Perspectives in Diabetes:

Postprandial Hyperglycemia and Diabetes Complications: Is It Time to Treat?

Antonio Ceriello
Diabetes 2005 54: 1 -7. [Abstract] [Full Text] [PDF]  

Metabolism:

Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes

Vladimir B. Ritov, Elizabeth V. Menshikova, Jing He, Robert E. Ferrell, Bret H. Goodpaster, and David E. Kelley
Diabetes 2005 54: 8 -14. [Abstract] [Full Text] [PDF]  

Signal Transduction:

Differential Effects of Glucose and Lactate on Glucosensing Neurons in the Ventromedial Hypothalamic Nucleus

Z. Song and V.H. Routh
Diabetes 2005 54: 15 -22. [Abstract] [Full Text] [PDF]  

HIV-1 Accessory Protein Vpr Inhibits the Effect of Insulin on the Foxo Subfamily of Forkhead Transcription Factors by Interfering With Their Binding to 14-3-3 Proteins: Potential Clinical Implications Regarding the Insulin Resistance of HIV-1–Infected Patients

Tomoshige Kino, Massimo U. De Martino, Evangelia Charmandari, Takamasa Ichijo, Taoufik Outas, and George P. Chrousos
Diabetes 2005 54: 23 -31. [Abstract] [Full Text] [PDF]  

Increased Glucocorticoid Receptor and 11ß-Hydroxysteroid Dehydrogenase Type 1 Expression in Hepatocytes May Contribute to the Phenotype of Type 2 Diabetes in db/db Mice

Yanjun Liu, Yuichi Nakagawa, Ying Wang, Reiko Sakurai, Pinky V. Tripathi, Kabirullah Lutfy, and Theodore C. Friedman
Diabetes 2005 54: 32 -40. [Abstract] [Full Text] [PDF]  

Increased Phosphorylation of Akt Substrate of 160 kDa (AS160) in Rat Skeletal Muscle in Response to Insulin or Contractile Activity

Matthew D. Bruss, Edward B. Arias, Gustav E. Lienhard, and Gregory D. Cartee
Diabetes 2005 54: 41 -50. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Growth Hormone Overexpression in the Central Nervous System Results in Hyperphagia-Induced Obesity Associated With Insulin Resistance and Dyslipidemia

Mohammad Bohlooly-Y, Bob Olsson, Carl E.G. Bruder, Daniel Lindén, Klara Sjögren, Mikael Bjursell, Emil Egecioglu, Lennart Svensson, Peter Brodin, John C. Waterton, Olle G.P. Isaksson, Frank Sundler, Bo Ahrén, Claes Ohlsson, Jan Oscarsson, and Jan Törnell
Diabetes 2005 54: 51 -62. [Abstract] [Full Text] [PDF]  

Enhanced Hypothalamic AMP-Activated Protein Kinase Activity Contributes to Hyperphagia in Diabetic Rats

Churl Namkoong, Min Seon Kim, Pil Geum Jang, Sung Min Han, Hye Sun Park, Eun Hee Koh, Woo Je Lee, Jong Yeon Kim, In Sun Park, Joong Yeol Park, and Ki Up Lee
Diabetes 2005 54: 63 -68. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Islet-infiltrating B-Cells in Nonobese Diabetic Mice Predominantly Target Nervous System Elements

Jorge Carrillo, Maria Carmen Puertas, Aurora Alba, Rosa Maria Ampudia, Xavier Pastor, Raquel Planas, Nadal Riutort, Nuria Alonso, Ricardo Pujol-Borrell, Pere Santamaria, Marta Vives-Pi, and Joan Verdaguer
Diabetes 2005 54: 69 -77. [Abstract] [Full Text] [PDF]  

Treatment With Granulocyte Colony–Stimulating Factor Prevents Diabetes in NOD Mice by Recruiting Plasmacytoid Dendritic Cells and Functional CD4⁺CD25⁺ Regulatory T-Cells

Hassen Kared, Annie Masson, Homa Adle-Biassette, Jean-François Bach, Lucienne Chatenoud, and Flora Zavala
Diabetes 2005 54: 78 -84. [Abstract] [Full Text] [PDF]  

Hyperglycemia Induces Monocytic Release of Interleukin-6 via Induction of Protein Kinase C- and -ß

Sridevi Devaraj, Senthil K. Venugopal, Uma Singh, and Ishwarlal Jialal
Diabetes 2005 54: 85 -91. [Abstract] [Full Text] [PDF]  

Defective Suppressor Function in CD4⁺CD25⁺ T-Cells From Patients With Type 1 Diabetes

Shelley Lindley, Colin M. Dayan, Amanda Bishop, Bart O. Roep, Mark Peakman, and Timothy I.M. Tree
Diabetes 2005 54: 92 -99. [Abstract] [Full Text] [PDF]  

ß-Cell Function Following Human Islet Transplantation for Type 1 Diabetes

Michael R. Rickels, Mark H. Schutta, James F. Markmann, Clyde F. Barker, Ali Naji, and Karen L. Teff
Diabetes 2005 54: 100 -106. [Abstract] [Full Text] [PDF]  

Autoimmune Diabetes and Resistance to Xenograft Transplantation Tolerance in NOD Mice

Ethel J. Gordon, Linda S. Wicker, Laurence B. Peterson, David V. Serreze, Thomas G. Markees, Leonard D. Shultz, Aldo A. Rossini, Dale L. Greiner, and John P. Mordes
Diabetes 2005 54: 107 -115. [Abstract] [Full Text] [PDF]  

Islet Studies:

Uncoupling of Nutrient Metabolism From Insulin Secretion by Overexpression of Cytosolic Phospholipase A₂

Helen M. Milne, Chris J. Burns, Paul E. Squires, Nicholas D. Evans, John Pickup, Peter M. Jones, and Shanta J. Persaud
Diabetes 2005 54: 116 -124. [Abstract] [Full Text] [PDF]  

Nuclear Factor-B Activity in ß-Cells Is Required for Glucose-Stimulated Insulin Secretion

Stefan Norlin, Ulf Ahlgren, and Helena Edlund
Diabetes 2005 54: 125 -132. [Abstract] [Full Text] [PDF]  

Genetic Background Determines the Size and Structure of the Endocrine Pancreas

Troels Bock, Bente Pakkenberg, and Karsten Buschard
Diabetes 2005 54: 133 -137. [Abstract] [Full Text] [PDF]  

Dynamic Changes in ß-Cell Mass and Pancreatic Insulin During the Evolution of Nutrition-Dependent Diabetes in Psammomys obesus: Impact of Glycemic Control

Nurit Kaiser, Michal Yuli, Gökhan Üçkaya, Andrei I. Oprescu, Marie-France Berthault, Catherine Kargar, Marc Y. Donath, Erol Cerasi, and Alain Ktorza
Diabetes 2005 54: 138 -145. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Glucagon-like Peptide 1 Can Directly Protect the Heart Against Ischemia/Reperfusion Injury

Amal K. Bose, Mihaela M. Mocanu, Richard D. Carr, Christian L. Brand, and Derek M. Yellon
Diabetes 2005 54: 146 -151. [Abstract] [Full Text] [PDF]  

Delayed Transcapillary Delivery of Insulin to Muscle Interstitial Fluid After Oral Glucose Load in Obese Subjects

Mikaela Sjöstrand, Soffia Gudbjörnsdottir, Lena Strindberg, and Peter Lönnroth
Diabetes 2005 54: 152 -157. [Abstract] [Full Text] [PDF]  

Physical Activity in the Prevention of Type 2 Diabetes: The Finnish Diabetes Prevention Study

David E. Laaksonen, Jaana Lindström, Timo A. Lakka, Johan G. Eriksson, Leo Niskanen, Katja Wikström, Sirkka Aunola, Sirkka Keinänen-Kiukaanniemi, Mauri Laakso, Timo T. Valle, Pirjo Ilanne-Parikka, Anne Louheranta, Helena Hämäläinen, Merja Rastas, Virpi Salminen, Zygimantas Cepaitis, Martti Hakumäki, Hannu Kaikkonen, Pirjo Härkönen, Jouko Sundvall, Jaakko Tuomilehto, Matti Uusitupa for the Finnish Diabetes Prevention Study Group
Diabetes 2005 54: 158 -165. [Abstract] [Full Text] [PDF]  

Predictors of and Longitudinal Changes in Insulin Sensitivity and Secretion Preceding Onset of Type 2 Diabetes

Valeriya Lyssenko, Peter Almgren, Dragi Anevski, Roland Perfekt, Kaj Lahti, Michael Nissén, Bo Isomaa, Björn Forsen, Nils Homström, Carola Saloranta, Marja-Riitta Taskinen, Leif Groop, Tiinamaija Tuomi for the Botnia Study Group
Diabetes 2005 54: 166 -174. [Abstract] [Full Text] [PDF]  

Insulin Deficiency Downregulated Heat Shock Protein 60 and IGF-1 Receptor Signaling in Diabetic Myocardium

Harn-Shen Chen, Yue-Xin Shan, Tung-Lin Yang, Hong-Da Lin, Jaw-Wen Chen, Shing-Jong Lin, and Ping H. Wang
Diabetes 2005 54: 175 -181. [Abstract] [Full Text] [PDF]  

Impairment of Host Resistance to Listeria monocytogenes Infection in Liver of db/db and ob/ob Mice

Shin Ikejima, Sanae Sasaki, Hiroshi Sashinami, Fumiaki Mori, Yoshiji Ogawa, Teruo Nakamura, Yoshinao Abe, Koichi Wakabayashi, Toshihiro Suda, and Akio Nakane
Diabetes 2005 54: 182 -189. [Abstract] [Full Text] [PDF]  

Evidence for Accelerated Rates of Glutathione Utilization and Glutathione Depletion in Adolescents With Poorly Controlled Type 1 Diabetes

Dominique Darmaun, Shiela D. Smith, Shawn Sweeten, Brenda K. Sager, Susan Welch, and Nelly Mauras
Diabetes 2005 54: 190 -196. [Abstract] [Full Text] [PDF]  

Postnatal Diet-Induced Obesity in Rats Upregulates Systemic and Adipose Tissue Glucocorticoid Metabolism During Development and in Adulthood: Its Relationship With the Metabolic Syndrome

Sandrine Boullu-Ciocca, Anne Dutour, Viviane Guillaume, Vincent Achard, Charles Oliver, and Michel Grino
Diabetes 2005 54: 197 -203. [Abstract] [Full Text] [PDF]  

Complications:

The Effect of Vitamin E on Endothelial Function of Micro- and Macrocirculation and Left Ventricular Function in Type 1 and Type 2 Diabetic Patients

Panayiotis A. Economides, Lalita Khaodhiar, Antonella Caselli, A. Enrique Caballero, Hillary Keenan, Sven-Erik Bursell, George L. King, Michael T. Johnstone, Edward S. Horton, and Aristidis Veves
Diabetes 2005 54: 204 -211. [Abstract] [Full Text] [PDF]  

Nitrergic Neurodegeneration in Cerebral Arteries of Streptozotocin-Induced Diabetic Rats: A New Insight into Diabetic Stroke

Selim Cellek, Patrick N. Anderson, and Neale A. Foxwell
Diabetes 2005 54: 212 -219. [Abstract] [Full Text] [PDF]  

a-Series Gangliosides Mediate the Effects of Advanced Glycation End Products on Pericyte and Mesangial Cell Proliferation: A Common Mediator for Retinal and Renal Microangiopathy?

Elodie Masson, Lysiane Troncy, Daniel Ruggiero, Nicolas Wiernsperger, Michel Lagarde, and Samer El Bawab
Diabetes 2005 54: 220 -227. [Abstract] [Full Text] [PDF]  

Altered Transcapillary Escape of Albumin and Microalbuminuria Reflects Two Different Pathogenetic Mechanisms

Romano Nosadini, Mario Velussi, Enrico Brocco, Cataldo Abaterusso, Francesco Piarulli, Giuseppe Morgia, Andrea Satta, Rossana Faedda, Avinash Abhyankar, Holger Luthman, and Giancarlo Tonolo
Diabetes 2005 54: 228 -233. [Abstract] [Full Text] [PDF]  

Aldose Reductase Inhibition Counteracts Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase Activation in Tissue Sites for Diabetes Complications

Irina G. Obrosova, Pal Pacher, Csaba Szabó, Zsuzsanna Zsengeller, Hiroko Hirooka, Martin J. Stevens, and Mark A. Yorek
Diabetes 2005 54: 234 -242. [Abstract] [Full Text] [PDF]  

Decreased Expression of Pigment Epithelium-Derived Factor Is Involved in the Pathogenesis of Diabetic Nephropathy

Joshua J. Wang, Sarah X. Zhang, Kangmo Lu, Ying Chen, Robert Mott, Sanai Sato, and Jian-xing Ma
Diabetes 2005 54: 243 -250. [Abstract] [Full Text] [PDF]  

Pharmacology and Therapeutics:

Development of a Long-Acting Insulin Analog Using Albumin Fusion Technology

Alokesh Duttaroy, Palanisamy Kanakaraj, Blaire L. Osborn, Helmut Schneider, Oxana K. Pickeral, Cecil Chen, Guiyi Zhang, Shashi Kaithamana, Mallika Singh, Robert Schulingkamp, Dan Crossan, Jason Bock, Thomas E. Kaufman, Peter Reavey, Melisa Carey-Barber, Surekha R. Krishnan, Andy Garcia, Kelly Murphy, Jana K. Siskind, Malia A. McLean, Susan Cheng, Steve Ruben, Charles E. Birse, and Olivier Blondel
Diabetes 2005 54: 251 -258. [Abstract] [Full Text] [PDF]  

Genetics:

Genetic Linkage and Association of the Growth Hormone Secretagogue Receptor (Ghrelin Receptor) Gene in Human Obesity

Andrea Baessler, Michael J. Hasinoff, Marcus Fischer, Wibke Reinhard, Gabriele E. Sonnenberg, Michael Olivier, Jeanette Erdmann, Heribert Schunkert, Angela Doering, Howard J. Jacob, Anthony G. Comuzzie, Ahmed H. Kissebah, and Anne E. Kwitek
Diabetes 2005 54: 259 -267. [Abstract] [Full Text] [PDF]  

Linkage of Plasma Adiponectin Levels to 3q27 Explained by Association With Variation in the APM1 Gene

Toni I. Pollin, Keith Tanner, Jeffrey R. O’Connell, Sandra H. Ott, Coleen M. Damcott, Alan R. Shuldiner, John C. McLenithan, and Braxton D. Mitchell
Diabetes 2005 54: 268 -274. [Abstract] [Full Text] [PDF]  

Heritability of Insulin Secretion, Peripheral and Hepatic Insulin Action, and Intracellular Glucose Partitioning in Young and Old Danish Twins

Pernille Poulsen, Klaus Levin, Inge Petersen, Kaare Christensen, Henning Beck-Nielsen, and Allan Vaag
Diabetes 2005 54: 275 -283. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians

Barbora Vozarova de Courten, Robert L. Hanson, Tohru Funahashi, Robert S. Lindsay, Yuji Matsuzawa, Sachiyo Tanaka, Farook Thameem, Jonathan D. Gruber, Philippe Froguel, and Johanna K. Wolford
Diabetes 2005 54: 284 -289. [Abstract] [Full Text] [PDF]  

A Genome Scan for Fasting Insulin and Fasting Glucose Identifies a Quantitative Trait Locus on Chromosome 17p: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

Stephen S. Rich, Donald W. Bowden, Steven M. Haffner, Jill M. Norris, Mohammed F. Saad, Braxton D. Mitchell, Jerome I. Rotter, Carl D. Langefeld, Catherine C. Hedrick, Lynne E. Wagenknecht, and Richard N. Bergman
Diabetes 2005 54: 290 -295. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Errata:

Erratum

Diabetes 2005 54: 296 . [Extract] [Full Text] [PDF]  

Erratum

Diabetes 2005 54: 296 . [Extract] [Full Text] [PDF]  

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