Editorial:

Impact of Treatment on Islet Function in Type 2 Diabetes

Jean-Claude Henquin, Christian Boitard, Erol Cerasi, Ele Ferrannini, Donald F. Steiner, and Suad Efendic
Diabetes 2004 53: S1-5. [Extract] [Full Text] [PDF]  

Section I: Insulin Resistance-Beta-Cell Connection in Type 2 Diabetes:

Metabolic Syndrome and Robustness Tradeoffs

Hiroaki Kitano, Kanae Oda, Tomomi Kimura, Yukiko Matsuoka, Marie Csete, John Doyle, and Masaaki Muramatsu
Diabetes 2004 53: S6-15. [Abstract] [Full Text] [PDF]  

Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes

Gordon C. Weir and Susan Bonner-Weir
Diabetes 2004 53: S16-21. [Abstract] [Full Text] [PDF]  

Suppression of Beta-Cell Secretion by Somatostatin Does Not Fully Reverse the Disproportionate Proinsulinemia of Type 2 Diabetes

Michael E. Røder and Steven E. Kahn
Diabetes 2004 53: S22-25. [Abstract] [Full Text] [PDF]  

Beta-Cell Function in Obesity: Effects of Weight Loss

Ele Ferrannini, Stefania Camastra, Amalia Gastaldelli, Anna Maria Sironi, Andrea Natali, Elza Muscelli, Geltrude Mingrone, and Andrea Mari
Diabetes 2004 53: S26-33. [Abstract] [Full Text] [PDF]  

Prevention of Type 2 Diabetes: Insulin Resistance and Beta-Cell Function

J.-L. Chiasson and Rémi Rabasa-Lhoret
Diabetes 2004 53: S34-38. [Abstract] [Full Text] [PDF]  

Intensive Integrated Therapy of Type 2 Diabetes: Implications for Long-Term Prognosis

Peter Gæde and Oluf Pedersen
Diabetes 2004 53: S39-47. [Abstract] [Full Text] [PDF]  

Section II: Beta-Cell Therapeutic Targets Other Than ATP-Sensitive K+ Channels:

Pathways in Beta-Cell Stimulus-Secretion Coupling as Targets for Therapeutic Insulin Secretagogues

Jean-Claude Henquin
Diabetes 2004 53: S48-58. [Abstract] [Full Text] [PDF]  

Integration of ATP, cAMP, and Ca²⁺ Signals in Insulin Granule Exocytosis

Tadao Shibasaki, Yasuhiro Sunaga, and Susumu Seino
Diabetes 2004 53: S59-62. [Abstract] [Full Text] [PDF]  

P2Y Purinergic Potentiation of Glucose-Induced Insulin Secretion and Pancreatic Beta-Cell Metabolism

A. Farret, M. Vignaud, S. Dietz, J. Vignon, P. Petit, and R. Gross
Diabetes 2004 53: S63-66. [Abstract] [Full Text] [PDF]  

AMP-Activated Protein Kinase: A New Beta-Cell Glucose Sensor?: Regulation by Amino Acids and Calcium Ions

Isabelle Leclerc and Guy A. Rutter
Diabetes 2004 53: S67-74. [Abstract] [Full Text] [PDF]  

Liver X Receptor Activation Stimulates Insulin Secretion via Modulation of Glucose and Lipid Metabolism in Pancreatic Beta-Cells

Alexander M. Efanov, Sabine Sewing, Krister Bokvist, and Jesper Gromada
Diabetes 2004 53: S75-78. [Abstract] [Full Text] [PDF]  

Effect of PPAR- Activation and Inhibition on Glucose-Stimulated Insulin Release in INS-1e Cells

Eleonora Santini, Poupak Fallahi, Silvia Martina Ferrari, Antonio Masoni, Alessandro Antonelli, and Ele Ferrannini
Diabetes 2004 53: S79-83. [Abstract] [Full Text] [PDF]  

Impact of Adenoviral Transduction With SREBP1c or AMPK on Pancreatic Islet Gene Expression Profile: Analysis With Oligonucleotide Microarrays

Frederique Diraison, Efthimios Motakis, Laura E. Parton, Guy P. Nason, Isabelle Leclerc, and Guy A. Rutter
Diabetes 2004 53: S84-91. [Abstract] [Full Text] [PDF]  

Beta-Cell-Targeted Expression of a Dominant-Negative Mutant of Hepatocyte Nuclear Factor-1 in Mice: Diabetes Model with ß-Cell Dysfunction Partially Rescued by Nonglucose Secretagogues

Maria Sörhede Winzell, Giovanni Pacini, Claes B. Wollheim, and Bo Ahrén
Diabetes 2004 53: S92-96. [Abstract] [Full Text] [PDF]  

The Potential Role of SOCS-3 in the Interleukin-1ß-Induced Desensitization of Insulin Signaling in Pancreatic Beta-Cells

Brice Emanuelli, Murielle Glondu, Chantal Filloux, Pascal Peraldi, and Emmanuel Van Obberghen
Diabetes 2004 53: S97-103. [Abstract] [Full Text] [PDF]  

Section III: The Beta-Cell ATP-Sensitive K+ Channels:

Toward Linking Structure With Function in ATP-Sensitive K+ Channels

Joseph Bryan, Wanda H. Vila-Carriles, Guiling Zhao, Audrey P. Babenko, and Lydia Aguilar-Bryan
Diabetes 2004 53: S104-112. [Abstract] [Full Text] [PDF]  

Metabolic Regulation of the Pancreatic Beta-Cell ATP-Sensitive K⁺ Channel: A Pas de Deux

Andrei Tarasov, Julien Dusonchet, and Frances Ashcroft
Diabetes 2004 53: S113-122. [Abstract] [Full Text] [PDF]  

Identification of a Functionally Important Negatively Charged Residue Within the Second Catalytic Site of the SUR1 Nucleotide-Binding Domains

Jeff D. Campbell, Peter Proks, Jonathan D. Lippiat, Mark S.P. Sansom, and Frances M. Ashcroft
Diabetes 2004 53: S123-127. [Abstract] [Full Text] [PDF]  

Effect of Two Amino Acids in TM17 of Sulfonylurea Receptor SUR1 on the Binding of ATP-Sensitive K⁺ Channel Modulators

Annette Hambrock, Tülay Kayar, Demet Stumpp, and Hartmut Osswald
Diabetes 2004 53: S128-134. [Abstract] [Full Text] [PDF]  

Glucose Dependence of Imidazoline-Induced Insulin Secretion: Different Characteristics of Two ATP-Sensitive K⁺ Channel–Blocking Compounds

Claudia Bleck, Antje Wienbergen, and Ingo Rustenbeck
Diabetes 2004 53: S135-139. [Abstract] [Full Text] [PDF]  

Desensitization of Insulin Secretion by Depolarizing Insulin Secretagogues

Ingo Rustenbeck, Antje Wienbergen, Claudia Bleck, and Anne Jörns
Diabetes 2004 53: S140-150. [Abstract] [Full Text] [PDF]  

Kinetics-Effect Relations of Insulin-Releasing Drugs in Patients With Type 2 Diabetes: Brief Overview

Arne Melander
Diabetes 2004 53: S151-155. [Abstract] [Full Text] [PDF]  

Section IV: Non-Beta-Cell ATP-Sensitive K+ Channels:

The Impact of ATP-Sensitive K⁺ Channel Subtype Selectivity of Insulin Secretagogues for the Coronary Vasculature and the Myocardium

Ulrich Quast, Damian Stephan, Susanne Bieger, and Ulrich Russ
Diabetes 2004 53: S156-164. [Abstract] [Full Text] [PDF]  

Genetic Disruption of Kir6.2, the Pore-Forming Subunit of ATP-Sensitive K⁺ Channel, Predisposes to Catecholamine-Induced Ventricular Dysrhythmia

Xiao-Ke Liu, Satsuki Yamada, Garvan C. Kane, Alexey E. Alekseev, Denice M. Hodgson, Fearghas O’Cochlain, Arshad Jahangir, Takashi Miki, Susumu Seino, and Andre Terzic
Diabetes 2004 53: S165-168. [Abstract] [Full Text] [PDF]  

ATP-Sensitive K⁺ Channel Knockout Compromises the Metabolic Benefit of Exercise Training, Resulting in Cardiac Deficits

Garvan C. Kane, Atta Behfar, Satsuki Yamada, Carmen Perez-Terzic, Fearghas O’Cochlain, Santiago Reyes, Petras P. Dzeja, Takashi Miki, Susumu Seino, and Andre Terzic
Diabetes 2004 53: S169-175. [Abstract] [Full Text] [PDF]  

Roles of ATP-Sensitive K+ Channels as Metabolic Sensors: Studies of Kir6.x Null Mice

Kohtaro Minami, Takashi Miki, Takashi Kadowaki, and Susumu Seino
Diabetes 2004 53: S176-180. [Abstract] [Full Text] [PDF]  

ATP-Sensitive K⁺ Channel–Dependent Regulation of Glucagon Release and Electrical Activity by Glucose in Wild-Type and SUR1^–/– Mouse -Cells

Jesper Gromada, Xiaosong Ma, Marianne Høy, Krister Bokvist, Albert Salehi, Per-Olof Berggren, and Patrik Rorsman
Diabetes 2004 53: S181-189. [Abstract] [Full Text] [PDF]  

Section V: The Incretin Pathway:

Gastric Inhibitory Polypeptide and Glucagon-Like Peptide-1 in the Pathogenesis of Type 2 Diabetes

Michael A. Nauck, Birgit Baller, and Juris J. Meier
Diabetes 2004 53: S190-196. [Abstract] [Full Text] [PDF]  

The Incretin Approach for Diabetes Treatment: Modulation of Islet Hormone Release by GLP-1 Agonism

Jens Juul Holst and Cathrine Ørskov
Diabetes 2004 53: S197-204. [Abstract] [Full Text] [PDF]  

Chronic Exposure to GLP-1R Agonists Promotes Homologous GLP-1 Receptor Desensitization In Vitro but Does Not Attenuate GLP-1R–Dependent Glucose Homeostasis In Vivo

Laurie L. Baggio, Jung-Guk Kim, and Daniel J. Drucker
Diabetes 2004 53: S205-214. [Abstract] [Full Text] [PDF]  

The High-Fat Diet–Fed Mouse: A Model for Studying Mechanisms and Treatment of Impaired Glucose Tolerance and Type 2 Diabetes

Maria Sörhede Winzell and Bo Ahrén
Diabetes 2004 53: S215-219. [Abstract] [Full Text] [PDF]  

Stimulation of Insulin Secretion by Intravenous Bolus Injection and Continuous Infusion of Gastric Inhibitory Polypeptide in Patients With Type 2 Diabetes and Healthy Control Subjects

Juris J. Meier, Baptist Gallwitz, Bartholomaeus Kask, Carolyn F. Deacon, Jens J. Holst, Wolfgang E. Schmidt, and Michael A. Nauck
Diabetes 2004 53: S220-224. [Abstract] [Full Text] [PDF]  

Signaling Elements Involved in the Metabolic Regulation of mTOR by Nutrients, Incretins, and Growth Factors in Islets

Guim Kwon, Connie A. Marshall, Kirk L. Pappan, Maria S. Remedi, and Michael L. McDaniel
Diabetes 2004 53: S225-232. [Abstract] [Full Text] [PDF]  

Amylin Agonists: A Novel Approach in the Treatment of Diabetes

Ole Schmitz, Birgitte Brock, and Jorgen Rungby
Diabetes 2004 53: S233-238. [Abstract] [Full Text] [PDF]  

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