PDF]

Genetic:

Genetics of the APM1 Locus and Its Contribution to Type 2 Diabetes Susceptibility in French Caucasians: Fernando Gibson and Philippe Froguel
Diabetes 2004 53: 2977 -2983. [Abstract] [Full Text] [PDF]

Association of Glomerulopathy With the 5'-End Polymorphism of the Aldose Reductase Gene and Renal Insufficiency in Type 2 Diabetic Patients: Hai-Lu Zhao, Peter C.Y. Tong, Fernand M.M. Lai, Brian Tomlinson, and Juliana C.N. Chan
Diabetes 2004 53: 2984 -2991. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

Variation in NCB5OR: Studies of Relationships to Type 2 Diabetes, Maturity-Onset Diabetes of the Young, and Gestational Diabetes Mellitus: Gitte Andersen, Lise Wegner, Christian Schack Rose, Jianxin Xie, Hao Zhu, Kevin Larade, Anders Johansen, Jakob Ek, Jeannet Lauenborg, Thomas Drivsholm, Knut Borch-Johnsen, Peter Damm, Torben Hansen, H. Franklin Bunn, and Oluf Pedersen
Diabetes 2004 53: 2992 -2997. [Abstract] [Full Text] [PDF]

Activating Mutations in the KCNJ11 Gene Encoding the ATP-Sensitive K⁺ Channel Subunit Kir6.2 Are Rare in Clinically Defined Type 1 Diabetes Diagnosed Before 2 Years: Emma L. Edghill, Anna L. Gloyn, Kathleen M. Gillespie, A. Paul Lambert, Neil T. Raymond, Peter G. Swift, Sian Ellard, Edwin A.M. Gale, and Andrew T. Hattersley
Diabetes 2004 53: 2998 -3001. [Abstract] [Full Text] [PDF]

Common Variants of the Hepatocyte Nuclear Factor-4 ${alpha}$ P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population: Michael N. Weedon, Katharine R. Owen, Beverley Shields, Graham Hitman, Mark Walker, Mark I. McCarthy, Latisha D. Love-Gregory, M. Alan Permutt, Andrew T. Hattersley, and Timothy M. Frayling
Diabetes 2004 53: 3002 -3006. [Abstract] [Full Text] [PDF] Online Appendix

Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Type 2 Diabetes: Jennifer L. Bento, Nicholette D. Palmer, Josyf C. Mychaleckyj, Leslie A. Lange, Carl D. Langefeld, Stephen S. Rich, Barry I. Freedman, and Donald W. Bowden
Diabetes 2004 53: 3007 -3012. [Abstract] [Full Text] [PDF] Online Appendix

Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Measures of Glucose Homeostasis in Hispanic Americans: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study: Nicholette D. Palmer, Jennifer L. Bento, Josyf C. Mychaleckyj, Carl D. Langefeld, Joel K. Campbell, Jill M. Norris, Stephen M. Haffner, Richard N. Bergman, and Donald W. Bowden
Diabetes 2004 53: 3013 -3019. [Abstract] [Full Text] [PDF] Supplemental Fig. 1

Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus: Deborah Smyth, Jason D. Cooper, Joanne E. Collins, Joanne M. Heward, Jayne A. Franklyn, Joanna M.M. Howson, Adrian Vella, Sarah Nutland, Helen E. Rance, Lisa Maier, Bryan J. Barratt, Cristian Guja, Constantin Ionescu-Tîrgoviste, David A. Savage, David B. Dunger, Barry Widmer, David P. Strachan, Susan M. Ring, Neil Walker, David G. Clayton, Rebecca C.J. Twells, Stephen C.L. Gough, and John A. Todd
Diabetes 2004 53: 3020 -3023. [Abstract] [Full Text] [PDF]

Pharmacology & Therapeutics:

Intranasal Insulin Reduces Body Fat in Men but not in Women: Manfred Hallschmid, Christian Benedict, Bernd Schultes, Horst-Lorenz Fehm, Jan Born, and Werner Kern
Diabetes 2004 53: 3024 -3029. [Abstract] [Full Text] [PDF]