Diabetes -- Table of Contents (August 2005, 54 [8])

Obesity Studies:

Proopiomelanocortin-Deficient Mice Are Hypersensitive to the Adverse Metabolic Effects of Glucocorticoids: Anthony P. Coll, Benjamin G. Challis, Miguel López, Sarah Piper, Giles S.H. Yeo, and Stephen O’Rahilly
Diabetes 2005 54: 2269 -2276. [Abstract] [Full Text] [PDF]

Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss: Raffaella Cancello, Corneliu Henegar, Nathalie Viguerie, Soraya Taleb, Christine Poitou, Christine Rouault, Muriel Coupaye, Veronique Pelloux, Danielle Hugol, Jean-Luc Bouillot, Anne Bouloumié, Giorgio Barbatelli, Saverio Cinti, Per-Arne Svensson, Gregory S. Barsh, Jean-Daniel Zucker, Arnaud Basdevant, Dominique Langin, and Karine Clément
Diabetes 2005 54: 2277 -2286. [Abstract] [Full Text] [PDF]

ß-Cell Function in Morbidly Obese Subjects During Free Living: Long-Term Effects of Weight Loss: Stefania Camastra, Melania Manco, Andrea Mari, Simona Baldi, Amalia Gastaldelli, Aldo V. Greco, Gertrude Mingrone, and Ele Ferrannini
Diabetes 2005 54: 2382 -2389. [Abstract] [Full Text] [PDF]

Subcutaneous Oxyntomodulin Reduces Body Weight in Overweight and Obese Subjects: A Double-Blind, Randomized, Controlled Trial: Katie Wynne, Adrian J. Park, Caroline J. Small, Michael Patterson, Sandra M. Ellis, Kevin G. Murphy, Alison M. Wren, Gary S. Frost, Karim Meeran, Mohammad A. Ghatei, and Stephen R. Bloom
Diabetes 2005 54: 2390 -2395. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Donor Islet Endothelial Cells Participate in Formation of Functional Vessels Within Pancreatic Islet Grafts: Daniel Nyqvist, Martin Köhler, Helene Wahlstedt, and Per-Olof Berggren
Diabetes 2005 54: 2287 -2293. [Abstract] [Full Text] [PDF] Online-Only Appendix

Disruption of the ${gamma}$ -Interferon Signaling Pathway at the Level of Signal Transducer and Activator of Transcription-1 Prevents Immune Destruction of ß-cells: Conny A. Gysemans, Laurence Ladrière, Hanne Callewaert, Joanne Rasschaert, Daisy Flamez, David E. Levy, Patrick Matthys, Décio L. Eizirik, and Chantal Mathieu
Diabetes 2005 54: 2396 -2403. [Abstract] [Full Text] [PDF]

Islet Studies:

Mechanisms of Compensatory ß-Cell Growth in Insulin-Resistant Rats: Roles of Akt Kinase: Thomas L. Jetton, James Lausier, Kyla LaRock, Winifred E. Trotman, Brooke Larmie, Aida Habibovic, Mina Peshavaria, and Jack L. Leahy
Diabetes 2005 54: 2294 -2304. [Abstract] [Full Text] [PDF]

Pathophysiology:

Expression of CD68 and Macrophage Chemoattractant Protein-1 Genes in Human Adipose and Muscle Tissues: Association With Cytokine Expression, Insulin Resistance, and Reduction by Pioglitazone: Gina B. Di Gregorio, Aiwei Yao-Borengasser, Neda Rasouli, Vijayalakshmi Varma, Tong Lu, Leslie M. Miles, Gouri Ranganathan, Charlotte A. Peterson, Robert E. McGehee, and Philip A. Kern
Diabetes 2005 54: 2305 -2313. [Abstract] [Full Text] [PDF]

Insulin Resistance and Type 2 Diabetes in High-Fat–Fed Mice Are Linked to High Glycotoxin Intake: Oana Sandu, Keying Song, Weijing Cai, Feng Zheng, Jaime Uribarri, and Helen Vlassara
Diabetes 2005 54: 2314 -2319. [Abstract] [Full Text] [PDF]

Role of Insulin Secretion and Sensitivity in the Evolution of Type 2 Diabetes in the Diabetes Prevention Program: Effects of Lifestyle Intervention and Metformin: The Diabetes Prevention Program Research Group
Diabetes 2005 54: 2404 -2414. [Abstract] [Full Text] [PDF]

Complications:

Carnosine as a Protective Factor in Diabetic Nephropathy: Association With a Leucine Repeat of the Carnosinase Gene CNDP1: Bart Janssen, Daniela Hohenadel, Paul Brinkkoetter, Verena Peters, Nina Rind, Christine Fischer, Ivan Rychlik, Marie Cerna, Marianna Romzova, Emile de Heer, Hans Baelde, Stephan J.L. Bakker, Mahmoud Zirie, Eric Rondeau, Peter Mathieson, Moin A. Saleem, Jochen Meyer, Hannes Köppel, Sibylle Sauerhoefer, Claus R. Bartram, Peter Nawroth, Hans-Peter Hammes, Benito A. Yard, Johannes Zschocke, and Fokko J. van der Woude
Diabetes 2005 54: 2320 -2327. [Abstract] [Full Text] [PDF]

Regulation of Renal Lipid Metabolism, Lipid Accumulation, and Glomerulosclerosis in FVB^db/db Mice With Type 2 Diabetes: Zhuowei Wang, Tao Jiang, Jinping Li, Gregory Proctor, James L. McManaman, Scott Lucia, Streamson Chua, and Moshe Levi
Diabetes 2005 54: 2328 -2335. [Abstract] [Full Text] [PDF]

Compromised Arterial Function in Human Type 2 Diabetic Patients: Elena B. Okon, Ada W.Y. Chung, Pooja Rauniyar, Eugenia Padilla, Teresa Tejerina, Bruce M. McManus, Honglin Luo, and Cornelis van Breemen
Diabetes 2005 54: 2415 -2423. [Abstract] [Full Text] [PDF]

3,4-Dideoxyglucosone-3-ene Induces Apoptosis in Renal Tubular Epithelial Cells: Pilar Justo, Ana Belén Sanz, Jesús Egido, and Alberto Ortiz
Diabetes 2005 54: 2424 -2429. [Abstract] [Full Text] [PDF]

Platelet Function Profiles in Patients With Type 2 Diabetes and Coronary Artery Disease on Combined Aspirin and Clopidogrel Treatment: Dominick J. Angiolillo, Antonio Fernandez-Ortiz, Esther Bernardo, Celia Ramírez, Manel Sabaté, Pilar Jimenez-Quevedo, Rosana Hernández, Raul Moreno, Javier Escaned, Fernando Alfonso, Camino Bañuelos, Marco A. Costa, Theodore A. Bass, and Carlos Macaya
Diabetes 2005 54: 2430 -2435. [Abstract] [Full Text] [PDF]

Genetics:

Association of Common Variation in the HNF1 ${alpha}$ Gene Region With Risk of Type 2 Diabetes: Wendy Winckler, Noël P. Burtt, Johan Holmkvist, Camilla Cervin, Paul I.W. de Bakker, Maria Sun, Peter Almgren, Tiinamaija Tuomi, Daniel Gaudet, Thomas J. Hudson, Kristin G. Ardlie, Mark J. Daly, Joel N. Hirschhorn, David Altshuler, and Leif Groop
Diabetes 2005 54: 2336 -2342. [Abstract] [Full Text] [PDF]

Metabolism:

Physiological Increases in Uncoupling Protein 3 Augment Fatty Acid Oxidation and Decrease Reactive Oxygen Species Production Without Uncoupling Respiration in Muscle Cells: J. Darcy MacLellan, Martin F. Gerrits, Adrienne Gowing, Peter J.S. Smith, Michael B. Wheeler, and Mary-Ellen Harper
Diabetes 2005 54: 2343 -2350. [Abstract] [Full Text] [PDF]

Signal Transduction:

Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle: Gautam K. Bandyopadhyay, Joseph G. Yu, Jachelle Ofrecio, and Jerold M. Olefsky
Diabetes 2005 54: 2351 -2359. [Abstract] [Full Text] [PDF]

Preconditioning the Diabetic Heart: The Importance of Akt Phosphorylation: Andrew Tsang, Derek J. Hausenloy, Mihaela M. Mocanu, Richard D. Carr, and Derek M. Yellon
Diabetes 2005 54: 2360 -2364. [Abstract] [Full Text] [PDF]

Skeletal Muscle AMP-Activated Protein Kinase Phosphorylation Parallels Metabolic Phenotype in Leptin Transgenic Mice Under Dietary Modification: Tomohiro Tanaka, Shuji Hidaka, Hiroaki Masuzaki, Shintaro Yasue, Yasuhiko Minokoshi, Ken Ebihara, Hideki Chusho, Yoshihiro Ogawa, Taro Toyoda, Kenji Sato, Fumiko Miyanaga, Muneya Fujimoto, Tsutomu Tomita, Toru Kusakabe, Nozomi Kobayashi, Hideki Tanioka, Tatsuya Hayashi, Kiminori Hosoda, Hironobu Yoshimatsu, Toshiie Sakata, and Kazuwa Nakao
Diabetes 2005 54: 2365 -2374. [Abstract] [Full Text] [PDF]

Insulin and Inositol 1,4,5-Trisphosphate Trigger Abnormal Cytosolic Ca²⁺ Transients and Reveal Mitochondrial Ca²⁺ Handling Defects in Cardiomyocytes of ob/ob Mice: Jérémy Fauconnier, Johanna T. Lanner, Shi-Jin Zhang, Pasi Tavi, Joseph D. Bruton, Abram Katz, and Håkan Westerblad
Diabetes 2005 54: 2375 -2381. [Abstract] [Full Text] [PDF]

Pharmacology and Therapeutics:

Chemical Ablation of Gastric Inhibitory Polypeptide Receptor Action by Daily (Pro³)GIP Administration Improves Glucose Tolerance and Ameliorates Insulin Resistance and Abnormalities of Islet Structure in Obesity-Related Diabetes: Victor A. Gault, Nigel Irwin, Brian D. Green, Jane T. McCluskey, Brett Greer, Clifford J. Bailey, Patrick Harriott, Finbarr P.M. O’Harte, and Peter R. Flatt
Diabetes 2005 54: 2436 -2446. [Abstract] [Full Text] [PDF]

Rosiglitazone Reduces Glucose-Stimulated Insulin Secretion Rate and Increases Insulin Clearance in Nondiabetic, Insulin-Resistant Individuals: Sun H. Kim, Fahim Abbasi, James W. Chu, Tracey L. McLaughlin, Cindy Lamendola, Kenneth S. Polonsky, and Gerald M. Reaven
Diabetes 2005 54: 2447 -2452. [Abstract] [Full Text] [PDF]

Glycogen Phosphorylase Inhibition in Type 2 Diabetes Therapy: A Systematic Evaluation of Metabolic and Functional Effects in Rat Skeletal Muscle: David J. Baker, James A. Timmons, and Paul L. Greenhaff
Diabetes 2005 54: 2453 -2459. [Abstract] [Full Text] [PDF] Online-Only Appendix

Therapeutic Roles of Peroxisome Proliferator–Activated Receptor Agonists: Bart Staels and Jean-Charles Fruchart
Diabetes 2005 54: 2460 -2470. [Abstract] [Full Text] [PDF]

Galanin-Like Peptide Rescues Reproductive Function in the Diabetic Rat: Angela G. Stoyanovitch, Marlie A. Johnson, Donald K. Clifton, Robert A. Steiner, and Gregory S. Fraley
Diabetes 2005 54: 2471 -2476. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

A Synonymous Coding Polymorphism in the ${alpha}$ 2-Heremans-Schmid Glycoprotein Gene Is Associated With Type 2 Diabetes in French Caucasians: Afshan Siddiq, Frederic Lepretre, Serge Hercberg, Philippe Froguel, and Fernando Gibson
Diabetes 2005 54: 2477 -2481. [Abstract] [Full Text] [PDF]

Association of Non-HLA Genes With Type 1 Diabetes Autoimmunity: Andrea K. Steck, Teodorica L. Bugawan, Ana Maria Valdes, Lisa M. Emery, Alan Blair, Jill M. Norris, Maria J. Redondo, Sunanda R. Babu, Henry A. Erlich, George S. Eisenbarth, and Marian J. Rewers
Diabetes 2005 54: 2482 -2486. [Abstract] [Full Text] [PDF] Online-Only Appendix

A Large-Scale Association Analysis of Common Variation of the HNF1 ${alpha}$ Gene With Type 2 Diabetes in the U.K. Caucasian Population: Michael N. Weedon, Katharine R. Owen, Beverley Shields, Graham Hitman, Mark Walker, Mark I. McCarthy, Andrew T. Hattersley, and Timothy M. Frayling
Diabetes 2005 54: 2487 -2491. [Abstract] [Full Text] [PDF] Online-Only Appendix

Association Between Common Polymorphisms of the Proopiomelanocortin Gene and Body Fat Distribution: A Family Study: Michelle Baker, Nicole Gaukrodger, Bongani M. Mayosi, Helen Imrie, Martin Farrall, Hugh Watkins, John M.C. Connell, Peter J. Avery, and Bernard Keavney
Diabetes 2005 54: 2492 -2496. [Abstract] [Full Text] [PDF]

Tribute:

Paul Eston Lacy, MD, PhD: R. Paul Robertson
Diabetes 2005 54: 2497 -2498. [Extract] [Full Text] [PDF]

Announcements:

Announcement From ADA's Publications Policy Committee: Diabetes 2005 54: 2499 . [PDF]