Signal Transduction:

Glucose-Dependent Transcriptional Regulation by an Evolutionarily Conserved Glucose-Sensing Module

Ming V. Li, Benny Chang, Minako Imamura, Naravat Poungvarin, and Lawrence Chan
Diabetes 2006 55: 1179 -1189. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Transcription Factor FoxO1 Mediates Glucagon-Like Peptide-1 Effects on Pancreatic ß-Cell Mass

Jean Buteau, Marianne L. Spatz, and Domenico Accili
Diabetes 2006 55: 1190 -1196. [Abstract] [Full Text] [PDF]  

Impact of Mitochondrial Reactive Oxygen Species and Apoptosis Signal–Regulating Kinase 1 on Insulin Signaling

Koujiro Imoto, Daisuke Kukidome, Takeshi Nishikawa, Takako Matsuhisa, Kazuhiro Sonoda, Kazuo Fujisawa, Miyuki Yano, Hiroyuki Motoshima, Tetsuya Taguchi, Kaku Tsuruzoe, Takeshi Matsumura, Hidenori Ichijo, and Eiichi Araki
Diabetes 2006 55: 1197 -1204. [Abstract] [Full Text] [PDF]  

Insulin Signaling and Glucose Transport in Skeletal Muscle From First-Degree Relatives of Type 2 Diabetic Patients

Håkan K.R. Karlsson, Maria Ahlsén, Juleen R. Zierath, Harriet Wallberg-Henriksson, and Heikki A. Koistinen
Diabetes 2006 55: 1283 -1288. [Abstract] [Full Text] [PDF]  

Methylglyoxal Impairs the Insulin Signaling Pathways Independently of the Formation of Intracellular Reactive Oxygen Species

Audrey Riboulet-Chavey, Anne Pierron, Isabelle Durand, Joseph Murdaca, Jean Giudicelli, and Emmanuel Van Obberghen
Diabetes 2006 55: 1289 -1299. [Abstract] [Full Text] [PDF]  

Imaging of Insulin Signaling in Skeletal Muscle of Living Mice Shows Major Role of T-Tubules

Hans P.M.M. Lauritzen, Thorkil Ploug, Clara Prats, Jeremy M. Tavaré, and Henrik Galbo
Diabetes 2006 55: 1300 -1306. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Phosphatidylinositol 3-Kinase–Dependent Activation of Akt, an Essential Signal for Hyperthermia-Induced Heat-Shock Protein 72, Is Attenuated in Streptozotocin-Induced Diabetic Heart

Tetsuji Shinohara, Naohiko Takahashi, Tatsuhiko Ooie, Masahide Hara, Sakuji Shigematsu, Mikiko Nakagawa, Hidetoshi Yonemochi, Tetsunori Saikawa, and Hironobu Yoshimatsu
Diabetes 2006 55: 1307 -1315. [Abstract] [Full Text] [PDF]  

Intestinal Insulin Resistance and Aberrant Production of Apolipoprotein B48 Lipoproteins in an Animal Model of Insulin Resistance and Metabolic Dyslipidemia: Evidence for Activation of Protein Tyrosine Phosphatase-1B, Extracellular Signal–Related Kinase, and Sterol Regulatory Element–Binding Protein-1c in the Fructose-Fed Hamster Intestine

Lisa M. Federico, Mark Naples, Denise Taylor, and Khosrow Adeli
Diabetes 2006 55: 1316 -1326. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice

Maria C. García, Ingrid Wernstedt, Anna Berndtsson, Maria Enge, Michal Bell, Olof Hultgren, Michael Horn, Bo Ahrén, Sven Enerback, Claes Ohlsson, Ville Wallenius, and John-Olov Jansson
Diabetes 2006 55: 1205 -1213. [Abstract] [Full Text] [PDF]  

Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA

Miguel López, Christopher J. Lelliott, Sulay Tovar, Wendy Kimber, Rosalía Gallego, Sam Virtue, Margaret Blount, Maria J. Vázquez, Nick Finer, Trevor J. Powles, Stephen O’Rahilly, Asish K. Saha, Carlos Diéguez, and Antonio J. Vidal-Puig
Diabetes 2006 55: 1327 -1336. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Sex-Discordant Associations With Adiponectin Levels and Lipid Profiles in Children

Ken K. Ong, Jan Frystyk, Allan Flyvbjerg, Clive J. Petry, the Avon Longitudinal Study of Parents and Children Study Team, Andy Ness, and David B. Dunger
Diabetes 2006 55: 1337 -1341. [Abstract] [Full Text] [PDF] Online-Only Appendix  

NFATc4 and ATF3 Negatively Regulate Adiponectin Gene Expression in 3T3-L1 Adipocytes

Hyun Bae Kim, Minyoung Kong, Tae Min Kim, Young Ho Suh, Won-Ho Kim, Joo Hyun Lim, Ji Hyun Song, and Myeong Ho Jung
Diabetes 2006 55: 1342 -1352. [Abstract] [Full Text] [PDF]  

Regional Differences in Adipose Tissue Metabolism in Women: Minor Effect of Obesity and Body Fat Distribution

André Tchernof, Chantal Bélanger, Anne-Sophie Morisset, Christian Richard, Jacques Mailloux, Philippe Laberge, and Pierre Dupont
Diabetes 2006 55: 1353 -1360. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

The Class I HLA Repertoire of Pancreatic Islets Comprises the Nonclassical Class Ib Antigen HLA-G

Vincenzo Cirulli, Jessie Zalatan, Michael McMaster, Robyn Prinsen, Daniel R. Salomon, Camillo Ricordi, Bruce E. Torbett, Paolo Meda, and Laura Crisa
Diabetes 2006 55: 1214 -1222. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Effect of Donor Age on Function of Isolated Human Islets

Sung-Hee Ihm, Ippei Matsumoto, Toshiya Sawada, Masahiko Nakano, Hui J. Zhang, Jeffrey D. Ansite, David E.R. Sutherland, and Bernhard J. Hering
Diabetes 2006 55: 1361 -1368. [Abstract] [Full Text] [PDF]  

Islet Studies:

Evidence for a Role of the Ubiquitin-Proteasome Pathway in Pancreatic Islets

María D. López-Avalos, Valérie F. Duvivier-Kali, Gang Xu, Susan Bonner-Weir, Arun Sharma, and Gordon C. Weir
Diabetes 2006 55: 1223 -1231. [Abstract] [Full Text] [PDF]  

Activation of Glucagon-Like Peptide-1 Receptor Signaling Does Not Modify the Growth or Apoptosis of Human Pancreatic Cancer Cells

Jacqueline A. Koehler and Daniel J. Drucker
Diabetes 2006 55: 1369 -1379. [Abstract] [Full Text] [PDF]  

Dexamethasone Induces Cell Death in Insulin-Secreting Cells, an Effect Reversed by Exendin-4

Felicia Ranta, Diana Avram, Susanne Berchtold, Martina Düfer, Gisela Drews, Florian Lang, and Susanne Ullrich
Diabetes 2006 55: 1380 -1390. [Abstract] [Full Text] [PDF]  

L-Cysteine Inhibits Insulin Release From the Pancreatic ß-Cell: Possible Involvement of Metabolic Production of Hydrogen Sulfide, a Novel Gasotransmitter

Yukiko Kaneko, Yuka Kimura, Hideo Kimura, and Ichiro Niki
Diabetes 2006 55: 1391 -1397. [Abstract] [Full Text] [PDF]  

Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and ß-Cell Lines

J. Jason Collier, Patrick T. Fueger, Hans E. Hohmeier, and Christopher B. Newgard
Diabetes 2006 55: 1398 -1406. [Abstract] [Full Text] [PDF]  

Complete Protection Against Interleukin-1ß–Induced Functional Suppression and Cytokine-Mediated Cytotoxicity in Rat Pancreatic Islets In Vitro Using an Interleukin-1 Cytokine Trap

Tobias Rydgren, Daniel Bengtsson, and Stellan Sandler
Diabetes 2006 55: 1407 -1412. [Abstract] [Full Text] [PDF]  

Blockade of ß1 Integrin–Laminin-5 Interaction Affects Spreading and Insulin Secretion of Rat ß-Cells Attached on Extracellular Matrix

Geraldine Parnaud, Eva Hammar, Dominique G. Rouiller, Mathieu Armanet, Philippe A. Halban, and Domenico Bosco
Diabetes 2006 55: 1413 -1420. [Abstract] [Full Text] [PDF]  

Munc13-1 Deficiency Reduces Insulin Secretion and Causes Abnormal Glucose Tolerance

Edwin P. Kwan, Li Xie, Laura Sheu, Christopher J. Nolan, Marc Prentki, Andrea Betz, Nils Brose, and Herbert Y. Gaisano
Diabetes 2006 55: 1421 -1429. [Abstract] [Full Text] [PDF]  

Complications:

2-(8-Hydroxy-6-Methoxy-1-Oxo-1H-2-Benzopyran-3-yl) Propionic Acid, an Inhibitor of Angiogenesis, Ameliorates Renal Alterations in Obese Type 2 Diabetic Mice

Kunihiro Ichinose, Yohei Maeshima, Yoshihiko Yamamoto, Masaru Kinomura, Kumiko Hirokoshi, Hiroyuki Kitayama, Yuki Takazawa, Hitoshi Sugiyama, Yasushi Yamasaki, Naoki Agata, and Hirofumi Makino
Diabetes 2006 55: 1232 -1242. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Human Vascular Smooth Muscle Cells From Diabetic Patients Are Resistant to Induced Apoptosis Due to High Bcl-2 Expression

Emilio Ruiz, Antonio Gordillo-Moscoso, Eugenia Padilla, Santiago Redondo, Enrique Rodriguez, Fernando Reguillo, Ana M. Briones, Cornelis van Breemen, Elena Okon, and Teresa Tejerina
Diabetes 2006 55: 1243 -1251. [Abstract] [Full Text] [PDF]  

Diabetes-Induced Activation of Canonical and Noncanonical Nuclear Factor-B Pathways in Renal Cortex

Jonathan M. Starkey, Sigmund J. Haidacher, Wanda S. LeJeune, Xiaoquan Zhang, Brian C. Tieu, Sanjeev Choudhary, Allan R. Brasier, Larry A. Denner, and Ronald G. Tilton
Diabetes 2006 55: 1252 -1259. [Abstract] [Full Text] [PDF]  

Elevated Activity of Transcription Factor Nuclear Factor of Activated T-Cells 5 (NFAT5) and Diabetic Nephropathy

Bingmei Yang, Andrea D. Hodgkinson, Peter J. Oates, Hyug Moo Kwon, Beverley A. Millward, and Andrew G. Demaine
Diabetes 2006 55: 1450 -1455. [Abstract] [Full Text] [PDF]  

Insulin Resistance and Microalbuminuria: A Cross-Sectional, Case-Control Study of 158 Patients With Type 2 Diabetes and Different Degrees of Urinary Albumin Excretion

Aneliya I. Parvanova, Roberto Trevisan, Ilian P. Iliev, Borislav D. Dimitrov, Monica Vedovato, Antonio Tiengo, Giuseppe Remuzzi, and Piero Ruggenenti
Diabetes 2006 55: 1456 -1462. [Abstract] [Full Text] [PDF]  

The 30-Year Natural History of Type 1 Diabetes Complications: The Pittsburgh Epidemiology of Diabetes Complications Study Experience

Georgia Pambianco, Tina Costacou, Demetrius Ellis, Dorothy J. Becker, Ronald Klein, and Trevor J. Orchard
Diabetes 2006 55: 1463 -1469. [Abstract] [Full Text] [PDF]  

Effects of Basic Fibroblast Growth Factor on Experimental Diabetic Neuropathy in Rats

Mika Nakae, Hideki Kamiya, Keiko Naruse, Naoichi Horio, Yasuki Ito, Ryuichi Mizubayashi, Yoji Hamada, Eitaro Nakashima, Noboru Akiyama, Yasuko Kobayashi, Atsuko Watarai, Nachi Kimura, Masayuki Horiguchi, Yasuhiko Tabata, Yutaka Oiso, and Jiro Nakamura
Diabetes 2006 55: 1470 -1477. [Abstract] [Full Text] [PDF]  

Aldose Reductase Pathway Inhibition Improved Vascular and C-Fiber Functions, Allowing for Pressure-Induced Vasodilation Restoration During Severe Diabetic Neuropathy

Claire Demiot, Maylis Tartas, Bérengère Fromy, Pierre Abraham, Jean Louis Saumet, and Dominique Sigaudo-Roussel
Diabetes 2006 55: 1478 -1483. [Abstract] [Full Text] [PDF]  

Brief Genetics Reports:

Hepatocyte Nuclear Factor-4 P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population

Kazuo Hara, Momoko Horikoshi, Hiroji Kitazato, Chikako Ito, Mitsuhiko Noda, Jun Ohashi, Philippe Froguel, Katsushi Tokunaga, Kazuyuki Tobe, Ryozo Nagai, and Takashi Kadowaki
Diabetes 2006 55: 1260 -1264. [Abstract] [Full Text] [PDF]  

Multi-SNP Analysis of MHC Region: Remarkable Conservation of HLA-A1-B8-DR3 Haplotype

Theresa A. Aly, Elise Eller, Akane Ide, Katherine Gowan, Sunanda R. Babu, Henry A. Erlich, Marian J. Rewers, George S. Eisenbarth, and Pamela R. Fain
Diabetes 2006 55: 1265 -1269. [Abstract] [Full Text] [PDF] Online-Only Appendix  

The ATGL Gene Is Associated With Free Fatty Acids, Triglycerides, and Type 2 Diabetes

Veit Schoenborn, Iris M. Heid, Caren Vollmert, Arno Lingenhel, Ted D. Adams, Paul N. Hopkins, Thomas Illig, Robert Zimmermann, Rudolf Zechner, Steven C. Hunt, and Florian Kronenberg
Diabetes 2006 55: 1270 -1275. [Abstract] [Full Text] [PDF] Online-Only Appendix  

No Evidence for Association of OAS1 With Type 1 Diabetes in Unaffected Siblings or Type 1 Diabetic Cases

Deborah J. Smyth, Jason D. Cooper, Christopher E. Lowe, Sarah Nutland, Neil M. Walker, David G. Clayton, and John A. Todd
Diabetes 2006 55: 1525 -1528. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Variants of the Interleukin-10 Promoter Gene Are Associated With Obesity and Insulin Resistance but Not Type 2 Diabetes in Caucasian Italian Subjects

Daniela Scarpelli, Marina Cardellini, Francesco Andreozzi, Emanuela Laratta, Marta Letizia Hribal, Maria Adelaide Marini, Vittorio Tassi, Renato Lauro, Francesco Perticone, and Giorgio Sesti
Diabetes 2006 55: 1529 -1533. [Abstract] [Full Text] [PDF]  

Metabolism:

Metabolic Sensors Mediate Hypoglycemic Detection at the Portal Vein

Aleksey V. Matveyenko and Casey M. Donovan
Diabetes 2006 55: 1276 -1282. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Insulin Secretion and Action in Subjects With Impaired Fasting Glucose and Impaired Glucose Tolerance: Results From the Veterans Administration Genetic Epidemiology Study

Muhammad A. Abdul-Ghani, Christopher P. Jenkinson, Dawn K. Richardson, Devjit Tripathy, and Ralph A. DeFronzo
Diabetes 2006 55: 1430 -1435. [Abstract] [Full Text] [PDF]  

Obesity Blunts Insulin-Mediated Microvascular Recruitment in Human Forearm Muscle

Lucy H. Clerk, Michelle A. Vincent, Linda A. Jahn, Zhenqi Liu, Jonathan R. Lindner, and Eugene J. Barrett
Diabetes 2006 55: 1436 -1442. [Abstract] [Full Text] [PDF]  

Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives

Anna Sapone, Laura de Magistris, Michelle Pietzak, Maria G. Clemente, Amit Tripathi, Francesco Cucca, Rosanna Lampis, Deborah Kryszak, Maria Cartenì, Maddalena Generoso, Dario Iafusco, Francesco Prisco, Francesca Laghi, Gabriele Riegler, Romano Carratu, Debra Counts, and Alessio Fasano
Diabetes 2006 55: 1443 -1449. [Abstract] [Full Text] [PDF]  

Pharmacology [amp ] Therapeutics:

Improvement of Glucose Tolerance and Hepatic Insulin Sensitivity by Oligofructose Requires a Functional Glucagon-Like Peptide 1 Receptor

Patrice D. Cani, Claude Knauf, Miguel A. Iglesias, Daniel J. Drucker, Nathalie M. Delzenne, and Rémy Burcelin
Diabetes 2006 55: 1484 -1490. [Abstract] [Full Text] [PDF]  

Plasma Phospholipid Transfer Protein Activity Is Decreased in Type 2 Diabetes During Treatment With Atorvastatin: A Role for Apolipoprotein E?

Geesje M. Dallinga-Thie, Arie van Tol, Hiroaki Hattori, Patrick C.N. Rensen, Eric J.G. Sijbrands for the Diabetes Atorvastatin Lipid Intervention (DALI) Study Group
Diabetes 2006 55: 1491 -1496. [Abstract] [Full Text] [PDF]  

Genetics:

A Functional Tyr1306Cys Variant in LARG Is Associated With Increased Insulin Action in Vivo

Peter Kovacs, Michael Stumvoll, Clifton Bogardus, Robert L. Hanson, and Leslie J. Baier
Diabetes 2006 55: 1497 -1503. [Abstract] [Full Text] [PDF]  

Variation in the UCP2-UCP3 Gene Cluster Predicts the Development of Type 2 Diabetes in Healthy Middle-Aged Men

David R. Gable, Jefferey W. Stephens, Jackie A. Cooper, George J. Miller, and Steve E. Humphries
Diabetes 2006 55: 1504 -1511. [Abstract] [Full Text] [PDF]  

Adiponectin Genetic Variability, Plasma Adiponectin, and Cardiovascular Risk in Patients With Type 2 Diabetes

Lu Qi, Alessandro Doria, JoAnn E. Manson, James B. Meigs, David Hunter, Christos S. Mantzoros, and Frank B. Hu
Diabetes 2006 55: 1512 -1516. [Abstract] [Full Text] [PDF]  

Differential Transmission of Type 1 Diabetes from Diabetic Fathers and Mothers to Their Offspring

Valma Harjutsalo, Antti Reunanen, and Jaakko Tuomilehto
Diabetes 2006 55: 1517 -1524. [Abstract] [Full Text] [PDF]  

Errata:

Erratum

Diabetes 2006 55: 1534 . [Extract] [Full Text] [PDF]  

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