Perspective in Diabetes:

Therapeutic Strategies Based on Glucagon-Like Peptide 1

Carolyn F. Deacon
Diabetes 2004 53: 2181 -2189. [Abstract] [Full Text] [PDF]  

New Methodology and Database:

An Adenovirus Vector for Efficient RNA Interference–Mediated Suppression of Target Genes in Insulinoma Cells and Pancreatic Islets of Langerhans

James R. Bain, Jonathan C. Schisler, Koji Takeuchi, Christopher B. Newgard, and Thomas C. Becker
Diabetes 2004 53: 2190 -2194. [Abstract] [Full Text] [PDF]  

Metabolism:

Expression of Adiponectin Receptor mRNA in Human Skeletal Muscle Cells Is Related to In Vivo Parameters of Glucose and Lipid Metabolism

Harald Staiger, Simone Kaltenbach, Katrin Staiger, Norbert Stefan, Andreas Fritsche, Alke Guirguis, Claudia Péterfi, Melanie Weisser, Fausto Machicao, Michael Stumvoll, and Hans-Ulrich Häring
Diabetes 2004 53: 2195 -2201. [Abstract] [Full Text] [PDF]  

Transcortical Direct Current Potential Shift Reflects Immediate Signaling of Systemic Insulin to the Human Brain

Manfred Hallschmid, Bernd Schultes, Lisa Marshall, Matthias Mölle, Werner Kern, Julia Bredthauer, Horst L. Fehm, and Jan Born
Diabetes 2004 53: 2202 -2208. [Abstract] [Full Text] [PDF]  

CD36 in Myocytes Channels Fatty Acids to a Lipase-Accessible Triglyceride Pool That Is Related to Cell Lipid and Insulin Responsiveness

Claire C. Bastie, Tahar Hajri, Victor A. Drover, Paul A. Grimaldi, and Nada A. Abumrad
Diabetes 2004 53: 2209 -2216. [Abstract] [Full Text] [PDF]  

Cholesterol Metabolism in Type 1 Diabetes

Helena Gylling, Juha A. Tuominen, Veikko A. Koivisto, and Tatu A. Miettinen
Diabetes 2004 53: 2217 -2222. [Abstract] [Full Text] [PDF]  

Signal Transduction:

Syntaxin 4 Transgenic Mice Exhibit Enhanced Insulin-Mediated Glucose Uptake in Skeletal Muscle

Beth A. Spurlin, So-Young Park, Angela K. Nevins, Jason K. Kim, and Debbie C. Thurmond
Diabetes 2004 53: 2223 -2231. [Abstract] [Full Text] [PDF]  

Suppressor of Cytokine Signaling 3 Expression and Insulin Resistance in Skeletal Muscle of Obese and Type 2 Diabetic Patients

Jennifer Rieusset, Karim Bouzakri, Emmanuel Chevillotte, Nadège Ricard, Delphine Jacquet, Jean-Philippe Bastard, Martine Laville, and Hubert Vidal
Diabetes 2004 53: 2232 -2241. [Abstract] [Full Text] [PDF]  

Induced Adiposity and Adipocyte Hypertrophy in Mice Lacking the AMP-Activated Protein Kinase-2 Subunit

Josep A. Villena, Benoit Viollet, Fabrizzio Andreelli, Axel Kahn, Sophie Vaulont, and Hei Sook Sul
Diabetes 2004 53: 2242 -2249. [Abstract] [Full Text] [PDF]  

Obesity Study:

Involvement of Hypothalamic Histamine H₁ Receptor in the Regulation of Feeding Rhythm and Obesity

Takayuki Masaki, Seiichi Chiba, Tohru Yasuda, Hitoshi Noguchi, Tetsuya Kakuma, Takeshi Watanabe, Toshiie Sakata, and Hironobu Yoshimatsu
Diabetes 2004 53: 2250 -2260. [Abstract] [Full Text] [PDF]  

Increased Serum Leptin Protects From Adiposity Despite the Increased Glucose Uptake in White Adipose Tissue in Mice Lacking p85 Phosphoinositide 3-Kinase

Yasuo Terauchi, Junji Matsui, Junji Kamon, Toshimasa Yamauchi, Naoto Kubota, Kajuro Komeda, Shinichi Aizawa, Yasuo Akanuma, Motowo Tomita, and Takashi Kadowaki
Diabetes 2004 53: 2261 -2270. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Mitochondrial Catalase Overexpression Protects Insulin-Producing Cells Against Toxicity of Reactive Oxygen Species and Proinflammatory Cytokines

Ewa Gurgul, Stephan Lortz, Markus Tiedge, Anne Jörns, and Sigurd Lenzen
Diabetes 2004 53: 2271 -2280. [Abstract] [Full Text] [PDF]  

Assessment of Cytotoxic Lymphocyte Gene Expression in the Peripheral Blood of Human Islet Allograft Recipients: Elevation Precedes Clinical Evidence of Rejection

Dongmei Han, Xiumin Xu, David Baidal, Jenifer Leith, Camillo Ricordi, Rodolfo Alejandro, and Norma S. Kenyon
Diabetes 2004 53: 2281 -2290. [Abstract] [Full Text] [PDF]  

Normalization of Multiple Hemostatic Abnormalities in Uremic Type 1 Diabetic Patients After Kidney-Pancreas Transplantation

Paolo Fiorina, Franco Folli, Armando D’Angelo, Giovanna Finzi, Fabio Pellegatta, Valeria Guzzi, Carlo Fedeli, Patrizia Della Valle, Luciana Usellini, Claudia Placidi, Francesco Bifari, Daniela Belloni, Elisabetta Ferrero, Carlo Capella, and Antonio Secchi
Diabetes 2004 53: 2291 -2300. [Abstract] [Full Text] [PDF]  

Peptides From Common Viral and Bacterial Pathogens Can Efficiently Activate Diabetogenic T-Cells

Valeria A. Judkowski, Gina M. Allicotti, Nora Sarvetnick, and Clemencia Pinilla
Diabetes 2004 53: 2301 -2309. [Abstract] [Full Text] [PDF]  

Islet Study:

Progression to Islet Destruction in a Cyclophosphamide-Induced Transgenic Model: A Microarray Overview

Michael Matos, Richard Park, Diane Mathis, and Christophe Benoist
Diabetes 2004 53: 2310 -2321. [Abstract] [Full Text] [PDF] Appendix  

Dissecting the Role of Glucocorticoids on Pancreas Development

Emilie Gesina, François Tronche, Pedro Herrera, Belinda Duchene, Willemène Tales, Paul Czernichow, and Bernadette Breant
Diabetes 2004 53: 2322 -2329. [Abstract] [Full Text] [PDF]  

Identification and Cloning of a ß-Cell–Specific Zinc Transporter, ZnT-8, Localized Into Insulin Secretory Granules

Fabrice Chimienti, Séverine Devergnas, Alain Favier, and Michel Seve
Diabetes 2004 53: 2330 -2337. [Abstract] [Full Text] [PDF]  

Long-Term Islet Graft Survival in NOD Mice by Abrogation of Recurrent Autoimmunity

Qixin Shi, Donghua Wang, Gregg A. Hadley, Adam W. Bingaman, Stephen T. Bartlett, and Donna L. Farber
Diabetes 2004 53: 2338 -2345. [Abstract] [Full Text] [PDF]  

Glucokinase Is an Integral Component of the Insulin Granules in Glucose-Responsive Insulin Secretory Cells and Does Not Translocate During Glucose Stimulation

Catherine Arden, Andrew Harbottle, Simone Baltrusch, Markus Tiedge, and Loranne Agius
Diabetes 2004 53: 2346 -2352. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Glucose Intolerance in a Large Cohort of Mediterranean Women With Polycystic Ovary Syndrome: Phenotype and Associated Factors

Alessandra Gambineri, Carla Pelusi, Elisa Manicardi, Valentina Vicennati, Mauro Cacciari, Antonio Maria Morselli-Labate, Uberto Pagotto, and Renato Pasquali
Diabetes 2004 53: 2353 -2358. [Abstract] [Full Text] [PDF]  

Reduced Hepatic Insulin Extraction in Response to Gastric Inhibitory Polypeptide Compensates for Reduced Insulin Secretion in Normal-Weight and Normal Glucose Tolerant First-Degree Relatives of Type 2 Diabetic Patients

Natalia N. Rudovich, Helmut J. Rochlitz, and Andreas F.H. Pfeiffer
Diabetes 2004 53: 2359 -2365. [Abstract] [Full Text] [PDF]  

Impaired Cardiac Efficiency and Increased Fatty Acid Oxidation in Insulin-Resistant ob/ob Mouse Hearts

Pradip K. Mazumder, Brian T. O’Neill, Matthew W. Roberts, Jonathan Buchanan, Ui Jeong Yun, Robert C. Cooksey, Sihem Boudina, and E. Dale Abel
Diabetes 2004 53: 2366 -2374. [Abstract] [Full Text] [PDF]  

Effect of a High-Protein, Low-Carbohydrate Diet on Blood Glucose Control in People With Type 2 Diabetes

Mary C. Gannon and Frank Q. Nuttall
Diabetes 2004 53: 2375 -2382. [Abstract] [Full Text] [PDF]  

Expression of Angiogenic Factors During Acute Coronary Syndromes in Human Type 2 Diabetes

Raffaele Marfella, Katherine Esposito, Francesco Nappo, Mario Siniscalchi, Ferdinando Carlo Sasso, Michele Portoghese, Maria Pia Di Marino, Alfonso Baldi, Salvatore Cuzzocrea, Clara Di Filippo, Guglielmo Barboso, Feliciano Baldi, Francesco Rossi, Michele D’Amico, and Dario Giugliano
Diabetes 2004 53: 2383 -2391. [Abstract] [Full Text] [PDF]  

Increased Expression of G_i-Coupled Muscarinic Acetylcholine Receptor and G_i in Atrium of Elderly Diabetic Subjects

Mark D. Richardson, Jason D. Kilts, and Madan M. Kwatra
Diabetes 2004 53: 2392 -2396. [Abstract] [Full Text] [PDF]  

Effect of Intravenous Infusion of Exenatide (Synthetic Exendin-4) on Glucose-Dependent Insulin Secretion and Counterregulation During Hypoglycemia

Kristine B. Degn, Birgitte Brock, Claus B. Juhl, Christian B. Djurhuus, Jaime Grubert, Dennis Kim, Jenny Han, Kristin Taylor, Mark Fineman, and Ole Schmitz
Diabetes 2004 53: 2397 -2403. [Abstract] [Full Text] [PDF]  

Complications:

Studies of Rat and Human Retinas Predict a Role for the Polyol Pathway in Human Diabetic Retinopathy

Zeina Dagher, Yong Seek Park, Veronica Asnaghi, Todd Hoehn, Chiara Gerhardinger, and Mara Lorenzi
Diabetes 2004 53: 2404 -2411. [Abstract] [Full Text] [PDF]  

Involvement of Brain-Derived Neurotrophic Factor in Early Retinal Neuropathy of Streptozotocin-Induced Diabetes in Rats: Therapeutic Potential of Brain-Derived Neurotrophic Factor for Dopaminergic Amacrine Cells

Masaaki Seki, Takayuki Tanaka, Hiroyuki Nawa, Tomoaki Usui, Takeo Fukuchi, Kazuhito Ikeda, Haruki Abe, and Nobuyuki Takei
Diabetes 2004 53: 2412 -2419. [Abstract] [Full Text] [PDF]  

Development of Albuminuria and Glomerular Lesions in Normoglycemic B6 Recipients of db/db Mice Bone Marrow: The Role of Mesangial Cell Progenitors

Feng Zheng, Flavia Cornacchia, Ivonne Schulman, Anita Banerjee, Qing-li Cheng, Mylene Potier, Anna Rita Plati, Mariana Berho, Sharon J. Elliot, Jie Li, Alessia Fornoni, Yun-Juan Zang, Ariel Zisman, Liliane J. Striker, and Gary E. Striker
Diabetes 2004 53: 2420 -2427. [Abstract] [Full Text] [PDF]  

Changes in IGF Activities in Human Diabetic Vitreous

Clyde Guidry, Richard Feist, Robert Morris, and Charles W. Hardwick
Diabetes 2004 53: 2428 -2435. [Abstract] [Full Text] [PDF]  

Nitration and Functional Loss of Voltage-Gated K⁺ Channels in Rat Coronary Microvessels Exposed to High Glucose

Hongwei Li, David D. Gutterman, Nancy J. Rusch, Aaron Bubolz, and Yanping Liu
Diabetes 2004 53: 2436 -2442. [Abstract] [Full Text] [PDF]  

Leptin Stimulates Ischemia-Induced Retinal Neovascularization: Possible Role of Vascular Endothelial Growth Factor Expressed in Retinal Endothelial Cells

Eri Suganami, Hitoshi Takagi, Hirokazu Ohashi, Kiyoshi Suzuma, Izumi Suzuma, Hideyasu Oh, Daisuke Watanabe, Tomonari Ojima, Takayoshi Suganami, Yasushi Fujio, Kazuwa Nakao, Yoshihiro Ogawa, and Nagahisa Yoshimura
Diabetes 2004 53: 2443 -2448. [Abstract] [Full Text] [PDF]  

Population-Based Assessment of Familial Clustering of Diabetic Nephropathy in Type 1 Diabetes

Valma Harjutsalo, Shuichi Katoh, Cinzia Sarti, Naoko Tajima, and Jaakko Tuomilehto
Diabetes 2004 53: 2449 -2454. [Abstract] [Full Text] [PDF]  

Functional Variants in the Glutathione Peroxidase-1 (GPx-1) Gene Are Associated With Increased Intima-Media Thickness of Carotid Arteries and Risk of Macrovascular Diseases in Japanese Type 2 Diabetic Patients

Tohru Hamanishi, Hiroto Furuta, Hisako Kato, Asako Doi, Masanori Tamai, Hiroko Shimomura, Setsuya Sakagashira, Masahiro Nishi, Hideyuki Sasaki, Tokio Sanke, and Kishio Nanjo
Diabetes 2004 53: 2455 -2460. [Abstract] [Full Text] [PDF]  

Studies of the Peptide YY and Neuropeptide Y2 Receptor Genes in Relation to Human Obesity and Obesity-Related Traits

Chiao-Chien Connie Hung, Fraser Pirie, Jian’an Luan, Emma Lank, Ayesha Motala, Giles S.H. Yeo, Julia M. Keogh, Nicholas J. Wareham, Stephen O’Rahilly, and I. Sadaf Farooqi
Diabetes 2004 53: 2461 -2466. [Abstract] [Full Text] [PDF] Appendix  

Genetic Variation in BEACON Influences Quantitative Variation in Metabolic Syndrome–Related Phenotypes

Jeremy B. Jowett, Kate S. Elliott, Joanne E. Curran, Nicola Hunt, Ken R. Walder, Greg R. Collier, Paul Z. Zimmet, and John Blangero
Diabetes 2004 53: 2467 -2472. [Abstract] [Full Text] [PDF]  

Adiponectin and the Development of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study

Bruce B. Duncan, Maria Inês Schmidt, James S. Pankow, Heejung Bang, David Couper, Christie M. Ballantyne, Ron C. Hoogeveen, and Gerardo Heiss
Diabetes 2004 53: 2473 -2478. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

Association Analysis of the Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Gene in Type 1 Diabetes

John S. Hulme, Bryan J. Barratt, Rebecca C.J. Twells, Jason D. Cooper, Chris E. Lowe, Joanna M.M. Howson, Alex C. Lam, Luc J. Smink, David A. Savage, Dag E. Undlien, Cristian Guja, Constantin Ionescu-Tîirgoviste, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, and John A. Todd
Diabetes 2004 53: 2479 -2482. [Abstract] [Full Text] [PDF] Appendix  

Polymorphisms in the Amino Acid Transporter Solute Carrier Family 6 (Neurotransmitter Transporter) Member 14 Gene Contribute to Polygenic Obesity in French Caucasians

Emmanuelle Durand, Philippe Boutin, David Meyre, M. Aline Charles, Karine Clement, Christian Dina, and Philippe Froguel
Diabetes 2004 53: 2483 -2486. [Abstract] [Full Text] [PDF]  

A Quantitative Trait Locus Influencing Fasting Plasma Glucose in Chromosome Region 18q22-23

Wei-Dong Li, Chuanhui Dong, Ding Li, Cathleen Garrigan, and R. Arlen Price
Diabetes 2004 53: 2487 -2491. [Abstract] [Full Text] [PDF]  

Pharmacology and Therapeutic:

A Recombinant Human Glucagon-Like Peptide (GLP)-1–Albumin Protein (Albugon) Mimics Peptidergic Activation of GLP-1 Receptor–Dependent Pathways Coupled With Satiety, Gastrointestinal Motility, and Glucose Homeostasis

Laurie L. Baggio, Qingling Huang, Theodore J. Brown, and Daniel J. Drucker
Diabetes 2004 53: 2492 -2500. [Abstract] [Full Text] [PDF]  

Regeneration of the Heart in Diabetes by Selective Copper Chelation

Garth J.S. Cooper, Anthony R.J. Phillips, Soon Y. Choong, Bridget L. Leonard, David J. Crossman, Dianne H. Brunton, ’Etuate L. Saafi, Ajith M. Dissanayake, Brett R. Cowan, Alistair A. Young, Christopher J. Occleshaw, Yih-Kai Chan, Fiona E. Leahy, Geraldine F. Keogh, Gregory D. Gamble, Grant R. Allen, Adèle J. Pope, Peter D.W. Boyd, Sally D. Poppitt, Thomas K. Borg, Robert N. Doughty, and John R. Baker
Diabetes 2004 53: 2501 -2508. [Abstract] [Full Text] [PDF]  

Recombinant Human Erythropoietin Stimulates Angiogenesis and Wound Healing in the Genetically Diabetic Mouse

Mariarosaria Galeano, Domenica Altavilla, Domenico Cucinotta, Giuseppina T. Russo, Margherita Calò, Alessandra Bitto, Herbert Marini, Rolando Marini, Elena B. Adamo, Paolo Seminara, Letteria Minutoli, Valerio Torre, and Francesco Squadrito
Diabetes 2004 53: 2509 -2517. [Abstract] [Full Text] [PDF]  

Errata:

Erratum

Diabetes 2004 53: 2518 . [Extract] [Full Text] [PDF]  

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