Perspectives in Diabetes:

Comparative Analysis of Insulin Gene Promoters: Implications for Diabetes Research

Colin W. Hay and Kevin Docherty
Diabetes 2006 55: 3201 -3213. [Abstract] [Full Text] [PDF]  

New Methodologies & Databases:

Probe-Independent and Direct Quantification of Insulin mRNA and Growth Hormone mRNA in Enriched Cell Preparations

Leentje Van Lommel, Kristel Janssens, Roel Quintens, Katsura Tsukamoto, Dirk Vander Mierde, Katleen Lemaire, Carl Denef, Jean-Christophe Jonas, Geert Martens, Daniel Pipeleers, and Frans C. Schuit
Diabetes 2006 55: 3214 -3220. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Signal Transduction:

Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats

Emmani B.M. Nascimento, Mariann Fodor, Gerard C.M. van der Zon, Ingrid M. Jazet, A. Edo Meinders, Peter J. Voshol, Ronald Vlasblom, Bart Baan, Jürgen Eckel, J. Antonie Maassen, Michaela Diamant, and D. Margriet Ouwens
Diabetes 2006 55: 3221 -3228. [Abstract] [Full Text] [PDF]  

Sodium-Coupled Glucose Cotransporters Contribute to Hypothalamic Glucose Sensing

Dervla O’Malley, Frank Reimann, Anna K. Simpson, and Fiona M. Gribble
Diabetes 2006 55: 3381 -3386. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Fatty Acid Transport Protein 1 Is Required for Nonshivering Thermogenesis in Brown Adipose Tissue

Qiwei Wu, Melissa Kazantzis, Holger Doege, Angelica M. Ortegon, Bernice Tsang, Alaric Falcon, and Andreas Stahl
Diabetes 2006 55: 3229 -3237. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Leptin Regulation of the Anorexic Response to Glucagon-Like Peptide-1 Receptor Stimulation

Diana L. Williams, Denis G. Baskin, and Michael W. Schwartz
Diabetes 2006 55: 3387 -3393. [Abstract] [Full Text] [PDF]  

Endogenous ApoE Expression Modulates Adipocyte Triglyceride Content and Turnover

Zhi Hua Huang, Catherine A. Reardon, and Theodore Mazzone
Diabetes 2006 55: 3394 -3402. [Abstract] [Full Text] [PDF]  

Effects of Rimonabant (SR141716) on Fasting-Induced Hypothalamic-Pituitary-Adrenal Axis and Neuronal Activation in Lean and Obese Zucker Rats

Christian Doyon, Raphaël G. Denis, Elena-Dana Baraboi, Pierre Samson, Josée Lalonde, Yves Deshaies, and Denis Richard
Diabetes 2006 55: 3403 -3410. [Abstract] [Full Text] [PDF]  

Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action

Juan C. Molero, Nigel Turner, Christine B.F. Thien, Wallace Y. Langdon, David E. James, and Gregory J. Cooney
Diabetes 2006 55: 3411 -3417. [Abstract] [Full Text] [PDF] Online-Only Appendix  

OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization

Nathan E. Wolins, Benjamin K. Quaynor, James R. Skinner, Anatoly Tzekov, Michelle A. Croce, Matthew C. Gropler, Vijayalakshmi Varma, Aiwei Yao-Borengasser, Neda Rasouli, Philip A. Kern, Brian N. Finck, and Perry E. Bickel
Diabetes 2006 55: 3418 -3428. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Lipin Deficiency Impairs Diurnal Metabolic Fuel Switching

Jun Xu, W.N. Paul Lee, Jack Phan, Mohammed F. Saad, Karen Reue, and Irwin J. Kurland
Diabetes 2006 55: 3429 -3438. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Effects of Autoimmunity and Immune Therapy on ß-Cell Turnover in Type 1 Diabetes

Nicole A. Sherry, Jake A. Kushner, Mariela Glandt, Tadahiro Kitamura, Anne-Marie B. Brillantes, and Kevan C. Herold
Diabetes 2006 55: 3238 -3245. [Abstract] [Full Text] [PDF]  

Expression of IGF-I in Pancreatic Islets Prevents Lymphocytic Infiltration and Protects Mice From Type 1 Diabetes

Alba Casellas, Ariana Salavert, Judith Agudo, Eduard Ayuso, Veronica Jimenez, Marta Moya, Sergio Muñoz, Sylvie Franckhauser, and Fatima Bosch
Diabetes 2006 55: 3246 -3255. [Abstract] [Full Text] [PDF]  

Recovery of Islet ß-Cell Function in Streptozotocin- Induced Diabetic Mice: An Indirect Role for the Spleen

Dengping Yin, Jing Tao, David D. Lee, Jikun Shen, Manami Hara, James Lopez, Andrey Kuznetsov, Louis H. Philipson, and Anita S. Chong
Diabetes 2006 55: 3256 -3263. [Abstract] [Full Text] [PDF]  

Altered Monocyte Cyclooxygenase Response to Lipopolysaccharide in Type 1 Diabetes

Huriya Beyan, Martin R. Goodier, Niga S. Nawroly, Mohammed I. Hawa, Stephen A. Bustin, William B. Ogunkolade, Marco Londei, Nasim Yousaf, and R. David G. Leslie
Diabetes 2006 55: 3439 -3445. [Abstract] [Full Text] [PDF]  

Insulin Treatment in Patients With Type 1 Diabetes Induces Upregulation of Regulatory T-Cell Markers in Peripheral Blood Mononuclear Cells Stimulated With Insulin In Vitro

Minna Tiittanen, Johanna T. Huupponen, Mikael Knip, and Outi Vaarala
Diabetes 2006 55: 3446 -3454. [Abstract] [Full Text] [PDF]  

Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility

Xinhui Ge, Jon D. Piganelli, Hubert M. Tse, Suzanne Bertera, Clayton E. Mathews, Massimo Trucco, Li Wen, and William A. Rudert
Diabetes 2006 55: 3455 -3462. [Abstract] [Full Text] [PDF]  

Islet Studies:

Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of ß-Cells

Elizabeth Tweedie, Isabella Artner, Laura Crawford, Greg Poffenberger, Bernard Thorens, Roland Stein, Alvin C. Powers, and Maureen Gannon
Diabetes 2006 55: 3264 -3270. [Abstract] [Full Text] [PDF]  

The Cell Cycle Inhibitory Protein p21^cip Is Not Essential for Maintaining ß-Cell Cycle Arrest or ß-Cell Function In Vivo

Irene Cozar-Castellano, Marcia Haught, and Andrew F. Stewart
Diabetes 2006 55: 3271 -3278. [Abstract] [Full Text] [PDF]  

Protein Inhibitor of Neuronal Nitric Oxide Synthase (PIN) Is a New Regulator of Glucose-Induced Insulin Secretion

Anne-Dominique Lajoix, Stéphanie Badiou, Sylvie Péraldi-Roux, Thierry Chardès, Samuel Dietz, Cindy Aknin, Florence Tribillac, Pierre Petit, and René Gross
Diabetes 2006 55: 3279 -3288. [Abstract] [Full Text] [PDF]  

Regulation of Pancreatic ß-Cell Regeneration in the Normoglycemic 60% Partial-Pancreatectomy Mouse

Mina Peshavaria, Brooke L. Larmie, James Lausier, Basanthi Satish, Aida Habibovic, Violet Roskens, Kyla LaRock, Brian Everill, Jack L. Leahy, and Thomas L. Jetton
Diabetes 2006 55: 3289 -3298. [Abstract] [Full Text] [PDF]  

Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal ß-Cell Growth

Päivi J. Miettinen, Jarkko Ustinov, Päivi Ormio, Ru Gao, Jaan Palgi, Elina Hakonen, Lisa Juntti-Berggren, Per-Olof Berggren, and Timo Otonkoski
Diabetes 2006 55: 3299 -3308. [Abstract] [Full Text] [PDF]  

Glucagon Receptor Knockout Mice Display Increased Insulin Sensitivity and Impaired ß-Cell Function

Heidi Sørensen, Maria Sörhede Winzell, Christian L. Brand, Keld Fosgerau, Richard W. Gelling, Erica Nishimura, and Bo Ahren
Diabetes 2006 55: 3463 -3469. [Abstract] [Full Text] [PDF]  

Nutrient Control of Insulin Secretion in Isolated Normal Human Islets

Jean-Claude Henquin, Denis Dufrane, and Myriam Nenquin
Diabetes 2006 55: 3470 -3477. [Abstract] [Full Text] [PDF]  

Modulation of Insulin Secretion by Fatty Acyl Analogs

Guy Las, Nina Mayorek, Kobie Dickstein, and Jacob Bar-Tana
Diabetes 2006 55: 3478 -3485. [Abstract] [Full Text] [PDF]  

Blockade of Pancreatic Islet–Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet–Induced Glucose Intolerance

Katsuya Dezaki, Hideyuki Sone, Masaru Koizumi, Masanori Nakata, Masafumi Kakei, Hideo Nagai, Hiroshi Hosoda, Kenji Kangawa, and Toshihiko Yada
Diabetes 2006 55: 3486 -3493. [Abstract] [Full Text] [PDF]  

Separately Inherited Defects in Insulin Exocytosis and ß-Cell Glucose Metabolism Contribute to Type 2 Diabetes

Charlotte Granhall, Anders H. Rosengren, Erik Renström, and Holger Luthman
Diabetes 2006 55: 3494 -3500. [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator–Activated Receptor- and Glucocorticoids Interactively Regulate Insulin Secretion During Pregnancy

Mark J. Holness, Gemma K. Greenwood, Nicholas D. Smith, and Mary C. Sugden
Diabetes 2006 55: 3501 -3508. [Abstract] [Full Text] [PDF]  

Contribution of Calcium Influx in Mediating Glucose-Stimulated Oxygen Consumption in Pancreatic Islets

Ian R. Sweet and Merle Gilbert
Diabetes 2006 55: 3509 -3519. [Abstract] [Full Text] [PDF]  

Differential Effects of p27 in Regulation of ß-Cell Mass During Development, Neonatal Period, and Adult Life

Latif Rachdi, Norman Balcazar, Lynda Elghazi, Daniel J. Barker, Irina Krits, Hiroaki Kiyokawa, and Ernesto Bernal-Mizrachi
Diabetes 2006 55: 3520 -3528. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Skeletal Muscle Mitochondrial Functions, Mitochondrial DNA Copy Numbers, and Gene Transcript Profiles in Type 2 Diabetic and Nondiabetic Subjects at Equal Levels of Low or High Insulin and Euglycemia

Yan W. Asmann, Craig S. Stump, Kevin R. Short, Jill M. Coenen-Schimke, ZengKui Guo, Maureen L. Bigelow, and K. Sreekumaran Nair
Diabetes 2006 55: 3309 -3319. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Effects of Sex and Hormone Replacement Therapy Use on the Prevalence of Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance in Subjects With a Family History of Type 2 Diabetes

Renate E. van Genugten, Kristina M. Utzschneider, Jenny Tong, Fernando Gerchman, Sakeneh Zraika, Jayalakshmi Udayasankar, Edward J. Boyko, Wilfred Y. Fujimoto, Steven E. Kahn, and and the American Diabetes Association GENNID Study Group
Diabetes 2006 55: 3529 -3535. [Abstract] [Full Text] [PDF]  

Pathogenesis of Pre-Diabetes: Mechanisms of Fasting and Postprandial Hyperglycemia in People With Impaired Fasting Glucose and/or Impaired Glucose Tolerance

Gerlies Bock, Chiara Dalla Man, Marco Campioni, Elizabeth Chittilapilly, Rita Basu, Gianna Toffolo, Claudio Cobelli, and Robert Rizza
Diabetes 2006 55: 3536 -3549. [Abstract] [Full Text] [PDF]  

Complications:

Tau Is Hyperphosphorylated at Multiple Sites in Mouse Brain In Vivo After Streptozotocin-Induced Insulin Deficiency

Buffie J. Clodfelder-Miller, Anna A. Zmijewska, Gail V.W. Johnson, and Richard S. Jope
Diabetes 2006 55: 3320 -3325. [Abstract] [Full Text] [PDF]  

Hyperglycemia Inhibits Retinoic Acid–Induced Activation of Rac1, Prevents Differentiation of Cortical Neurons, and Causes Oxidative Stress in a Rat Model of Diabetic Pregnancy

Rakeshwar S. Guleria, Jing Pan, Donald DiPette, and Ugra S. Singh
Diabetes 2006 55: 3326 -3334. [Abstract] [Full Text] [PDF]  

The Leptin-Deficient (ob/ob) Mouse: A New Animal Model of Peripheral Neuropathy of Type 2 Diabetes and Obesity

Viktor R. Drel, Nazar Mashtalir, Olga Ilnytska, Jeho Shin, Fei Li, Valeriy V. Lyzogubov, and Irina G. Obrosova
Diabetes 2006 55: 3335 -3343. [Abstract] [Full Text] [PDF]  

Irbesartan Treatment Reduces Biomarkers of Inflammatory Activity in Patients With Type 2 Diabetes and Microalbuminuria: An IRMA 2 Substudy

Frederik Persson, Peter Rossing, Peter Hovind, Coen D.A. Stehouwer, Casper Schalkwijk, Lise Tarnow, and Hans-Henrik Parving
Diabetes 2006 55: 3550 -3555. [Abstract] [Full Text] [PDF]  

The Effect of Intensive Glycemic Treatment on Coronary Artery Calcification in Type 1 Diabetic Participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study

Patricia A. Cleary, Trevor J. Orchard, Saul Genuth, Nathan D. Wong, Robert Detrano, Jye-Yu C. Backlund, Bernard Zinman, Alan Jacobson, Wanjie Sun, John M. Lachin, David M. Nathan for the DCCT/EDIC Research Group
Diabetes 2006 55: 3556 -3565. [Abstract] [Full Text] [PDF]  

Effect of Eucaloric High- and Low-Sucrose Diets With Identical Macronutrient Profile on Insulin Resistance and Vascular Risk: A Randomized Controlled Trial

R. Neil A. Black, Michelle Spence, Ross O. McMahon, Geraldine J. Cuskelly, Cieran N. Ennis, David R. McCance, Ian S. Young, Patrick M. Bell, and Steven J. Hunter
Diabetes 2006 55: 3566 -3572. [Abstract] [Full Text] [PDF]  

Diabetes Alters Sphingolipid Metabolism in the Retina: A Potential Mechanism of Cell Death in Diabetic Retinopathy

Todd E. Fox, Xianlin Han, Samuel Kelly, Alfred H. Merrill, Jr., Rex E. Martin, Robert E. Anderson, Thomas W. Gardner, and Mark Kester
Diabetes 2006 55: 3573 -3580. [Abstract] [Full Text] [PDF]  

C-Peptide Reverses Nociceptive Neuropathy in Type 1 Diabetes

Hideki Kamiya, Weixian Zhang, Karin Ekberg, John Wahren, and Anders A.F. Sima
Diabetes 2006 55: 3581 -3587. [Abstract] [Full Text] [PDF]  

Reduced Expression of G_i in Erythrocytes of Humans With Type 2 Diabetes Is Associated With Impairment of Both cAMP Generation and ATP Release

Randy S. Sprague, Alan H. Stephenson, Elizabeth A. Bowles, Madelyn S. Stumpf, and Andrew J. Lonigro
Diabetes 2006 55: 3588 -3593. [Abstract] [Full Text] [PDF]  

Pharmacology & Therapeutics:

Feasibility of Automating Insulin Delivery for the Treatment of Type 1 Diabetes

Garry M. Steil, Kerstin Rebrin, Christine Darwin, Farzam Hariri, and Mohammed F. Saad
Diabetes 2006 55: 3344 -3350. [Abstract] [Full Text] [PDF]  

Treatment of Spontaneously Hypertensive Rats With Rosiglitazone and/or Enalapril Restores Balance Between Vasodilator and Vasoconstrictor Actions of Insulin With Simultaneous Improvement in Hypertension and Insulin Resistance

Maria A. Potenza, Flora L. Marasciulo, Mariela Tarquinio, Michael J. Quon, and Monica Montagnani
Diabetes 2006 55: 3594 -3603. [Abstract] [Full Text] [PDF]  

Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo

Dale S. Edgerton, Alan D. Cherrington, Phillip Williams, Doss W. Neal, Melanie Scott, Larry Bowen, Warren Wilson, Charles H. Hobbs, Chet Leach, Mei-chang Kuo, and Thomas R. Strack
Diabetes 2006 55: 3604 -3610. [Abstract] [Full Text] [PDF]  

Genetics:

Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats

Jessica M. Fuller, Anne E. Kwitek, Tyson J. Hawkins, Daniel H. Moralejo, Wen Lu, Terry D. Tupling, Armand J. MacMurray, Gretta Borchardt, Michael Hasinoff, and Åke Lernmark
Diabetes 2006 55: 3351 -3357. [Abstract] [Full Text] [PDF] Table 1Table 2  

A Genome-Wide Linkage Scan for Genes Controlling Variation in Renal Function Estimated by Serum Cystatin C Levels in Extended Families With Type 2 Diabetes

Grzegorz Placha, G. David Poznik, Jonathon Dunn, Adam Smiles, Bozena Krolewski, Timothy Glew, Sobha Puppala, Jennifer Schneider, John J. Rogus, Stephen S. Rich, Ravindranath Duggirala, James H. Warram, and Andrzej S. Krolewski
Diabetes 2006 55: 3358 -3365. [Abstract] [Full Text] [PDF]  

The Idd4 Locus Displays Sex-Specific Epistatic Effects on Type 1 Diabetes Susceptibility in Nonobese Diabetic Mice

Evgueni A. Ivakine, Steven M. Mortin-Toth, Omid M. Gulban, Aneta Valova, Angelo Canty, Christopher Scott, and Jayne S. Danska
Diabetes 2006 55: 3611 -3619. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Brief Genetics Reports:

Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene

Juliette Gray, Giles S.H. Yeo, James J. Cox, Jenny Morton, Anna-Lynne R. Adlam, Julia M. Keogh, Jack A. Yanovski, Areeg El Gharbawy, Joan C. Han, Y.C. Loraine Tung, John R. Hodges, F. Lucy Raymond, Stephen O’Rahilly, and I. Sadaf Farooqi
Diabetes 2006 55: 3366 -3371. [Abstract] [Full Text] [PDF] Online-Only Appendix  

The Krüppel-Like Factor 11 (KLF11) Q62R Polymorphism Is Not Associated With Type 2 Diabetes in 8,676 People

Jose C. Florez, Richa Saxena, Wendy Winckler, Noël P. Burtt, Peter Almgren, Kristina Bengtsson Boström, Tiinamaija Tuomi, Daniel Gaudet, Kristin G. Ardlie, Mark J. Daly, David Altshuler, Joel N. Hirschhorn, and Leif Groop
Diabetes 2006 55: 3620 -3624. [Abstract] [Full Text] [PDF]  

CHRM3 Gene Variation Is Associated With Decreased Acute Insulin Secretion and Increased Risk for Early-Onset Type 2 Diabetes in Pima Indians

Yan Guo, Michael Traurig, Lijun Ma, Sayuko Kobes, Inge Harper, Aniello M. Infante, Clifton Bogardus, Leslie J. Baier, and Michal Prochazka
Diabetes 2006 55: 3625 -3629. [Abstract] [Full Text] [PDF]  

Polymorphism in the Transcription Factor 7-Like 2 (TCF7L2) Gene Is Associated With Reduced Insulin Secretion in Nondiabetic Women

Julian Munoz, Kerry H. Lok, Barbara A. Gower, Jose R. Fernandez, Gary R. Hunter, Cristina Lara-Castro, Maria De Luca, and W. Timothy Garvey
Diabetes 2006 55: 3630 -3634. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Metabolism:

Decreased Hepatic Futile Cycling Compensates for Increased Glucose Disposal in the Pten Heterodeficient Mouse

Jun Xu, Lori Gowen, Christian Raphalides, Katrina K. Hoyer, Jason G. Weinger, Mathilde Renard, Joshua J. Troke, Bhavapriya Vaitheesyaran, W.N. Paul Lee, Mohammed F. Saad, Mark W. Sleeman, Michael A. Teitell, and Irwin J. Kurland
Diabetes 2006 55: 3372 -3380. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Errata:

Errata

Diabetes 2006 55: 3635 . [Extract] [Full Text] [PDF]  

Errata

Diabetes 2006 55: 3635 . [Extract] [Full Text] [PDF]  

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