Signal Transduction:

Peripheral Hyperinsulinemia Promotes Tau Phosphorylation In Vivo

Susanna Freude, Leona Plum, Jessika Schnitker, Uschi Leeser, Michael Udelhoven, Wilhelm Krone, Jens C. Bruning, and Markus Schubert
Diabetes 2005 54: 3343 -3348. [Abstract] [Full Text] [PDF]  

Skeletal Muscle Insulin Signaling Defects Downstream of Phosphatidylinositol 3-Kinase at the Level of Akt Are Associated With Impaired Nonoxidative Glucose Disposal in HIV Lipodystrophy

Steen B. Haugaard, Ove Andersen, Sten Madsbad, Christian Frøsig, Johan Iversen, Jens Ole Nielsen, and Jørgen F.P. Wojtaszewski
Diabetes 2005 54: 3474 -3483. [Abstract] [Full Text] [PDF]  

Changes in Exercise-Induced Gene Expression in 5'-AMP–Activated Protein Kinase 3–Null and 3 R225Q Transgenic Mice

Brian R. Barnes, Yun Chau Long, Tatiana L. Steiler, Ying Leng, Dana Galuska, Jørgen F.P. Wojtaszewski, Leif Andersson, and Juleen R. Zierath
Diabetes 2005 54: 3484 -3489. [Abstract] [Full Text] [PDF]  

The Lack of ß-Adrenoceptors Results in Enhanced Insulin Sensitivity in Mice Exhibiting Increased Adiposity and Glucose Intolerance

Cédric Asensio, Maria Jimenez, Françoise Kühne, Françoise Rohner-Jeanrenaud, and Patrick Muzzin
Diabetes 2005 54: 3490 -3495. [Abstract] [Full Text] [PDF]  

Plasma Free Fatty Acids and Peroxisome Proliferator–Activated Receptor in the Control of Myocardial Uncoupling Protein Levels

Andrew J. Murray, Marcello Panagia, David Hauton, Geoffrey F. Gibbons, and Kieran Clarke
Diabetes 2005 54: 3496 -3502. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Expression of Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase/PFKFB3 Isoforms in Adipocytes and Their Potential Role in Glycolytic Regulation

Toshiya Atsumi, Taro Nishio, Hirokatsu Niwa, Jun Takeuchi, Hidenori Bando, Chikara Shimizu, Narihito Yoshioka, Richard Bucala, and Takao Koike
Diabetes 2005 54: 3349 -3357. [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator–Activated Receptor (PPAR) Activation Increases Adiponectin Receptors and Reduces Obesity-Related Inflammation in Adipose Tissue: Comparison of Activation of PPAR, PPAR, and Their Combination

Atsushi Tsuchida, Toshimasa Yamauchi, Sato Takekawa, Yusuke Hada, Yusuke Ito, Toshiyuki Maki, and Takashi Kadowaki
Diabetes 2005 54: 3358 -3370. [Abstract] [Full Text] [PDF]  

A Polygenic Model of the Metabolic Syndrome With Reduced Circulating and Intra-Adipose Glucocorticoid Action

Nicholas M. Morton, Valerie Densmore, Malgorzata Wamil, Lynne Ramage, Katherine Nichol, Lutz Bünger, Jonathan R. Seckl, and Christopher J. Kenyon
Diabetes 2005 54: 3371 -3378. [Abstract] [Full Text] [PDF]  

Whole-body Insulin Resistance in the Absence of Obesity in FVB Mice With Overexpression of Dgat1 in Adipose Tissue

Nancy Chen, Li Liu, Yiying Zhang, Henry N. Ginsberg, and Yi-Hao Yu
Diabetes 2005 54: 3379 -3386. [Abstract] [Full Text] [PDF]  

Decreased Fat Mass in Interleukin-1 Receptor Antagonist–Deficient Mice: Impact on Adipogenesis, Food Intake, and Energy Expenditure

Emmanuel Somm, Elvire Henrichot, Agnès Pernin, Cristiana E. Juge-Aubry, Patrick Muzzin, Jean-Michel Dayer, Martin J.H. Nicklin, and Christoph A. Meier
Diabetes 2005 54: 3503 -3509. [Abstract] [Full Text] [PDF]  

Resistance to Diet-Induced Obesity in µ-Opioid Receptor–Deficient Mice: Evidence for a "Thrifty Gene"

Antoine Tabarin, Yolanda Diz-Chaves, Maria del Carmen Carmona, Bogdan Catargi, Eric P. Zorrilla, Amanda J. Roberts, Donald V. Coscina, Sophie Rousset, Anabelle Redonnet, Graham C. Parker, Koki Inoue, Daniel Ricquier, Luc Pénicaud, Brigitte L. Kieffer, and Georges F. Koob
Diabetes 2005 54: 3510 -3516. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Growth and Functional Maturation of ß-Cells in Implants of Endocrine Cells Purified From Prenatal Porcine Pancreas

Marika Bogdani, Krista Suenens, Troels Bock, Miriam Pipeleers-Marichal, Peter In’t Veld, and Daniel Pipeleers
Diabetes 2005 54: 3387 -3394. [Abstract] [Full Text] [PDF]  

On the Edge of Autoimmunity: T-Cell Stimulation by Steady-State Dendritic Cells Prevents Autoimmune Diabetes

Dunja Bruder, Astrid M. Westendorf, Wiebke Hansen, Silvia Prettin, Achim D. Gruber, Yingjie Qian, Harald von Boehmer, Karsten Mahnke, and Jan Buer
Diabetes 2005 54: 3395 -3401. [Abstract] [Full Text] [PDF]  

Islet Studies:

The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas

Maria E. Wilson, Katherine Y. Yang, Anna Kalousova, Janet Lau, Yasuhiro Kosaka, Francis C. Lynn, Juehu Wang, Caroline Mrejen, Vasso Episkopou, Hans C. Clevers, and Michael S. German
Diabetes 2005 54: 3402 -3409. [Abstract] [Full Text] [PDF]  

Inhibition of Preproinsulin Gene Expression by Leptin Induction of Suppressor of Cytokine Signaling 3 in Pancreatic ß-Cells

Katharina Laubner, Timothy J. Kieffer, Ni T. Lam, Xinjie Niu, Franz Jakob, and Jochen Seufert
Diabetes 2005 54: 3410 -3417. [Abstract] [Full Text] [PDF]  

Individual Mice Can Be Distinguished by the Period of Their Islet Calcium Oscillations: Is There an Intrinsic Islet Period That Is Imprinted In Vivo?

Craig S. Nunemaker, Min Zhang, David H. Wasserman, Owen P. McGuinness, Alvin C. Powers, Richard Bertram, Arthur Sherman, and Leslie S. Satin
Diabetes 2005 54: 3517 -3522. [Abstract] [Full Text] [PDF]  

Rho Guanosine Diphosphate–Dissociation Inhibitor Plays a Negative Modulatory Role in Glucose-Stimulated Insulin Secretion

Anjaneyulu Kowluru and Rajakrishnan Veluthakal
Diabetes 2005 54: 3523 -3529. [Abstract] [Full Text] [PDF]  

Complications:

Aspirin at Low-Intermediate Concentrations Protects Retinal Vessels in Experimental Diabetic Retinopathy Through Non–Platelet-Mediated Effects

Wei Sun, Chiara Gerhardinger, Zeina Dagher, Todd Hoehn, and Mara Lorenzi
Diabetes 2005 54: 3418 -3426. [Abstract] [Full Text] [PDF]  

Glucose Transporters in Human Renal Proximal Tubular Cells Isolated From the Urine of Patients With Non–Insulin-Dependent Diabetes

Hassan Rahmoune, Paul W. Thompson, Joanna M. Ward, Chari D. Smith, Guizhu Hong, and John Brown
Diabetes 2005 54: 3427 -3434. [Abstract] [Full Text] [PDF]  

Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy: The Relation Is Revisited

Irina G. Obrosova, Viktor R. Drel, Pal Pacher, Olga Ilnytska, Zhong Q. Wang, Martin J. Stevens, and Mark A. Yorek
Diabetes 2005 54: 3435 -3441. [Abstract] [Full Text] [PDF]  

Polymorphisms in IGF-Binding Protein 1 Are Associated With Impaired Renal Function in Type 2 Diabetes

Richard H. Stephens, Patrick McElduff, Adrian H. Heald, John P. New, Jane Worthington, William E. Ollier, and J. Martin Gibson
Diabetes 2005 54: 3547 -3553. [Abstract] [Full Text] [PDF]  

Plasma Cholesteryl Ester Transfer Is a Determinant of Intima-Media Thickness in Type 2 Diabetic and Nondiabetic Subjects: Role of CETP and Triglycerides

Rindert de Vries, Frank G. Perton, Geesje M. Dallinga-Thie, Arie M. van Roon, Bruce H.R. Wolffenbuttel, Arie van Tol, and Robin P.F. Dullaart
Diabetes 2005 54: 3554 -3559. [Abstract] [Full Text] [PDF]  

Pharmacology and Therapeutics:

Molecular Characterization of New Selective Peroxisome Proliferator–Activated Receptor Modulators With Angiotensin Receptor Blocking Activity

Michael Schupp, Markus Clemenz, Romain Gineste, Henning Witt, Jürgen Janke, Stephane Helleboid, Nathalie Hennuyer, Patricia Ruiz, Thomas Unger, Bart Staels, and Ulrich Kintscher
Diabetes 2005 54: 3442 -3452. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Brief Genetics Reports:

Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice

Thomas C. Brodnicki, Anne L. Fletcher, Daniel G. Pellicci, Stuart P. Berzins, Peter McClive, Fiona Quirk, Kylie E. Webster, Hamish S. Scott, Richard L. Boyd, Dale I. Godfrey, and Grant Morahan
Diabetes 2005 54: 3453 -3457. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Patterns of Linkage Disequilibrium in the Type 2 Diabetes Gene Calpain-10

M. Geoffrey Hayes, Laura del Bosque-Plata, Takafumi Tsuchiya, Craig L. Hanis, Graeme I. Bell, and Nancy J. Cox
Diabetes 2005 54: 3573 -3576. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Insulin Resistance Syndrome in Subjects With Mutated RING Finger Protein TRIM37

Niklas Karlberg, Hannu Jalanko, Jukka Kallijärvi, Anna-Elina Lehesjoki, and Marita Lipsanen-Nyman
Diabetes 2005 54: 3577 -3581. [Abstract] [Full Text] [PDF]  

Genetic Heterogeneity in Association of the SUMO4 M55V Variant With Susceptibility to Type 1 Diabetes

Shinsuke Noso, Hiroshi Ikegami, Tomomi Fujisawa, Yumiko Kawabata, Katsuaki Asano, Yoshihisa Hiromine, Masako Tsurumaru, Shigetaka Sugihara, Inkyu Lee, Eiji Kawasaki, Takuya Awata, and Toshio Ogihara
Diabetes 2005 54: 3582 -3586. [Abstract] [Full Text] [PDF]  

Single Nucleotide Polymorphisms in the Peroxisome Proliferator–Activated Receptor Gene Are Associated With Skeletal Muscle Glucose Uptake

Markku Vänttinen, Pirjo Nuutila, Teemu Kuulasmaa, Jussi Pihlajamäki, Kirsti Hällsten, Kirsi A. Virtanen, Riikka Lautamäki, Pauliina Peltoniemi, Teemu Takala, Antti P.M. Viljanen, Juhani Knuuti, and Markku Laakso
Diabetes 2005 54: 3587 -3591. [Abstract] [Full Text] [PDF]  

Metabolism:

Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-B Pathway in Rat Liver

Guenther Boden, Pengxiang She, Maria Mozzoli, Peter Cheung, Kiranmai Gumireddy, Prekumar Reddy, Xiaqin Xiang, Zhijan Luo, and Neil Ruderman
Diabetes 2005 54: 3458 -3465. [Abstract] [Full Text] [PDF]  

Glucose Metabolism in Mice Lacking Muscle Glycogen Synthase

Bartholomew A. Pederson, Jill M. Schroeder, Gretchen E. Parker, Micah W. Smith, Anna A. DePaoli-Roach, and Peter J. Roach
Diabetes 2005 54: 3466 -3473. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Unraveling the Temporal Pattern of Diet-Induced Insulin Resistance in Individual Organs and Cardiac Dysfunction in C57BL/6 Mice

So-Young Park, You-Ree Cho, Hyo-Jeong Kim, Takamasa Higashimori, Cheryl Danton, Mi-Kyung Lee, Asim Dey, Beverly Rothermel, Young-Bum Kim, April Kalinowski, Kerry S. Russell, and Jason K. Kim
Diabetes 2005 54: 3530 -3540. [Abstract] [Full Text] [PDF]  

Nonalcoholic Fatty Liver Disease and Risk of Future Cardiovascular Events Among Type 2 Diabetic Patients

Giovanni Targher, Lorenzo Bertolini, Felice Poli, Stefano Rodella, Luca Scala, Roberto Tessari, Luciano Zenari, and Giancarlo Falezza
Diabetes 2005 54: 3541 -3546. [Abstract] [Full Text] [PDF]  

Genetics:

A Functional Variant in the Human Betacellulin Gene Promoter Is Associated With Type 2 Diabetes

Yoshio Nakano, Hiroto Furuta, Asako Doi, Shohei Matsuno, Takayuki Nakagawa, Hiroko Shimomura, Setsuya Sakagashira, Yukio Horikawa, Masahiro Nishi, Hideyuki Sasaki, Tokio Sanke, and Kishio Nanjo
Diabetes 2005 54: 3560 -3566. [Abstract] [Full Text] [PDF] Online-Only Appendix  

HFE Genetic Variability, Body Iron Stores, and the Risk of Type 2 Diabetes in U.S. Women

Lu Qi, James Meigs, JoAnn E. Manson, Jing Ma, David Hunter, Nader Rifai, and Frank B. Hu
Diabetes 2005 54: 3567 -3572. [Abstract] [Full Text] [PDF]  

Perspectives in Diabetes:

Mechanisms of Hypoglycemia-Associated Autonomic Failure and Its Component Syndromes in Diabetes

Philip E. Cryer
Diabetes 2005 54: 3592 -3601. [Abstract] [Full Text] [PDF]  

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