New Methodologies and Databases:

Imaging Islets Labeled With Magnetic Nanoparticles at 1.5 Tesla

Joo Ho Tai, Paula Foster, Alma Rosales, Biao Feng, Craig Hasilo, Violetta Martinez, Soha Ramadan, Jonatan Snir, C.W. James Melling, Savita Dhanvantari, Brian Rutt, and David J.G. White
Diabetes 2006 55: 2931 -2938. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Increase in Glucose-6-Phosphate Dehydrogenase in Adipocytes Stimulates Oxidative Stress and Inflammatory Signals

Jiyoung Park, Sung Sik Choe, A Hyun Choi, Kang Ho Kim, Myeong Jin Yoon, Takayoshi Suganami, Yoshihiro Ogawa, and Jae Bum Kim
Diabetes 2006 55: 2939 -2949. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Ghrelin Attenuates the Inhibitory Effects of Glucagon-Like Peptide-1 and Peptide YY(3-36) on Food Intake and Gastric Emptying in Rats

Prasanth K. Chelikani, Alvin C. Haver, and Roger D. Reidelberger
Diabetes 2006 55: 3038 -3046. [Abstract] [Full Text] [PDF]  

Pubertal Timing Is an Independent Predictor of Central Adiposity in Young Adult Males: The Gothenburg Osteoporosis and Obesity Determinants Study

Jenny M. Kindblom, Mattias Lorentzon, Ensio Norjavaara, Lars Lönn, John Brandberg, Jan-Erik Angelhed, Åsa Hellqvist, Staffan Nilsson, and Claes Ohlsson
Diabetes 2006 55: 3047 -3052. [Abstract] [Full Text] [PDF]  

Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity

Matthias Blüher, Stefan Engeli, Nora Klöting, Janin Berndt, Mathias Fasshauer, Sándor Bátkai, Pál Pacher, Michael R. Schön, Jens Jordan, and Michael Stumvoll
Diabetes 2006 55: 3053 -3060. [Abstract] [Full Text] [PDF]  

Islet Studies:

p27 Regulates the Transition of ß-Cells From Quiescence to Proliferation

Senta Georgia and Anil Bhushan
Diabetes 2006 55: 2950 -2956. [Abstract] [Full Text] [PDF]  

Expression of ATP-Insensitive K_ATP Channels in Pancreatic ß-Cells Underlies a Spectrum of Diabetic Phenotypes

Joseph C. Koster, Maria S. Remedi, Ricard Masia, Brian Patton, Ailing Tong, and Colin G. Nichols
Diabetes 2006 55: 2957 -2964. [Abstract] [Full Text] [PDF]  

Islet Microvasculature in Islet Hyperplasia and Failure in a Model of Type 2 Diabetes

Xianquan Li, Lanjing Zhang, Sasha Meshinchi, Claudia Dias-Leme, Diane Raffin, Jeffery D. Johnson, Mary K. Treutelaar, and Charles F. Burant
Diabetes 2006 55: 2965 -2973. [Abstract] [Full Text] [PDF]  

Pancreatic Islet Production of Vascular Endothelial Growth Factor-A Is Essential for Islet Vascularization, Revascularization, and Function

Marcela Brissova, Alena Shostak, Masakazu Shiota, Peter O. Wiebe, Greg Poffenberger, Jeannelle Kantz, Zhongyi Chen, Chad Carr, W. Gray Jerome, Jin Chen, H. Scott Baldwin, Wendell Nicholson, David M. Bader, Thomas Jetton, Maureen Gannon, and Alvin C. Powers
Diabetes 2006 55: 2974 -2985. [Abstract] [Full Text] [PDF] Online-Only Appendix  

A Kir6.2 Mutation Causing Neonatal Diabetes Impairs Electrical Activity and Insulin Secretion From INS-1 ß-Cells

Andrei I. Tarasov, Hannah J. Welters, Sabine Senkel, Gerhart U. Ryffel, Andrew T. Hattersley, Noel G. Morgan, and Frances M. Ashcroft
Diabetes 2006 55: 3075 -3082. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Attenuation of Insulin-Evoked Responses in Brain Networks Controlling Appetite and Reward in Insulin Resistance: The Cerebral Basis for Impaired Control of Food Intake in Metabolic Syndrome?

Karen Anthony, Laurence J. Reed, Joel T. Dunn, Emma Bingham, David Hopkins, Paul K. Marsden, and Stephanie A. Amiel
Diabetes 2006 55: 2986 -2992. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Loss of Resistin Improves Glucose Homeostasis in Leptin Deficiency

Yong Qi, Zhenying Nie, Yun-Sik Lee, Neel S. Singhal, Philipp E. Scherer, Mitchell A. Lazar, and Rexford S. Ahima
Diabetes 2006 55: 3083 -3090. [Abstract] [Full Text] [PDF]  

Neuropeptide Y Deficiency Attenuates Responses to Fasting and High-Fat Diet in Obesity-Prone Mice

Hiralben R. Patel, Yong Qi, Evan J. Hawkins, Stanley M. Hileman, Joel K. Elmquist, Yumi Imai, and Rexford S. Ahima
Diabetes 2006 55: 3091 -3098. [Abstract] [Full Text] [PDF]  

Complications:

Modular Activation of Nuclear Factor-B Transcriptional Programs in Human Diabetic Nephropathy

Holger Schmid, Anissa Boucherot, Yoshinari Yasuda, Anna Henger, Bodo Brunner, Felix Eichinger, Almut Nitsche, Eva Kiss, Markus Bleich, Hermann-Josef Gröne, Peter J. Nelson, Detlef Schlöndorff, Clemens D. Cohen, Matthias Kretzler for the European Renal cDNA Bank (ERCB) Consortium
Diabetes 2006 55: 2993 -3003. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Poly(ADP-Ribose) Polymerase Inhibitors Ameliorate Nephropathy of Type 2 Diabetic Lepr^db/db Mice

Csaba Szabó, Alisha Biser, Rita Benko, Erwin Böttinger, and Katalin Suszták
Diabetes 2006 55: 3004 -3012. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Defective Metabolism of Oxidized Phospholipid by HDL From People With Type 2 Diabetes

Maria Mastorikou, Mike Mackness, and Bharti Mackness
Diabetes 2006 55: 3099 -3103. [Abstract] [Full Text] [PDF]  

Diabetes-Induced Extracellular Matrix Protein Expression Is Mediated by Transcription Coactivator p300

Harkiran Kaur, Shali Chen, Xiping Xin, Jane Chiu, Zia A. Khan, and Subrata Chakrabarti
Diabetes 2006 55: 3104 -3111. [Abstract] [Full Text] [PDF]  

Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase Cß–Null Mice

Yuzuru Ohshiro, Ronald C. Ma, Yutaka Yasuda, Junko Hiraoka-Yamamoto, Allen C. Clermont, Keiji Isshiki, Kunimasa Yagi, Emi Arikawa, Timothy S. Kern, and George L. King
Diabetes 2006 55: 3112 -3120. [Abstract] [Full Text] [PDF]  

Saturated, but Not Unsaturated, Fatty Acids Induce Apoptosis of Human Coronary Artery Endothelial Cells via Nuclear Factor-B Activation

Katrin Staiger, Harald Staiger, Cora Weigert, Carina Haas, Hans-Ulrich Häring, and Monika Kellerer
Diabetes 2006 55: 3121 -3126. [Abstract] [Full Text] [PDF]  

Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers

W. Stephen Waring, John A. McKnight, David J. Webb, and Simon R.J. Maxwell
Diabetes 2006 55: 3127 -3132. [Abstract] [Full Text] [PDF]  

Endothelial Nitric Oxide Synthase–Dependent Tyrosine Nitration of Prostacyclin Synthase in Diabetes In Vivo

Hong Nie, Ji-liang Wu, Miao Zhang, Jian Xu, and Ming-Hui Zou
Diabetes 2006 55: 3133 -3141. [Abstract] [Full Text] [PDF]  

Metabolism:

Splanchnic Cortisol Production in Dogs Occurs Primarily in the Liver: Evidence for Substantial Hepatic Specific 11ß Hydroxysteroid Dehydrogenase Type 1 Activity

Rita Basu, Dale S. Edgerton, Ravinder J. Singh, Alan Cherrington, and Robert A. Rizza
Diabetes 2006 55: 3013 -3019. [Abstract] [Full Text] [PDF]  

PDH-E1 Dephosphorylation and Activation in Human Skeletal Muscle During Exercise: Effect of Intralipid Infusion

Henriette Pilegaard, Jesper B. Birk, Massimo Sacchetti, Marina Mourtzakis, D. Graham Hardie, Greg Stewart, P. Darrell Neufer, Bengt Saltin, Gerrit van Hall, and Jorgen F.P. Wojtaszewski
Diabetes 2006 55: 3020 -3027. [Abstract] [Full Text] [PDF]  

Interactions Between Delivery, Transport, and Phosphorylation of Glucose in Governing Uptake Into Human Skeletal Muscle

Alessandra Bertoldo, R. Richard Pencek, Koichiro Azuma, Julie C. Price, Carol Kelley, Claudio Cobelli, and David E. Kelley
Diabetes 2006 55: 3028 -3037. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Immunology and Transplantation:

Identification of Novel HLA-A*0201–Restricted Epitopes in Recent-Onset Type 1 Diabetic Subjects and Antibody-Positive Relatives

Nathan E. Standifer, Qin Ouyang, Constadina Panagiotopoulos, C. Bruce Verchere, Rusung Tan, Carla J. Greenbaum, Catherine Pihoker, and Gerald T. Nepom
Diabetes 2006 55: 3061 -3067. [Abstract] [Full Text] [PDF]  

Recognition of HLA Class I–Restricted ß-Cell Epitopes in Type 1 Diabetes

Qin Ouyang, Nathan E. Standifer, Huilian Qin, Peter Gottlieb, C. Bruce Verchere, Gerald T. Nepom, Rusung Tan, and Constadina Panagiotopoulos
Diabetes 2006 55: 3068 -3074. [Abstract] [Full Text] [PDF]  

Pharmacology and Therapeutics:

Oral Glucosamine for 6 Weeks at Standard Doses Does Not Cause or Worsen Insulin Resistance or Endothelial Dysfunction in Lean or Obese Subjects

Ranganath Muniyappa, Rajaram J. Karne, Gail Hall, Sonja K. Crandon, Joel A. Bronstein, Maria R. Ver, Glen L. Hortin, and Michael J. Quon
Diabetes 2006 55: 3142 -3150. [Abstract] [Full Text] [PDF]  

Intensive Insulin Therapy in Mixed Medical/Surgical Intensive Care Units: Benefit Versus Harm

Greet Van den Berghe, Alexander Wilmer, Ilse Milants, Pieter J. Wouters, Bernard Bouckaert, Frans Bruyninckx, Roger Bouillon, and Miet Schetz
Diabetes 2006 55: 3151 -3159. [Abstract] [Full Text] [PDF]  

Genetics:

Differential Expression of Matrix Metalloproteinase 3 (MMP3) in Preadipocytes/Stromal Vascular Cells From Nonobese Nondiabetic Versus Obese Nondiabetic Pima Indians

Michael T. Traurig, Paska A. Permana, Saraswathy Nair, Sayuko Kobes, Clifton Bogardus, and Leslie J. Baier
Diabetes 2006 55: 3160 -3165. [Abstract] [Full Text] [PDF]  

Analysis of 14 Candidate Genes for Diabetic Nephropathy on Chromosome 3q in European Populations: Strongest Evidence for Association With a Variant in the Promoter Region of the Adiponectin Gene

Nathalie Vionnet, David Tregouët, Gbenga Kazeem, Ivo Gut, Per-Henrik Groop, Lise Tarnow, Hans-Henrik Parving, Samy Hadjadj, Carol Forsblom, Martin Farrall, Dominique Gauguier, Roger Cox, Fumihiko Matsuda, Simon Heath, Alexandre Thévard, Rachel Rousseau, François Cambien, Michel Marre, and Mark Lathrop
Diabetes 2006 55: 3166 -3174. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Brief Genetics Reports:

No Evidence of Association of ENPP1 Variants With Type 2 Diabetes or Obesity in a Study of 8,089 U.K. Caucasians

Michael N. Weedon, Beverley Shields, Graham Hitman, Mark Walker, Mark I. McCarthy, Andrew T. Hattersley, and Timothy M. Frayling
Diabetes 2006 55: 3175 -3179. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Common Variants in the ENPP1 Gene Are Not Reproducibly Associated With Diabetes or Obesity

Helen N. Lyon, Jose C. Florez, Todd Bersaglieri, Richa Saxena, Wendy Winckler, Peter Almgren, Ulf Lindblad, Tiinamaija Tuomi, Daniel Gaudet, Xiaofeng Zhu, Richard Cooper, Kristin G. Ardlie, Mark J. Daly, David Altshuler, Leif Groop, and Joel N. Hirschhorn
Diabetes 2006 55: 3180 -3184. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Islet Autoimmunity in Children With Down’s Syndrome

Kathleen M. Gillespie, Rachel J. Dix, Alistair J.K. Williams, Richard Newton, Zoey F. Robinson, Polly J. Bingley, Edwin A.M. Gale, and Julian P.H. Shield
Diabetes 2006 55: 3185 -3188. [Abstract] [Full Text] [PDF]  

TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population: The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study

Stéphane Cauchi, David Meyre, Hélène Choquet, Christian Dina, Catherine Born, Michel Marre, Beverley Balkau, Philippe Froguel for the DESIR Study Group
Diabetes 2006 55: 3189 -3192. [Abstract] [Full Text] [PDF] Online-Only Appendix  

The HADHSC Gene Encoding Short-Chain L-3-Hydroxyacyl-CoA Dehydrogenase (SCHAD) and Type 2 Diabetes Susceptibility: The DAMAGE Study

Els C. van Hove, Torben Hansen, Jacqueline M. Dekker, Erwin Reiling, Giel Nijpels, Torben Jørgensen, Knut Borch-Johnsen, Yasmin H. Hamid, Robert J. Heine, Oluf Pedersen, J. Antonie Maassen, and Leen M. 't Hart
Diabetes 2006 55: 3193 -3196. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Errata:

Erratum

Diabetes 2006 55: 3197 . [Extract] [Full Text] [PDF]  

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