Perspectives in Diabetes:

Interventional Strategies to Prevent ß-Cell Apoptosis in Islet Transplantation

Juliet A. Emamaullee and A.M. James Shapiro
Diabetes 2006 55: 1907 -1914. [Abstract] [Full Text] [PDF]  

Signal Transduction:

Regulation of Metabolic Responses by Adipocyte/ Macrophage Fatty Acid–Binding Proteins in Leptin-Deficient Mice

Haiming Cao, Kazuhisa Maeda, Cem Z. Gorgun, Hyo-Jeong Kim, So-Young Park, Gerald I. Shulman, Jason K. Kim, and Gökhan S. Hotamisligil
Diabetes 2006 55: 1915 -1922. [Abstract] [Full Text] [PDF]  

A Glucose Sensor Role for Glucokinase in Anterior Pituitary Cells

Dorothy Zelent, Maria L. Golson, Brigitte Koeberlein, Roel Quintens, Leentje van Lommel, Carol Buettger, Heather Weik-Collins, Rebecca Taub, Joseph Grimsby, Frans Schuit, Klaus H. Kaestner, and Franz M. Matschinsky
Diabetes 2006 55: 1923 -1929. [Abstract] [Full Text] [PDF]  

Leptin Suppresses Stearoyl-CoA Desaturase 1 by Mechanisms Independent of Insulin and Sterol Regulatory Element–Binding Protein-1c

Sudha B. Biddinger, Makoto Miyazaki, Jeremie Boucher, James M. Ntambi, and C. Ronald Kahn
Diabetes 2006 55: 2032 -2041. [Abstract] [Full Text] [PDF]  

Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action

Varman T. Samuel, Cheol Soo Choi, Trevor G. Phillips, Anthony J. Romanelli, John G. Geisler, Sanjay Bhanot, Robert McKay, Brett Monia, John R. Shutter, Richard A. Lindberg, Gerald I. Shulman, and Murielle M. Veniant
Diabetes 2006 55: 2042 -2050. [Abstract] [Full Text] [PDF]  

AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

Jonas T. Treebak, Stephan Glund, Atul Deshmukh, Ditte K. Klein, Yun Chau Long, Thomas E. Jensen, Sebastian B. Jørgensen, Benoit Viollet, Leif Andersson, Dietbert Neumann, Theo Wallimann, Erik A. Richter, Alexander V. Chibalin, Juleen R. Zierath, and Jørgen F.P. Wojtaszewski
Diabetes 2006 55: 2051 -2058. [Abstract] [Full Text] [PDF]  

Serum- and Glucocorticoid-Inducible Kinase 1 Mediates Salt Sensitivity of Glucose Tolerance

Krishna M. Boini, Anita M. Hennige, Dan Yang Huang, Björn Friedrich, Monica Palmada, Christoph Boehmer, Florian Grahammer, Ferruh Artunc, Susanne Ullrich, Diana Avram, Hartmut Osswald, Peer Wulff, Dietmar Kuhl, Volker Vallon, Hans-Ulrich Häring, and Florian Lang
Diabetes 2006 55: 2059 -2066. [Abstract] [Full Text] [PDF]  

Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle

Henning F. Kramer, Carol A. Witczak, Nobuharu Fujii, Niels Jessen, Eric B. Taylor, David E. Arnolds, Kei Sakamoto, Michael F. Hirshman, and Laurie J. Goodyear
Diabetes 2006 55: 2067 -2076. [Abstract] [Full Text] [PDF]  

The Role of Ca²⁺ Influx for Insulin-Mediated Glucose Uptake in Skeletal Muscle

Johanna T. Lanner, Abram Katz, Pasi Tavi, Marie E. Sandström, Shi-Jin Zhang, Charlott Wretman, Stephen James, Jérémy Fauconnier, Jan Lännergren, Joseph D. Bruton, and Håkan Westerblad
Diabetes 2006 55: 2077 -2083. [Abstract] [Full Text] [PDF]  

Mitochondrial Reactive Oxygen Species Are Required for Hypothalamic Glucose Sensing

Corinne Leloup, Christophe Magnan, Alexandre Benani, Emilie Bonnet, Thierry Alquier, Géraldine Offer, Audrey Carriere, Alain Périquet, Yvette Fernandez, Alain Ktorza, Louis Casteilla, and Luc Pénicaud
Diabetes 2006 55: 2084 -2090. [Abstract] [Full Text] [PDF]  

Islet Studies:

Spontaneous Recovery From Hyperglycemia by Regeneration of Pancreatic ß-Cells in Kir6.2G132S Transgenic Mice

Kazunobu Oyama, Kohtaro Minami, Katsuhiko Ishizaki, Masanori Fuse, Takashi Miki, and Susumu Seino
Diabetes 2006 55: 1930 -1938. [Abstract] [Full Text] [PDF]  

ß-Cell Deficit Due to Increased Apoptosis in the Human Islet Amyloid Polypeptide Transgenic (HIP) Rat Recapitulates the Metabolic Defects Present in Type 2 Diabetes

Aleksey V. Matveyenko and Peter C. Butler
Diabetes 2006 55: 2106 -2114. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Cystic Fibrosis Transmembrane Conductance Regulator Deficiency Exacerbates Islet Cell Dysfunction After ß-Cell Injury

Michael S. Stalvey, Christian Muller, Desmond A. Schatz, Clive H. Wasserfall, Martha L. Campbell-Thompson, Douglas W. Theriaque, Terence R. Flotte, and Mark A. Atkinson
Diabetes 2006 55: 1939 -1945. [Abstract] [Full Text] [PDF]  

Complications:

Aldose Reductase–Deficient Mice Are Protected From Delayed Motor Nerve Conduction Velocity, Increased c-Jun NH₂-Terminal Kinase Activation, Depletion of Reduced Glutathione, Increased Superoxide Accumulation, and DNA Damage

Eric C.M. Ho, Karen S.L. Lam, Yuk Shan Chen, Johnny C.W. Yip, Meena Arvindakshan, Shin-Ichiro Yamagishi, Soroku Yagihashi, Peter J. Oates, Craig A. Ellery, Stephen S.M. Chung, and Sookja K. Chung
Diabetes 2006 55: 1946 -1953. [Abstract] [Full Text] [PDF]  

Comparison of Serum High–Molecular Weight (HMW) Adiponectin With Total Adiponectin Concentrations in Type 2 Diabetic Patients With Coronary Artery Disease Using a Novel Enzyme-Linked Immunosorbent Assay to Detect HMW Adiponectin

Yoshimasa Aso, Ruriko Yamamoto, Sadao Wakabayashi, Toshihiko Uchida, Kan Takayanagi, Kohzo Takebayashi, Takehiko Okuno, Teruo Inoue, Koichi Node, Takashi Tobe, Toshihiko Inukai, and Yasuko Nakano
Diabetes 2006 55: 1954 -1960. [Abstract] [Full Text] [PDF]  

Increased Dicarbonyl Metabolism in Endothelial Cells in Hyperglycemia Induces Anoikis and Impairs Angiogenesis by RGD and GFOGER Motif Modification

Darin Dobler, Naila Ahmed, Lijiang Song, Kevin E. Eboigbodin, and Paul J. Thornalley
Diabetes 2006 55: 1961 -1969. [Abstract] [Full Text] [PDF]  

Mesangial Cell Hypertrophy by High Glucose Is Mediated by Downregulation of the Tumor Suppressor PTEN

Lenin Mahimainathan, Falguni Das, Balachandar Venkatesan, and Goutam Ghosh Choudhury
Diabetes 2006 55: 2115 -2125. [Abstract] [Full Text] [PDF] Online-Only Appendix  

The Relationship Between Plasma Osteoprotegerin and Endothelium-Dependent Arterial Dilation in Type 2 Diabetes

Guang-da Xiang, Lin Xu, Lin-shuang Zhao, Ling Yue, and Jie Hou
Diabetes 2006 55: 2126 -2131. [Abstract] [Full Text] [PDF]  

ACE and ACE2 Activity in Diabetic Mice

Jan Wysocki, Minghao Ye, Maria José Soler, Susan B. Gurley, Hong D. Xiao, Kenneth E. Bernstein, Thomas M. Coffman, Sheldon Chen, and Daniel Batlle
Diabetes 2006 55: 2132 -2139. [Abstract] [Full Text] [PDF]  

Genetics:

Common Hepatic Nuclear Factor-4 Variants Are Associated With High Serum Lipid Levels and the Metabolic Syndrome

Daphna Weissglas-Volkov, Adriana Huertas-Vazquez, Elina Suviolahti, Jenny Lee, Christopher Plaisier, Samuel Canizales-Quinteros, Teresa Tusie-Luna, Carlos Aguilar-Salinas, Marja-Riitta Taskinen, and Päivi Pajukanta
Diabetes 2006 55: 1970 -1977. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Transgenic Insulin (B:9-23) T-Cell Receptor Mice Develop Autoimmune Diabetes Dependent Upon RAG Genotype, H-2^g7 Homozygosity, and Insulin 2 Gene Knockout

Jean M. Jasinski, Liping Yu, Maki Nakayama, Marcella M. Li, Myra A. Lipes, George S. Eisenbarth, and Edwin Liu
Diabetes 2006 55: 1978 -1984. [Abstract] [Full Text] [PDF]  

Coincident Linkage of Type 2 Diabetes, Metabolic Syndrome, and Measures of Cardiovascular Disease in a Genome Scan of the Diabetes Heart Study

Donald W. Bowden, Megan Rudock, Julie Ziegler, Allison B. Lehtinen, Jianzhao Xu, Lynne E. Wagenknecht, David Herrington, Stephen S. Rich, Barry I. Freedman, J. Jeffrey Carr, and Carl D. Langefeld
Diabetes 2006 55: 1985 -1994. [Abstract] [Full Text] [PDF]  

Common Variants of the Endothelial Nitric Oxide Synthase Gene and the Risk of Coronary Heart Disease Among U.S. Diabetic Men

Cuilin Zhang, Ruy Lopez-Ridaura, David J. Hunter, Nader Rifai, and Frank B. Hu
Diabetes 2006 55: 2140 -2147. [Abstract] [Full Text] [PDF]  

New Methodologies and Databases:

Evaluation of the Effect of Gain on the Meal Response of an Automated Closed-Loop Insulin Delivery System

Antonios E. Panteleon, Mikhail Loutseiko, Garry M. Steil, and Kerstin Rebrin
Diabetes 2006 55: 1995 -2000. [Abstract] [Full Text] [PDF]  

Metabolism:

Effects of Age and Sex on Postprandial Glucose Metabolism: Differences in Glucose Turnover, Insulin Secretion, Insulin Action, and Hepatic Insulin Extraction

Rita Basu, Chiara Dalla Man, Marco Campioni, Ananda Basu, George Klee, Gianna Toffolo, Claudio Cobelli, and Robert A. Rizza
Diabetes 2006 55: 2001 -2014. [Abstract] [Full Text] [PDF]  

A Choline-Deficient Diet Exacerbates Fatty Liver but Attenuates Insulin Resistance and Glucose Intolerance in Mice Fed a High-Fat Diet

Peter J. Raubenheimer, Moffat J. Nyirenda, and Brian R. Walker
Diabetes 2006 55: 2015 -2020. [Abstract] [Full Text] [PDF]  

Plasma Interleukin-6 Levels Are Independently Associated With Insulin Secretion in a Cohort of Italian-Caucasian Nondiabetic Subjects

Francesco Andreozzi, Emanuela Laratta, Marina Cardellini, Maria A. Marini, Renato Lauro, Marta L. Hribal, Francesco Perticone, and Giorgio Sesti
Diabetes 2006 55: 2021 -2024. [Abstract] [Full Text] [PDF]  

Mechanisms of Recovery From Type 2 Diabetes After Malabsorptive Bariatric Surgery

Caterina Guidone, Melania Manco, Elena Valera-Mora, Amerigo Iaconelli, Donatella Gniuli, Andrea Mari, Giuseppe Nanni, Marco Castagneto, Menotti Calvani, and Geltrude Mingrone
Diabetes 2006 55: 2025 -2031. [Abstract] [Full Text] [PDF]  

Obesity Studies:

Identification of a Novel Member of the Carboxylesterase Family That Hydrolyzes Triacylglycerol: A Potential Role in Adipocyte Lipolysis

Hiroaki Okazaki, Masaki Igarashi, Makiko Nishi, Makiko Tajima, Motohiro Sekiya, Sachiko Okazaki, Naoya Yahagi, Ken Ohashi, Kazuhisa Tsukamoto, Michiyo Amemiya-Kudo, Takashi Matsuzaka, Hitoshi Shimano, Nobuhiro Yamada, Junken Aoki, Rei Morikawa, Yasukazu Takanezawa, Hiroyuki Arai, Ryozo Nagai, Takashi Kadowaki, Jun-ichi Osuga, and Shun Ishibashi
Diabetes 2006 55: 2091 -2097. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Deficiency in NOD Antigen-Presenting Cell Function May Be Responsible for Suboptimal CD4⁺CD25⁺ T-Cell–Mediated Regulation and Type 1 Diabetes Development in NOD Mice

Pascale Alard, Jean N. Manirarora, Sarah A. Parnell, Jason L. Hudkins, Sherry L. Clark, and Michele M. Kosiewicz
Diabetes 2006 55: 2098 -2105. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Brief Genetics Reports:

Single Nucleotide Polymorphisms of PPARD in Combination With the Gly482Ser Substitution of PGC-1A and the Pro12Ala Substitution of PPARG2 Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes: The STOP-NIDDM Trial

Laura Andrulionyte, Paula Peltola, Jean-Louis Chiasson, Markku Laakso for the STOP-NIDDM Study Group
Diabetes 2006 55: 2148 -2152. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice

Helen C. Freeman, Alison Hugill, Neil T. Dear, Frances M. Ashcroft, and Roger D. Cox
Diabetes 2006 55: 2153 -2156. [Abstract] [Full Text] [PDF] Online-Only Appendix  

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