Diabetes -- Table of Contents (May 2005, 54 [5])

OSA Lecture 2004:

Thirty Years of Investigating the Autoimmune Basis for Type 1 Diabetes: Why Can’t We Prevent or Reverse This Disease?: Mark A. Atkinson
Diabetes 2005 54: 1253 -1263. [Abstract] [Full Text] [PDF]

Perspectives in Diabetes:

Insulin Signaling in the Central Nervous System: A Critical Role in Metabolic Homeostasis and Disease From C. elegans to Humans: Daniel Porte, Jr., Denis G. Baskin, and Michael W. Schwartz
Diabetes 2005 54: 1264 -1276. [Abstract] [Full Text] [PDF]

Metabolism:

Glycogen Synthesis in Human Gastrocnemius Muscle Is Not Representative of Whole-Body Muscle Glycogen Synthesis: Mireille J.M. Serlie, Jacco H. de Haan, Cees J. Tack, Hein J. Verberne, Mariette T. Ackermans, Arend Heerschap, and Hans P. Sauerwein
Diabetes 2005 54: 1277 -1282. [Abstract] [Full Text] [PDF]

Proteome Analysis of Skeletal Muscle From Obese and Morbidly Obese Women: Dustin S. Hittel, Yetrib Hathout, Eric P. Hoffman, and Joseph A. Houmard
Diabetes 2005 54: 1283 -1288. [Abstract] [Full Text] [PDF]

Impact of Genetic Versus Environmental Factors on the Control of Muscle Glycogen Synthase Activation in Twins: Pernille Poulsen, Jørgen F.P. Wojtaszewski, Inge Petersen, Kaare Christensen, Erik A. Richter, Henning Beck-Nielsen, and Allan Vaag
Diabetes 2005 54: 1289 -1296. [Abstract] [Full Text] [PDF]

Oscillations of Fatty Acid and Glycerol Release From Human Subcutaneous Adipose Tissue In Vivo: Fredrik Karpe, Barbara A. Fielding, Simon W. Coppack, Victor J. Lawrence, Ian A. Macdonald, and Keith N. Frayn
Diabetes 2005 54: 1297 -1303. [Abstract] [Full Text] [PDF]

Signal Transduction:

Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity in Male Wistar Rats: Hiroaki Satoh, M.T. Audrey Nguyen, Maria Trujillo, Takeshi Imamura, Isao Usui, Philipp E. Scherer, and Jerrold M. Olefsky
Diabetes 2005 54: 1304 -1313. [Abstract] [Full Text] [PDF]

Effects of Diet and Genetic Background on Sterol Regulatory Element-Binding Protein-1c, Stearoyl-CoA Desaturase 1, and the Development of the Metabolic Syndrome: Sudha B. Biddinger, Katrine Almind, Makoto Miyazaki, Efi Kokkotou, James M. Ntambi, and C. Ronald Kahn
Diabetes 2005 54: 1314 -1323. [Abstract] [Full Text] [PDF] Appendix

Parasympathetic Innervation and Function of Endocrine Pancreas Requires the Glial Cell Line–Derived Factor Family Receptor ${alpha}$ 2 (GFR ${alpha}$ 2): Jari Rossi, Paavo Santamäki, Matti S. Airaksinen, and Karl-Heinz Herzig
Diabetes 2005 54: 1324 -1330. [Abstract] [Full Text] [PDF] Appendix

Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver: Marc Foretz, Nicolas Ancellin, Fabrizio Andreelli, Yannick Saintillan, Pascal Grondin, Axel Kahn, Bernard Thorens, Sophie Vaulont, and Benoît Viollet
Diabetes 2005 54: 1331 -1339. [Abstract] [Full Text] [PDF] Online-Only Appendix

A Role for iNOS in Fasting Hyperglycemia and Impaired Insulin Signaling in the Liver of Obese Diabetic Mice: Masaki Fujimoto, Nobuyuki Shimizu, Kaiko Kunii, J.A. Jeevendra Martyn, Kohjiro Ueki, and Masao Kaneki
Diabetes 2005 54: 1340 -1348. [Abstract] [Full Text] [PDF] Online-Only Appendix

Akt2 Is Essential for the Full Effect of Calorie Restriction on Insulin-Stimulated Glucose Uptake in Skeletal Muscle: Carrie E. McCurdy and Gregory D. Cartee
Diabetes 2005 54: 1349 -1356. [Abstract] [Full Text] [PDF]

Essential Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor II in Insulin Secretion and Insulin Sensitivity Revealed by Conditional Gene Knockout: Pascale Bardoux, Pili Zhang, Daisy Flamez, Anaïs Perilhou, Tiphaine Aguirre Lavin, Jean-François Tanti, Karine Hellemans, Emmanuel Gomas, Cécile Godard, Fabrizio Andreelli, Maria Antonietta Buccheri, Axel Kahn, Yannick Le Marchand-Brustel, Rémy Burcelin, Frans Schuit, and Mireille Vasseur-Cognet
Diabetes 2005 54: 1357 -1363. [Abstract] [Full Text] [PDF]

Obesity Studies:

The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans: Ruth Andrew, Jukka Westerbacka, John Wahren, Hannele Yki-Järvinen, and Brian R. Walker
Diabetes 2005 54: 1364 -1370. [Abstract] [Full Text] [PDF]

Differential Association of Basal and Postprandial Plasma Ghrelin With Leptin, Insulin, and Type 2 Diabetes: Johannes Erdmann, Florian Lippl, Stefan Wagenpfeil, and Volker Schusdziarra
Diabetes 2005 54: 1371 -1378. [Abstract] [Full Text] [PDF]

Rosiglitazone Increases Indexes of Stearoyl-CoA Desaturase Activity in Humans: Link to Insulin Sensitization and the Role of Dominant-Negative Mutation in Peroxisome Proliferator-Activated Receptor- ${gamma}$: Ulf Risérus, Garry D. Tan, Barbara A. Fielding, Matt J. Neville, Jenny Currie, David B. Savage, V. Krishna Chatterjee, Keith N. Frayn, Stephen O’Rahilly, and Fredrik Karpe
Diabetes 2005 54: 1379 -1384. [Abstract] [Full Text] [PDF]

Uncoupling Protein 1 Is Necessary for Norepinephrine-Induced Glucose Utilization in Brown Adipose Tissue: Ken-ichi Inokuma, Yuko Ogura-Okamatsu, Chitoku Toda, Kazuhiro Kimura, Hitoshi Yamashita, and Masayuki Saito
Diabetes 2005 54: 1385 -1391. [Abstract] [Full Text] [PDF]

Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo: Iwona Bogacka, Hui Xie, George A. Bray, and Steven R. Smith
Diabetes 2005 54: 1392 -1399. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Donor Treatment With Carbon Monoxide Can Yield Islet Allograft Survival and Tolerance: Hongjun Wang, Soo Sun Lee, Wenda Gao, Eva Czismadia, James McDaid, Robert Öllinger, Miguel P. Soares, Kenichiro Yamashita, and Fritz H. Bach
Diabetes 2005 54: 1400 -1406. [Abstract] [Full Text] [PDF]

Functional Defects and the Influence of Age on the Frequency of CD4⁺CD25⁺ T-Cells in Type 1 Diabetes: Todd M. Brusko, Clive H. Wasserfall, Michael J. Clare-Salzler, Desmond A. Schatz, and Mark A. Atkinson
Diabetes 2005 54: 1407 -1414. [Abstract] [Full Text] [PDF]

Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells: Sylvaine You, Mériam Belghith, Stephen Cobbold, Marie-Alexandra Alyanakian, Christine Gouarin, Samia Barriot, Corinne Garcia, Herman Waldmann, Jean-François Bach, and Lucienne Chatenoud
Diabetes 2005 54: 1415 -1422. [Abstract] [Full Text] [PDF]

Tumor Suppressor p53 Inhibits Autoimmune Inflammation and Macrophage Function: Shi-Jun Zheng, Salah-Eddine Lamhamedi-Cherradi, Pu Wang, Lingyun Xu, and Youhai H. Chen
Diabetes 2005 54: 1423 -1428. [Abstract] [Full Text] [PDF]

Islet Studies:

Sphingosine Kinase Activity and Sphingosine-1 Phosphate Production in Rat Pancreatic Islets and INS-1 Cells: Response to Cytokines: Lucy D. Mastrandrea, Shawn M. Sessanna, and Suzanne G. Laychock
Diabetes 2005 54: 1429 -1436. [Abstract] [Full Text] [PDF]

MnSOD and Catalase Transgenes Demonstrate That Protection of Islets From Oxidative Stress Does Not Alter Cytokine Toxicity: Hainan Chen, Xiaoyan Li, and Paul N. Epstein
Diabetes 2005 54: 1437 -1446. [Abstract] [Full Text] [PDF]

Pathophysiology:

Insulin Signaling in the Central Nervous System Is Critical for the Normal Sympathoadrenal Response to Hypoglycemia: Simon J. Fisher, Jens C. Brüning, Scott Lannon, and C. Ronald Kahn
Diabetes 2005 54: 1447 -1451. [Abstract] [Full Text] [PDF]

Pyruvate Administered After Severe Hypoglycemia Reduces Neuronal Death and Cognitive Impairment: Sang Won Suh, Koji Aoyama, Yasuhiko Matsumori, Jialing Liu, and Raymond A. Swanson
Diabetes 2005 54: 1452 -1458. [Abstract] [Full Text] [PDF]

Effects of Metformin and Rosiglitazone Treatment on Insulin Signaling and Glucose Uptake in Patients With Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Study: Håkan K.R. Karlsson, Kirsti Hällsten, Marie Björnholm, Hiroki Tsuchida, Alexander V. Chibalin, Kirsi A. Virtanen, Olli J. Heinonen, Fredrik Lönnqvist, Pirjo Nuutila, and Juleen R. Zierath
Diabetes 2005 54: 1459 -1467. [Abstract] [Full Text] [PDF]

Demonstration of a Hyperglycemia-Driven Pathogenic Abnormality of Copper Homeostasis in Diabetes and Its Reversibility by Selective Chelation: Quantitative Comparisons Between the Biology of Copper and Eight Other Nutritionally Essential Elements in Normal and Diabetic Individuals: Garth J.S. Cooper, Yih-Kai Chan, Ajith M. Dissanayake, Fiona E. Leahy, Geraldine F. Keogh, Chris M. Frampton, Gregory D. Gamble, Dianne H. Brunton, John R. Baker, and Sally D. Poppitt
Diabetes 2005 54: 1468 -1476. [Abstract] [Full Text] [PDF]

Complications:

G(–) Anaerobes–Reactive CD4⁺ T-Cells Trigger RANKL-Mediated Enhanced Alveolar Bone Loss in Diabetic NOD Mice: Deeqa A. Mahamed, Annette Marleau, Mawadda Alnaeeli, Bhagirath Singh, Xiaoxia Zhang, Joseph M. Penninger, and Yen-Tung A. Teng
Diabetes 2005 54: 1477 -1486. [Abstract] [Full Text] [PDF]

Nonproteinuric Diabetes-Associated Nephropathy in the Cohen Rat Model of Type 2 Diabetes: Chana Yagil, Adiel Barak, David Ben-Dor, Eliezer Rosenmann, Joel Bernheim, Mordechai Rosner, Yael Segev, Sarah Weksler-Zangen, Itamar Raz, and Yoram Yagil
Diabetes 2005 54: 1487 -1496. [Abstract] [Full Text] [PDF]

The Effect of C-Peptide on Cognitive Dysfunction and Hippocampal Apoptosis in Type 1 Diabetic Rats: Anders A.F. Sima and Zhen-guo Li
Diabetes 2005 54: 1497 -1505. [Abstract] [Full Text] [PDF]

Linoleic Acid Increases Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Expression in Human Aortic Endothelial Cells: Fritz Maingrette and Geneviève Renier
Diabetes 2005 54: 1506 -1513. [Abstract] [Full Text] [PDF]

Low-Dose Poly(ADP-Ribose) Polymerase Inhibitor-Containing Combination Therapies Reverse Early Peripheral Diabetic Neuropathy: Fei Li, Viktor R. Drel, Csaba Szabó, Martin J. Stevens, and Irina G. Obrosova
Diabetes 2005 54: 1514 -1522. [Abstract] [Full Text] [PDF]

Mannose-Binding Lectin as a Predictor of Microalbuminuria in Type 1 Diabetes: An Inception Cohort Study: Peter Hovind, Troels Krarup Hansen, Lise Tarnow, Steffen Thiel, Rudi Steffensen, Allan Flyvbjerg, and Hans-Henrik Parving
Diabetes 2005 54: 1523 -1527. [Abstract] [Full Text] [PDF]

Reduced Insulin and IGF-I Signaling, not Hyperglycemia, Underlies the Diabetes-Associated Depletion of Interstitial Cells of Cajal in the Murine Stomach: Viktor J. Horváth, Harsha Vittal, and Tamás Ördög
Diabetes 2005 54: 1528 -1533. [Abstract] [Full Text] [PDF]

Neutrophils Are Associated With Capillary Closure in Spontaneously Diabetic Monkey Retinas: Sahng Y. Kim, Mary A. Johnson, D. Scott McLeod, Theresa Alexander, Barbara C. Hansen, and Gerard A. Lutty
Diabetes 2005 54: 1534 -1542. [Abstract] [Full Text] [PDF]

Wound Inflammation in Diabetic ob/ob Mice: Functional Coupling of Prostaglandin Biosynthesis to Cyclooxygenase-1 Activity in Diabetes-Impaired Wound Healing: Heiko Kämpfer, Ronald Schmidt, Gerd Geisslinger, Josef Pfeilschifter, and Stefan Frank
Diabetes 2005 54: 1543 -1551. [Abstract] [Full Text] [PDF]

Pharmacology and Therapeutics:

Inhibitory Effects of Antipsychotics on Carbachol-Enhanced Insulin Secretion From Perifused Rat Islets: Role of Muscarinic Antagonism in Antipsychotic-Induced Diabetes and Hyperglycemia: David E. Johnson, Hanae Yamazaki, Karen M. Ward, Anne W. Schmidt, Wesley S. Lebel, Judith L. Treadway, E. Michael Gibbs, Walter S. Zawalich, and Hans Rollema
Diabetes 2005 54: 1552 -1558. [Abstract] [Full Text] [PDF]

Minocycline Reduces Proinflammatory Cytokine Expression, Microglial Activation, and Caspase-3 Activation in a Rodent Model of Diabetic Retinopathy: J. Kyle Krady, Anirban Basu, Colleen M. Allen, Yuping Xu, Kathryn F. LaNoue, Thomas W. Gardner, and Steven W. Levison
Diabetes 2005 54: 1559 -1565. [Abstract] [Full Text] [PDF]

Intensive Lifestyle Intervention or Metformin on Inflammation and Coagulation in Participants With Impaired Glucose Tolerance: The Diabetes Prevention Program Research Group
Diabetes 2005 54: 1566 -1572. [Abstract] [Full Text] [PDF]

Kallikrein Gene Delivery Improves Serum Glucose and Lipid Profiles and Cardiac Function in Streptozotocin-Induced Diabetic Rats: David Montanari, Hang Yin, Eric Dobrzynski, Jun Agata, Hideaki Yoshida, Julie Chao, and Lee Chao
Diabetes 2005 54: 1573 -1580. [Abstract] [Full Text] [PDF]

Genetics:

Subcellular Localization of ALMS1 Supports Involvement of Centrosome and Basal Body Dysfunction in the Pathogenesis of Obesity, Insulin Resistance, and Type 2 Diabetes: Tom Hearn, Cosma Spalluto, Victoria J. Phillips, Glenn L. Renforth, Nane Copin, Neil A. Hanley, and David I. Wilson
Diabetes 2005 54: 1581 -1587. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes: L. Leigh Field, Vagn Bonnevie-Nielsen, Flemming Pociot, Shao Lu, Thomas B. Nielsen, and Henning Beck-Nielsen
Diabetes 2005 54: 1588 -1591. [Abstract] [Full Text] [PDF]

Single Nucleotide Polymorphisms in K_ATP Channels: Muscular Impact on Type 2 Diabetes: Li Li, Yun Shi, Xueren Wang, Weiwei Shi, and Chun Jiang
Diabetes 2005 54: 1592 -1597. [Abstract] [Full Text] [PDF] Appendix

Variations in Peptide YY and Y2 Receptor Genes Are Associated With Severe Obesity in Pima Indian Men: Lijun Ma, P. Antonio Tataranni, Robert L. Hanson, Aniello M. Infante, Sayuko Kobes, Clifton Bogardus, and Leslie J. Baier
Diabetes 2005 54: 1598 -1602. [Abstract] [Full Text] [PDF] Online Appendix

Major Histocompatibility Complex–Linked Diabetes Susceptibility in NOD/Lt Mice: Subcongenic Analysis Localizes a Component of Idd16 at the H2-D End of the Diabetogenic H2^g7 Complex: Darcy P. Pomerleau, Rebecca J. Bagley, David V. Serreze, Clayton E. Mathews, and Edward H. Leiter
Diabetes 2005 54: 1603 -1606. [Abstract] [Full Text] [PDF]

The +276 Polymorphism of the APM1 Gene, Plasma Adiponectin Concentration, and Cardiovascular Risk in Diabetic Men: Lu Qi, Tricia Li, Eric Rimm, Cuilin Zhang, Nader Rifai, David Hunter, Alessandro Doria, and Frank B. Hu
Diabetes 2005 54: 1607 -1610. [Abstract] [Full Text] [PDF] Online-Only Appendix