Diabetes -- Table of Contents (June 2006, 55 [6])

Lilly Lecture 2005:

Adipose Tissue: From Lipid Storage Compartment to Endocrine Organ: Philipp E. Scherer
Diabetes 2006 55: 1537 -1545. [Abstract] [Full Text] [PDF]

Metabolism:

Reversal of Type 1 Diabetes by Engineering a Glucose Sensor in Skeletal Muscle: Alex Mas, Joel Montané, Xavier M. Anguela, Sergio Muñoz, Anne M. Douar, Efren Riu, Pedro Otaegui, and Fatima Bosch
Diabetes 2006 55: 1546 -1553. [Abstract] [Full Text] [PDF]

Inhibition of Fructose 1,6-Bisphosphatase Reduces Excessive Endogenous Glucose Production and Attenuates Hyperglycemia in Zucker Diabetic Fatty Rats: Paul D. van Poelje, Scott C. Potter, Visvanathan C. Chandramouli, Bernard R. Landau, Qun Dang, and Mark D. Erion
Diabetes 2006 55: 1747 -1754. [Abstract] [Full Text] [PDF]

Activation of AMP-Activated Protein Kinase Within the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses in Rats With Defective Counterregulation: Rory J. McCrimmon, Xiaoning Fan, Haiying Cheng, Ewan McNay, Owen Chan, Margaret Shaw, Yuyan Ding, Wanling Zhu, and Robert S. Sherwin
Diabetes 2006 55: 1755 -1760. [Abstract] [Full Text] [PDF]

Time-Dependent Effects of Free Fatty Acids on Glucose Effectiveness in Type 2 Diabetes: Preeti Kishore, Julia Tonelli, Sudha Koppaka, Corina Fratila, Anita Bose, Do-Eun Lee, Kalpana Reddy, and Meredith Hawkins
Diabetes 2006 55: 1761 -1768. [Abstract] [Full Text] [PDF]

Reduced Access to Insulin-Sensitive Tissues in Dogs With Obesity Secondary to Increased Fat Intake: Martin Ellmerer, Marianthe Hamilton-Wessler, Stella P. Kim, Katrin Huecking, Erlinda Kirkman, Jenny Chiu, Joyce Richey, and Richard N. Bergman
Diabetes 2006 55: 1769 -1775. [Abstract] [Full Text] [PDF]

Obesity Studies:

Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity: Raffaella Cancello, Joan Tordjman, Christine Poitou, Gaël Guilhem, Jean Luc Bouillot, Danielle Hugol, Christiane Coussieu, Arnaud Basdevant, Avner Bar Hen, Pierre Bedossa, Michèle Guerre-Millo, and Karine Clément
Diabetes 2006 55: 1554 -1561. [Abstract] [Full Text] [PDF]

Downregulation of Electron Transport Chain Genes in Visceral Adipose Tissue in Type 2 Diabetes Independent of Obesity and Possibly Involving Tumor Necrosis Factor- ${alpha}$: Ingrid Dahlman, Margaretha Forsgren, Annelie Sjögren, Elisabet Arvidsson Nordström, Maria Kaaman, Erik Näslund, Anneli Attersand, and Peter Arner
Diabetes 2006 55: 1792 -1799. [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Lymphocytic Infiltration and Immune Activation in Metallothionein Promoter–Exendin-4 (MT-Exendin) Transgenic Mice: Laurie L. Baggio, Dianne Holland, Joan Wither, and Daniel J. Drucker
Diabetes 2006 55: 1562 -1570. [Abstract] [Full Text] [PDF] Online-Only Appendix

Induction of Tolerance in Type 1 Diabetes via Both CD4⁺CD25⁺ T Regulatory Cells and T Regulatory Type 1 Cells: Manuela Battaglia, Angela Stabilini, Elena Draghici, Barbara Migliavacca, Silvia Gregori, Ezio Bonifacio, and Maria-Grazia Roncarolo
Diabetes 2006 55: 1571 -1580. [Abstract] [Full Text] [PDF]

Islet Studies:

Glucose Regulates Foxo1 Through Insulin Receptor Signaling in the Pancreatic Islet ß-cell: Sara C. Martinez, Corentin Cras-Méneur, Ernesto Bernal-Mizrachi, and M. Alan Permutt
Diabetes 2006 55: 1581 -1591. [Abstract] [Full Text] [PDF] Online-Only Appendix

Metallothionein and Catalase Sensitize to Diabetes in Nonobese Diabetic Mice: Reactive Oxygen Species May Have a Protective Role in Pancreatic ß-Cells: Xiaoyan Li, Hainan Chen, and Paul N. Epstein
Diabetes 2006 55: 1592 -1604. [Abstract] [Full Text] [PDF] Online-Only Appendix

Peroxisome Proliferator–Activated Receptor ${alpha}$ Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets: Fanny Lalloyer, Brigitte Vandewalle, Frédéric Percevault, Gérard Torpier, Julie Kerr-Conte, Maaike Oosterveer, Réjane Paumelle, Jean-Charles Fruchart, Folkert Kuipers, François Pattou, Catherine Fiévet, and Bart Staels
Diabetes 2006 55: 1605 -1613. [Abstract] [Full Text] [PDF] Online-Only Appendix

The Role of Phosphoinositide 3-Kinase/Akt Signaling in Low-Dose Mercury–Induced Mouse Pancreatic ß-Cell Dysfunction In Vitro and In Vivo: Ya Wen Chen, Chun Fa Huang, Keh Sung Tsai, Rong Sen Yang, Cheng Chieh Yen, Ching Yao Yang, Shoei Yn Lin-Shiau, and Shing Hwa Liu
Diabetes 2006 55: 1614 -1624. [Abstract] [Full Text] [PDF]

Pathophysiology:

Islet Inflammation and Fibrosis in a Spontaneous Model of Type 2 Diabetes, the GK Rat: Françoise Homo-Delarche, Sophie Calderari, Jean-Claude Irminger, Marie-Noëlle Gangnerau, Josiane Coulaud, Katharina Rickenbach, Manuel Dolz, Philippe Halban, Bernard Portha, and Patricia Serradas
Diabetes 2006 55: 1625 -1633. [Abstract] [Full Text] [PDF]

Nutritional Supplementation With trans-10, cis-12–Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue: Hélène Poirier, Jennifer S. Shapiro, Roy J. Kim, and Mitchell A. Lazar
Diabetes 2006 55: 1634 -1641. [Abstract] [Full Text] [PDF]

Cognitive Performance, Psychological Well-Being, and Brain Magnetic Resonance Imaging in Older Patients With Type 1 Diabetes: Augustina M.A. Brands, Roy P.C. Kessels, Roel P.L.M. Hoogma, Johanna M.L. Henselmans, Johanna W. van der Beek Boter, L. Jaap Kappelle, Edward H.F. de Haan, and Geert Jan Biessels
Diabetes 2006 55: 1800 -1806. [Abstract] [Full Text] [PDF]

Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans: Michiel E. Stegenga, Saskia N. van der Crabben, Marcel Levi, Alex F. de Vos, Michael W. Tanck, Hans P. Sauerwein, and Tom van der Poll
Diabetes 2006 55: 1807 -1812. [Abstract] [Full Text] [PDF]

Decreased Muscle Strength and Quality in Older Adults With Type 2 Diabetes: The Health, Aging, and Body Composition Study: Seok Won Park, Bret H. Goodpaster, Elsa S. Strotmeyer, Nathalie de Rekeneire, Tamara B. Harris, Ann V. Schwartz, Frances A. Tylavsky, and Anne B. Newman
Diabetes 2006 55: 1813 -1818. [Abstract] [Full Text] [PDF]

The Intrauterine Environment as Reflected by Birth Size and Twin and Zygosity Status Influences Insulin Action and Intracellular Glucose Metabolism in an Age- or Time-Dependent Manner: Pernille Poulsen and Allan Vaag
Diabetes 2006 55: 1819 -1825. [Abstract] [Full Text] [PDF]

Complications:

Deletion of p66^Shc Longevity Gene Protects Against Experimental Diabetic Glomerulopathy by Preventing Diabetes-Induced Oxidative Stress: Stefano Menini, Lorena Amadio, Giovanna Oddi, Carlo Ricci, Carlo Pesce, Francesco Pugliese, Marco Giorgio, Enrica Migliaccio, PierGiuseppe Pelicci, Carla Iacobini, and Giuseppe Pugliese
Diabetes 2006 55: 1642 -1650. [Abstract] [Full Text] [PDF] Online-Only Appendix

Altered Endothelial Nitric Oxide Synthase Targeting and Conformation and Caveolin-1 Expression in the Diabetic Kidney: Radko Komers, William E. Schutzer, John F. Reed, Jessie N. Lindsley, Terry T. Oyama, David C. Buck, Scott L. Mader, and Sharon Anderson
Diabetes 2006 55: 1651 -1659. [Abstract] [Full Text] [PDF]

Apoptosis Signal-Regulating Kinase 1 Mediates Cellular Senescence Induced by High Glucose in Endothelial Cells: Toyohiko Yokoi, Keisuke Fukuo, Osamu Yasuda, Mizuo Hotta, Junichi Miyazaki, Yukihiro Takemura, Hidenobu Kawamoto, Hidenori Ichijo, and Toshio Ogihara
Diabetes 2006 55: 1660 -1665. [Abstract] [Full Text] [PDF]

Thiazolidinediones Ameliorate Diabetic Nephropathy via Cell Cycle–Dependent Mechanisms: Tatsuo Okada, Jun Wada, Kazuyuki Hida, Jun Eguchi, Izumi Hashimoto, Masako Baba, Akihiro Yasuhara, Kenichi Shikata, and Hirofumi Makino
Diabetes 2006 55: 1666 -1677. [Abstract] [Full Text] [PDF]

Salutary Effect of Pigment Epithelium–Derived Factor in Diabetic Nephropathy: Evidence for Antifibrogenic Activities: Joshua J. Wang, Sarah X. Zhang, Robert Mott, Ryan R. Knapp, Wei Cao, Kai Lau, and Jian-xing Ma
Diabetes 2006 55: 1678 -1685. [Abstract] [Full Text] [PDF]

Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy: Olga Ilnytska, Valeriy V. Lyzogubov, Martin J. Stevens, Viktor R. Drel, Nazar Mashtalir, Pal Pacher, Mark A. Yorek, and Irina G. Obrosova
Diabetes 2006 55: 1686 -1694. [Abstract] [Full Text] [PDF]

Diabetic Nephropathy Is Associated With Gene Expression Levels of Oxidative Phosphorylation and Related Pathways: Chunmei Huang, Youngki Kim, M. Luiza Caramori, Jason H. Moore, Stephen S. Rich, Josyf C. Mychaleckyj, Paul C. Walker, and Michael Mauer
Diabetes 2006 55: 1826 -1831. [Abstract] [Full Text] [PDF]

Risk Factors for Renal Dysfunction in Type 2 Diabetes: U.K. Prospective Diabetes Study 74: Ravi Retnakaran, Carole A. Cull, Kerensa I. Thorne, Amanda I. Adler, Rury R. Holman for the UKPDS Study Group
Diabetes 2006 55: 1832 -1839. [Abstract] [Full Text] [PDF]

Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells: Evidence for Involvement of a cAMP Signaling Pathway: Raogo Ouedraogo, Xiangdong Wu, Shi-Qiong Xu, Lauren Fuchsel, Hiroyuki Motoshima, Kalyankar Mahadev, Kelly Hough, Rosario Scalia, and Barry J. Goldstein
Diabetes 2006 55: 1840 -1846. [Abstract] [Full Text] [PDF]

Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy: Sally A. Price, Carolyn Dent, Beatriz Duran-Jimenez, Yuxin Liang, Lei Zhang, Edward J. Rebar, Casey C. Case, Philip D. Gregory, Tyler J. Martin, S. Kaye Spratt, and David R. Tomlinson
Diabetes 2006 55: 1847 -1854. [Abstract] [Full Text] [PDF]

Pharmacology & Therapeutics:

Chronic Inhibition of Dipeptidyl Peptidase-4 With a Sitagliptin Analog Preserves Pancreatic ß-Cell Mass and Function in a Rodent Model of Type 2 Diabetes: James Mu, John Woods, Yun-Ping Zhou, Ranabir Sinha Roy, Zhihua Li, Emanuel Zycband, Yue Feng, Lan Zhu, Cai Li, Andrew D. Howard, David. E. Moller, Nancy A. Thornberry, and Bei B. Zhang
Diabetes 2006 55: 1695 -1704. [Abstract] [Full Text] [PDF]

Genetics:

Mutations at the Same Residue (R50) of Kir6.2 (KCNJ11) That Cause Neonatal Diabetes Produce Different Functional Effects: Kenju Shimomura, Christophe A.J. Girard, Peter Proks, Joanna Nazim, Jonathan D. Lippiat, Franco Cerutti, Renata Lorini, Sian Ellard, Andrew T. Hattersley, Fabrizio Barbetti, and Frances M. Ashcroft
Diabetes 2006 55: 1705 -1712. [Abstract] [Full Text] [PDF]

From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation: Jørn V. Sagen, Stella Odili, Lise Bjørkhaug, Dorothy Zelent, Carol Buettger, Jae Kwagh, Charles Stanley, Knut Dahl-Jørgensen, Carine de Beaufort, Graeme I. Bell, Yi Han, Joseph Grimsby, Rebecca Taub, Anders Molven, Oddmund Søvik, Pål R. Njølstad, and Franz M. Matschinsky
Diabetes 2006 55: 1713 -1722. [Abstract] [Full Text] [PDF]

Genome-Wide Linkage of Plasma Adiponectin Reveals a Major Locus on Chromosome 3q Distinct From the Adiponectin Structural Gene: The IRAS Family Study: Xiuqing Guo, Mohammed F. Saad, Carl D. Langefeld, Adrienne H. Williams, Jinrui Cui, Kent D. Taylor, Jill M. Norris, Sujata Jinagouda, Christine H. Darwin, Braxton D. Mitchell, Richard N. Bergman, Beth Sutton, Y.-D. Ida Chen, Lynne E. Wagenknecht, Donald W. Bowden, and Jerome I. Rotter
Diabetes 2006 55: 1723 -1730. [Abstract] [Full Text] [PDF]

Functional Effects of Mutations at F35 in the NH₂-terminus of Kir6.2 (KCNJ11), Causing Neonatal Diabetes, and Response to Sulfonylurea Therapy: Peter Proks, Christophe Girard, Halvor Bævre, Pål R. Njølstad, and Frances M. Ashcroft
Diabetes 2006 55: 1731 -1737. [Abstract] [Full Text] [PDF] Online-Only Appendix

Kir6.2 Mutations Associated With Neonatal Diabetes Reduce Expression of ATP-Sensitive K⁺ channels: Implications in Disease Mechanism and Sulfonylurea Therapy: Chia-Wei Lin, Yu-Wen Lin, Fei-Fei Yan, Jillene Casey, Malini Kochhar, Emily B. Pratt, and Show-Ling Shyng
Diabetes 2006 55: 1738 -1746. [Abstract] [Full Text] [PDF] Online-Only Appendix

Combination of HLA-A24, -DQA1*03, and -DR9 Contributes to Acute-Onset and Early Complete ß-Cell Destruction in Type 1 Diabetes: Longitudinal Study of Residual ß-Cell Function: Koji Nakanishi and Hidetoshi Inoko
Diabetes 2006 55: 1862 -1868. [Abstract] [Full Text] [PDF]

Signal Transduction:

Exercise-Induced Phosphorylation of the Novel Akt Substrates AS160 and Filamin A in Human Skeletal Muscle: Atul Deshmukh, Vernon G. Coffey, Zhihui Zhong, Alexander V. Chibalin, John A. Hawley, and Juleen R. Zierath
Diabetes 2006 55: 1776 -1782. [Abstract] [Full Text] [PDF]

Evidence for a Mitochondrial Regulatory Pathway Defined by Peroxisome Proliferator–Activated Receptor- ${gamma}$ Coactivator-1 ${alpha}$ , Estrogen-Related Receptor- ${alpha}$ , and Mitofusin 2: Francesc X. Soriano, Marc Liesa, Daniel Bach, David C. Chan, Manuel Palacín, and Antonio Zorzano
Diabetes 2006 55: 1783 -1791. [Abstract] [Full Text] [PDF]

Pharmacology [amp ] Therapeutics:

The Experimental Type 2 Diabetes Therapy Glycogen Phosphorylase Inhibition Can Impair Aerobic Muscle Function During Prolonged Contraction: David J. Baker, Paul L. Greenhaff, Alan MacInnes, and James A. Timmons
Diabetes 2006 55: 1855 -1861. [Abstract] [Full Text] [PDF]

Brief Genetics Reports:

A Novel –192c/g Mutation in the Proximal P2 Promoter of the Hepatocyte Nuclear Factor-4 ${alpha}$ Gene (HNF4A) Associates With Late-Onset Diabetes: Jakob Ek, Sara P. Hansen, Maria Lajer, Carine Nicot, Trine W. Boesgaard, Stepanka Pruhova, Anders Johansen, Anders Albrechtsen, Knud Yderstræde, Jeannet Lauenborg, Marcelina Parrizas, Sylvia F. Boj, Torben Jørgensen, Knut Borch-Johnsen, Peter Damm, Jorge Ferrer, Jan Lebl, Oluf Pedersen, and Torben Hansen
Diabetes 2006 55: 1869 -1873. [Abstract] [Full Text] [PDF] Online-Only Appendix

Fasting Insulin and Obesity-Related Phenotypes Are Linked to Chromosome 2p: The Strong Heart Family Study: Vincent P. Diego, Harald H.H. Göring, Shelley A. Cole, Laura Almasy, Thomas D. Dyer, John Blangero, Ravindranath Duggirala, Sandra Laston, Charlotte Wenger, Teresa Cantu, Bennett Dyke, Kari North, Theodore Schurr, Lyle G. Best, Richard B. Devereux, Richard R. Fabsitz, Barbara V. Howard, and Jean W. MacCluer
Diabetes 2006 55: 1874 -1878. [Abstract] [Full Text] [PDF]

Linkage but Not Association of Calpain-10 to Type 2 Diabetes Replicated in Northern Sweden: Elisabet Einarsdottir, Sofia Mayans, Karin Ruikka, Stefan A. Escher, Petter Lindgren, Åsa Ågren, Mats Eliasson, and Dan Holmberg
Diabetes 2006 55: 1879 -1883. [Abstract] [Full Text] [PDF] Online-Only Appendix

Significant Linkage of BMI to Chromosome 10p in the U.K. Population and Evaluation of GAD2 as a Positional Candidate: Christopher J. Groves, Eleftheria Zeggini, Mark Walker, Graham A. Hitman, Jonathan C. Levy, Stephen O’Rahilly, Andrew T. Hattersley, Mark I. McCarthy, and Steven Wiltshire
Diabetes 2006 55: 1884 -1889. [Abstract] [Full Text] [PDF]

The Variable Number of Tandem Repeats Upstream of the Insulin Gene Is a Susceptibility Locus for Latent Autoimmune Diabetes in Adults: Minal Desai, Eleftheria Zeggini, Virginia A. Horton, Katharine R. Owen, Andrew T. Hattersley, Jonathan C. Levy, Graham A. Hitman, Mark Walker, Rury R. Holman, Mark I. McCarthy, and Anne Clark
Diabetes 2006 55: 1890 -1894. [Abstract] [Full Text] [PDF]

HLA Genotyping Supports a Nonautoimmune Etiology in Patients Diagnosed With Diabetes Under the Age of 6 Months: Emma L. Edghill, Rachel J. Dix, Sarah E. Flanagan, Polly J. Bingley, Andrew T. Hattersley, Sian Ellard, and Kathleen M. Gillespie
Diabetes 2006 55: 1895 -1898. [Abstract] [Full Text] [PDF] Online-Only Appendix

A Hepatocyte Nuclear Factor-4 ${alpha}$ Gene (HNF4A) P2 Promoter Haplotype Linked With Late-Onset Diabetes: Studies of HNF4A Variants in the Norwegian MODY Registry: Helge Ræder, Lise Bjørkhaug, Stefan Johansson, Kjersti Mangseth, Jørn V. Sagen, Anne Hunting, Ivar Følling, Odd Johansen, Marit Bjørgaas, Povel N. Paus, Oddmund Søvik, Anders Molven, and Pål R. Njølstad
Diabetes 2006 55: 1899 -1903. [Abstract] [Full Text] [PDF] Online-Only Appendix

Errata:

Errata: Diabetes 2006 55: 1904 . [Extract] [Full Text] [PDF]