Diabetes -- Table of Contents (December 2004, 53 [12])

Perspectives in Diabetes:

Age-Dependent Influences on the Origins of Autoimmune Diabetes: Evidence and Implications: R. David G. Leslie and Michela Delli Castelli
Diabetes 2004 53: 3033 -3040. [Extract] [Full Text] [PDF]

Metabolism:

Exercise-Induced Changes in Insulin and Glucagon Are Not Required for Enhanced Hepatic Glucose Uptake After Exercise but Influence the Fate of Glucose Within the Liver: R. Richard Pencek, Freyja D. James, D. Brooks Lacy, Kareem Jabbour, Phillip E. Williams, Patrick T. Fueger, and David H. Wasserman
Diabetes 2004 53: 3041 -3047. [Abstract] [Full Text] [PDF]

Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes: Martin Krssak, Attila Brehm, Elisabeth Bernroider, Christian Anderwald, Peter Nowotny, Chiara Dalla Man, Claudio Cobelli, Gary W. Cline, Gerald I. Shulman, Werner Waldhäusl, and Michael Roden
Diabetes 2004 53: 3048 -3056. [Abstract] [Full Text] [PDF]

Signal Transduction:

Hepatic PTP-1B Expression Regulates the Assembly and Secretion of Apolipoprotein B–Containing Lipoproteins: Evidence From Protein Tyrosine Phosphatase-1B Overexpression, Knockout, and RNAi Studies: Wei Qiu, Rita Kohen Avramoglu, Nadia Dubé, Taryne M. Chong, Mark Naples, Crystal Au, Konstantinos G. Sidiropoulos, Gary F. Lewis, Jeffrey S. Cohn, Michel L. Tremblay, and Khosrow Adeli
Diabetes 2004 53: 3057 -3066. [Abstract] [Full Text] [PDF]

LRb-STAT3 Signaling Is Required for the Neuroendocrine Regulation of Energy Expenditure by Leptin: Sarah H. Bates, Trevor A. Dundon, Matthew Seifert, Michael Carlson, Eleftheria Maratos-Flier, and Martin G. Myers, Jr
Diabetes 2004 53: 3067 -3073. [Abstract] [Full Text] [PDF]

The ${alpha}$ 2–5'AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading: Sebastian B. Jørgensen, Jakob N. Nielsen, Jesper B. Birk, Grith Skytte Olsen, Benoit Viollet, Fabrizio Andreelli, Peter Schjerling, Sophie Vaulont, D. Grahame Hardie, Bo F. Hansen, Erik A. Richter, and Jørgen F.P. Wojtaszewski
Diabetes 2004 53: 3074 -3081. [Abstract] [Full Text] [PDF]

G-Protein Signaling Participates in the Development of Diabetic Cardiomyopathy: Ian S. Harris, Ilya Treskov, Michael W. Rowley, Scott Heximer, Kevin Kaltenbronn, Brian N. Finck, Richard W. Gross, Daniel P. Kelly, Kendall J. Blumer, and Anthony J. Muslin
Diabetes 2004 53: 3082 -3090. [Abstract] [Full Text] [PDF]

Obesity Study:

Pancreatic Polypeptide Is Involved in the Regulation of Body Weight in Pima Indian Male Subjects: Juraj Koska, Angelo DelParigi, Barbora de Courten, Christian Weyer, and P. Antonio Tataranni
Diabetes 2004 53: 3091 -3096. [Abstract] [Full Text] [PDF]

Fibroblast Growth Factor 1: A Key Regulator of Human Adipogenesis: Louise Hutley, Wenda Shurety, Felicity Newell, Ross McGeary, Nicole Pelton, Jennifer Grant, Adrian Herington, Donald Cameron, Jon Whitehead, and Johannes Prins
Diabetes 2004 53: 3097 -3106. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Islet Graft Assessment in the Edmonton Protocol: Implications for Predicting Long-Term Clinical Outcome: Cale N. Street, Jonathan R.T. Lakey, A.M. James Shapiro, Sharleen Imes, Ray V. Rajotte, Edmond A. Ryan, James G. Lyon, Tatsuya Kin, Jose Avila, Toshiaki Tsujimura, and Gregory S. Korbutt
Diabetes 2004 53: 3107 -3114. [Abstract] [Full Text] [PDF]

Absence of Lymph Nodes in NOD Mice Treated With Lymphotoxin-ß Receptor Immunoglobulin Protects From Diabetes: Matteo G. Levisetti, Anish Suri, Katherine Frederick, and Emil R. Unanue
Diabetes 2004 53: 3115 -3119. [Abstract] [Full Text] [PDF]

Islet Study:

Characterization of Mice Doubly Transgenic for Parathyroid Hormone-Related Protein and Murine Placental Lactogen: A Novel Role for Placental Lactogen in Pancreatic ß-Cell Survival: Yuichi Fujinaka, Darinka Sipula, Adolfo Garcia-Ocaña, and Rupangi C. Vasavada
Diabetes 2004 53: 3120 -3130. [Abstract] [Full Text] [PDF]

Pancreatic-Specific Inactivation of IGF-I Gene Causes Enlarged Pancreatic Islets and Significant Resistance to Diabetes: Yarong Lu, Pedro L. Herrera, Yubin Guo, David Sun, Zhengyi Tang, Derek LeRoith, and Jun-Li Liu
Diabetes 2004 53: 3131 -3141. [Abstract] [Full Text] [PDF]

Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca²⁺ Signaling in ß-Cells: Implication in the Glycemic Control in Rodents: Katsuya Dezaki, Hiroshi Hosoda, Masafumi Kakei, Suzuko Hashiguchi, Masatomo Watanabe, Kenji Kangawa, and Toshihiko Yada
Diabetes 2004 53: 3142 -3151. [Abstract] [Full Text] [PDF]

Massive Augmentation of Stimulated Insulin Secretion Induced by Fatty Acid–Free BSA in Rat Pancreatic Islets: Susanne G. Straub and Geoffrey W. G. Sharp
Diabetes 2004 53: 3152 -3158. [Abstract] [Full Text] [PDF]

Diet-Induced Glucose Intolerance in Mice With Decreased ß-Cell ATP-Sensitive K⁺ Channels: Maria S. Remedi, Joseph. C. Koster, Kamelia Markova, Susumu Seino, Takashi Miki, Brian L. Patton, Michael L. McDaniel, and Colin G. Nichols
Diabetes 2004 53: 3159 -3167. [Abstract] [Full Text] [PDF]

High Glucose Is Necessary for Complete Maturation of Pdx1-VP16–Expressing Hepatic Cells into Functional Insulin-Producing Cells: Li-Zhen Cao, Dong-Qi Tang, Marko E. Horb, Shi-Wu Li, and Li-Jun Yang
Diabetes 2004 53: 3168 -3178. [Abstract] [Full Text] [PDF] Appendix

Stimulation of Insulin Release by Glucose Is Associated With an Increase in the Number of Docked Granules in the ß-Cells of Rat Pancreatic Islets: Susanne G. Straub, Geetha Shanmugam, and Geoffrey W.G. Sharp
Diabetes 2004 53: 3179 -3183. [Abstract] [Full Text] [PDF]

Pathophysiology:

Insulin Stimulates and Diabetes Inhibits O-Linked N-Acetylglucosamine Transferase and O-Glycosylation of Sp1: Gipsy Majumdar, Jeremiah Wright, Paul Markowitz, Antonio Martinez-Hernandez, Rajendra Raghow, and Solomon S. Solomon
Diabetes 2004 53: 3184 -3192. [Abstract] [Full Text] [PDF]

Phenotypic Characteristics of GAD Antibody-Positive Recently Diagnosed Patients With Type 2 Diabetes in North America and Europe: Bernard Zinman, Steven E. Kahn, Steven M. Haffner, M. Colleen O’Neill, Mark A. Heise, Martin I. Freed ADOPT Study Group*
Diabetes 2004 53: 3193 -3200. [Abstract] [Full Text] [PDF]

Decreased Sarcoplasmic Reticulum Activity and Contractility in Diabetic db/db Mouse Heart: Darrell D. Belke, Eric A. Swanson, and Wolfgang H. Dillmann
Diabetes 2004 53: 3201 -3208. [Abstract] [Full Text] [PDF]

Palmitate-Induced Interleukin-6 Expression in Human Coronary Artery Endothelial Cells: Harald Staiger, Katrin Staiger, Norbert Stefan, Hans Günther Wahl, Fausto Machicao, Monika Kellerer, and Hans-Ulrich Häring
Diabetes 2004 53: 3209 -3216. [Abstract] [Full Text] [PDF]

Complication:

Hyperlipidemia in Concert With Hyperglycemia Stimulates the Proliferation of Macrophages in Atherosclerotic Lesions: Potential Role of Glucose-Oxidized LDL: Najib Lamharzi, Catherine B. Renard, Farah Kramer, Subramaniam Pennathur, Jay W. Heinecke, Alan Chait, and Karin E. Bornfeldt
Diabetes 2004 53: 3217 -3225. [Abstract] [Full Text] [PDF]

Hyperglycemia Regulates Hypoxia-Inducible Factor-1 ${alpha}$ Protein Stability and Function: Sergiu-Bogdan Catrina, Kensaku Okamoto, Teresa Pereira, Kerstin Brismar, and Lorenz Poellinger
Diabetes 2004 53: 3226 -3232. [Abstract] [Full Text] [PDF]

Effect of Long-Term Administration of ${alpha}$ -Lipoic Acid on Retinal Capillary Cell Death and the Development of Retinopathy in Diabetic Rats: Renu A. Kowluru and Sarah Odenbach
Diabetes 2004 53: 3233 -3238. [Abstract] [Full Text] [PDF]

Effects of Polyol Pathway Hyperactivity on Protein Kinase C Activity, Nociceptive Peptide Expression, and Neuronal Structure in Dorsal Root Ganglia in Diabetic Mice: Kenji Uehara, Shin-Ichiro Yamagishi, Saori Otsuki, Shyunsuke Chin, and Soroku Yagihashi
Diabetes 2004 53: 3239 -3247. [Abstract] [Full Text] [PDF]

Development of Late-Stage Diabetic Nephropathy in OVE26 Diabetic Mice: Shirong Zheng, William T. Noonan, Naira S. Metreveli, Susan Coventry, Patricia M. Kralik, Edward C. Carlson, and Paul N. Epstein
Diabetes 2004 53: 3248 -3257. [Abstract] [Full Text] [PDF]

Pharmacology & Therapeutic:

Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms: Mark E. Cleasby, Nicolas Dzamko, Bronwyn D. Hegarty, Gregory J. Cooney, Edward W. Kraegen, and Ji-Ming Ye
Diabetes 2004 53: 3258 -3266. [Abstract] [Full Text] [PDF]

A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects: Sajjad A. Qureshi, Mari Rios Candelore, Dan Xie, Xiaodong Yang, Laurie M. Tota, Victor D.-H. Ding, Zhihua Li, Alka Bansal, Corin Miller, Sheila M. Cohen, Guoqiang Jiang, Ed Brady, Richard Saperstein, Joseph L. Duffy, James R. Tata, Kevin T. Chapman, David E. Moller, and Bei B. Zhang
Diabetes 2004 53: 3267 -3273. [Abstract] [Full Text] [PDF]

Genetic:

Genetic Determinants of Energy Expenditure and Insulin Resistance in Diet-Induced Obesity in Mice: Katrine Almind and C. Ronald Kahn
Diabetes 2004 53: 3274 -3285. [Abstract] [Full Text] [PDF]

Heterogeneity in the Magnitude of the Insulin Gene Effect on HLA Risk in Type 1 Diabetes: Costantino Motzo, Daniela Contu, Heather J. Cordell, Rosanna Lampis, Mauro Congia, Maria Giovanna Marrosu, John A. Todd, Marcella Devoto, and Francesco Cucca
Diabetes 2004 53: 3286 -3291. [Abstract] [Full Text] [PDF] Appendix

Polymorphism in the Calsequestrin 1 (CASQ1) Gene on Chromosome 1q21 Is Associated With Type 2 Diabetes in the Old Order Amish: Mao Fu, Coleen M. Damcott, Mona Sabra, Toni I. Pollin, Sandra H. Ott, Jian Wang, Michael J. Garant, Jeffrey R. O’Connell, Braxton D. Mitchell, and Alan R. Shuldiner
Diabetes 2004 53: 3292 -3299. [Abstract] [Full Text] [PDF] Appendix

Brief Genetic Report:

Calsquestrin 1 (CASQ1) Gene Polymorphisms Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes in Northern European Caucasians: Swapan Kumar Das, Winston Chu, Zhengxian Zhang, Sandra J. Hasstedt, and Steven C. Elbein
Diabetes 2004 53: 3300 -3306. [Abstract] [Full Text] [PDF] Appendix

Linkage Analysis of Diabetes Status Among Hypertensive Families: The Hypertension Genetic Epidemiology Network Study: Christy L. Avery, Barry I. Freedman, Gerardo Heiss, Aldi Kraja, Treva Rice, Donna Arnett, Michael B. Miller, James S. Pankow, Cora E. Lewis, Richard H. Myers, Steven C. Hunt, Laura Almasy, and Kari E. North
Diabetes 2004 53: 3307 -3312. [Abstract] [Full Text] [PDF] Data Supplement

Association Testing in 9,000 People Fails to Confirm the Association of the Insulin Receptor Substrate-1 G972R Polymorphism With Type 2 Diabetes: Jose C. Florez, Marketa Sjögren, Noël Burtt, Marju Orho-Melander, Steve Schayer, Maria Sun, Peter Almgren, Ulf Lindblad, Tiinamaija Tuomi, Daniel Gaudet, Thomas J. Hudson, Mark J. Daly, Kristin G. Ardlie, Joel N. Hirschhorn, David Altshuler, and Leif Groop
Diabetes 2004 53: 3313 -3318. [Abstract] [Full Text] [PDF]

Association Studies of Insulin Receptor Substrate 1 Gene (IRS1) Variants in Type 2 Diabetes Samples Enriched for Family History and Early Age of Onset: Eleftheria Zeggini, James Parkinson, Stephanie Halford, Katharine R. Owen, Timothy M. Frayling, Mark Walker, Graham A. Hitman, Jonathan C. Levy, Mike J. Sampson, Edith J.M. Feskens, Andrew T. Hattersley, and Mark I. McCarthy
Diabetes 2004 53: 3319 -3322. [Abstract] [Full Text] [PDF]

Mapping Non–Class II H2-Linked Loci for Type 1 Diabetes in Nonobese Diabetic Mice: Nathalie Deruytter, Olivier Boulard, and Henri-Jean Garchon
Diabetes 2004 53: 3323 -3327. [Abstract] [Full Text] [PDF]

Quantitative Trait Loci for Obesity- and Diabetes-Related Traits and Their Dietary Responses to High-Fat Feeding in LGXSM Recombinant Inbred Mouse Strains: James M. Cheverud, Thomas H. Ehrich, Tomas Hrbek, Jane P. Kenney, L. Susan Pletscher, and Clay F. Semenkovich
Diabetes 2004 53: 3328 -3336. [Abstract] [Full Text] [PDF] Online Appendix

Polymorphisms in Both Promoters of Hepatocyte Nuclear Factor 4- ${alpha}$ Are Associated With Type 2 Diabetes in the Amish: Coleen M. Damcott, Nicole Hoppman, Sandra H. Ott, Laurie J. Reinhart, Jian Wang, Toni I. Pollin, Jeffrey R. O’Connell, Braxton D. Mitchell, and Alan R. Shuldiner
Diabetes 2004 53: 3337 -3341. [Abstract] [Full Text] [PDF]

Variation in the Interleukin-6 Receptor Gene Associates With Type 2 Diabetes in Danish Whites: Yasmin H. Hamid, Søren A. Urhammer, Dorit P. Jensen, Charlotte Glümer, Knut Borch-Johnsen, Torben Jørgensen, Torben Hansen, and Oluf Pedersen
Diabetes 2004 53: 3342 -3345. [Abstract] [Full Text] [PDF] Appendix