Diabetes -- Table of Contents (October 2006, 55 [10])

Signal Transduction:

Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor ${gamma}$ Function (P465L PPAR ${gamma}$ ) in Mice: Sarah L. Gray, Edoardo Dalla Nora, Johannes Grosse, Monia Manieri, Tobias Stoeger, Gema Medina-Gomez, Keith Burling, Sigrid Wattler, Andreas Russ, Giles S.H. Yeo, V. Krishna Chatterjee, Stephen O’Rahilly, Peter J. Voshol, Saverio Cinti, and Antonio Vidal-Puig
Diabetes 2006 55: 2669 -2677. [Abstract] [Full Text] [PDF] Online-Appendix Only

Bradykinin Augments Insulin-Stimulated Glucose Transport in Rat Adipocytes via Endothelial Nitric Oxide Synthase–Mediated Inhibition of Jun NH₂-Terminal Kinase: Kristin M. Beard, Huogen Lu, Karen Ho, and I. George Fantus
Diabetes 2006 55: 2678 -2687. [Abstract] [Full Text] [PDF]

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase: Andrew L. Carey, Gregory R. Steinberg, S. Lance Macaulay, Walter G. Thomas, Anna G. Holmes, Georg Ramm, Oja Prelovsek, Cordula Hohnen-Behrens, Matthew J. Watt, David E. James, Bruce E. Kemp, Bente K. Pedersen, and Mark A. Febbraio
Diabetes 2006 55: 2688 -2697. [Abstract] [Full Text] [PDF]

Mechanisms of the Depot Specificity of Peroxisome Proliferator–Activated Receptor ${gamma}$ Action on Adipose Tissue Metabolism: Mathieu Laplante, William T. Festuccia, Geneviève Soucy, Yves Gélinas, Josée Lalonde, Joel P. Berger, and Yves Deshaies
Diabetes 2006 55: 2771 -2778. [Abstract] [Full Text] [PDF]

Palmitate-Mediated Downregulation of Peroxisome Proliferator–Activated Receptor- ${gamma}$ Coactivator 1 ${alpha}$ in Skeletal Muscle Cells Involves MEK1/2 and Nuclear Factor- ${kappa}$ B Activation: Teresa Coll, Mireia Jové, Ricardo Rodríguez-Calvo, Elena Eyre, Xavier Palomer, Rosa M. Sánchez, Manuel Merlos, Juan Carlos Laguna, and Manuel Vázquez-Carrera
Diabetes 2006 55: 2779 -2787. [Abstract] [Full Text] [PDF]

Central and Opposing Effects of IGF-I and IGF-Binding Protein-3 on Systemic Insulin Action: Radhika H. Muzumdar, Xiaohui Ma, Sigal Fishman, Xiaoman Yang, Gil Atzmon, Patricia Vuguin, Francine H. Einstein, David Hwang, Pinchas Cohen, and Nir Barzilai
Diabetes 2006 55: 2788 -2796. [Abstract] [Full Text] [PDF]

Rosiglitazone Treatment Enhances Acute AMP-Activated Protein Kinase–Mediated Muscle and Adipose Tissue Glucose Uptake in High-Fat–Fed Rats: Ji-Ming Ye, Nick Dzamko, Andrew J. Hoy, Miguel A. Iglesias, Bruce Kemp, and Edward Kraegen
Diabetes 2006 55: 2797 -2804. [Abstract] [Full Text] [PDF]

Obesity Studies:

Impaired Adipose Tissue Development in Mice With Inactivation of Placental Growth Factor Function: H. Roger Lijnen, Valerie Christiaens, Ilse Scroyen, Gabor Voros, Marc Tjwa, Peter Carmeliet, and Désiré Collen
Diabetes 2006 55: 2698 -2704. [Abstract] [Full Text] [PDF]

Retinol-Binding Protein 4 in Human Obesity: Jürgen Janke, Stefan Engeli, Michael Boschmann, Frauke Adams, Jana Böhnke, Friedrich C. Luft, Arya M. Sharma, and Jens Jordan
Diabetes 2006 55: 2805 -2810. [Abstract] [Full Text] [PDF]

Lipin Expression Is Attenuated in Adipose Tissue of Insulin-Resistant Human Subjects and Increases With Peroxisome Proliferator–Activated Receptor ${gamma}$ Activation: Aiwei Yao-Borengasser, Neda Rasouli, Vijayalakshmi Varma, Leslie M. Miles, Bounleut Phanavanh, Tasha N. Starks, Jack Phan, Horace J. Spencer, III, Robert E. McGehee, Jr., Karen Reue, and Philip A. Kern
Diabetes 2006 55: 2811 -2818. [Abstract] [Full Text] [PDF]

Islet Studies:

STAT5 Activity in Pancreatic ß-Cells Influences the Severity of Diabetes in Animal Models of Type 1 and 2 Diabetes: Malene Jackerott, Annette Møldrup, Peter Thams, Elisabeth D. Galsgaard, Jakob Knudsen, Ying C. Lee, and Jens Høiriis Nielsen
Diabetes 2006 55: 2705 -2712. [Abstract] [Full Text] [PDF]

Low Concentration of Interleukin-1ß Induces FLICE-Inhibitory Protein–Mediated ß-Cell Proliferation in Human Pancreatic Islets: Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier, and Marc Y. Donath
Diabetes 2006 55: 2713 -2722. [Abstract] [Full Text] [PDF]

Impact of Defined Matrix Interactions on Insulin Production by Cultured Human ß-Cells: Effect on Insulin Content, Secretion, and Gene Transcription: Thomas Kaido, Mayra Yebra, Vincenzo Cirulli, Christopher Rhodes, Giuseppe Diaferia, and Anthony M. Montgomery
Diabetes 2006 55: 2723 -2729. [Abstract] [Full Text] [PDF]

Foxa1-Deficient Mice Exhibit Impaired Insulin Secretion due to Uncoupled Oxidative Phosphorylation: Marko Z. Vatamaniuk, Rana K. Gupta, Kristen A. Lantz, Nicolai M. Doliba, Franz M. Matschinsky, and Klaus H. Kaestner
Diabetes 2006 55: 2730 -2736. [Abstract] [Full Text] [PDF]

Suppressed Insulin Signaling and Increased Apoptosis in Cd38-Null Islets: James D. Johnson, Eric L. Ford, Ernesto Bernal-Mizrachi, Kim L. Kusser, Dan S. Luciani, Zhiqiang Han, Hung Tran, Troy D. Randall, Frances E. Lund, and Kenneth S. Polonsky
Diabetes 2006 55: 2737 -2746. [Abstract] [Full Text] [PDF]

Imaging Docking and Fusion of Insulin Granules Induced by Antidiabetes Agents: Sulfonylurea and Glinide Drugs Preferentially Mediate the Fusion of Newcomer, but Not Previously Docked, Insulin Granules: Shinya Nagamatsu, Mica Ohara-Imaizumi, Yoko Nakamichi, Toshiteru Kikuta, and Chiyono Nishiwaki
Diabetes 2006 55: 2819 -2825. [Abstract] [Full Text] [PDF] Online-Only Appendix

C16:0 Sulfatide Inhibits Insulin Secretion in Rat ß-Cells by Reducing the Sensitivity of K_ATP Channels to ATP Inhibition: Karsten Buschard, Maria Blomqvist, Jan-Eric Månsson, Pam Fredman, Kirstine Juhl, and Jesper Gromada
Diabetes 2006 55: 2826 -2834. [Abstract] [Full Text] [PDF]

Identification of Insulin Signaling Elements in Human ß-Cells: Autocrine Regulation of Insulin Gene Expression: Dany Muller, Guo Cai Huang, Stephanie Amiel, Peter M. Jones, and Shanta J. Persaud
Diabetes 2006 55: 2835 -2842. [Abstract] [Full Text] [PDF]

Complications:

Altered Gene Expression Related to Glomerulogenesis and Podocyte Structure in Early Diabetic Nephropathy of db/db Mice and Its Restoration by Pioglitazone: Hisashi Makino, Yoshihiro Miyamoto, Kazutomo Sawai, Kiyoshi Mori, Masashi Mukoyama, Kazuwa Nakao, Yasunao Yoshimasa, and Shin-ichi Suga
Diabetes 2006 55: 2747 -2756. [Abstract] [Full Text] [PDF]

A Selective Aldose Reductase Inhibitor of a New Structural Class Prevents or Reverses Early Retinal Abnormalities in Experimental Diabetic Retinopathy: Wei Sun, Peter J. Oates, James B. Coutcher, Chiara Gerhardinger, and Mara Lorenzi
Diabetes 2006 55: 2757 -2762. [Abstract] [Full Text] [PDF]

Insulin Restores Metabolic Function in Cultured Cortical Neurons Subjected to Oxidative Stress: Ana I. Duarte, Teresa Proença, Catarina R. Oliveira, Maria S. Santos, and A. Cristina Rego
Diabetes 2006 55: 2863 -2870. [Abstract] [Full Text] [PDF]

Genetics:

Common Haplotypes at the Adiponectin Receptor 1 (ADIPOR1) Locus Are Associated With Increased Risk of Coronary Artery Disease in Type 2 Diabetes: Teresa Soccio, Yuan-Yuan Zhang, Simonetta Bacci, Wojciech Mlynarski, Grzegorz Placha, Greer Raggio, Rosa Di Paola, Antonella Marucci, Michael T. Johnstone, Ernest V. Gervino, Nada A. Abumrad, Samuel Klein, Vincenzo Trischitta, and Alessandro Doria
Diabetes 2006 55: 2763 -2770. [Abstract] [Full Text] [PDF] Online-Appendix Only

Bardet-Biedl Syndrome Gene Variants Are Associated With Both Childhood and Adult Common Obesity in French Caucasians: Michael Benzinou, Andrew Walley, Stephan Lobbens, Marie-Aline Charles, Béatrice Jouret, Frédéric Fumeron, Beverley Balkau, David Meyre, and Philippe Froguel
Diabetes 2006 55: 2876 -2882. [Abstract] [Full Text] [PDF] Online-Only Appendix

A Haplotype-Based Analysis of the PTPN22 Locus in Type 1 Diabetes: Suna Onengut-Gumuscu, Jane H. Buckner, and Patrick Concannon
Diabetes 2006 55: 2883 -2889. [Abstract] [Full Text] [PDF]

Pathophysiology:

Immunoneutralization of Endogenous Glucagon Reduces Hepatic Glucose Output and Improves Long-Term Glycemic Control in Diabetic ob/ob Mice: Heidi Sørensen, Christian L. Brand, Susanne Neschen, Jens Juul Holst, Keld Fosgerau, Erica Nishimura, and Gerald I. Shulman
Diabetes 2006 55: 2843 -2848. [Abstract] [Full Text] [PDF]

Whole-Body Proteolysis Rate Is Elevated in HIV-Associated Insulin Resistance: Dominic N. Reeds, W. Todd Cade, Bruce W. Patterson, William G. Powderly, Samuel Klein, and Kevin E. Yarasheski
Diabetes 2006 55: 2849 -2855. [Abstract] [Full Text] [PDF]

Vitamin E and Risk of Type 2 Diabetes in the Women’s Health Study Randomized Controlled Trial: Simin Liu, I-Min Lee, Yiqing Song, Martin Van Denburgh, Nancy R. Cook, JoAnn E. Manson, and Julie E. Buring
Diabetes 2006 55: 2856 -2862. [Abstract] [Full Text] [PDF]

Pharmacology and Therapeutics:

Serum Visfatin Increases With Progressive ß-Cell Deterioration: Abel López-Bermejo, Berta Chico-Julià, Mercè Fernàndez-Balsells, Mònica Recasens, Eduardo Esteve, Roser Casamitjana, Wifredo Ricart, and José-Manuel Fernández-Real
Diabetes 2006 55: 2871 -2875. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

Common Single Nucleotide Polymorphisms in TCF7L2 Are Reproducibly Associated With Type 2 Diabetes and Reduce the Insulin Response to Glucose in Nondiabetic Individuals: Richa Saxena, Lauren Gianniny, Noël P. Burtt, Valeriya Lyssenko, Candace Giuducci, Marketa Sjögren, Jose C. Florez, Peter Almgren, Bo Isomaa, Marju Orho-Melander, Ulf Lindblad, Mark J. Daly, Tiinamaija Tuomi, Joel N. Hirschhorn, Kristin G. Ardlie, Leif C. Groop, and David Altshuler
Diabetes 2006 55: 2890 -2895. [Abstract] [Full Text] [PDF] Online-Only Appendix

Common Polymorphisms in the Promoter of the Visfatin Gene (PBEF1) Influence Plasma Insulin Levels in a French-Canadian Population: Swneke D. Bailey, J C. Loredo-Osti, Pierre Lepage, Janet Faith, Joelle Fontaine, Katia M. Desbiens, Thomas J. Hudson, Claude Bouchard, Daniel Gaudet, Louis Pérusse, Marie-Claude Vohl, and James C. Engert
Diabetes 2006 55: 2896 -2902. [Abstract] [Full Text] [PDF] Online-Only Appendix

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human ß-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes: Stéphane Cauchi, David Meyre, Christian Dina, Hélène Choquet, Chantal Samson, Sophie Gallina, Beverley Balkau, Guillaume Charpentier, François Pattou, Volodymyr Stetsyuk, Raphaël Scharfmann, Bart Staels, Gema Frühbeck, and Philippe Froguel
Diabetes 2006 55: 2903 -2908. [Abstract] [Full Text] [PDF] Online-Only Appendix

Role of a Proline Insertion in the Insulin Promoter Factor 1 (IPF1) Gene in African Americans With Type 2 Diabetes: Steven C. Elbein, Xiaoqin Wang, Mohammad A. Karim, Barry I. Freedman, Donald W. Bowden, Alan R. Shuldiner, Frederick L. Brancati, and Wen Hong Linda Kao
Diabetes 2006 55: 2909 -2914. [Abstract] [Full Text] [PDF] Online-Only Appendix

IL6 Gene Promoter Polymorphisms and Type 2 Diabetes: Joint Analysis of Individual Participants’ Data From 21 Studies: Cornelia Huth, Iris M. Heid, Caren Vollmert, Christian Gieger, Harald Grallert, Johanna K. Wolford, Birgit Langer, Barbara Thorand, Norman Klopp, Yasmin H. Hamid, Oluf Pedersen, Torben Hansen, Valeriya Lyssenko, Leif Groop, Christa Meisinger, Angela Döring, Hannelore Löwel, Wolfgang Lieb, Christian Hengstenberg, Wolfgang Rathmann, Stephan Martin, Jeffrey W. Stephens, Helen Ireland, Hugh Mather, George J. Miller, Heather M. Stringham, Michael Boehnke, Jaakko Tuomilehto, Heiner Boeing, Matthias Möhlig, Joachim Spranger, Andreas Pfeiffer, Ingrid Wernstedt, Anders Niklason, Abel López-Bermejo, José-Manuel Fernández-Real, Robert L. Hanson, Luis Gallart, Joan Vendrell, Anastasia Tsiavou, Erifili Hatziagelaki, Steve E. Humphries, H.-Erich Wichmann, Christian Herder, and Thomas Illig
Diabetes 2006 55: 2915 -2921. [Abstract] [Full Text] [PDF] Online-Appendix Only

The ${alpha}$ -Adducin Gene Is Associated With Macrovascular Complications and Mortality in Patients With Type 2 Diabetes: Mojgan Yazdanpanah, Fakhredin A. Sayed-Tabatabaei, Albert Hofman, Yurii S. Aulchenko, Ben A. Oostra, Bruno H.C. Stricker, Huibert A.P. Pols, Steven W.J. Lamberts, Jacqueline C.M. Witteman, Joop A.M.J.L. Janssen, and Cornelia M. van Duijn
Diabetes 2006 55: 2922 -2927. [Abstract] [Full Text] [PDF]