Diabetes -- Table of Contents (April 2005, 54 [4])

Perspectives in Diabetes:

A Burning Question: Does an Adipokine-Induced Activation of the Immune System Mediate the Effect of Overnutrition on Type 2 Diabetes?: Pietro A. Tataranni and Emilio Ortega
Diabetes 2005 54: 917 -927. [Abstract] [Full Text] [PDF]

Metabolism:

Long-Term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats: Rasmus Pold, Lasse S. Jensen, Niels Jessen, Esben S. Buhl, Ole Schmitz, Allan Flyvbjerg, Nobuharu Fujii, Laurie J. Goodyear, Carsten F. Gotfredsen, Christian L. Brand, and Sten Lund
Diabetes 2005 54: 928 -934. [Abstract] [Full Text] [PDF]

Altered Hepatic and Muscle Substrate Utilization Provoked by GLUT4 Ablation: Mollie Ranalletta, Hua Jiang, Jing Li, T.S. Tsao, Antine E. Stenbit, Masayoshi Yokoyama, Ellen B. Katz, and Maureen J. Charron
Diabetes 2005 54: 935 -943. [Abstract] [Full Text] [PDF]

Modular Kinetic Analysis of the Adenine Nucleotide Translocator–Mediated Effects of Palmitoyl-CoA on the Oxidative Phosphorylation in Isolated Rat Liver Mitochondria: Jolita Ciapaite, Gerco Van Eikenhorst, Stephan J.L. Bakker, Michaela Diamant, Robert J. Heine, Marijke J. Wagner, Hans V. Westerhoff, and Klaas Krab
Diabetes 2005 54: 944 -951. [Abstract] [Full Text] [PDF]

Acute Induction of Gene Expression in Brain and Liver by Insulin-Induced Hypoglycemia: Jason W. Mastaitis, Elisa Wurmbach, Hui Cheng, Stuart C. Sealfon, and Charles V. Mobbs
Diabetes 2005 54: 952 -958. [Abstract] [Full Text] [PDF]

Signal Transduction:

S-Nitrosation of the Insulin Receptor, Insulin Receptor Substrate 1, and Protein Kinase B/Akt: A Novel Mechanism of Insulin Resistance: Marco A. Carvalho-Filho, Mirian Ueno, Sandro M. Hirabara, Amedea B. Seabra, José B.C. Carvalheira, Marcelo G. de Oliveira, Lício A. Velloso, Rui Curi, and Mario J.A. Saad
Diabetes 2005 54: 959 -967. [Abstract] [Full Text] [PDF]

Endoplasmic Reticulum Stress–Induced Apoptosis Is Partly Mediated by Reduced Insulin Signaling Through Phosphatidylinositol 3-Kinase/Akt and Increased Glycogen Synthase Kinase-3ß in Mouse Insulinoma Cells: Shanthi Srinivasan, Mitsuru Ohsugi, Zhonghao Liu, Szabolcs Fatrai, Ernesto Bernal-Mizrachi, and M. Alan Permutt
Diabetes 2005 54: 968 -975. [Abstract] [Full Text] [PDF]

Chronic Hyperglycemia Enhances PEPCK Gene Expression and Hepatocellular Glucose Production Via Elevated Liver Activating Protein/Liver Inhibitory Protein Ratio: Jianhua Shao, Liping Qiao, Rachel C. Janssen, Michael Pagliassotti, and Jacob E. Friedman
Diabetes 2005 54: 976 -984. [Abstract] [Full Text] [PDF]

Obesity Studies:

Insulin, C-Peptide, and Leptin Concentrations Predict Increased Visceral Adiposity at 5- and 10-Year Follow-Ups in Nondiabetic Japanese Americans: Jenny Tong, Wilfred Y. Fujimoto, Steven E. Kahn, David S. Weigle, Marguerite J. McNeely, Donna L. Leonetti, Jane B. Shofer, and Edward J. Boyko
Diabetes 2005 54: 985 -990. [Abstract] [Full Text] [PDF]

Deletion of the Angiotensin Type 2 Receptor (AT2R) Reduces Adipose Cell Size and Protects From Diet-Induced Obesity and Insulin Resistance: Laurent Yvan-Charvet, Patrick Even, May Bloch-Faure, Michèle Guerre-Millo, Naima Moustaid-Moussa, Pascal Ferre, and Annie Quignard-Boulange
Diabetes 2005 54: 991 -999. [Abstract] [Full Text] [PDF]

Androgen Receptor Null Male Mice Develop Late-Onset Obesity Caused by Decreased Energy Expenditure and Lipolytic Activity but Show Normal Insulin Sensitivity With High Adiponectin Secretion: WuQiang Fan, Toshihiko Yanase, Masatoshi Nomura, Taijiro Okabe, Kiminobu Goto, Takashi Sato, Hirotaka Kawano, Shigeaki Kato, and Hajime Nawata
Diabetes 2005 54: 1000 -1008. [Abstract] [Full Text] [PDF]

PDX-1/VP16 Fusion Protein, Together With NeuroD or Ngn3, Markedly Induces Insulin Gene Transcription and Ameliorates Glucose Tolerance: Hideaki Kaneto, Yoshihisa Nakatani, Takeshi Miyatsuka, Taka-aki Matsuoka, Munehide Matsuhisa, Masatsugu Hori, and Yoshimitsu Yamasaki
Diabetes 2005 54: 1009 -1022. [Abstract] [Full Text] [PDF]

Adipocyte-Specific Glucocorticoid Inactivation Protects Against Diet-Induced Obesity: Erin E. Kershaw, Nicholas M. Morton, Harveen Dhillon, Lynne Ramage, Jonathan R. Seckl, and Jeffrey S. Flier
Diabetes 2005 54: 1023 -1031. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Reversal of Diabetes in Pancreatectomized Pigs After Transplantation of Neonatal Porcine Islets: Tatsuya Kin, Gregory S. Korbutt, Tsunehiro Kobayashi, Jannette M. Dufour, and Ray V. Rajotte
Diabetes 2005 54: 1032 -1039. [Abstract] [Full Text] [PDF]

In Vivo Control of Diabetogenic T-Cells by Regulatory CD4⁺CD25⁺ T-Cells Expressing Foxp3: Dorthe Lundsgaard, Thomas Lindebo Holm, Lars Hornum, and Helle Markholst
Diabetes 2005 54: 1040 -1047. [Abstract] [Full Text] [PDF]

Achieving Permanent Survival of Islet Xenografts by Independent Manipulation of Direct and Indirect T-Cell Responses: Vincenzo Mirenda, Dela Golshayan, Joseph Read, Ivan Berton, Anthony N. Warrens, Anthony Dorling, and Robert I. Lechler
Diabetes 2005 54: 1048 -1055. [Abstract] [Full Text] [PDF]

Islet Studies:

Distinct Effects of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 on Insulin Secretion and Gut Motility: Takashi Miki, Kohtaro Minami, Hidehiro Shinozaki, Kimio Matsumura, Atsunori Saraya, Hiroki Ikeda, Yuichiro Yamada, Jens Juul Holst, and Susumu Seino
Diabetes 2005 54: 1056 -1063. [Abstract] [Full Text] [PDF]

Neuronatin, a Downstream Target of BETA2/NeuroD1 in the Pancreas, Is Involved in Glucose-Mediated Insulin Secretion: Khoi Chu and Ming-Jer Tsai
Diabetes 2005 54: 1064 -1073. [Abstract] [Full Text] [PDF]

Pancreatic ß-Cell Failure and Diabetes in Mice With a Deletion Mutation of the Endoplasmic Reticulum Molecular Chaperone Gene P58^IPK: Warren C. Ladiges, Sue E. Knoblaugh, John F. Morton, Marcus J. Korth, Bryce L. Sopher, Carole R. Baskin, Alasdair MacAuley, Alan G. Goodman, Renee C. LeBoeuf, and Michael G. Katze
Diabetes 2005 54: 1074 -1081. [Abstract] [Full Text] [PDF]

Inducible Nitric Oxide Synthase Has Divergent Effects on Vascular and Metabolic Function in Obesity: Brian T. Noronha, Jian-Mei Li, Stephen B. Wheatcroft, Ajay M. Shah, and Mark T. Kearney
Diabetes 2005 54: 1082 -1089. [Abstract] [Full Text] [PDF]

Serum- and Glucocorticoid-Inducible Kinase 1 (SGK1) Mediates Glucocorticoid-Induced Inhibition of Insulin Secretion: Susanne Ullrich, Susanne Berchtold, Felicia Ranta, Guiscard Seebohm, Guido Henke, Adrian Lupescu, Andreas F. Mack, Cho-Ming Chao, Jiping Su, Roland Nitschke, Dorothea Alexander, Björn Friedrich, Peer Wulff, Dietmar Kuhl, and Florian Lang
Diabetes 2005 54: 1090 -1099. [Abstract] [Full Text] [PDF]

Pathophysiology:

The Role of Amylin and Glucagon in the Dampening of Glycemic Excursions in Children With Type 1 Diabetes: Rubina A. Heptulla, Luisa M. Rodriguez, Lisa Bomgaars, and Morey W. Haymond
Diabetes 2005 54: 1100 -1107. [Abstract] [Full Text] [PDF]

Skeletal Muscle Lipid Accumulation in Type 2 Diabetes May Involve the Liver X Receptor Pathway: Eili T. Kase, Andreas J. Wensaas, Vigdis Aas, Kurt Højlund, Klaus Levin, G. Hege Thoresen, Henning Beck-Nielsen, Arild C. Rustan, and Michael Gaster
Diabetes 2005 54: 1108 -1115. [Abstract] [Full Text] [PDF]

Complications:

Loss of Heparan N-Sulfotransferase in Diabetic Liver: Role of Angiotensin II: Kevin Jon Williams, Ming-Lin Liu, Yanqing Zhu, Xiangsheng Xu, William R. Davidson, Peter McCue, and Kumar Sharma
Diabetes 2005 54: 1116 -1122. [Abstract] [Full Text] [PDF]

Metformin Prevents Glucose-Induced Protein Kinase C-ß2 Activation in Human Umbilical Vein Endothelial Cells Through an Antioxidant Mechanism: Alessandra Gallo, Giulio Ceolotto, Paolo Pinton, Elisabetta Iori, Ellen Murphy, Guy A. Rutter, Rosario Rizzuto, Andrea Semplicini, and Angelo Avogaro
Diabetes 2005 54: 1123 -1131. [Abstract] [Full Text] [PDF]

The Calcium-Dependent Protease Calpain Causes Endothelial Dysfunction in Type 2 Diabetes: Timothy J. Stalker, Yulan Gong, and Rosario Scalia
Diabetes 2005 54: 1132 -1140. [Abstract] [Full Text] [PDF]

Nonhuman Primate Models for Diabetic Ocular Neovascularization Using AAV2-Mediated Overexpression of Vascular Endothelial Growth Factor: Corinna Lebherz, Albert M. Maguire, Alberto Auricchio, Waixing Tang, Tomas S. Aleman, Zhangyong Wei, Rebecca Grant, Artur V. Cideciyan, Samuel G. Jacobson, James M. Wilson, and Jean Bennett
Diabetes 2005 54: 1141 -1149. [Abstract] [Full Text] [PDF]

Pharmacology & Therapeutics:

Prevention of Type 2 Diabetes With Troglitazone in the Diabetes Prevention Program: The Diabetes Prevention Program Research Group*
Diabetes 2005 54: 1150 -1156. [Abstract] [Full Text] [PDF]

Direct Activation of Glucose Transport in Primary Human Myotubes After Activation of Peroxisome Proliferator–Activated Receptor ${delta}$: David Kitz Krämer, Lubna Al-Khalili, Sebastio Perrini, Josefin Skogsberg, Per Wretenberg, Katja Kannisto, Harriet Wallberg-Henriksson, Ewa Ehrenborg, Juleen R. Zierath, and Anna Krook
Diabetes 2005 54: 1157 -1163. [Abstract] [Full Text] [PDF]

Inhalation of Insulin (Exubera) Is Associated With Augmented Disposal of Portally Infused Glucose in Dogs: Dale S. Edgerton, Doss W. Neal, Melanie Scott, Larry Bowen, Warren Wilson, Charles H. Hobbs, Chet Leach, Shantha Sivakumaran, Thomas R. Strack, and Alan D. Cherrington
Diabetes 2005 54: 1164 -1170. [Abstract] [Full Text] [PDF]

Genetics:

Genetic Variations in the Gene Encoding ELMO1 Are Associated With Susceptibility to Diabetic Nephropathy: Atsuyuki Shimazaki, Yoshihiro Kawamura, Akio Kanazawa, Akihiro Sekine, Susumu Saito, Tatsuhiko Tsunoda, Daisuke Koya, Tetsuya Babazono, Yasushi Tanaka, Masafumi Matsuda, Koichi Kawai, Tomohiro Iiizumi, Masahito Imanishi, Toshihiro Shinosaki, Toru Yanagimoto, Minoru Ikeda, Shigeki Omachi, Atsunori Kashiwagi, Kohei Kaku, Yasuhiko Iwamoto, Ryuzou Kawamori, Ryuichi Kikkawa, Masatoshi Nakajima, Yusuke Nakamura, and Shiro Maeda
Diabetes 2005 54: 1171 -1178. [Abstract] [Full Text] [PDF] Appendix

The Exon 1 Cys7Gly Polymorphism Within the Betacellulin Gene Is Associated With Type 2 Diabetes in African Americans: Kristi Silver, Magdalena Tolea, Jian Wang, Toni I. Pollin, Flora Yao, and Braxton D. Mitchell
Diabetes 2005 54: 1179 -1184. [Abstract] [Full Text] [PDF] Appendix

Genetic Analysis of HNF4A Polymorphisms in Caucasian-American Type 2 Diabetes: Allison M. Bagwell, Jennifer L. Bento, Josyf C. Mychaleckyj, Barry I. Freedman, Carl D. Langefeld, and Donald W. Bowden
Diabetes 2005 54: 1185 -1190. [Abstract] [Full Text] [PDF] Appendix

Ultrafine Mapping of SNPs From Mouse Strains C57BL/6J, DBA/2J, and C57BLKS/J for Loci Contributing to Diabetes and Atherosclerosis Susceptibility: Richard C. Davis, Eric E. Schadt, Alessandra C.L. Cervino, Miklós Péterfy, and Aldons J. Lusis
Diabetes 2005 54: 1191 -1199. [Abstract] [Full Text] [PDF] Appendix

An Autosomal Genome-wide Scan for Loci Linked to Pre-Diabetic Phenotypes in Nondiabetic Chinese Subjects From the Stanford Asia-Pacific Program of Hypertension and Insulin Resistance Family Study: Yen-Feng Chiu, Lee-Ming Chuang, Chin-Fu Hsiao, Yi-Jen Hung, Ming-Wei Lin, Ying-Tsung Chen, John Grove, Eric Jorgenson, Thomas Quertermous, Neil Risch, and Chao A. Hsiung
Diabetes 2005 54: 1200 -1206. [Abstract] [Full Text] [PDF]

ENPP1/PC-1 K121Q Polymorphism and Genetic Susceptibility to Type 2 Diabetes: Nicola Abate, Manisha Chandalia, Pankaj Satija, Beverley Adams-Huet, Scott M. Grundy, Sreedharan Sandeep, Venkatesan Radha, Raj Deepa, and Viswanathan Mohan
Diabetes 2005 54: 1207 -1213. [Abstract] [Full Text] [PDF]

A Single Nucleotide Polymorphism in MGEA5 Encoding O-GlcNAc–selective N-Acetyl-ß-D Glucosaminidase Is Associated With Type 2 Diabetes in Mexican Americans: Donna M. Lehman, Dong-Jing Fu, Angela B. Freeman, Kelly J. Hunt, Robin J. Leach, Teresa Johnson-Pais, Jeanette Hamlington, Thomas D. Dyer, Rector Arya, Hanna Abboud, Harald H.H. Göring, Ravindranath Duggirala, John Blangero, Robert J. Konrad, and Michael P. Stern
Diabetes 2005 54: 1214 -1221. [Abstract] [Full Text] [PDF] Appendix

Variation in the Gene for Muscle-Specific AMP Deaminase Is Associated With Insulin Clearance, a Highly Heritable Trait: Mark O. Goodarzi, Kent D. Taylor, Xiuqing Guo, Manuel J. Quiñones, Jinrui Cui, Xiaohui Li, Tieu Hang, Huiying Yang, Edward Holmes, Willa A. Hsueh, Jerrold Olefsky, and Jerome I. Rotter
Diabetes 2005 54: 1222 -1227. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

Association of the Diabetes Gene Calpain-10 With Subclinical Atherosclerosis: The Mexican-American Coronary Artery Disease Study: Mark O. Goodarzi, Kent D. Taylor, Xiuqing Guo, Manuel J. Quiñones, Jinrui Cui, Yanjie Li, Mohammad F. Saad, Huiying Yang, Willa A. Hsueh, Howard N. Hodis, and Jerome I. Rotter
Diabetes 2005 54: 1228 -1232. [Abstract] [Full Text] [PDF]

The Rat Diabetes Susceptibility Locus Iddm4 and at Least One Additional Gene Are Required for Autoimmune Diabetes Induced by Viral Infection: Elizabeth P. Blankenhorn, Lucy Rodemich, Cristina Martin-Fernandez, Jean Leif, Dale L. Greiner, and John P. Mordes
Diabetes 2005 54: 1233 -1237. [Abstract] [Full Text] [PDF] Appendix

Genetic Variation at the ACE Gene Is Associated With Persistent Microalbuminuria and Severe Nephropathy in Type 1 Diabetes: The DCCT/EDIC Genetics Study: Andrew P. Boright, Andrew D. Paterson, Lucia Mirea, Shelley B. Bull, Alireza Mowjoodi, Stephen W. Scherer, Bernard Zinman and the DCCT/EDIC Research Group
Diabetes 2005 54: 1238 -1244. [Abstract] [Full Text] [PDF] Appendix

Is Puberty an Accelerator of Type 1 Diabetes in IL6-174CC Females?: Kathleen M. Gillespie, Runa Nolsøe, Virginie M. Betin, Ole P. Kristiansen, Polly J. Bingley, Thomas Mandrup-Poulsen, and Edwin A.M. Gale
Diabetes 2005 54: 1245 -1248. [Abstract] [Full Text] [PDF]

Errata:

Errata: Diabetes 2005 54: 1249 . [Extract] [Full Text] [PDF]