Editorial:

Editorial: Toward a Systems Biology of Insulin Secretion and Type 2 Diabetes

Donald F. Steiner, Christian Boitard, Erol Cerasi, Suad Efendic, Jean-Claude Henquin, and Ele Ferrannini
Diabetes 2006 55: S S1 -S4. [Extract] [Full Text] [PDF]  

Introduction:

Control of Metabolism and Growth Through Insulin-Like Peptides in Drosophila

Charles Géminard, Nathalie Arquier, Sophie Layalle, Marc Bourouis, Maija Slaidina, Renald Delanoue, Marianne Bjordal, Mickael Ohanna, May Ma, Julien Colombani, and Pierre Léopold
Diabetes 2006 55: S S5 -S8. [Abstract] [Full Text] [PDF]  

Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction

Katsutaro Morino, Kitt Falk Petersen, and Gerald I. Shulman
Diabetes 2006 55: S S9 -S15. [Abstract] [Full Text] [PDF]  

Section I: The Adipocyte Connection:

Fatty Acid Signaling in the ß-Cell and Insulin Secretion

Christopher J. Nolan, Murthy S.R. Madiraju, Viviane Delghingaro-Augusto, Marie-Line Peyot, and Marc Prentki
Diabetes 2006 55: S S16 -S23. [Abstract] [Full Text] [PDF]  

ß-Cell Lipases and Insulin Secretion

Malin Fex, Stephanie Lucas, Maria Sörhede Winzell, Bo Ahrén, Cecilia Holm, and Hindrik Mulder
Diabetes 2006 55: S S24 -S31. [Abstract] [Full Text] [PDF]  

Adiponectin-Dependent and -Independent Pathways in Insulin-Sensitizing and Antidiabetic Actions of Thiazolidinediones

Naoto Kubota, Toshimasa Yamauchi, Kazuyuki Tobe, and Takashi Kadowaki
Diabetes 2006 55: S S32 -S38. [Extract] [Full Text] [PDF]  

Section II: The Muscle and Liver Connections:

Amino Acid Metabolism, ß-Cell Function, and Diabetes

Philip Newsholme, Lorraine Brennan, and Katrin Bender
Diabetes 2006 55: S S39 -S47. [Abstract] [Full Text] [PDF]  

Interleukin-6 Regulation of AMP-Activated Protein Kinase: Potential Role in the Systemic Response to Exercise and Prevention of the Metabolic Syndrome

Neil B. Ruderman, Charlotte Keller, Ann-Marie Richard, Asish K. Saha, Zhijun Luo, Xiaoqin Xiang, Mercedes Giralt, Vladimir B. Ritov, Elizabeth V. Menshikova, David E. Kelley, Juan Hidalgo, Bente K. Pedersen, and Meghan Kelly
Diabetes 2006 55: S S48 -S54. [Abstract] [Full Text] [PDF]  

Glucokinase Regulatory Network in Pancreatic ß-Cells and Liver

Simone Baltrusch and Markus Tiedge
Diabetes 2006 55: S S55 -S64. [Abstract] [Full Text] [PDF]  

The Inhibitory Effects of Insulin on Hepatic Glucose Production Are Both Direct and Indirect

Jean Girard
Diabetes 2006 55: S S65 -S69. [Abstract] [Full Text] [PDF]  

Section III: The Gastrointestinal Connection:

Glucagon-Like Peptide 1 Secretion by the L-Cell: The View From Within

Gareth E. Lim and Patricia L. Brubaker
Diabetes 2006 55: S S70 -S77. [Abstract] [Full Text] [PDF]  

Signaling Mechanisms Underlying the Release of Glucagon-Like Peptide 1

Frank Reimann, Patrick S. Ward, and Fiona M. Gribble
Diabetes 2006 55: S S78 -S85. [Abstract] [Full Text] [PDF]  

Pancreatic and Extrapancreatic Effects of Gastric Inhibitory Polypeptide

Yuichiro Yamada, Kazumasa Miyawaki, Katsushi Tsukiyama, Norio Harada, Chizumi Yamada, and Yutaka Seino
Diabetes 2006 55: S S86 -S91. [Abstract] [Full Text] [PDF]  

Impact of Gastric Bypass Surgery on Gut Hormones and Glucose Homeostasis in Type 2 Diabetes

Erik Näslund and John G. Kral
Diabetes 2006 55: S S92 -S97. [Abstract] [Full Text] [PDF]  

Neuropeptides and the Regulation of Islet Function

Bo Ahrén, Nils Wierup, and Frank Sundler
Diabetes 2006 55: S S98 -S107. [Abstract] [Full Text] [PDF]  

Distinct Classes of Central GLUT2-Dependent Sensors Control Counterregulation and Feeding

Nell Marty, Isabelle Bady, and Bernard Thorens
Diabetes 2006 55: S S108 -S113. [Abstract] [Full Text] [PDF]  

Section IV: The Brain Connection:

The Brain-Gut-Islet Connection

Stephen C. Woods, Stephen C. Benoit, and Deborah J. Clegg
Diabetes 2006 55: S S114 -S121. [Abstract] [Full Text] [PDF]  

Role of Neuronal Glucosensing in the Regulation of Energy Homeostasis

Barry E. Levin, Ling Kang, Nicole M. Sanders, and Ambrose A. Dunn-Meynell
Diabetes 2006 55: S S122 -S130. [Abstract] [Full Text] [PDF]  

Translocable Glucose Transporters in the Brain: Where Are We in 2006?

Thierry Alquier, Corinne Leloup, Anne Lorsignol, and Luc Pénicaud
Diabetes 2006 55: S S131 -S138. [Abstract] [Full Text] [PDF]  

Fatty Acid Signaling in the Hypothalamus and the Neural Control of Insulin Secretion

Stéphanie Migrenne, Céline Cruciani-Guglielmacci, Ling Kang, Ruokun Wang, Claude Rouch, Anne-Laure Lefèvre, Alain Ktorza, Vanessa H. Routh, Barry E. Levin, and Christophe Magnan
Diabetes 2006 55: S S139 -S144. [Abstract] [Full Text] [PDF]  

Brain Adipocytokine Action and Metabolic Regulation

Rexford S. Ahima, Yong Qi, Neel S. Singhal, Malaka B. Jackson, and Philipp E. Scherer
Diabetes 2006 55: S S145 -S154. [Abstract] [Full Text] [PDF]  

Conclusion:

Central Regulation of Energy Homeostasis: The Key Role of Insulin

Daniel Porte, Jr.
Diabetes 2006 55: S S155 -S160. [Abstract] [Full Text] [PDF]  

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