Diabetes -- Table of Contents (April 2006, 55 [4])

Signal Transduction:

5-Aminoimidazole-4-Carboxamide-1-ß-D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase–Independent Effect on Glucokinase Translocation: Bruno Guigas, Luc Bertrand, Nellie Taleux, Marc Foretz, Nicolas Wiernsperger, Didier Vertommen, Fabrizio Andreelli, Benoit Viollet, and Louis Hue
Diabetes 2006 55: 865 -874. [Abstract] [Full Text] [PDF] Online-Only Appendix

Opposite Effect of JAK2 on Insulin-Dependent Activation of Mitogen-Activated Protein Kinases and Akt in Muscle Cells: Possible Target to Ameliorate Insulin Resistance: Ana C.P. Thirone, Lellean JeBailey, Philip J. Bilan, and Amira Klip
Diabetes 2006 55: 942 -951. [Abstract] [Full Text] [PDF]

Insulin Signaling in Human Visceral and Subcutaneous Adipose Tissue In Vivo: Luigi Laviola, Sebastio Perrini, Angelo Cignarelli, Annalisa Natalicchio, Anna Leonardini, Francesca De Stefano, Marilena Cuscito, Michele De Fazio, Vincenzo Memeo, Vincenzo Neri, Mauro Cignarelli, Riccardo Giorgino, and Francesco Giorgino
Diabetes 2006 55: 952 -961. [Abstract] [Full Text] [PDF]

Islet Studies:

Widespread and Stable Pancreatic Gene Transfer by Adeno-Associated Virus Vectors via Different Routes: Zhong Wang, Tong Zhu, Khaja K. Rehman, Suzanne Bertera, Jian Zhang, Chunlian Chen, Glenn Papworth, Simon Watkins, Massimo Trucco, Paul D. Robbins, Juan Li, and Xiao Xiao
Diabetes 2006 55: 875 -884. [Abstract] [Full Text] [PDF]

Protection of INS-1 Cells From Free Fatty Acid–Induced Apoptosis by Targeting hOGG1 to Mitochondria: Lyudmila I. Rachek, Nancy P. Thornley, Valentina I. Grishko, Susan P. LeDoux, and Glenn L. Wilson
Diabetes 2006 55: 1022 -1028. [Abstract] [Full Text] [PDF]

Mechanisms of Time-Dependent Potentiation of Insulin Release: Involvement of Nitric Oxide Synthase: Subhadra C. Gunawardana, Jonathan V. Rocheleau, W. Steven Head, and David W. Piston
Diabetes 2006 55: 1029 -1033. [Abstract] [Full Text] [PDF]

Blockers of the Delayed-Rectifier Potassium Current in Pancreatic ß-Cells Enhance Glucose-Dependent Insulin Secretion: James Herrington, Yun-Ping Zhou, Randal M. Bugianesi, Paula M. Dulski, Yue Feng, Vivien A. Warren, McHardy M. Smith, Martin G. Kohler, Victor M. Garsky, Manuel Sanchez, Michael Wagner, Kristin Raphaelli, Priya Banerjee, Chinweze Ahaghotu, Denise Wunderler, Birgit T. Priest, John T. Mehl, Maria L. Garcia, Owen B. McManus, Gregory J. Kaczorowski, and Robert S. Slaughter
Diabetes 2006 55: 1034 -1042. [Abstract] [Full Text] [PDF]

Genistein Acutely Stimulates Insulin Secretion in Pancreatic ß-Cells Through a cAMP-Dependent Protein Kinase Pathway: Dongmin Liu, Wei Zhen, Zandong Yang, Jeffery D. Carter, Hongwei Si, and Kathryn A. Reynolds
Diabetes 2006 55: 1043 -1050. [Abstract] [Full Text] [PDF]

Postprandial Suppression of Glucagon Secretion Depends on Intact Pulsatile Insulin Secretion: Further Evidence for the Intraislet Insulin Hypothesis: Juris J. Meier, Lise L. Kjems, Johannes D. Veldhuis, Pierre Lefèbvre, and Peter C. Butler
Diabetes 2006 55: 1051 -1056. [Abstract] [Full Text] [PDF]

Sustained Exposure to High Glucose Concentrations Modifies Glucose Signaling and the Mechanics of Secretory Vesicle Fusion in Primary Rat Pancreatic ß-Cells: Takashi Tsuboi, Magalie A. Ravier, Laura E. Parton, and Guy A. Rutter
Diabetes 2006 55: 1057 -1065. [Abstract] [Full Text] [PDF] Online-Only Appendix

Inhibition of Glucose-Stimulated Activation of Extracellular Signal–Regulated Protein Kinases 1 and 2 by Epinephrine in Pancreatic ß-Cells: Tara Beers Gibson, Michael C. Lawrence, Craig J. Gibson, Colleen A. Vanderbilt, Kathleen McGlynn, Don Arnette, Wei Chen, Julie Collins, Bashoo Naziruddin, Marlon F. Levy, Barbara E. Ehrlich, and Melanie H. Cobb
Diabetes 2006 55: 1066 -1073. [Abstract] [Full Text] [PDF]

Complications:

Accelerated Diabetic Nephropathy in Mice Lacking the Peroxisome Proliferator–Activated Receptor ${alpha}$: Cheol Whee Park, Hyeong Wook Kim, Seung Hyun Ko, Hyun Wha Chung, Sun Woo Lim, Chul Woo Yang, Yoon Sik Chang, Akira Sugawara, YouFei Guan, and Matthew D. Breyer
Diabetes 2006 55: 885 -893. [Abstract] [Full Text] [PDF]

ZO-1 Expression and Phosphorylation in Diabetic Nephropathy: Hernan Rincon-Choles, Tetyana L. Vasylyeva, Pablo E. Pergola, Basant Bhandari, Kusum Bhandari, Jian-Hua Zhang, Wen Wang, Yves Gorin, Jeffrey L. Barnes, and Hanna E. Abboud
Diabetes 2006 55: 894 -900. [Abstract] [Full Text] [PDF]

Contribution of Aldose Reductase to Diabetic Hyperproliferation of Vascular Smooth Muscle Cells: Sanjay Srivastava, Kota V. Ramana, Ravinder Tammali, Satish K. Srivastava, and Aruni Bhatnagar
Diabetes 2006 55: 901 -910. [Abstract] [Full Text] [PDF]

Endothelial Glycocalyx Damage Coincides With Microalbuminuria in Type 1 Diabetes: Max Nieuwdorp, Hans L. Mooij, Jojanneke Kroon, Bektas Atasever, Jos A.E. Spaan, Can Ince, Frits Holleman, Michaela Diamant, Robert J. Heine, Joost B.L. Hoekstra, John J.P. Kastelein, Erik S.G. Stroes, and Hans Vink
Diabetes 2006 55: 1127 -1132. [Abstract] [Full Text] [PDF]

Clustering of Insulin Resistance With Vascular Dysfunction and Low-Grade Inflammation in Type 2 Diabetes: Andrea Natali, Elena Toschi, Stephanie Baldeweg, Demetrio Ciociaro, Stefania Favilla, Luigi Saccà, and Ele Ferrannini
Diabetes 2006 55: 1133 -1140. [Abstract] [Full Text] [PDF]

Insulin Treatment Ameliorates Impaired Corneal Reepithelialization in Diabetic Rats: Ian S. Zagon, Joseph W. Sassani, and Patricia J. McLaughlin
Diabetes 2006 55: 1141 -1147. [Abstract] [Full Text] [PDF]

Diabetes Reduces Basal Retinal Insulin Receptor Signaling: Reversal With Systemic and Local Insulin: Chad E.N. Reiter, Xiaohua Wu, Lakshman Sandirasegarane, Makoto Nakamura, Kirk A. Gilbert, Ravi S.J. Singh, Patrice E. Fort, David A. Antonetti, and Thomas W. Gardner
Diabetes 2006 55: 1148 -1156. [Abstract] [Full Text] [PDF]

Genetics:

Genetic Mapping of Disposition Index and Acute Insulin Response Loci on Chromosome 11q: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study: Nicholette D. Palmer, Carl D. Langefeld, Joel K. Campbell, Adrienne H. Williams, Mohammed Saad, Jill M. Norris, Stephen M. Haffner, Jerome I. Rotter, Lynne E. Wagenknecht, Richard N. Bergman, Stephen S. Rich, and Donald W. Bowden
Diabetes 2006 55: 911 -918. [Abstract] [Full Text] [PDF] Online-Only Appendix

The PPARG Pro12Ala Polymorphism Is Associated With a Decreased Risk of Developing Hyperglycemia Over 6 Years and Combines With the Effect of the APM1 G-11391A Single Nucleotide Polymorphism: The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study: Riphed Jaziri, Stephane Lobbens, Roberte Aubert, Franck Péan, Saida Lahmidi, Martine Vaxillaire, Isabelle Porchay, Naïma Bellili, Jean Tichet, Beverley Balkau, Philippe Froguel, Michel Marre, Frédéric Fumeron for the DESIR Study Group
Diabetes 2006 55: 1157 -1162. [Abstract] [Full Text] [PDF]

Genetic and Functional Analysis of the Nkt1 Locus Using Congenic NOD Mice: Improved V ${alpha}$ 14-NKT Cell Performance but Failure to Protect Against Type 1 Diabetes: Ana-Claudia Rocha-Campos, Rahma Melki, Ren Zhu, Nathalie Deruytter, Diane Damotte, Michel Dy, André Herbelin, and Henri-Jean Garchon
Diabetes 2006 55: 1163 -1170. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

A Polymorphism in the AMPK ${alpha}$ 2 Subunit Gene Is Associated With Insulin Resistance and Type 2 Diabetes in the Japanese Population: Momoko Horikoshi, Kazuo Hara, Jun Ohashi, Kazuaki Miyake, Katsushi Tokunaga, Chikako Ito, Masato Kasuga, Ryozo Nagai, and Takashi Kadowaki
Diabetes 2006 55: 919 -923. [Abstract] [Full Text] [PDF] Online-Only Appendix

EIF4A2 Is a Positional Candidate Gene at the 3q27 Locus Linked to Type 2 Diabetes in French Families: Claire Cheyssac, Christian Dina, Frédéric Leprêtre, Valérie Vasseur-Delannoy, Aurélie Dechaume, Stéphane Lobbens, Beverley Balkau, Juan Ruiz, Guillaume Charpentier, François Pattou, Erik Joly, Marc Prentki, Torben Hansen, Oluf Pedersen, Martine Vaxillaire, and Philippe Froguel
Diabetes 2006 55: 1171 -1176. [Abstract] [Full Text] [PDF] Online-Only Appendix

Metabolism:

Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor- ${gamma}$ –Dependent Mechanism in Mice: Susanne Neschen, Katsutaro Morino, Jörg C. Rossbacher, Rebecca L. Pongratz, Gary W. Cline, Saki Sono, Matthew Gillum, and Gerald I. Shulman
Diabetes 2006 55: 924 -928. [Abstract] [Full Text] [PDF]

Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes: Graeme F. Mason, Kitt F. Petersen, Vincent Lebon, Douglas L. Rothman, and Gerald I. Shulman
Diabetes 2006 55: 929 -934. [Abstract] [Full Text] [PDF]

Group 1B Phospholipase A₂–Mediated Lysophospholipid Absorption Directly Contributes to Postprandial Hyperglycemia: Eric D. Labonté, R. Jason Kirby, Nicholas M. Schildmeyer, April M. Cannon, Kevin W. Huggins, and David Y. Hui
Diabetes 2006 55: 935 -941. [Abstract] [Full Text] [PDF]

Obesity Studies:

Characterization of Peripheral Circadian Clocks in Adipose Tissues: Sanjin Zvonic, Andrey A. Ptitsyn, Steven A. Conrad, L. Keith Scott, Z. Elizabeth Floyd, Gail Kilroy, Xiying Wu, Brian C. Goh, Randall L. Mynatt, and Jeffrey M. Gimble
Diabetes 2006 55: 962 -970. [Abstract] [Full Text] [PDF] Online-Only Appendix

Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice: Dai Chida, Toshimasa Osaka, Okito Hashimoto, and Yoichiro Iwakura
Diabetes 2006 55: 971 -977. [Abstract] [Full Text] [PDF]

Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin: Deborah J. Clegg, Lynda M. Brown, Stephen C. Woods, and Stephen C. Benoit
Diabetes 2006 55: 978 -987. [Abstract] [Full Text] [PDF]

Evidence From Glut2-Null Mice That Glucose Is a Critical Physiological Regulator of Feeding: Isabelle Bady, Nell Marty, Michel Dallaporta, Martine Emery, Jöel Gyger, David Tarussio, Marc Foretz, and Bernard Thorens
Diabetes 2006 55: 988 -995. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Decreased In Vitro Type 1 Immune Response Against Coxsackie Virus B4 in Children With Type 1 Diabetes: Susanne Skarsvik, Julia Puranen, Jarno Honkanen, Merja Roivainen, Jorma Ilonen, Hanna Holmberg, Johnny Ludvigsson, and Outi Vaarala
Diabetes 2006 55: 996 -1003. [Abstract] [Full Text] [PDF]

Atorvastatin Fails to Prevent the Development of Autoimmune Diabetes Despite Inhibition of Pathogenic ß-Cell–Specific CD8 T-Cells: Biliana Lozanoska-Ochser, Francesca Barone, Costantino Pitzalis, and Mark Peakman
Diabetes 2006 55: 1004 -1010. [Abstract] [Full Text] [PDF]

CD4⁺CD25⁺ Regulatory T-Cells Inhibit the Islet Innate Immune Response and Promote Islet Engraftment: Dongmei Chen, Nan Zhang, Shuang Fu, Bernd Schröppel, Qiongfen Guo, Alexandre Garin, Sergio A. Lira, and Jonathan S. Bromberg
Diabetes 2006 55: 1011 -1021. [Abstract] [Full Text] [PDF]

Pathophysiology:

Coordinate Changes in Plasma Glucose and Pancreatic ß-Cell Function in Latino Women at High Risk for Type 2 Diabetes: Anny H. Xiang, Chengwei Wang, Ruth K. Peters, Enrique Trigo, Siri L. Kjos, and Thomas A. Buchanan
Diabetes 2006 55: 1074 -1079. [Abstract] [Full Text] [PDF]

Blockade of GABA_A Receptors in the Ventromedial Hypothalamus Further Stimulates Glucagon and Sympathoadrenal but Not the Hypothalamo-Pituitary-Adrenal Response to Hypoglycemia: Owen Chan, Wanling Zhu, Yuyan Ding, Rory J. McCrimmon, and Robert S. Sherwin
Diabetes 2006 55: 1080 -1087. [Abstract] [Full Text] [PDF]

Cognitive and Neural Hippocampal Effects of Long-Term Moderate Recurrent Hypoglycemia: Ewan C. McNay, Anne Williamson, Rory J. McCrimmon, and Robert S. Sherwin
Diabetes 2006 55: 1088 -1095. [Abstract] [Full Text] [PDF]

Survival Benefits of Intensive Insulin Therapy in Critical Illness: Impact of Maintaining Normoglycemia Versus Glycemia-Independent Actions of Insulin: Björn Ellger, Yves Debaveye, Ilse Vanhorebeek, Lies Langouche, Annapaula Giulietti, Evelyne Van Etten, Paul Herijgers, Chantal Mathieu, and Greet Van den Berghe
Diabetes 2006 55: 1096 -1105. [Abstract] [Full Text] [PDF]

Brain Magnetic Resonance Imaging Correlates of Impaired Cognition in Patients With Type 2 Diabetes: Sanne M. Manschot, Augustina M.A. Brands, Jeroen van der Grond, Roy P.C. Kessels, Ale Algra, L. Jaap Kappelle, Geert Jan Biessels on behalf of the Utrecht Diabetic Encephalopathy Study Group
Diabetes 2006 55: 1106 -1113. [Abstract] [Full Text] [PDF]

The Natural Course of ß-Cell Function in Nondiabetic and Diabetic Individuals: The Insulin Resistance Atherosclerosis Study: Andreas Festa, Ken Williams, Ralph D’Agostino, Jr., Lynne E. Wagenknecht, and Steven M. Haffner
Diabetes 2006 55: 1114 -1120. [Abstract] [Full Text] [PDF]

Antecedent Hypercortisolemia Is Not Primarily Responsible for Generating Hypoglycemia-Associated Autonomic Failure: Philip A. Goldberg, Ram Weiss, Rory J. McCrimmon, Ellen V. Hintz, James D. Dziura, and Robert S. Sherwin
Diabetes 2006 55: 1121 -1126. [Abstract] [Full Text] [PDF]