Diabetes -- Table of Contents (September 2005, 54 [9])

Perspectives in Diabetes:

Activating Mutations in Kir6.2 and Neonatal Diabetes: New Clinical Syndromes, New Scientific Insights, and New Therapy: Andrew T. Hattersley and Frances M. Ashcroft
Diabetes 2005 54: 2503 -2513. [Abstract] [Full Text] [PDF]

Signal Transduction:

Cardiac-Specific Overexpression of Peroxisome Proliferator–Activated Receptor- ${alpha}$ Causes Insulin Resistance in Heart and Liver: So-Young Park, You-Ree Cho, Brian N. Finck, Hyo-Jeong Kim, Takamasa Higashimori, Eun-Gyoung Hong, Mi-Kyung Lee, Cheryl Danton, Swati Deshmukh, Gary W. Cline, Julie J. Wu, Anton M. Bennett, Beverly Rothermel, April Kalinowski, Kerry S. Russell, Young-Bum Kim, Daniel P. Kelly, and Jason K. Kim
Diabetes 2005 54: 2514 -2524. [Abstract] [Full Text] [PDF]

Acute Bidirectional Manipulation of Muscle Glucose Uptake by In Vivo Electrotransfer of Constructs Targeting Glucose Transporter Genes: Mark E. Cleasby, Jonathan R. Davey, Tracie A. Reinten, Michael W. Graham, David E. James, Edward W. Kraegen, and Gregory J. Cooney
Diabetes 2005 54: 2702 -2711. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: I. Pathophysiological Analysis: Chul-Ho Lee, Peter C. Reifsnyder, Jürgen K. Naggert, Clive Wasserfall, Mark A. Atkinson, Jing Chen, and Edward H. Leiter
Diabetes 2005 54: 2525 -2532. [Abstract] [Full Text] [PDF]

The X-Linked Inhibitor of Apoptosis Protein Enhances Survival of Murine Islet Allografts: Annette Plesner, Peter Liston, Rusung Tan, Robert G. Korneluk, and C. Bruce Verchere
Diabetes 2005 54: 2533 -2540. [Abstract] [Full Text] [PDF]

XIAP Overexpression in Human Islets Prevents Early Posttransplant Apoptosis and Reduces the Islet Mass Needed to Treat Diabetes: Juliet A. Emamaullee, Ray V. Rajotte, Peter Liston, Robert G. Korneluk, Jonathan R.T. Lakey, A.M. James Shapiro, and John F. Elliott
Diabetes 2005 54: 2541 -2548. [Abstract] [Full Text] [PDF]

Interferon- ${alpha}$ as a Mediator of Polyinosinic:Polycytidylic Acid–Induced Type 1 Diabetes: Devasenan Devendra, Jean Jasinski, Evie Melanitou, Maki Nakayama, Marcella Li, Brooke Hensley, Johanna Paronen, Hiroaki Moriyama, Dongmei Miao, George S. Eisenbarth, and Edwin Liu
Diabetes 2005 54: 2549 -2556. [Abstract] [Full Text] [PDF]

LEW.1WR1 Rats Develop Autoimmune Diabetes Spontaneously and in Response to Environmental Perturbation: John P. Mordes, Dennis L. Guberski, Jean H. Leif, Bruce A. Woda, Joan F. Flanagan, Dale L. Greiner, Edward H. Kislauskis, and Rebecca S. Tirabassi
Diabetes 2005 54: 2727 -2733. [Abstract] [Full Text] [PDF] Online-Only Appendix

Islet Studies:

Very Slow Turnover of ß-Cells in Aged Adult Mice: Monica Teta, Simon Y. Long, Lynn M. Wartschow, Matthew M. Rankin, and Jake A. Kushner
Diabetes 2005 54: 2557 -2567. [Abstract] [Full Text] [PDF]

Differentiation of Human Liver-Derived, Insulin-Producing Cells Toward the ß-Cell Phenotype: Michal Zalzman, Leeat Anker-Kitai, and Shimon Efrat
Diabetes 2005 54: 2568 -2575. [Abstract] [Full Text] [PDF]

Essential Role for Membrane Lipid Rafts in Interleukin-1ß–Induced Nitric Oxide Release From Insulin-Secreting Cells: Potential Regulation by Caveolin-1⁺: Rajakrishnan Veluthakal, Irina Chvyrkova, Marie Tannous, Phillip McDonald, Rajesh Amin, Timothy Hadden, Debbie C. Thurmond, Michael J. Quon, and Anjaneyulu Kowluru
Diabetes 2005 54: 2576 -2585. [Abstract] [Full Text] [PDF]

Conditional Expression Demonstrates the Role of the Homeodomain Transcription Factor Pdx1 in Maintenance and Regeneration of ß-Cells in the Adult Pancreas: Andrew M. Holland, L. Jorge Góñez, Gaetano Naselli, Raymond J. MacDonald, and Leonard C. Harrison
Diabetes 2005 54: 2586 -2595. [Abstract] [Full Text] [PDF]

Combination Therapy With Epidermal Growth Factor and Gastrin Increases ß-Cell Mass and Reverses Hyperglycemia in Diabetic NOD Mice: Wilma L. Suarez-Pinzon, Yanhua Yan, Robert Power, Stephen J. Brand, and Alex Rabinovitch
Diabetes 2005 54: 2596 -2601. [Abstract] [Full Text] [PDF]

Exposure to Chronic High Glucose Induces ß-Cell Apoptosis Through Decreased Interaction of Glucokinase With Mitochondria: Downregulation of Glucokinase in Pancreatic ß-Cells: Won-Ho Kim, June Woo Lee, Young Ho Suh, Shin Hee Hong, Joo Sun Choi, Joo Hyun Lim, Ji Hyun Song, Bin Gao, and Myeong Ho Jung
Diabetes 2005 54: 2602 -2611. [Abstract] [Full Text] [PDF]

Matrix Metalloproteinases Contribute to Insulin Insufficiency in Zucker Diabetic Fatty Rats: Yun-Ping Zhou, Azadeh Madjidi, Maria E. Wilson, David A. Nothhelfer, John H. Johnson, John F. Palma, Anthony Schweitzer, Charles Burant, John E. Blume, and Jeffrey D. Johnson
Diabetes 2005 54: 2612 -2619. [Abstract] [Full Text] [PDF]

Glucagon-Like Peptide 1 Regulates Sequential and Compound Exocytosis in Pancreatic Islet ß-Cells: Edwin P. Kwan and Herbert Y. Gaisano
Diabetes 2005 54: 2734 -2743. [Abstract] [Full Text] [PDF] Online-Only Appendix

Transgenic Mouse Overexpressing Syntaxin-1A as a Diabetes Model: Patrick P.L. Lam, Yuk-Man Leung, Laura Sheu, James Ellis, Robert G. Tsushima, Lucy R. Osborne, and Herbert Y. Gaisano
Diabetes 2005 54: 2744 -2754. [Abstract] [Full Text] [PDF]

Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of ß-Cell Differentiation and Secretory Function in the db/db Mouse Model of Diabetes: Cecilie Kjørholt, Mia C. Åkerfeldt, Trevor J. Biden, and D. Ross Laybutt
Diabetes 2005 54: 2755 -2763. [Abstract] [Full Text] [PDF]

Pathophysiology:

Marked Increase in White Adipose Tissue Blood Perfusion in the Type 2 Diabetic GK Rat: Caroline Kampf, Birgitta Bodin, Örjan Källskog, Carina Carlsson, and Leif Jansson
Diabetes 2005 54: 2620 -2627. [Abstract] [Full Text] [PDF] Online-Only Appendix

Experimental Diabetes Attenuates Cerebral Cortical–Evoked Forelimb Motor Responses: April J. Emerick, Michael P. Richards, Gwendolyn L. Kartje, Edward J. Neafsey, and Evan B. Stubbs, Jr.
Diabetes 2005 54: 2764 -2771. [Abstract] [Full Text] [PDF]

Adiponectin Is Lower Among African Americans and Is Independently Related to Insulin Sensitivity in Children and Adolescents: Nikki C. Bush, Betty E. Darnell, Robert A. Oster, Michael I. Goran, and Barbara A. Gower
Diabetes 2005 54: 2772 -2778. [Abstract] [Full Text] [PDF]

Activation of Peripheral Blood CD14⁺ Monocytes Occurs in Diabetes: Christine Cipolletta, Kathryn E. Ryan, Elinor V. Hanna, and Elisabeth R. Trimble
Diabetes 2005 54: 2779 -2786. [Abstract] [Full Text] [PDF]

Complications:

Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy: Zhonghua Qi, Hiroki Fujita, Jianping Jin, Linda S. Davis, Yihan Wang, Agnes B. Fogo, and Matthew D. Breyer
Diabetes 2005 54: 2628 -2637. [Abstract] [Full Text] [PDF]

Type 2 Diabetes Causes Remodeling of Cerebrovasculature via Differential Regulation of Matrix Metalloproteinases and Collagen Synthesis: Role of Endothelin-1: Alex K. Harris, Jim R. Hutchinson, Kamakshi Sachidanandam, Maribeth H. Johnson, Anne M. Dorrance, David W. Stepp, Susan C. Fagan, and Adviye Ergul
Diabetes 2005 54: 2638 -2644. [Abstract] [Full Text] [PDF]

Genetics:

ATP and Sulfonylurea Sensitivity of Mutant ATP-Sensitive K⁺ Channels in Neonatal Diabetes: Implications for Pharmacogenomic Therapy: Joseph C. Koster, Maria S. Remedi, Crystal Dao, and Colin G. Nichols
Diabetes 2005 54: 2645 -2654. [Abstract] [Full Text] [PDF]

Genome-Wide Linkage Analyses of Type 2 Diabetes in Mexican Americans: The San Antonio Family Diabetes/Gallbladder Study: Kelly J. Hunt, Donna M. Lehman, Rector Arya, Sharon Fowler, Robin J. Leach, Harald H.H. Göring, Laura Almasy, John Blangero, Tom D. Dyer, Ravindranath Duggirala, and Michael P. Stern
Diabetes 2005 54: 2655 -2662. [Abstract] [Full Text] [PDF]

Variation in the eNOS Gene Modifies the Association Between Total Energy Expenditure and Glucose Intolerance: Paul W. Franks, Jian’an Luan, Inês Barroso, Søren Brage, Jose Luis Gonzalez Sanchez, Ulf Ekelund, Manuel Serrano Ríos, Alan J. Schafer, Stephen O’Rahilly, and Nicholas J. Wareham
Diabetes 2005 54: 2795 -2801. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

Co-occurrence of Two Partially Inactivating Polymorphisms of MC3R Is Associated With Pediatric-Onset Obesity: Ningping Feng, Sharla F. Young, Greti Aguilera, Elena Puricelli, Diane C. Adler-Wailes, Nancy G. Sebring, and Jack A. Yanovski
Diabetes 2005 54: 2663 -2667. [Abstract] [Full Text] [PDF]

Haptoglobin Polymorphism Predicts 30-Day Mortality and Heart Failure in Patients With Diabetes and Acute Myocardial Infarction: Mahmoud Suleiman, Doron Aronson, Rabea Asleh, Michael R. Kapeliovich, Ariel Roguin, Simcha R. Meisel, Michael Shochat, Abeer Sulieman, Shimon A. Reisner, Walter Markiewicz, Haim Hammerman, Rachel Lotan, Nina S. Levy, and Andrew P. Levy
Diabetes 2005 54: 2802 -2806. [Abstract] [Full Text] [PDF]

The Functional Q84R Polymorphism of Mammalian Tribbles Homolog TRB3 Is Associated With Insulin Resistance and Related Cardiovascular Risk in Caucasians From Italy: Sabrina Prudente, Marta Letizia Hribal, Elisabetta Flex, Federica Turchi, Eleonora Morini, Salvatore De Cosmo, Simonetta Bacci, Vittorio Tassi, Marina Cardellini, Renato Lauro, Giorgio Sesti, Bruno Dallapiccola, and Vincenzo Trischitta
Diabetes 2005 54: 2807 -2811. [Abstract] [Full Text] [PDF] Online-Only Appendix

INS VNTR Class Genotype and Indexes of Body Size and Obesity: Population-Based Studies of 7,999 Middle-Aged Men and Women: Manjinder S. Sandhu, Barbara Heude, Elizabeth H. Young, Robert Luben, Jian’an Luan, Kay-Tee Khaw, John Todd, and Nicholas J. Wareham
Diabetes 2005 54: 2812 -2815. [Abstract] [Full Text] [PDF]

Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations: Robert Hermann, Jussi Mantere, Kati Lipponen, Riitta Veijola, Gyula Soltesz, Timo Otonkoski, Olli Simell, Mikael Knip, and Jorma Ilonen
Diabetes 2005 54: 2816 -2819. [Abstract] [Full Text] [PDF]

Colocalization of Mouse Autoimmune Diabetes Loci Idd21.1 and Idd21.2 With IDDM6 (Human) and Iddm3 (Rat): Jade E. Hollis-Moffatt, Sarah M. Hook, and Tony R. Merriman
Diabetes 2005 54: 2820 -2825. [Abstract] [Full Text] [PDF]

Metabolism:

Spillover of Dietary Fatty Acids and Use of Serum Nonesterified Fatty Acids for the Synthesis of VLDL-Triacylglycerol Under Two Different Feeding Regimens: Brian R. Barrows, Maureen T. Timlin, and Elizabeth J. Parks
Diabetes 2005 54: 2668 -2673. [Abstract] [Full Text] [PDF]

Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased Amino Acid Availability: Frédéric Tremblay, Michael Krebs, Luce Dombrowski, Attila Brehm, Elisabeth Bernroider, Erich Roth, Peter Nowotny, Werner Waldhäusl, André Marette, and Michael Roden
Diabetes 2005 54: 2674 -2684. [Abstract] [Full Text] [PDF]

Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle: Effects of Type 2 Diabetes, Obesity, Weight Loss, and the Regulatory Role of Tumor Necrosis Factor ${alpha}$ and Interleukin-6: Daniel Bach, Deborah Naon, Sara Pich, Francesc X. Soriano, Nathalie Vega, Jennifer Rieusset, Martine Laville, Christelle Guillet, Yves Boirie, Harriet Wallberg-Henriksson, Melania Manco, Menotti Calvani, Marco Castagneto, Manuel Palacín, Geltrude Mingrone, Juleen R. Zierath, Hubert Vidal, and Antonio Zorzano
Diabetes 2005 54: 2685 -2693. [Abstract] [Full Text] [PDF]

Increased Dietary Substrate Delivery Alters Hepatic Fatty Acid Recycling in Healthy Men: Maureen T. Timlin, Brian R. Barrows, and Elizabeth J. Parks
Diabetes 2005 54: 2694 -2701. [Abstract] [Full Text] [PDF]

Obesity Studies:

Changes of Adiponectin Oligomer Composition by Moderate Weight Reduction: Thomas Bobbert, Helmut Rochlitz, Uta Wegewitz, Suzan Akpulat, Knut Mai, Martin O. Weickert, Matthias Möhlig, Andreas F.H. Pfeiffer, and Joachim Spranger
Diabetes 2005 54: 2712 -2719. [Abstract] [Full Text] [PDF]

Increased Fat Mass Compensates for Insulin Resistance in Abdominal Obesity and Type 2 Diabetes: A Positron-Emitting Tomography Study: Kirsi A. Virtanen, Patricia Iozzo, Kirsti Hällsten, Risto Huupponen, Riitta Parkkola, Tuula Janatuinen, Fredrik Lönnqvist, Tapio Viljanen, Tapani Rönnemaa, Peter Lönnroth, Juhani Knuuti, Ele Ferrannini, and Pirjo Nuutila
Diabetes 2005 54: 2720 -2726. [Abstract] [Full Text] [PDF]

Pharmacology & Therapeutics:

Rosiglitazone Improves Myocardial Glucose Uptake in Patients With Type 2 Diabetes and Coronary Artery Disease: A 16-Week Randomized, Double-Blind, Placebo-Controlled Study: Riikka Lautamäki, K.E. Juhani Airaksinen, Marko Seppänen, Jyri Toikka, Matti Luotolahti, Elizabeth Ball, Ronald Borra, Risto Härkönen, Patricia Iozzo, Murray Stewart, Juhani Knuuti, and Pirjo Nuutila
Diabetes 2005 54: 2787 -2794. [Abstract] [Full Text] [PDF]

Errata:

Erratum: Diabetes 2005 54: 2826 . [Extract] [Full Text] [PDF]