Editorial:

Editorial: Novel Factors in the Regulation of ß-Cell Function

Christian Boitard, Erol Cerasi, Suad Efendic, Jean-Claude Henquin, Donald F. Steiner, and Ele Ferrannini
Diabetes 2004 53: S1-3. [Extract] [Full Text] [PDF]  

Section I: Genetic Factors in Type 2 Diabetes -- In Search of New Links:

Differential Levels of Diabetogenic Stress in Two New Mouse Models of Obesity and Type 2 Diabetes

Edward H. Leiter and Peter C. Reifsnyder
Diabetes 2004 53: S4-11. [Abstract] [Full Text] [PDF]  

Structure, Activation, and Biology of Calpain

Koichi Suzuki, Shoji Hata, Yukiko Kawabata, and Hiroyuki Sorimachi
Diabetes 2004 53: S12-18. [Abstract] [Full Text] [PDF]  

Linkage of Calpain 10 to Type 2 Diabetes: The Biological Rationale

Nancy J. Cox, M. Geoffrey Hayes, Cheryl A. Roe, Takafumi Tsuchiya, and Graeme I. Bell
Diabetes 2004 53: S19-25. [Abstract] [Full Text] [PDF]  

Genetic Factors and Insulin Secretion: Gene Variants in the IGF Genes

Leen M. ’t Hart, Andreas Fritsche, Ingrid Rietveld, Jacqueline M. Dekker, Giel Nijpels, Fausto Machicao, Michael Stumvoll, Cornelia M. van Duijn, Hans U. Häring, Robert J. Heine, J. Antonie Maassen, and Timon W. van Haeften
Diabetes 2004 53: S26-30. [Abstract] [Full Text] [PDF]  

Single Nucleotide Polymorphisms in the Proximal Promoter Region of the Adiponectin (APM1) Gene Are Associated With Type 2 Diabetes in Swedish Caucasians

Harvest F. Gu, Adili Abulaiti, Claes-Göran Östenson, Keith Humphreys, Claes Wahlestedt, Anthony J. Brookes, and Suad Efendic
Diabetes 2004 53: S31-35. [Abstract] [Full Text] [PDF]  

Section II: Nuclear Receptors and Islet Function:

Putative Metabolic Effects of the Liver X Receptor (LXR)

Knut R. Steffensen and Jan-Åke Gustafsson
Diabetes 2004 53: S36-42. [Abstract] [Full Text] [PDF]  

The Biology of Peroxisome Proliferator-Activated Receptors: Relationship With Lipid Metabolism and Insulin Sensitivity

Pascal Ferré
Diabetes 2004 53: S43-50. [Abstract] [Full Text] [PDF]  

Aged Transgenic Mice With Increased Glucocorticoid Sensitivity in Pancreatic ß-Cells Develop Diabetes

Behrous Davani, Neil Portwood, Galina Bryzgalova, Martina Kvist Reimer, Thomas Heiden, Claes-Göran Östenson, Sam Okret, Bo Ahren, Suad Efendic, and Akhtar Khan
Diabetes 2004 53: S51-59. [Abstract] [Full Text] [PDF]  

Role of Peroxisome Proliferator-Activated Receptor- in the Glucose-Sensing Apparatus of Liver and ß-Cells

Ha-il Kim and Yong-ho Ahn
Diabetes 2004 53: S60-65. [Abstract] [Full Text] [PDF]  

Liver Glucokinase Can Be Activated by Peroxisome Proliferator-Activated Receptor-

So-youn Kim, Ha-il Kim, Sang-Kyu Park, Seung-Soon Im, Tianzhu Li, Hyae Gyeong Cheon, and Yong-ho Ahn
Diabetes 2004 53: S66-70. [Abstract] [Full Text] [PDF]  

Potential Role of Peroxisome Proliferator-Activated Receptor- in the Modulation of Glucose-Stimulated Insulin Secretion

Mary C. Sugden and Mark J. Holness
Diabetes 2004 53: S71-81. [Abstract] [Full Text] [PDF]  

Nuclear Protein p8 Is Associated With Glucose-Induced Pancreatic ß-Cell Growth

Günter Päth, Anne Opel, Anita Knoll, and Jochen Seufert
Diabetes 2004 53: S82-85. [Abstract] [Full Text] [PDF]  

Novel Players in Pancreatic Islet Signaling: From Membrane Receptors to Nuclear Channels

Bernat Soria, Ivan Quesada, Ana B. Ropero, José A. Pertusa, Franz Martín, and Angel Nadal
Diabetes 2004 53: S86-91. [Abstract] [Full Text] [PDF]  

Nutrients Induce Different Ca²⁺ Signals in Cytosol and Nucleus in Pancreatic ß-Cells

Ivan Quesada, Franz Martin, Enrique Roche, and Bernat Soria
Diabetes 2004 53: S92-95. [Abstract] [Full Text] [PDF]  

Section III: Mitochondria, Beta-Cell Function, and Type 2 Diabetes:

Roles of Mitochondria in Health and Disease

Michael R. Duchen
Diabetes 2004 53: S96-102. [Abstract] [Full Text] [PDF]  

Mitochondrial Diabetes: Molecular Mechanisms and Clinical Presentation

J. Antonie Maassen, Leen. M. ‘t Hart, Einar van Essen, Rob J. Heine, Giel Nijpels, Roshan S. Jahangir Tafrechi, Anton K. Raap, George M.C. Janssen, and Herman H.P.J. Lemkes
Diabetes 2004 53: S103-109. [Abstract] [Full Text] [PDF]  

Prevention of Mitochondrial Oxidative Damage as a Therapeutic Strategy in Diabetes

Katherine Green, Martin D. Brand, and Michael P. Murphy
Diabetes 2004 53: S110-118. [Abstract] [Full Text] [PDF]  

ß-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes

R. Paul Robertson, Jamie Harmon, Phuong Oanh T. Tran, and Vincent Poitout
Diabetes 2004 53: S119-124. [Abstract] [Full Text] [PDF]  

ALS/Lt: A New Type 2 Diabetes Mouse Model Associated With Low Free Radical Scavenging Potential

Clayton E. Mathews, Rebecca Bagley, and Edward H. Leiter
Diabetes 2004 53: S125-129. [Abstract] [Full Text] [PDF]  

The Biology of Mitochondrial Uncoupling Proteins

Sophie Rousset, Marie-Clotilde Alves-Guerra, Julien Mozo, Bruno Miroux, Anne-Marie Cassard-Doulcier, Frédéric Bouillaud, and Daniel Ricquier
Diabetes 2004 53: S130-135. [Abstract] [Full Text] [PDF]  

Uncoupling Protein 2 and Islet Function

Catherine B. Chan, Monique C. Saleh, Vasilij Koshkin, and Michael B. Wheeler
Diabetes 2004 53: S136-142. [Abstract] [Full Text] [PDF]  

Section IV: Lipid Modulators of Islet Function:

Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism

Peter J. Havel
Diabetes 2004 53: S143-151. [Abstract] [Full Text] [PDF]  

Leptin Effects on Pancreatic ß-Cell Gene Expression and Function

Jochen Seufert
Diabetes 2004 53: S152-158. [Abstract] [Full Text] [PDF]  

Chronic Effects of Fatty Acids on Pancreatic ß-Cell Function: New Insights From Functional Genomics

Trevor J. Biden, Darren Robinson, Damien Cordery, William E. Hughes, and Anna K. Busch
Diabetes 2004 53: S159-165. [Abstract] [Full Text] [PDF]  

Acute -3 Fatty Acid Enrichment Selectively Reverses High-Saturated Fat Feeding-Induced Insulin Hypersecretion But Does Not Improve Peripheral Insulin Resistance

Mark J. Holness, Nicholas D. Smith, Gemma K. Greenwood, and Mary C. Sugden
Diabetes 2004 53: S166-171. [Abstract] [Full Text] [PDF]  

The Role of Cytosolic Phospholipase A₂ in Insulin Secretion

Peter M. Jones, Christopher J. Burns, Véronique D. Belin, Helen M. Roderigo-Milne, and Shanta J. Persaud
Diabetes 2004 53: S172-178. [Abstract] [Full Text] [PDF]  

Islet Complex Lipids: Involvement in the Actions of Group VIA Calcium-Independent Phospholipase A₂ in ß-Cells

Sasanka Ramanadham, Haowei Song, Shunzhong Bao, Fong-Fu Hsu, Sheng Zhang, Zhongmin Ma, Chun Jin, and John Turk
Diabetes 2004 53: S179-185. [Abstract] [Full Text] [PDF]  

ß-Cell Calcium-Independent Group VIA Phospholipase A₂ (iPLA₂ß): Tracking iPLA₂ß Movements in Response to Stimulation With Insulin Secretagogues in INS-1 Cells

Shunzhong Bao, Chun Jin, Sheng Zhang, John Turk, Zhongmin Ma, and Sasanka Ramanadham
Diabetes 2004 53: S186-189. [Abstract] [Full Text] [PDF]  

Glucose-Induced Regulation of COX-2 Expression in Human Islets of Langerhans

Shanta J. Persaud, Chris J. Burns, Véronique D. Belin, and Peter M. Jones
Diabetes 2004 53: S190-192. [Abstract] [Full Text] [PDF]  

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