Diabetes -- Table of Contents (August 2006, 55 [8])

Signal Transduction:

Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice: Renaud Dentin, Fadila Benhamed, Isabelle Hainault, Véronique Fauveau, Fabienne Foufelle, Jason R.B. Dyck, Jean Girard, and Catherine Postic
Diabetes 2006 55: 2159 -2170. [Abstract] [Full Text] [PDF] Online-Only Appendix

Temporal Dynamics of Tyrosine Phosphorylation in Insulin Signaling: Katrin Schmelzle, Susan Kane, Scott Gridley, Gustav E. Lienhard, and Forest M. White
Diabetes 2006 55: 2171 -2179. [Abstract] [Full Text] [PDF] Online-Only Appendix

Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice: Mengwei Zang, Shanqin Xu, Karlene A. Maitland-Toolan, Adriana Zuccollo, Xiuyun Hou, Bingbing Jiang, Michel Wierzbicki, Tony J. Verbeuren, and Richard A. Cohen
Diabetes 2006 55: 2180 -2191. [Abstract] [Full Text] [PDF] Online-Only Appendix

Free Fatty Acids Inhibit Insulin Signaling–Stimulated Endothelial Nitric Oxide Synthase Activation Through Upregulating PTEN or Inhibiting Akt Kinase: Xing Li Wang, Lin Zhang, Keith Youker, Ming-Xiang Zhang, Jian Wang, Scott A. LeMaire, Joseph S. Coselli, and Ying H. Shen
Diabetes 2006 55: 2301 -2310. [Abstract] [Full Text] [PDF]

Insulin Regulation of Skeletal Muscle PDK4 mRNA Expression Is Impaired in Acute Insulin-Resistant States: Young I. Kim, Felix N. Lee, Woo S. Choi, Sarah Lee, and Jang H. Youn
Diabetes 2006 55: 2311 -2317. [Abstract] [Full Text] [PDF]

Islet Studies:

Impaired NH₂-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death: Lucy Marzban, Christopher J. Rhodes, Donald F. Steiner, Leena Haataja, Philippe A. Halban, and C. Bruce Verchere
Diabetes 2006 55: 2192 -2201. [Abstract] [Full Text] [PDF]

A Conditional Model Reveals That Induction of Hepatocyte Nuclear Factor-1 ${alpha}$ in Hnf1 ${alpha}$ -Null Mutant ß-Cells Can Activate Silenced Genes Postnatally, Whereas Overexpression Is Deleterious: Reini F. Luco, Miguel A. Maestro, Natalia del Pozo, William M. Philbrick, Pablo Perez de la Ossa, and Jorge Ferrer
Diabetes 2006 55: 2202 -2211. [Abstract] [Full Text] [PDF] Online-Only Appendix

Granzyme B–Mediated Death of Pancreatic ß-Cells Requires the Proapoptotic BH3-Only Molecule Bid: Eugene Estella, Mark D. McKenzie, Tara Catterall, Vivien R. Sutton, Phillip I. Bird, Joseph A. Trapani, Thomas W. Kay, and Helen E. Thomas
Diabetes 2006 55: 2212 -2219. [Abstract] [Full Text] [PDF]

ERK1/2 Control Phosphorylation and Protein Level of cAMP-Responsive Element–Binding Protein: A Key Role in Glucose-Mediated Pancreatic ß-Cell Survival: Safia Costes, Christophe Broca, Gyslaine Bertrand, Anne-Dominique Lajoix, Dominique Bataille, Joel Bockaert, and Stéphane Dalle
Diabetes 2006 55: 2220 -2230. [Abstract] [Full Text] [PDF]

Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations: Albert Salehi, Elaine Vieira, and Erik Gylfe
Diabetes 2006 55: 2318 -2323. [Abstract] [Full Text] [PDF]

Intrahepatic Transplanted Islets in Humans Secrete Insulin in a Coordinate Pulsatile Manner Directly Into the Liver: Juris J. Meier, Irene Hong-McAtee, Ryan Galasso, Johannes D. Veldhuis, Antoinette Moran, Bernhard J. Hering, and Peter C. Butler
Diabetes 2006 55: 2324 -2332. [Abstract] [Full Text] [PDF]

Complications:

Benfotiamine Counteracts Glucose Toxicity Effects on Endothelial Progenitor Cell Differentiation via Akt/FoxO Signaling: Valentina Marchetti, Rossella Menghini, Stefano Rizza, Alessia Vivanti, Tiziana Feccia, Davide Lauro, Akiyoshi Fukamizu, Renato Lauro, and Massimo Federici
Diabetes 2006 55: 2231 -2237. [Abstract] [Full Text] [PDF]

${alpha}$ -Lipoic Acid Prevents the Increase in Atherosclerosis Induced by Diabetes in Apolipoprotein E–Deficient Mice Fed High-Fat/Low-Cholesterol Diet: Xianwen Yi and Nobuyo Maeda
Diabetes 2006 55: 2238 -2244. [Abstract] [Full Text] [PDF]

Receptor for Advanced Glycation End Products Is Involved in Impaired Angiogenic Response in Diabetes: Takuhito Shoji, Hidenori Koyama, Tomoaki Morioka, Shinji Tanaka, Akane Kizu, Kohka Motoyama, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Noriko Shimogaito, Masayoshi Takeuchi, Yasuhiko Yamamoto, Hideto Yonekura, Hiroshi Yamamoto, and Yoshiki Nishizawa
Diabetes 2006 55: 2245 -2255. [Abstract] [Full Text] [PDF]

Pharmacology & Therapeutics:

Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States: Yun S. Lee, Woo S. Kim, Kang H. Kim, Myung J. Yoon, Hye J. Cho, Yun Shen, Ji-Ming Ye, Chul H. Lee, Won K. Oh, Chul T. Kim, Cordula Hohnen-Behrens, Alison Gosby, Edward W. Kraegen, David E. James, and Jae B. Kim
Diabetes 2006 55: 2256 -2264. [Abstract] [Full Text] [PDF] Online-Only Appendix Data Supplement Data Supplement Data Supplement Data Supplement Data Supplement Data Supplement Data Supplement Data Supplement Data Supplement Data Supplement Data Supplement

Effects of Recombinant Human IGF-I/IGF-Binding Protein-3 Complex on Glucose and Glycerol Metabolism in Type 1 Diabetes: Tero Saukkonen, Fariba Shojaee-Moradie, Rachel M. Williams, Rakesh Amin, Kevin C. Yuen, Angie Watts, Carlo L. Acerini, A. Margot Umpleby, and David B. Dunger
Diabetes 2006 55: 2365 -2370. [Abstract] [Full Text] [PDF]

Pioglitazone but Not Glibenclamide Improves Cardiac Expression of Heat Shock Protein 72 and Tolerance Against Ischemia/Reperfusion Injury in the Heredity Insulin-Resistant Rat: Yayoi Taniguchi, Tatsuhiko Ooie, Naohiko Takahashi, Tetsuji Shinohara, Mikiko Nakagawa, Hidetoshi Yonemochi, Masahide Hara, Hironobu Yoshimatsu, and Tetsunori Saikawa
Diabetes 2006 55: 2371 -2378. [Abstract] [Full Text] [PDF]

Genetics:

Impact of Chromosome 2 Obesity Loci on Cardiovascular Complications of Insulin Resistance in LDL Receptor–Deficient C57BL/6 Mice: Daria Estrada-Smith, Alan R. Collins, Xuping Wang, Craig Crockett, Lawrence Castellani, Aldons J. Lusis, and Richard C. Davis
Diabetes 2006 55: 2265 -2271. [Abstract] [Full Text] [PDF] Online-Only Appendix

Brief Genetics Reports:

Assessment of the Role of Common Genetic Variation in the Transient Neonatal Diabetes Mellitus (TNDM) Region in Type 2 Diabetes: A Comparative Genomic and Tagging Single Nucleotide Polymorphism Approach: Anna L. Gloyn, Deborah J.G. Mackay, Michael N. Weedon, Mark I. McCarthy, Mark Walker, Graham Hitman, Bridget A. Knight, Katharine R. Owen, Andrew T. Hattersley, and Timothy M. Frayling
Diabetes 2006 55: 2272 -2276. [Abstract] [Full Text] [PDF] Online-Only Appendix

Association Studies of Variants in the Genes Involved in Pancreatic ß-Cell Function in Type 2 Diabetes in Japanese Subjects: Norihide Yokoi, Masao Kanamori, Yukio Horikawa, Jun Takeda, Tokio Sanke, Hiroto Furuta, Kishio Nanjo, Hiroyuki Mori, Masato Kasuga, Kazuo Hara, Takashi Kadowaki, Yukio Tanizawa, Yoshitomo Oka, Yukiko Iwami, Hisako Ohgawara, Yuichiro Yamada, Yutaka Seino, Hideki Yano, Nancy J. Cox, and Susumu Seino
Diabetes 2006 55: 2379 -2386. [Abstract] [Full Text] [PDF] Online-Only Appendix

An IGF-I Gene Polymorphism Modifies the Risk of Diabetic Retinopathy: Ingrid Rietveld, M. Kamran Ikram, Johannes R. Vingerling, Albert Hofman, Huibert A.P. Pols, Steven W.J. Lamberts, Paulus T.V.M. de Jong, Cornelia M. van Duijn, and Joop A.M.J.L. Janssen
Diabetes 2006 55: 2387 -2391. [Abstract] [Full Text] [PDF]

Metabolism:

Increased Malonyl-CoA Levels in Muscle From Obese and Type 2 Diabetic Subjects Lead to Decreased Fatty Acid Oxidation and Increased Lipogenesis; Thiazolidinedione Treatment Reverses These Defects: Gautam K. Bandyopadhyay, Joseph G. Yu, Jachelle Ofrecio, and Jerrold M. Olefsky
Diabetes 2006 55: 2277 -2285. [Abstract] [Full Text] [PDF]

Altered Skeletal Muscle Subsarcolemmal Mitochondrial Compartment During Catch-Up Fat After Caloric Restriction: Raffaella Crescenzo, Lillà Lionetti, Maria Pina Mollica, Marialuisa Ferraro, Elvira D’Andrea, Davide Mainieri, Abdul G. Dulloo, Giovanna Liverini, and Susanna Iossa
Diabetes 2006 55: 2286 -2293. [Abstract] [Full Text] [PDF]

Noninvasive Analysis of Hepatic Glycogen Kinetics Before and After Breakfast with Deuterated Water and Acetaminophen: John G. Jones, Ana Fagulha, Cristina Barosa, Margarida Bastos, Luisa Barros, Carla Baptista, M. Madalena Caldeira, and Manuela Carvalheiro
Diabetes 2006 55: 2294 -2300. [Abstract] [Full Text] [PDF]

Pathophysiology:

Insulin Resistance Is Associated With Increased Serum Concentration of IGF-Binding Protein–Related Protein 1 (IGFBP-rP1/MAC25): Abel López-Bermejo, Javad Khosravi, José Manuel Fernández-Real, Vivian Hwa, Katherine L. Pratt, Roser Casamitjana, Maria M. Garcia-Gil, Ron G. Rosenfeld, and Wifredo Ricart
Diabetes 2006 55: 2333 -2339. [Abstract] [Full Text] [PDF]

Systemic Immune Mediators and Lifestyle Changes in the Prevention of Type 2 Diabetes: Results From the Finnish Diabetes Prevention Study: Christian Herder, Markku Peltonen, Wolfgang Koenig, Ilka Kräft, Sylvia Müller-Scholze, Stephan Martin, Timo Lakka, Pirjo Ilanne-Parikka, Johan G. Eriksson, Helena Hämäläinen, Sirkka Keinänen-Kiukaanniemi, Timo T. Valle, Matti Uusitupa, Jaana Lindström, Hubert Kolb, Jaakko Tuomilehto for the Finnish Diabetes Prevention Study Group
Diabetes 2006 55: 2340 -2346. [Abstract] [Full Text] [PDF]

Mechanisms of Impaired Fasting Glucose and Glucose Intolerance Induced by a $~$ 50% Pancreatectomy: Aleksey V. Matveyenko, Johannes D. Veldhuis, and Peter C. Butler
Diabetes 2006 55: 2347 -2356. [Abstract] [Full Text] [PDF]

Obesity Is a Major Determinant of the Association of C-Reactive Protein Levels and the Metabolic Syndrome in Type 2 Diabetes: Steven E. Kahn, Bernard Zinman, Steven M. Haffner, M. Colleen O’Neill, Barbara G. Kravitz, Dahong Yu, Martin I. Freed, William H. Herman, Rury R. Holman, Nigel P. Jones, John M. Lachin, Giancarlo C. Viberti, and the ADOPT Study Group
Diabetes 2006 55: 2357 -2364. [Abstract] [Full Text] [PDF]

Perspectives in Diabetes:

Molecular Mechanisms of Insulin Resistance: Serine Phosphorylation of Insulin Receptor Substrate-1 and Increased Expression of p85 ${alpha}$ : The Two Sides of a Coin: Boris Draznin
Diabetes 2006 55: 2392 -2397. [Abstract] [Full Text] [PDF]