Diabetes -- Table of Contents (July 2004, 53 [7])

Perspectives in Diabetes:

Lilly Lecture 2003: The Struggle for Mastery in Insulin Action: From Triumvirate to Republic: Domenico Accili
Diabetes 2004 53: 1633 -1642. [Abstract] [Full Text] [PDF]

Metabolism:

Interleukin-6 Is a Novel Factor Mediating Glucose Homeostasis During Skeletal Muscle Contraction: Mark A. Febbraio, Natalie Hiscock, Massimo Sacchetti, Christian P. Fischer, and Bente K. Pedersen
Diabetes 2004 53: 1643 -1648. [Abstract] [Full Text] [PDF]

AMP-Activated Protein Kinase Activation by AICAR Increases Both Muscle Fatty Acid and Glucose Uptake in White Muscle of Insulin-Resistant Rats In Vivo: Miguel A. Iglesias, Stuart M. Furler, Gregory J. Cooney, Edward W. Kraegen, and Ji-Ming Ye
Diabetes 2004 53: 1649 -1654. [Abstract] [Full Text] [PDF]

Enhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker Rats: Susan L.M. Coort, Danny M. Hasselbaink, Debby P.Y. Koonen, Jodil Willems, Will A. Coumans, Adrian Chabowski, Ger J. van der Vusse, Arend Bonen, Jan F.C. Glatz, and Joost J.F.P. Luiken
Diabetes 2004 53: 1655 -1663. [Abstract] [Full Text] [PDF]

Signal Transduction:

C-Peptide Induces Chemotaxis of Human CD4-Positive Cells: Involvement of Pertussis Toxin–Sensitive G-Proteins and Phosphoinositide 3-Kinase: Daniel Walcher, Milos Aleksic, Verena Jerg, Vinzenz Hombach, Arthur Zieske, Satoki Homma, Jack Strong, and Nikolaus Marx
Diabetes 2004 53: 1664 -1670. [Abstract] [Full Text] [PDF]

Obesity Study:

Regulation of Resistin Expression and Circulating Levels in Obesity, Diabetes, and Fasting: Michael W. Rajala, Yong Qi, Hiral R. Patel, Nobuhiko Takahashi, Ronadip Banerjee, Utpal B. Pajvani, Madhur K. Sinha, Ronald L. Gingerich, Philipp E. Scherer, and Rexford S. Ahima
Diabetes 2004 53: 1671 -1679. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

In Vitro–Deranged Intestinal Immune Response to Gliadin in Type 1 Diabetes: Renata Auricchio, Francesco Paparo, Maria Maglio, Adriana Franzese, Francesca Lombardi, Giuliana Valerio, Gerardo Nardone, Selvaggia Percopo, Luigi Greco, and Riccardo Troncone
Diabetes 2004 53: 1680 -1683. [Abstract] [Full Text] [PDF]

Targeted Disruption of the IA-2ß Gene Causes Glucose Intolerance and Impairs Insulin Secretion but Does Not Prevent the Development of Diabetes in NOD Mice: Atsutaka Kubosaki, Steffen Gross, Junnosuke Miura, Keiichi Saeki, Min Zhu, Shinichiro Nakamura, Wiljan Hendriks, and Abner Louis Notkins
Diabetes 2004 53: 1684 -1691. [Abstract] [Full Text] [PDF]

HLA-DQ–Regulated T-Cell Responses to Islet Cell Autoantigens Insulin and GAD65: Timothy I.M. Tree, Gaby Duinkerken, Sabine Willemen, René R.P. de Vries, and Bart O. Roep
Diabetes 2004 53: 1692 -1699. [Abstract] [Full Text] [PDF]

Cure of Overt Diabetes in NOD Mice by Transient Treatment With Anti-Lymphocyte Serum and Exendin-4: Norihiko Ogawa, James F. List, Joel F. Habener, and Takashi Maki
Diabetes 2004 53: 1700 -1705. [Abstract] [Full Text] [PDF]

Islet Study:

Glucose- and Interleukin-1ß-Induced ß-Cell Apoptosis Requires Ca²⁺ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K⁺ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets: Kathrin Maedler, Joachim Størling, Jeppe Sturis, Richard A. Zuellig, Giatgen A. Spinas, Per O.G. Arkhammar, Thomas Mandrup-Poulsen, and Marc Y. Donath
Diabetes 2004 53: 1706 -1713. [Abstract] [Full Text] [PDF]

Muscarinic Stimulation of Pancreatic Insulin and Glucagon Release Is Abolished in M₃ Muscarinic Acetylcholine Receptor–Deficient Mice: Alokesh Duttaroy, Charles L. Zimliki, Dinesh Gautam, Yinghong Cui, David Mears, and Jürgen Wess
Diabetes 2004 53: 1714 -1720. [Abstract] [Full Text] [PDF]

In Vivo and In Vitro Characterization of Insulin-Producing Cells Obtained From Murine Bone Marrow: Dong-Qi Tang, Li-Zhen Cao, Brant R. Burkhardt, Chang-Qi Xia, Sally A. Litherland, Mark A. Atkinson, and Li-Jun Yang
Diabetes 2004 53: 1721 -1732. [Abstract] [Full Text] [PDF]

Hormone-Sensitive Lipase Has a Role in Lipid Signaling for Insulin Secretion but Is Nonessential for the Incretin Action of Glucagon-Like Peptide 1: Marie-Line Peyot, Christopher J. Nolan, Krishnakant Soni, Erik Joly, Roxane Lussier, Barbara E. Corkey, Shu Pei Wang, Grant A. Mitchell, and Marc Prentki
Diabetes 2004 53: 1733 -1742. [Abstract] [Full Text] [PDF]

A Novel Variant of Ionotropic Glutamate Receptor Regulates Somatostatin Secretion From ${delta}$ -Cells of Islets of Langerhans: Akiko Muroyama, Shunsuke Uehara, Shouki Yatsushiro, Noriko Echigo, Riyo Morimoto, Mitsuhiro Morita, Mitsuko Hayashi, Akitsugu Yamamoto, Duk-Su Koh, and Yoshinori Moriyama
Diabetes 2004 53: 1743 -1753. [Abstract] [Full Text] [PDF]

The Proximal Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Autoantigen Promoter Is Sufficient to Initiate but not Maintain Transgene Expression in Mouse Islets in Vivo: Claudia Frigeri, Cyrus C. Martin, Christina A. Svitek, James K. Oeser, John C. Hutton, Maureen Gannon, and Richard M. O’Brien
Diabetes 2004 53: 1754 -1764. [Abstract] [Full Text] [PDF]

Insulin Feedback Alters Mitochondrial Activity Through an ATP-sensitive K⁺ Channel–Dependent Pathway in Mouse Islets and ß-Cells: Craig S. Nunemaker, Min Zhang, and Leslie S. Satin
Diabetes 2004 53: 1765 -1772. [Abstract] [Full Text] [PDF]

Pathophysiology:

Metabolic and Inflammation Variable Clusters and Prediction of Type 2 Diabetes: Factor Analysis Using Directly Measured Insulin Sensitivity: Anthony J.G. Hanley, Andreas Festa, Ralph B. D’Agostino, Lynne E. Wagenknecht, Peter J. Savage, Russell P. Tracy, Mohammed F. Saad, and Steven M. Haffner
Diabetes 2004 53: 1773 -1781. [Abstract] [Full Text] [PDF] Data Supplement

Population-Based Incidence Rates and Risk Factors for Type 2 Diabetes in White Individuals: The Bruneck Study: Enzo Bonora, Stefan Kiechl, Johann Willeit, Friedrich Oberhollenzer, Georg Egger, James B. Meigs, Riccardo C. Bonadonna, and Michele Muggeo
Diabetes 2004 53: 1782 -1789. [Abstract] [Full Text] [PDF]

Single-Dose Dexamethasone Induces Whole-Body Insulin Resistance and Alters Both Cardiac Fatty Acid and Carbohydrate Metabolism: Dake Qi, Thomas Pulinilkunnil, Ding An, Sanjoy Ghosh, Ashraf Abrahani, John Andrew Pospisilik, Roger Brownsey, Rich Wambolt, Michael Allard, and Brian Rodrigues
Diabetes 2004 53: 1790 -1797. [Abstract] [Full Text] [PDF]

Effects of Low and Moderate Antecedent Exercise on Counterregulatory Responses to Subsequent Hypoglycemia in Type 1 Diabetes: Darleen A. Sandoval, Deanna L. Aftab Guy, M. Antoinette Richardson, Andrew C. Ertl, and Stephen N. Davis
Diabetes 2004 53: 1798 -1806. [Abstract] [Full Text] [PDF]

Complications:

Ciliary Neurotrophic Factor Improves Nerve Conduction and Ameliorates Regeneration Deficits in Diabetic Rats: Andrew P. Mizisin, Yvonne Vu, Michelle Shuff, and Nigel A. Calcutt
Diabetes 2004 53: 1807 -1812. [Abstract] [Full Text] [PDF]

Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis: Josephine M. Forbes, Louis Teo Loon Yee, Vicki Thallas, Markus Lassila, Riccardo Candido, Karin A. Jandeleit-Dahm, Merlin C. Thomas, Wendy C. Burns, Elizabeth K. Deemer, Susan R. Thorpe, Mark E. Cooper, and Terri J. Allen
Diabetes 2004 53: 1813 -1823. [Abstract] [Full Text] [PDF]

Direct Insulin Signaling of Neurons Reverses Diabetic Neuropathy: Valentine Brussee, F. Alexander Cunningham, and Douglas W. Zochodne
Diabetes 2004 53: 1824 -1830. [Abstract] [Full Text] [PDF]

Tumstatin Peptide, an Inhibitor of Angiogenesis, Prevents Glomerular Hypertrophy in the Early Stage of Diabetic Nephropathy: Yoshihiko Yamamoto, Yohei Maeshima, Hiroyuki Kitayama, Shinji Kitamura, Yuki Takazawa, Hitoshi Sugiyama, Yasushi Yamasaki, and Hirofumi Makino
Diabetes 2004 53: 1831 -1840. [Abstract] [Full Text] [PDF]

Regulation of Inducible Nitric Oxide Synthase Expression in Advanced Glycation End Product–Stimulated RAW 264.7 Cells: The Role of Heme Oxygenase-1 and Endogenous Nitric Oxide: Daigo Sumi and Louis J. Ignarro
Diabetes 2004 53: 1841 -1850. [Abstract] [Full Text] [PDF]

Mitogen-Activated Protein Kinase p38 Mediates Reduced Nerve Conduction Velocity in Experimental Diabetic Neuropathy: Interactions With Aldose Reductase: Sally A. Price, Sithiporn Agthong, Alicia B. Middlemas, and David R. Tomlinson
Diabetes 2004 53: 1851 -1856. [Abstract] [Full Text] [PDF]

Genetics:

Genome-wide Linkage Analysis for Severe Obesity in French Caucasians Finds Significant Susceptibility Locus on Chromosome 19q: Christopher G. Bell, Michael Benzinou, Afshan Siddiq, Cécile Lecoeur, Christian Dina, Arnaud Lemainque, Karine Clément, Arnaud Basdevant, Bernard Guy-Grand, Charles A. Mein, David Meyre, and Philippe Froguel
Diabetes 2004 53: 1857 -1865. [Abstract] [Full Text] [PDF]

Identification of Quantitative Trait Loci for Glucose Homeostasis: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study: Stephen S. Rich, Donald W. Bowden, Steven M. Haffner, Jill M. Norris, Mohammed F. Saad, Braxton D. Mitchell, Jerome I. Rotter, Carl D. Langefeld, Lynne E. Wagenknecht, and Richard N. Bergman
Diabetes 2004 53: 1866 -1875. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

Wolcott-Rallison Syndrome: Clinical, Genetic, and Functional Study of EIF2AK3 Mutations and Suggestion of Genetic Heterogeneity: Valérie Senée, Krishna M. Vattem, Marc Delépine, Lynn A. Rainbow, Céline Haton, Annick Lecoq, Nick J. Shaw, Jean-Jacques Robert, Raoul Rooman, Catherine Diatloff-Zito, Jacques L. Michaud, Bassan Bin-Abbas, Doris Taha, Bernard Zabel, Piergiorgio Franceschini, A. Kemal Topaloglu, G. Mark Lathrop, Timothy G. Barrett, Marc Nicolino, Ronald C. Wek, and Cécile Julier
Diabetes 2004 53: 1876 -1883. [Abstract] [Full Text] [PDF]

Remapping the Insulin Gene/IDDM2 Locus in Type 1 Diabetes: Bryan J. Barratt, Felicity Payne, Chris E. Lowe, Robert Hermann, Barry C. Healy, Denise Harold, Patrick Concannon, Neda Gharani, Mark I. McCarthy, Mark G. Olavesen, Rose McCormack, Cristian Guja, Constantin Ionescu-Tîrgoviste, Dag E. Undlien, Kjersti S. Rønningen, Kathleen M. Gillespie, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Simon T. Bennett, David G. Clayton, Heather J. Cordell, and John A. Todd
Diabetes 2004 53: 1884 -1889. [Abstract] [Full Text] [PDF] Data supplement

A 212-kb Region on Chromosome 6q25 Containing the TAB2 Gene Is Associated With Susceptibility to Type 1 Diabetes: David Owerbach, Lazaro Piña, and Kenneth H. Gabbay
Diabetes 2004 53: 1890 -1893. [Abstract] [Full Text] [PDF]

Cosegregation of MIDD and MODY in a Pedigree: Functional and Clinical Consequences: Camilla Cervin, Brita Liljeström, Tiinamaija Tuomi, Seija Heikkinen, Juha S. Tapanainen, Leif Groop, and Corrado M. Cilio
Diabetes 2004 53: 1894 -1899. [Abstract] [Full Text] [PDF]

Polymorphisms in Type II SH2 Domain–Containing Inositol 5-Phosphatase (INPPL1, SHIP2) Are Associated With Physiological Abnormalities of the Metabolic Syndrome: Pamela J. Kaisaki, Marc Delépine, Peng Y. Woon, Liam Sebag-Montefiore, Steven P. Wilder, Stephan Menzel, Nathalie Vionnet, Evelyne Marion, Jean-Pierre Riveline, Guillaume Charpentier, Stéphane Schurmans, Jonathan C. Levy, Mark Lathrop, Martin Farrall, and Dominique Gauguier
Diabetes 2004 53: 1900 -1904. [Abstract] [Full Text] [PDF] Data supplement

The –866A/A Genotype in the Promoter of the Human Uncoupling Protein 2 Gene Is Associated With Insulin Resistance and Increased Risk of Type 2 Diabetes: Monica D’Adamo, Lucia Perego, Marina Cardellini, Maria Adelaide Marini, Simona Frontoni, Francesco Andreozzi, Angela Sciacqua, Davide Lauro, Paolo Sbraccia, Massimo Federici, Michele Paganelli, Antonio E. Pontiroli, Renato Lauro, Francesco Perticone, Franco Folli, and Giorgio Sesti
Diabetes 2004 53: 1905 -1910. [Abstract] [Full Text] [PDF]

No Association Between Variation of the FOXP3 Gene and Common Type 1 Diabetes in the Sardinian Population: Patrizia Zavattari, Elisabetta Deidda, Maristella Pitzalis, Barbara Zoa, Loredana Moi, Rosanna Lampis, Daniela Contu, Costantino Motzo, Paola Frongia, Efisio Angius, Mario Maioli, John A. Todd, and Francesco Cucca
Diabetes 2004 53: 1911 -1914. [Abstract] [Full Text] [PDF] Data Supplement

A Novel Missense Substitution (Val1483Ile) in the Fatty Acid Synthase Gene (FAS) Is Associated With Percentage of Body Fat and Substrate Oxidation Rates in Nondiabetic Pima Indians: Peter Kovacs, Inge Harper, Robert L. Hanson, Aniello M. Infante, Clifton Bogardus, P. Antonio Tataranni, and Leslie J. Baier
Diabetes 2004 53: 1915 -1919. [Abstract] [Full Text] [PDF]

Pharmacology and Therapeutics:

Characterization of Adenosine-A1 Receptor–Mediated Antilipolysis in Rats by Tissue Microdialysis, ¹H-Spectroscopy, and Glucose Clamp Studies: Corinna Schoelch, Johanna Kuhlmann, Matthias Gossel, Guenter Mueller, Claudia Neumann-Haefelin, Ulrich Belz, Juergen Kalisch, Gabriele Biemer-Daub, Werner Kramer, Hans-Paul Juretschke, and Andreas W. Herling
Diabetes 2004 53: 1920 -1926. [Abstract] [Full Text] [PDF]

Restoration of Cardiomyocyte Functional Properties by Angiotensin II Receptor Blockade in Diabetic Rats: Laura Raimondi, Petra De Paoli, Edoardo Mannucci, Giuseppe Lonardo, Laura Sartiani, Grazia Banchelli, Renato Pirisino, Alessandro Mugelli, and Elisabetta Cerbai
Diabetes 2004 53: 1927 -1933. [Abstract] [Full Text] [PDF]

Errata:

Erratum: Diabetes 2004 53: 1934 . [Extract] [Full Text] [PDF]