Diabetes -- Table of Contents (June 2005, 54 [6])

Banting Lecture 2004:

The Pathobiology of Diabetic Complications: A Unifying Mechanism: Michael Brownlee
Diabetes 2005 54: 1615 -1625. [Extract] [Full Text] [PDF]

Perspectives in Diabetes:

From the Periphery of the Glomerular Capillary Wall Toward the Center of Disease: Podocyte Injury Comes of Age in Diabetic Nephropathy: Gunter Wolf, Sheldon Chen, and Fuad N. Ziyadeh
Diabetes 2005 54: 1626 -1634. [Abstract] [Full Text] [PDF]

Metabolism:

Continuous Glucose Monitoring in Interstitial Subcutaneous Adipose Tissue and Skeletal Muscle Reflects Excursions in Cerebral Cortex: Jannik Kruse Nielsen, Christian Born Djurhuus, Claus Højbjerg Gravholt, Andreas Christiansen Carus, Jacob Granild-Jensen, Hans Ørskov, and Jens Sandahl Christiansen
Diabetes 2005 54: 1635 -1639. [Abstract] [Full Text] [PDF]

Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling: Renata Belfort, Lawrence Mandarino, Sangeeta Kashyap, Kelly Wirfel, Thongchai Pratipanawatr, Rachele Berria, Ralph A. DeFronzo, and Kenneth Cusi
Diabetes 2005 54: 1640 -1648. [Abstract] [Full Text] [PDF]

Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans: Juris J. Meier, Johannes D. Veldhuis, and Peter C. Butler
Diabetes 2005 54: 1649 -1656. [Abstract] [Full Text] [PDF]

Adipocyte-Specific Overexpression of FOXC2 Prevents Diet-Induced Increases in Intramuscular Fatty Acyl CoA and Insulin Resistance: Jason K. Kim, Hyo-Jeong Kim, So-Young Park, Anna Cederberg, Rickard Westergren, Daniel Nilsson, Takamasa Higashimori, You-Ree Cho, Zhen-Xiang Liu, Jianying Dong, Gary W. Cline, Sven Enerback, and Gerald I. Shulman
Diabetes 2005 54: 1657 -1663. [Abstract] [Full Text] [PDF]

Signal Transduction:

Gene Transfer of Constitutively Active Akt Markedly Improves Human Islet Transplant Outcomes in Diabetic Severe Combined Immunodeficient Mice: Poornima Rao, Jennifer Roccisana, Karen K. Takane, Rita Bottino, Allan Zhao, Massimo Trucco, and Adolfo García-Ocaña
Diabetes 2005 54: 1664 -1675. [Abstract] [Full Text] [PDF]

Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes: Emma M. Allister, Nica M. Borradaile, Jane Y. Edwards, and Murray W. Huff
Diabetes 2005 54: 1676 -1683. [Abstract] [Full Text] [PDF]

Glucose-Stimulated Upregulation of GLUT2 Gene Is Mediated by Sterol Response Element–Binding Protein-1c in the Hepatocytes: Seung-Soon Im, Seung-Youn Kang, So-Youn Kim, Ha-il Kim, Jae-Woo Kim, Kyung-Sup Kim, and Yong-Ho Ahn
Diabetes 2005 54: 1684 -1691. [Abstract] [Full Text] [PDF]

Insulin-Stimulated Phosphorylation of the Akt Substrate AS160 Is Impaired in Skeletal Muscle of Type 2 Diabetic Subjects: Håkan K.R. Karlsson, Juleen R. Zierath, Susan Kane, Anna Krook, Gustav E. Lienhard, and Harriet Wallberg-Henriksson
Diabetes 2005 54: 1692 -1697. [Abstract] [Full Text] [PDF]

Phosphatidylinositol 4,5-Bisphosphate Reverses Endothelin-1–Induced Insulin Resistance via an Actin-Dependent Mechanism: Andrew B. Strawbridge and Jeffrey S. Elmendorf
Diabetes 2005 54: 1698 -1705. [Abstract] [Full Text] [PDF]

Obesity Studies:

The Link Between Nutritional Status and Insulin Sensitivity Is Dependent on the Adipocyte-Specific Peroxisome Proliferator–Activated Receptor- ${gamma}$ 2 Isoform: Gema Medina-Gomez, Sam Virtue, Christopher Lelliott, Romina Boiani, Mark Campbell, Constantinos Christodoulides, Christophe Perrin, Mercedes Jimenez-Linan, Margaret Blount, John Dixon, Dirk Zahn, Rosemary R. Thresher, Sam Aparicio, Mark Carlton, William H. Colledge, Mikko I. Kettunen, Tuulikki Seppänen-Laakso, Jaswinder K. Sethi, Stephen O’Rahilly, Kevin Brindle, Saverio Cinti, Matej Oresic, Remy Burcelin, and Antonio Vidal-Puig
Diabetes 2005 54: 1706 -1716. [Abstract] [Full Text] [PDF] Online-Only Appendix

Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor: Hung-Yun Lin, Qingquan Xu, Shuyuan Yeh, Ruey-Sheng Wang, Janet D. Sparks, and Chawnshang Chang
Diabetes 2005 54: 1717 -1725. [Abstract] [Full Text] [PDF]

A Human-Specific Role of Cell Death-Inducing DFFA (DNA Fragmentation Factor- ${alpha}$ )-Like Effector A (CIDEA) in Adipocyte Lipolysis and Obesity: Elisabet Arvidsson Nordström, Mikael Rydén, Emma C. Backlund, Ingrid Dahlman, Maria Kaaman, Lennart Blomqvist, Barbara Cannon, Jan Nedergaard, and Peter Arner
Diabetes 2005 54: 1726 -1734. [Abstract] [Full Text] [PDF]

ß-Cell Function Across the Spectrum of Glucose Tolerance in Obese Youth: Ram Weiss, Sonia Caprio, Maddalena Trombetta, Sara E. Taksali, William V. Tamborlane, and Riccardo Bonadonna
Diabetes 2005 54: 1735 -1743. [Abstract] [Full Text] [PDF]

C/EBP ${alpha}$ Regulates Human Adiponectin Gene Transcription Through an Intronic Enhancer: Liping Qiao, Paul S. MacLean, Jerome Schaack, David J. Orlicky, Christian Darimont, Michael Pagliassotti, Jacob E. Friedman, and Jianhua Shao
Diabetes 2005 54: 1744 -1754. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Tissue Factor Produced by the Endocrine Cells of the Islets of Langerhans Is Associated With a Negative Outcome of Clinical Islet Transplantation: Helena Johansson, Agneta Lukinius, Lisa Moberg, Torbjörn Lundgren, Christian Berne, Aksel Foss, Marie Felldin, Ragnar Källen, Kaija Salmela, Annika Tibell, Gunnar Tufveson, Kristina Nilsson Ekdahl, Graciela Elgue, Olle Korsgren, and Bo Nilsson
Diabetes 2005 54: 1755 -1762. [Abstract] [Full Text] [PDF]

A Single Course of Anti-CD3 Monoclonal Antibody hOKT3 ${gamma}$ 1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes: Kevan C. Herold, Stephen E. Gitelman, Umesh Masharani, William Hagopian, Brygida Bisikirska, David Donaldson, Kristina Rother, Beverly Diamond, David M. Harlan, and Jeffrey A. Bluestone
Diabetes 2005 54: 1763 -1769. [Abstract] [Full Text] [PDF]

Prevention of Type 1 Diabetes with Major Histocompatibility Complex–Compatible and Nonmarrow Ablative Hematopoietic Stem Cell Transplants: Georg F. Beilhack, Rosa R. Landa, Marilyn A. Masek, and Judith A. Shizuru
Diabetes 2005 54: 1770 -1779. [Abstract] [Full Text] [PDF]

Islet Studies:

Imaging ß-Cell Death With a Near-Infrared Probe: Zdravka Medarova, Susan Bonner-Weir, Myra Lipes, and Anna Moore
Diabetes 2005 54: 1780 -1788. [Abstract] [Full Text] [PDF]

Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic ${alpha}$ -Cells: Magalie A. Ravier and Guy A. Rutter
Diabetes 2005 54: 1789 -1797. [Abstract] [Full Text] [PDF]

Loss of Connexin36 Channels Alters ß-Cell Coupling, Islet Synchronization of Glucose-Induced Ca²⁺ and Insulin Oscillations, and Basal Insulin Release: Magalie A. Ravier, Martin Güldenagel, Anne Charollais, Asllan Gjinovci, Dorothée Caille, Goran Söhl, Claes B. Wollheim, Klaus Willecke, Jean-Claude Henquin, and Paolo Meda
Diabetes 2005 54: 1798 -1807. [Abstract] [Full Text] [PDF]

ß-Cell Secretory Products Activate ${alpha}$ -Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release: Isobel Franklin, Jesper Gromada, Asllan Gjinovci, Sten Theander, and Claes B. Wollheim
Diabetes 2005 54: 1808 -1815. [Abstract] [Full Text] [PDF]

Complications:

Albumin Excretion Rate and Cardiovascular Risk: Could the Association Be Explained by Early Microvascular Dysfunction?: W. David Strain, Nish Chaturvedi, Christopher J. Bulpitt, Chakravarthi Rajkumar, and Angela C. Shore
Diabetes 2005 54: 1816 -1822. [Abstract] [Full Text] [PDF]

Therapeutic Neovascularization Using Cord Blood–Derived Endothelial Progenitor Cells for Diabetic Neuropathy: Keiko Naruse, Yoji Hamada, Eitaro Nakashima, Koichi Kato, Ryuichi Mizubayashi, Hideki Kamiya, Yukio Yuzawa, Seiichi Matsuo, Toyoaki Murohara, Tatsuaki Matsubara, Yutaka Oiso, and Jiro Nakamura
Diabetes 2005 54: 1823 -1828. [Abstract] [Full Text] [PDF]

Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy: Lu Cai, Jianxun Wang, Yan Li, Xuihua Sun, Lipeng Wang, Zhanxiang Zhou, and Y. James Kang
Diabetes 2005 54: 1829 -1837. [Abstract] [Full Text] [PDF]

Palmitate-Induced Apoptosis in Cultured Bovine Retinal Pericytes: Roles of NAD(P)H Oxidase, Oxidant Stress, and Ceramide: Jose M. Cacicedo, Sunun Benjachareowong, Eva Chou, Neil B. Ruderman, and Yasuo Ido
Diabetes 2005 54: 1838 -1845. [Abstract] [Full Text] [PDF]

Pharmacology & Therapeutics:

Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism: Lynnetta M. Watts, Vara Prasad Manchem, Thomas A. Leedom, Amber L. Rivard, Robert A. McKay, Dingjiu Bao, Teri Neroladakis, Brett P. Monia, Diane M. Bodenmiller, Julia Xiao-Chun Cao, Hong Yan Zhang, Amy L. Cox, Steven J. Jacobs, M. Dodson Michael, Kyle W. Sloop, and Sanjay Bhanot
Diabetes 2005 54: 1846 -1853. [Abstract] [Full Text] [PDF]

Genetics:

Pharmacogenetic Analysis of Rosiglitazone-Induced Hepatosteatosis in New Mouse Models of Type 2 Diabetes: Huei-Ju Pan, Peter Reifsnyder, Dennis E. Vance, Qiang Xiao, and Edward H. Leiter
Diabetes 2005 54: 1854 -1862. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

Fine-Mapping Gene-by-Diet Interactions on Chromosome 13 in a LG/J x SM/J Murine Model of Obesity: Thomas H. Ehrich, Tomas Hrbek, Jane P. Kenney-Hunt, L. Susan Pletscher, Bing Wang, Clay F. Semenkovich, and James M. Cheverud
Diabetes 2005 54: 1863 -1872. [Abstract] [Full Text] [PDF] Online-Only Appendix

Type A Insulin Resistance Syndrome Revealing a Novel Lamin A Mutation: Jacques Young, Louise Morbois-Trabut, Béatrice Couzinet, Olivier Lascols, Elisabeth Dion, Véronique Béréziat, Bruno Fève, Isabelle Richard, Jacqueline Capeau, Philippe Chanson, and Corinne Vigouroux
Diabetes 2005 54: 1873 -1878. [Abstract] [Full Text] [PDF] Online-Only Appendix

"Extended" A1, B8, DR3 Haplotype Shows Remarkable Linkage Disequilibrium but Is Similar to Nonextended Haplotypes in Terms of Diabetes Risk: Akane Ide, Sunanda R. Babu, David T. Robles, Tianbao Wang, Henry A. Erlich, Teodorica L. Bugawan, Marian Rewers, Pamela R. Fain, and George S. Eisenbarth
Diabetes 2005 54: 1879 -1883. [Abstract] [Full Text] [PDF]

Association Testing of the Protein Tyrosine Phosphatase 1B Gene (PTPN1) With Type 2 Diabetes in 7,883 People: Jose C. Florez, Christina M. Agapakis, Noël P. Burtt, Maria Sun, Peter Almgren, Lennart Råstam, Tiinamaija Tuomi, Daniel Gaudet, Thomas J. Hudson, Mark J. Daly, Kristin G. Ardlie, Joel N. Hirschhorn, Leif Groop, and David Altshuler
Diabetes 2005 54: 1884 -1891. [Abstract] [Full Text] [PDF] Online-Only Appendix

Evidence that the Mitochondrial Leucyl tRNA Synthetase (LARS2) Gene Represents a Novel Type 2 Diabetes Susceptibility Gene: Leen M. ‘t Hart, Torben Hansen, Ingrid Rietveld, Jacqueline M. Dekker, Giel Nijpels, George M.C. Janssen, Pascal A. Arp, André G. Uitterlinden, Torben Jørgensen, Knut Borch-Johnsen, Huibert A.P. Pols, Oluf Pedersen, Cornelia M. van Duijn, Robert J. Heine, and J. Antonie Maassen
Diabetes 2005 54: 1892 -1895. [Abstract] [Full Text] [PDF] Online-Only Appendix