Diabetes -- Table of Contents (January 2006, 55 [1])

Perspectives in Diabetes:

The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy: Franz M. Matschinsky, Mark A. Magnuson, Dorothy Zelent, Tom L. Jetton, Nicolai Doliba, Yi Han, Rebecca Taub, and Joseph Grimsby
Diabetes 2006 55: 1 -12. [Abstract] [Full Text] [PDF]

New Methodology and Database:

Noninvasive Diagnosis of Focal Hyperinsulinism of Infancy With [¹⁸F]-DOPA Positron Emission Tomography: Timo Otonkoski, Kirsti Näntö-Salonen, Marko Seppänen, Riitta Veijola, Hanna Huopio, Khalid Hussain, Päivi Tapanainen, Olli Eskola, Riitta Parkkola, Klas Ekström, Yves Guiot, Jacques Rahier, Markku Laakso, Risto Rintala, Pirjo Nuutila, and Heikki Minn
Diabetes 2006 55: 13 -18. [Abstract] [Full Text] [PDF]

Obesity Studies:

Y2Y4 Receptor Double Knockout Protects Against Obesity Due to a High-Fat Diet or Y1 Receptor Deficiency in Mice: Amanda Sainsbury, Hugo T. Bergen, Dana Boey, Darja Bamming, Gregory J. Cooney, Shu Lin, Michelle Couzens, Nikolas Stroth, Nicola J. Lee, Diana Lindner, Nicolas Singewald, Tim Karl, Liesl Duffy, Ronaldo Enriquez, Katy Slack, Günther Sperk, and Herbert Herzog
Diabetes 2006 55: 19 -26. [Abstract] [Full Text] [PDF]

Adiponectin Does Not Cross the Blood-Brain Barrier but Modifies Cytokine Expression of Brain Endothelial Cells: Joachim Spranger, Sulekha Verma, Isabel Göhring, Thomas Bobbert, Joseph Seifert, Amy L. Sindler, Andreas Pfeiffer, Stanley M. Hileman, Matthias Tschöp, and William A. Banks
Diabetes 2006 55: 141 -147. [Abstract] [Full Text] [PDF]

Adipose Triglyceride Lipase: Function, Regulation by Insulin, and Comparison With Adiponutrin: Erin E. Kershaw, Jonathan K. Hamm, Linda A.W. Verhagen, Odile Peroni, Masa Katic, and Jeffrey S. Flier
Diabetes 2006 55: 148 -157. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Costimulation Blockade of Both Inducible Costimulator and CD40 Ligand Induces Dominant Tolerance to Islet Allografts and Prevents Spontaneous Autoimmune Diabetes in the NOD Mouse: Sulaiman A. Nanji, Wayne W. Hancock, Bin Luo, Colleen D. Schur, Rena L. Pawlick, Lin Fu Zhu, Colin C. Anderson, and A.M. James Shapiro
Diabetes 2006 55: 27 -33. [Abstract] [Full Text] [PDF]

Natural Killer T-Cells Participate in Rejection of Islet Allografts in the Liver of Mice: Atsushi Toyofuku, Yohichi Yasunami, Kentaroh Nabeyama, Masahiko Nakano, Masayuki Satoh, Nobuhide Matsuoka, Junko Ono, Toshinori Nakayama, Masaru Taniguchi, Masao Tanaka, and Seiyo Ikeda
Diabetes 2006 55: 34 -39. [Abstract] [Full Text] [PDF]

Rapamycin and Interleukin-10 Treatment Induces T Regulatory Type 1 Cells That Mediate Antigen-Specific Transplantation Tolerance: Manuela Battaglia, Angela Stabilini, Elena Draghici, Silvia Gregori, Cristina Mocchetti, Ezio Bonifacio, and Maria-Grazia Roncarolo
Diabetes 2006 55: 40 -49. [Abstract] [Full Text] [PDF]

Coexpression of CD25 and OX40 (CD134) Receptors Delineates Autoreactive T-cells in Type 1 Diabetes: Josef Endl, Silke Rosinger, Barbara Schwarz, Sven-Olaf Friedrich, Gregor Rothe, Wolfram Karges, Michael Schlosser, Thomas Eiermann, Dolores J. Schendel, and Bernhard O. Boehm
Diabetes 2006 55: 50 -60. [Abstract] [Full Text] [PDF]

Interleukin-7 Is a Survival Factor for CD4⁺ CD25⁺ T-Cells and Is Expressed by Diabetes-Suppressive Dendritic Cells: Jo Harnaha, Jennifer Machen, Marietta Wright, Robert Lakomy, Alexis Styche, Massimo Trucco, Sami Makaroun, and Nick Giannoukakis
Diabetes 2006 55: 158 -170. [Abstract] [Full Text] [PDF]

Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis: Chul-Ho Lee, Yi-Guang Chen, Jing Chen, Peter C. Reifsnyder, David V. Serreze, Michael Clare-Salzler, Michelle Rodriguez, Clive Wasserfall, Mark A. Atkinson, and Edward H. Leiter
Diabetes 2006 55: 171 -178. [Abstract] [Full Text] [PDF]

Transforming Growth Factor-ß and Natural Killer T-Cells Are Involved in the Protective Effect of a Bacterial Extract on Type 1 Diabetes: Marie-Alexandra Alyanakian, Françoise Grela, Aude Aumeunier, Carlo Chiavaroli, Christine Gouarin, Emilie Bardel, Gérard Normier, Lucienne Chatenoud, Nathalie Thieblemont, and Jean-François Bach
Diabetes 2006 55: 179 -185. [Abstract] [Full Text] [PDF]

The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4⁺CD25⁺ Regulatory T-Cells: Ute Christine Rogner, Françoise Lepault, Marie-Claude Gagnerault, David Vallois, Joëlle Morin, Philip Avner, and Christian Boitard
Diabetes 2006 55: 186 -192. [Abstract] [Full Text] [PDF]

Islet Studies:

A vHNF1/TCF2-HNF6 Cascade Regulates the Transcription Factor Network That Controls Generation of Pancreatic Precursor Cells: Aurélie V. Poll, Christophe E. Pierreux, Ludmilla Lokmane, Cécile Haumaitre, Younes Achouri, Patrick Jacquemin, Guy G. Rousseau, Silvia Cereghini, and Frédéric P. Lemaigre
Diabetes 2006 55: 61 -69. [Abstract] [Full Text] [PDF]

Evaluation of ß-Cell Replication in Mice Transgenic for Hepatocyte Growth Factor and Placental Lactogen: Comprehensive Characterization of the G₁/S Regulatory Proteins Reveals Unique Involvement of p21^cip: Irene Cozar-Castellano, Matthew Weinstock, Marcia Haught, Silvia Velázquez-Garcia, Darinka Sipula, and Andrew F. Stewart
Diabetes 2006 55: 70 -77. [Abstract] [Full Text] [PDF] Online-Only Appendix

Glibenclamide Treatment Recruits ß-Cell Subpopulation Into Elevated and Sustained Basal Insulin Synthetic Activity: Zhidong Ling, Qidi Wang, Geert Stangé, Peter In’t Veld, and Daniel Pipeleers
Diabetes 2006 55: 78 -85. [Abstract] [Full Text] [PDF]

Leucine Regulation of Glucokinase and ATP Synthase Sensitizes Glucose-Induced Insulin Secretion in Pancreatic ß-Cells: Jichun Yang, Ryan K. Wong, MieJung Park, Jianmei Wu, Joshua R. Cook, David A. York, Shaoping Deng, James Markmann, Ali Naji, Bryan A. Wolf, and Zhiyong Gao
Diabetes 2006 55: 193 -201. [Abstract] [Full Text] [PDF]

Complications:

Effect of Combined Antisense Oligonucleotides Against High-Glucose–and Diabetes-Induced Overexpression of Extracellular Matrix Components and Increased Vascular Permeability: Toshiyuki Oshitari, Peter Polewski, Manish Chadda, An-Fei Li, Tsuyoshi Sato, and Sayon Roy
Diabetes 2006 55: 86 -92. [Abstract] [Full Text] [PDF]

Glucosamine-Induced Endoplasmic Reticulum Dysfunction Is Associated With Accelerated Atherosclerosis in a Hyperglycemic Mouse Model: Geoff H. Werstuck, Mohammad I. Khan, Giuseppe Femia, Anna J. Kim, Vivienne Tedesco, Bernardo Trigatti, and Yuanyuan Shi
Diabetes 2006 55: 93 -101. [Abstract] [Full Text] [PDF] Online-Only Appendix

Nitric Oxide Cytoskeletal–Induced Alterations Reverse the Endothelial Progenitor Cell Migratory Defect Associated With Diabetes: Mark S. Segal, Ronak Shah, Aqeela Afzal, Cecile M. Perrault, Kyunghee Chang, Anna Schuler, Elaine Beem, Lynn C. Shaw, Sergio Li Calzi, Jeffrey K. Harrison, Roger Tran-Son-Tay, and Maria B. Grant
Diabetes 2006 55: 102 -109. [Abstract] [Full Text] [PDF]

The Thromboxane Receptor Antagonist S18886 Attenuates Renal Oxidant Stress and Proteinuria in Diabetic Apolipoprotein E-Deficient Mice: Shanqin Xu, Bingbing Jiang, Karlene A. Maitland, Hossein Bayat, Jiali Gu, Jerry L. Nadler, Stefano Corda, Gilbert Lavielle, Tony J. Verbeuren, Adriana Zuccollo, and Richard A. Cohen
Diabetes 2006 55: 110 -119. [Abstract] [Full Text] [PDF]

Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells: Daisuke Kukidome, Takeshi Nishikawa, Kazuhiro Sonoda, Koujiro Imoto, Kazuo Fujisawa, Miyuki Yano, Hiroyuki Motoshima, Tetsuya Taguchi, Takeshi Matsumura, and Eiichi Araki
Diabetes 2006 55: 120 -127. [Abstract] [Full Text] [PDF]

Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy: Katalin Susztak, Amanda C. Raff, Mario Schiffer, and Erwin P. Böttinger
Diabetes 2006 55: 225 -233. [Abstract] [Full Text] [PDF] Online-Only Appendix

Increased Renal Arterial Resistance Predicts the Course of Renal Function in Type 2 Diabetes With Microalbuminuria: Romano Nosadini, Mario Velussi, Enrico Brocco, Cataldo Abaterusso, Andrea Carraro, Francesco Piarulli, Giuseppe Morgia, Andrea Satta, Rossana Faedda, Avinash Abhyankar, Holgher Luthman, and Giancarlo Tonolo
Diabetes 2006 55: 234 -239. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

High-Density Haplotype Structure and Association Testing of the Insulin-Degrading Enzyme (IDE) Gene With Type 2 Diabetes in 4,206 People: Jose C. Florez, Steven Wiltshire, Christina M. Agapakis, Noël P. Burtt, Paul I.W. de Bakker, Peter Almgren, Kristina Bengtsson Boström, Tiinamaija Tuomi, Daniel Gaudet, Mark J. Daly, Joel N. Hirschhorn, Mark I. McCarthy, David Altshuler, and Leif Groop
Diabetes 2006 55: 128 -135. [Abstract] [Full Text] [PDF] Online-Only Appendix

Variants in the Human Insulin Gene That Affect Pre-mRNA Splicing: Is –23HphI a Functional Single Nucleotide Polymorphism at IDDM2?: Jana Královicová, Tom R. Gaunt, Santiago Rodriguez, Peter J. Wood, Ian N.M. Day, and Igor Vorechovsky
Diabetes 2006 55: 260 -264. [Abstract] [Full Text] [PDF] Online-Only Appendix

Metabolism:

Increased Lipid Availability Impairs Insulin-Stimulated ATP Synthesis in Human Skeletal Muscle: Attila Brehm, Martin Krssak, Albrecht I. Schmid, Peter Nowotny, Werner Waldhäusl, and Michael Roden
Diabetes 2006 55: 136 -140. [Abstract] [Full Text] [PDF]

Pathophysiology:

Effects of Hyperglycemia and Hyperinsulinemia on Circulating Tissue Factor Procoagulant Activity and Platelet CD40 Ligand: Vijender R. Vaidyula, A. Koneti Rao, Maria Mozzoli, Carol Homko, Peter Cheung, and Guenther Boden
Diabetes 2006 55: 202 -208. [Abstract] [Full Text] [PDF]

Phagocytic NADPH Oxidase Overactivity Underlies Oxidative Stress in Metabolic Syndrome: Ana Fortuño, Gorka San José, María U. Moreno, Oscar Beloqui, Javier Díez, and Guillermo Zalba
Diabetes 2006 55: 209 -215. [Abstract] [Full Text] [PDF]

Natural Antibiotics and Insulin Sensitivity: The Role of Bactericidal/Permeability-Increasing Protein: Carme Gubern, Abel López-Bermejo, Josefina Biarnés, Joan Vendrell, Wifredo Ricart, and José Manuel Fernández-Real
Diabetes 2006 55: 216 -224. [Abstract] [Full Text] [PDF]

Pharmacology & Therapeutics:

Muraglitazar, a Novel Dual ( ${alpha}$ / ${gamma}$ ) Peroxisome Proliferator–Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves ß-Cell Function in db/db Mice: Thomas Harrity, Dennis Farrelly, Aaron Tieman, Cuixia Chu, Lori Kunselman, Liqun Gu, Randolph Ponticiello, Michael Cap, Fucheng Qu, Chunning Shao, Wei Wang, Hao Zhang, William Fenderson, Sean Chen, Pratik Devasthale, Yoon Jeon, Ramakrishna Seethala, Wen-Pin Yang, Jimmy Ren, Min Zhou, Denis Ryono, Scott Biller, Kasim A. Mookhtiar, John Wetterau, Richard Gregg, Peter T. Cheng, and Narayanan Hariharan
Diabetes 2006 55: 240 -248. [Abstract] [Full Text] [PDF]

Genetics:

Adiponectin Multimeric Complexes and the Metabolic Syndrome Trait Cluster: Cristina Lara-Castro, Nanlan Luo, Penny Wallace, Richard L. Klein, and W. Timothy Garvey
Diabetes 2006 55: 249 -259. [Abstract] [Full Text] [PDF]

Tribute:

Karl Sussman, MD: Boris Draznin
Diabetes 2006 55: 265 . [Extract] [Full Text] [PDF]