Perspectives in Diabetes:

Transcriptional Control of Apolipoprotein A-I Gene Expression in Diabetes

Arshag D. Mooradian, Michael J. Haas, and Norman C.W. Wong
Diabetes 2004 53: 513 -520. [Abstract] [Full Text] [PDF]  

Metabolism:

Systemic and Forearm Triglyceride Metabolism: Fate of Lipoprotein Lipase-Generated Glycerol and Free Fatty Acids

John M. Miles, Yongsoon S. Park, Dorota Walewicz, Crystal Russell-Lopez, Sheryl Windsor, William L. Isley, Simon W. Coppack, and William S. Harris
Diabetes 2004 53: 521 -527. [Abstract] [Full Text] [PDF]  

Muscle-Type Specific Intramyocellular and Hepatic Lipid Metabolism During Starvation in Wistar Rats

Claudia Neumann-Haefelin, Anja Beha, Johanna Kuhlmann, Ulrich Belz, Martin Gerl, Manfred Quint, Gabriele Biemer-Daub, Mark Broenstrup, Marion Stein, Elke Kleinschmidt, Hans-Ludwig Schaefer, Dieter Schmoll, Werner Kramer, Hans-Paul Juretschke, and Andreas W. Herling
Diabetes 2004 53: 528 -534. [Abstract] [Full Text] [PDF]  

Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators

Katy J. Brocklehurst, Victoria A. Payne, Rick A. Davies, Debra Carroll, Helen L. Vertigan, Heather J. Wightman, Susan Aiston, Ian D. Waddell, Brendan Leighton, Matthew P. Coghlan, and Loranne Agius
Diabetes 2004 53: 535 -541. [Abstract] [Full Text] [PDF]  

Reduced Lipid Oxidation in Skeletal Muscle From Type 2 Diabetic Subjects May Be of Genetic Origin: Evidence From Cultured Myotubes

Michael Gaster, Arild C. Rustan, Vigdis Aas, and Henning Beck-Nielsen
Diabetes 2004 53: 542 -548. [Abstract] [Full Text] [PDF]  

Signal Transduction:

Physiological and Molecular Characteristics of Rat Hypothalamic Ventromedial Nucleus Glucosensing Neurons

Ling Kang, Vanessa H. Routh, Eldo V. Kuzhikandathil, Larry D. Gaspers, and Barry E. Levin
Diabetes 2004 53: 549 -559. [Abstract] [Full Text] [PDF]  

Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice

Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi, Michiyo Amemiya-Kudo, Hiroaki Okazaki, Yoshiaki Tamura, Yoko Iizuka, Ken Ohashi, Sachiko Tomita, Motohiro Sekiya, Alyssa Hasty, Yoshimi Nakagawa, Hirohito Sone, Hideo Toyoshima, Shun Ishibashi, Jun-ichi Osuga, and Nobuhiro Yamada
Diabetes 2004 53: 560 -569. [Abstract] [Full Text] [PDF]  

Obesity Study:

Leptin Resistance and Enhancement of Feeding Facilitation by Melanin-Concentrating Hormone in Mice Lacking Bombesin Receptor Subtype-3

Fumihiko Maekawa, Hun-Meng A. Quah, Kohichi Tanaka, and Hiroko Ohki-Hamazaki
Diabetes 2004 53: 570 -576. [Abstract] [Full Text] [PDF]  

Mice with Targeted Disruption of the Dio2 Gene Have Cold-Induced Overexpression of the Uncoupling Protein 1 Gene but Fail to Increase Brown Adipose Tissue Lipogenesis and Adaptive Thermogenesis

Marcelo A. Christoffolete, Camila C.G. Linardi, Lucia de Jesus, Katia Naomi Ebina, Suzy D. Carvalho, Miriam O. Ribeiro, Rogerio Rabelo, Cyntia Curcio, Luciane Martins, Edna T. Kimura, and Antonio C. Bianco
Diabetes 2004 53: 577 -584. [Abstract] [Full Text] [PDF]  

Discrimination Between Obesity and Insulin Resistance in the Relationship With Adiponectin

Fahim Abbasi, James W. Chu, Cindy Lamendola, Tracey McLaughlin, John Hayden, Gerald M. Reaven, and Peter D. Reaven
Diabetes 2004 53: 585 -590. [Abstract] [Full Text] [PDF]  

Immunology:

Virally Induced Inflammation Triggers Fratricide of Fas-Ligand–Expressing ß-Cells

Urs Christen, Rima Darwiche, Helen E. Thomas, Tom Wolfe, Evelyn Rodrigo, Alexander Chervonsky, Richard A. Flavell, and Matthias G. von Herrath
Diabetes 2004 53: 591 -596. [Abstract] [Full Text] [PDF]  

Islet Study:

Expression of Voltage-Gated Potassium Channels in Human and Rhesus Pancreatic Islets

Lizhen Yan, David J. Figueroa, Christopher P. Austin, Yuan Liu, Randal M. Bugianesi, Robert S. Slaughter, Gregory J. Kaczorowski, and Martin G. Kohler
Diabetes 2004 53: 597 -607. [Abstract] [Full Text] [PDF]  

Activin A and Betacellulin: Effect on Regeneration of Pancreatic ß-Cells in Neonatal Streptozotocin-Treated Rats

Lei Li, Zhaohong Yi, Masaharu Seno, and Itaru Kojima
Diabetes 2004 53: 608 -615. [Abstract] [Full Text] [PDF]  

No Evidence for Significant Transdifferentiation of Bone Marrow Into Pancreatic ß-Cells In Vivo

Andreas Lechner, Yong-Guang Yang, Robyn A. Blacken, Lan Wang, Anna L. Nolan, and Joel F. Habener
Diabetes 2004 53: 616 -623. [Abstract] [Full Text] [PDF]  

Structural and Functional Abnormalities in the Islets Isolated From Type 2 Diabetic Subjects

Shaoping Deng, Marko Vatamaniuk, Xiaolun Huang, Nicolai Doliba, Moh-Moh Lian, Adam Frank, Ergun Velidedeoglu, Niraj M. Desai, Brigitte Koeberlein, Bryan Wolf, Clyde F. Barker, Ali Naji, Franz M. Matschinsky, and James F. Markmann
Diabetes 2004 53: 624 -632. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Consequences on ß-Cell Function and Reserve After Long-Term Pancreas Transplantation

R. Paul Robertson
Diabetes 2004 53: 633 -644. [Abstract] [Full Text] [PDF]  

Ketosis-Prone Type 2 Diabetes in Patients of Sub-Saharan African Origin: Clinical Pathophysiology and Natural History of ß-Cell Dysfunction and Insulin Resistance

Franck Mauvais-Jarvis, Eugène Sobngwi, Raphaël Porcher, Jean-Pierre Riveline, Jean-Philippe Kevorkian, Christian Vaisse, Guillaume Charpentier, Pierre-Jean Guillausseau, Patrick Vexiau, and Jean-François Gautier
Diabetes 2004 53: 645 -653. [Abstract] [Full Text] [PDF]  

Secretion, Degradation, and Elimination of Glucagon-Like Peptide 1 and Gastric Inhibitory Polypeptide in Patients with Chronic Renal Insufficiency and Healthy Control Subjects

Juris J. Meier, Michael A. Nauck, Daniel Kranz, Jens J. Holst, Carolyn F. Deacon, Dirk Gaeckler, Wolfgang E. Schmidt, and Baptist Gallwitz
Diabetes 2004 53: 654 -662. [Abstract] [Full Text] [PDF]  

Parasympathetic Blockade Attenuates Augmented Pancreatic Polypeptide But Not Insulin Secretion in Pima Indians

Barbora Vozarova de Courten, Christian Weyer, Norbert Stefan, Mark Horton, Angelo DelParigi, Peter Havel, Clifton Bogardus, and P. Antonio Tataranni
Diabetes 2004 53: 663 -671. [Abstract] [Full Text] [PDF]  

In Vitro Transcriptional Induction of the Human Apolipoprotein A-II Gene by Glucose

Dominique Sauvaget, Valérie Chauffeton, Sonia Dugué-Pujol, Athina-Despina Kalopissis, Isabelle Guillet-Deniau, Fabienne Foufelle, Jean Chambaz, Armelle Leturque, Philippe Cardot, and Agnès Ribeiro
Diabetes 2004 53: 672 -678. [Abstract] [Full Text] [PDF]  

The Effects of Dehydroepiandrosterone Sulfate on Counterregulatory Responses During Repeated Hypoglycemia in Conscious Normal Rats

Darleen A. Sandoval, Ling Ping, Ray Anthony Neill, Sachiko Morrey, and Stephen N. Davis
Diabetes 2004 53: 679 -686. [Abstract] [Full Text] [PDF]  

Magnetic Resonance Imaging of the Brain in Diabetes: The Cardiovascular Determinants of Dementia (CASCADE) Study

Reinhold Schmidt, Lenore J. Launer, Lars-Göran Nilsson, Andrzej Pajak, Susanna Sans, Klaus Berger, Monique M. Breteler, Maria de Ridder, Carole Dufouil, Rebecca Fuhrer, Simona Giampaoli, and Albert Hofman
Diabetes 2004 53: 687 -692. [Abstract] [Full Text] [PDF]  

Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women

Frank B. Hu, James B. Meigs, Tricia Y. Li, Nader Rifai, and JoAnn E. Manson
Diabetes 2004 53: 693 -700. [Abstract] [Full Text] [PDF]  

Effect of Postprandial Hypertriglyceridemia and Hyperglycemia on Circulating Adhesion Molecules and Oxidative Stress Generation and the Possible Role of Simvastatin Treatment

Antoniom Ceriello, Lisa Quagliaro, Ludovica Piconi, Roberta Assaloni, Roberto Da Ros, Amabile Maier, Katherine Esposito, and Dario Giugliano
Diabetes 2004 53: 701 -710. [Abstract] [Full Text] [PDF]  

Complication:

Role of Poly(ADP-Ribose) Polymerase Activation in Diabetic Neuropathy

Irina G. Obrosova, Fei Li, Omorodola I. Abatan, Mark A. Forsell, Katalin Komjáti, Pal Pacher, Csaba Szabó, and Martin J. Stevens
Diabetes 2004 53: 711 -720. [Abstract] [Full Text] [PDF]  

Impaired Pressure-Induced Vasodilation at the Foot in Young Adults With Type 1 Diabetes

Audrey Koïtka, Pierre Abraham, Beatrice Bouhanick, Dominique Sigaudo-Roussel, Claire Demiot, and Jean Louis Saumet
Diabetes 2004 53: 721 -725. [Abstract] [Full Text] [PDF]  

Uncoupling Proteins Prevent Glucose-Induced Neuronal Oxidative Stress and Programmed Cell Death

Andrea M. Vincent, James A. Olzmann, Michael Brownlee, W.I. Sivitz, and James W. Russell
Diabetes 2004 53: 726 -734. [Abstract] [Full Text] [PDF]  

Initial Characterization of a Rat Model of Diabetic Nephropathy

Marcelo A. Nobrega, Stewart Fleming, Richard J. Roman, Masahide Shiozawa, Nancy Schlick, Jozef Lazar, and Howard J. Jacob
Diabetes 2004 53: 735 -742. [Abstract] [Full Text] [PDF]  

Divergent Pathways of Gene Expression Are Activated by the RAGE Ligands S100b and AGE-BSA

Jessica V. Valencia, Manisha Mone, Jin Zhang, Marla Weetall, Frank P. Buxton, and Thomas E. Hughes
Diabetes 2004 53: 743 -751. [Abstract] [Full Text] [PDF]  

Hyperglycemia-Induced Defects in Angiogenesis in the Chicken Chorioallantoic Membrane Model

Etienne Larger, Michel Marre, Pierre Corvol, and Jean-Marie Gasc
Diabetes 2004 53: 752 -761. [Abstract] [Full Text] [PDF]  

Attenuation of Renal Injury in db/db Mice Overexpressing Superoxide Dismutase: Evidence for Reduced Superoxide-Nitric Oxide Interaction

Frederick R. DeRubertis, Patricia A. Craven, Mona F. Melhem, and Eman M. Salah
Diabetes 2004 53: 762 -768. [Abstract] [Full Text] [PDF]  

Electrically Stimulated Axon Reflexes Are Diminished in Diabetic Small Fiber Neuropathies

Heidrun H. Krämer, Martin Schmelz, Frank Birklein, and Andreas Bickel
Diabetes 2004 53: 769 -774. [Abstract] [Full Text] [PDF]  

Potential Contributory Role of H-Ras, a Small G-Protein, in the Development of Retinopathy in Diabetic Rats

Renu A. Kowluru, Anjaneyulu Kowluru, Subrata Chakrabarti, and Zia Khan
Diabetes 2004 53: 775 -783. [Abstract] [Full Text] [PDF]  

Molecular Profiling of Diabetic Mouse Kidney Reveals Novel Genes Linked to Glomerular Disease

Katalin Susztak, Erwin Böttinger, Akiva Novetsky, Dan Liang, Yanqing Zhu, Emilio Ciccone, Dona Wu, Stephen Dunn, Peter McCue, and Kumar Sharma
Diabetes 2004 53: 784 -794. [Abstract] [Full Text] [PDF] Online Appendix  

Molecular Mechanisms of High Glucose-Induced Cyclooxygenase-2 Expression in Monocytes

Narkunaraja Shanmugam, Irene T. Gaw Gonzalo, and Rama Natarajan
Diabetes 2004 53: 795 -802. [Abstract] [Full Text] [PDF]  

Genetics:

A Genome-Wide Scan for Childhood Obesity–Associated Traits in French Families Shows Significant Linkage on Chromosome 6q22.31-q23.2

David Meyre, Cécile Lecoeur, Jérôme Delplanque, Stephan Francke, Vincent Vatin, Emmanuelle Durand, Jacques Weill, Christian Dina, and Philippe Froguel
Diabetes 2004 53: 803 -811. [Abstract] [Full Text] [PDF]  

An Obesity-Related Locus in Chromosome Region 12q23-24

Wei-Dong Li, Chuanhui Dong, Ding Li, Hongyu Zhao, and R. Arlen Price
Diabetes 2004 53: 812 -820. [Abstract] [Full Text] [PDF]  

A Large Set of Finnish Affected Sibling Pair Families With Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14

Kaisa Silander, Laura J. Scott, Timo T. Valle, Karen L. Mohlke, Heather M. Stringham, Kerry R. Wiles, William L. Duren, Kimberly F. Doheny, Elizabeth W. Pugh, Peter Chines, Narisu Narisu, Peggy P. White, Tasha E. Fingerlin, Anne U. Jackson, Chun Li, Soumitra Ghosh, Victoria L. Magnuson, Kimberly Colby, Michael R. Erdos, Jason E. Hill, Pablo Hollstein, Kathleen M. Humphreys, Roshni A. Kasad, Jessica Lambert, Konstantinos N. Lazaridis, George Lin, Anabelle Morales-Mena, Kristin Patzkowski, Carrie Pfahl, Rachel Porter, David Rha, Leonid Segal, Yong D. Suh, Jason Tovar, Arun Unni, Christian Welch, Julie A. Douglas, Michael P. Epstein, Elizabeth R. Hauser, William Hagopian, Thomas A. Buchanan, Richard M. Watanabe, Richard N. Bergman, Jaakko Tuomilehto, Francis S. Collins, and Michael Boehnke
Diabetes 2004 53: 821 -829. [Abstract] [Full Text] [PDF]  

A Genome-Wide Scan for Type 2 Diabetes in African-American Families Reveals Evidence for a Locus on Chromosome 6q

Michèle M. Sale, Barry I. Freedman, Carl D. Langefeld, Adrienne H. Williams, Pamela J. Hicks, Carla J. Colicigno, Stephanie R. Beck, W. Mark Brown, Stephen S. Rich, and Donald W. Bowden
Diabetes 2004 53: 830 -837. [Abstract] [Full Text] [PDF] Online Appendix  

Brief Genetics Reports:

A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in West Africans: The Africa America Diabetes Mellitus (AADM) Study

Charles N. Rotimi, Guanjie Chen, Adebowale A. Adeyemo, Paulette Furbert-Harris, Debra Guass, Jie Zhou, Kate Berg, Olufemi Adegoke, Albert Amoah, Samuel Owusu, Joseph Acheampong, Kofi Agyenim-Boateng, Benjamin A. Eghan, Jr., Johnnie Oli, Godfrey Okafor, Ester Ofoegbu, Babatunde Osotimehin, Fayeofori Abbiyesuku, Thomas Johnson, Theresa Rufus, Olufemi Fasanmade, Rick Kittles, Harold Daniel, Yuanxiu Chen, Georgia Dunston, and Francis S. Collins
Diabetes 2004 53: 838 -841. [Abstract] [Full Text] [PDF]  

Genetic Variants in Human Sterol Regulatory Element Binding Protein-1c in Syndromes of Severe Insulin Resistance and Type 2 Diabetes

Matthias Laudes, Inês Barroso, Jian’an Luan, Maria A. Soos, Giles Yeo, Aline Meirhaeghe, Lisa Logie, Antonio Vidal-Puig, Alan J. Schafer, Nick J. Wareham, and Stephen O’Rahilly
Diabetes 2004 53: 842 -846. [Abstract] [Full Text] [PDF]  

Genetic Polymorphisms in Peroxisome Proliferator-Activated Receptor Associated With Obesity

Hyoung Doo Shin, Byung Lae Park, Lyoung Hyo Kim, Hye Seung Jung, Young Min Cho, Min Kyong Moon, Young Joo Park, Hong Kyu Lee, and Kyong Soo Park
Diabetes 2004 53: 847 -851. [Abstract] [Full Text] [PDF] Appendix  

Association of Human Endogenous Retrovirus K-18 Polymorphisms With Type 1 Diabetes

Samuel Marguerat, William Y.S. Wang, John A. Todd, and Bernard Conrad
Diabetes 2004 53: 852 -854. [Abstract] [Full Text] [PDF]  

Evidence From a Large U.K. Family Collection That Genes Influencing Age of Onset of Type 2 Diabetes Map to Chromosome 12p and to the MODY3/NIDDM2 Locus on 12q24

Steven Wiltshire, Timothy M. Frayling, Christopher J. Groves, Jonathan C. Levy, Graham A. Hitman, Mike Sampson, Mark Walker, Stephan Menzel, Andrew T. Hattersley, Lon R. Cardon, and Mark I. McCarthy
Diabetes 2004 53: 855 -860. [Abstract] [Full Text] [PDF]  

Association of the VEGF Gene With Proliferative Diabetic Retinopathy But Not Proteinuria in Diabetes

David Ray, Manoj Mishra, Shirley Ralph, Ian Read, Robert Davies, and Paul Brenchley
Diabetes 2004 53: 861 -864. [Abstract] [Full Text] [PDF]  

Scrutiny of the Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1) Locus Reveals Conserved Haplotype Block Structure not Associated With Diabetic Nephropathy

Daniel P.K. Ng, William H. Walker, Kee-Seng Chia, Serena Choo, James H. Warram, and Andrzej S. Krolewski
Diabetes 2004 53: 865 -869. [Abstract] [Full Text] [PDF] Online Appendix  

Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes

Christina Eftychi, Joanna M.M. Howson, Bryan J. Barratt, Adrian Vella, Felicity Payne, Deborah J. Smyth, Rebecca C.J. Twells, Neil M. Walker, Helen E. Rance, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Dag E. Undlien, Kjersti S. Rønningen, Cristian Guja, Constantin Ionescu-Tîirgoviste, David A. Savage, and John A. Todd
Diabetes 2004 53: 870 -873. [Abstract] [Full Text] [PDF]  

Errata:

Erratum

Diabetes 2004 53: 874 . [Extract] [Full Text] [PDF]  

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