Perspectives in Diabetes:

Diabetic Retinopathy: Seeing Beyond Glucose-Induced Microvascular Disease

David A. Antonetti, Alistair J. Barber, Sarah K. Bronson, Willard M. Freeman, Thomas W. Gardner, Leonard S. Jefferson, Mark Kester, Scot R. Kimball, J. Kyle Krady, Kathryn F. LaNoue, Christopher C. Norbury, Patrick G. Quinn, Lakshman Sandirasegarane, Ian A. Simpson for the JDRF Diabetic Retinopathy Center Group
Diabetes 2006 55: 2401 -2411. [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy ß-Cells via the Perforin and Fas Pathways

Nadine L. Dudek, Helen E. Thomas, Lina Mariana, Robyn M. Sutherland, Janette Allison, Eugene Estella, Eveline Angstetra, Joseph A. Trapani, Pere Santamaria, Andrew M. Lew, and Thomas W.H. Kay
Diabetes 2006 55: 2412 -2418. [Abstract] [Full Text] [PDF]  

In Vivo Imaging of Immune Rejection in Transplanted Pancreatic Islets

Natalia V. Evgenov, Zdravka Medarova, John Pratt, Pamela Pantazopoulos, Simone Leyting, Susan Bonner-Weir, and Anna Moore
Diabetes 2006 55: 2419 -2428. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Sirolimus Is Associated With Reduced Islet Engraftment and Impaired ß-Cell Function

Nan Zhang, Dongming Su, Shen Qu, Tonia Tse, Rita Bottino, A.N. Balamurugan, Jing Xu, Jonathan S. Bromberg, and H. Henry Dong
Diabetes 2006 55: 2429 -2436. [Abstract] [Full Text] [PDF]  

Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes: Results of a Blinded Controlled Study

Vicki Seyfert-Margolis, Trang D. Gisler, Adam L. Asare, Richard S. Wang, H. Michael Dosch, Barbara Brooks-Worrell, George S. Eisenbarth, Jerry P. Palmer, Carla J. Greenbaum, Stephen E. Gitelman, Gerald T. Nepom, Jeffrey A. Bluestone, and Kevan C. Herold
Diabetes 2006 55: 2588 -2594. [Abstract] [Full Text] [PDF]  

Isolation and Characterization of Proinsulin-Producing Medullary Thymic Epithelial Cell Clones

Michael O. Palumbo, Dina Levi, Aziz Alami Chentoufi, and Constantin Polychronakos
Diabetes 2006 55: 2595 -2601. [Abstract] [Full Text] [PDF]  

Islet Studies:

CD40–CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets

Florencia M. Barbé-Tuana, Dagmar Klein, Hirohito Ichii, Dora M. Berman, Lane Coffey, Norma S. Kenyon, Camillo Ricordi, and Ricardo L. Pastori
Diabetes 2006 55: 2437 -2445. [Abstract] [Full Text] [PDF]  

ATP Sensitivity of the ATP-Sensitive K⁺ Channel in Intact and Permeabilized Pancreatic ß-Cells

Andrei I. Tarasov, Christophe A.J. Girard, and Frances M. Ashcroft
Diabetes 2006 55: 2446 -2454. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Aging Correlates With Decreased ß-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: A Potential Role for Fas and Pancreatic Duodenal Homeobox-1

Kathrin Maedler, Desiree M. Schumann, Fabienne Schulthess, José Oberholzer, Domenico Bosco, Thierry Berney, and Marc Y. Donath
Diabetes 2006 55: 2455 -2462. [Abstract] [Full Text] [PDF]  

Glucose Induces Opposite Intracellular Ca²⁺ Concentration Oscillatory Patterns in Identified - and ß-Cells Within Intact Human Islets of Langerhans

Ivan Quesada, Mariana G. Todorova, Paloma Alonso-Magdalena, Marta Beltrá, Everardo M. Carneiro, Franz Martin, Angel Nadal, and Bernat Soria
Diabetes 2006 55: 2463 -2469. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Fibroblast Growth Factor-21 Improves Pancreatic ß-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

Wolf Wente, Alexander M. Efanov, Martin Brenner, Alexei Kharitonenkov, Anja Köster, George E. Sandusky, Sabine Sewing, Iris Treinies, Heike Zitzer, and Jesper Gromada
Diabetes 2006 55: 2470 -2478. [Abstract] [Full Text] [PDF]  

Glucose Toxicity Is Responsible for the Development of Impaired Regulation of Endogenous Glucose Production and Hepatic Glucokinase in Zucker Diabetic Fatty Rats

Yuka Fujimoto, Tracy P. Torres, E. Patrick Donahue, and Masakazu Shiota
Diabetes 2006 55: 2479 -2490. [Abstract] [Full Text] [PDF]  

Nuclear Factor-B Regulates ß-Cell Death: A Critical Role for A20 in ß-Cell Protection

David Liuwantara, Mark Elliot, Mariya W. Smith, Andrew O. Yam, Stacy N. Walters, Eliana Marino, Andy McShea, and Shane T. Grey
Diabetes 2006 55: 2491 -2501. [Abstract] [Full Text] [PDF]  

Complications:

Regulation of Renal Fatty Acid and Cholesterol Metabolism, Inflammation, and Fibrosis in Akita and OVE26 Mice With Type 1 Diabetes

Gregory Proctor, Tao Jiang, Mieko Iwahashi, Zhuowei Wang, Jinping Li, and Moshe Levi
Diabetes 2006 55: 2502 -2509. [Abstract] [Full Text] [PDF]  

RAGE Control of Diabetic Nephropathy in a Mouse Model: Effects of RAGE Gene Disruption and Administration of Low–Molecular Weight Heparin

Khin-Mar Myint, Yasuhiko Yamamoto, Toshio Doi, Ichiro Kato, Ai Harashima, Hideto Yonekura, Takuo Watanabe, Harumichi Shinohara, Masayoshi Takeuchi, Koichi Tsuneyama, Noriyoshi Hashimoto, Masahide Asano, Shin Takasawa, Hiroshi Okamoto, and Hiroshi Yamamoto
Diabetes 2006 55: 2510 -2522. [Abstract] [Full Text] [PDF]  

Enhanced Proatherogenic Responses in Macrophages and Vascular Smooth Muscle Cells Derived From Diabetic db/db Mice

Shu-lian Li, Marpadga A. Reddy, Qiangjun Cai, Li Meng, Hang Yuan, Linda Lanting, and Rama Natarajan
Diabetes 2006 55: 2611 -2619. [Abstract] [Full Text] [PDF]  

Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the Development of Microalbuminuria in Type 1 Diabetes

Gianpaolo Zerbini, Riccardo Bonfanti, Franco Meschi, Emilio Bognetti, Pier Luigi Paesano, Luigi Gianolli, Marialuisa Querques, Anna Maestroni, Giliola Calori, Alessandro Del Maschio, Ferruccio Fazio, Livio Luzi, and Giuseppe Chiumello
Diabetes 2006 55: 2620 -2625. [Abstract] [Full Text] [PDF]  

Pharmacology & Therapeutics:

Halofenate Is a Selective Peroxisome Proliferator–Activated Receptor Modulator With Antidiabetic Activity

Tamara Allen, Fang Zhang, Shonna A. Moodie, L. Edward Clemens, Aaron Smith, Francine Gregoire, Andrea Bell, George E.O. Muscat, and Thomas A. Gustafson
Diabetes 2006 55: 2523 -2533. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Genetics:

Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns

Lori L. Bonnycastle, Cristen J. Willer, Karen N. Conneely, Anne U. Jackson, Cecily P. Burrill, Richard M. Watanabe, Peter S. Chines, Narisu Narisu, Laura J. Scott, Sareena T. Enloe, Amy J. Swift, William L. Duren, Heather M. Stringham, Michael R. Erdos, Nancy L. Riebow, Thomas A. Buchanan, Timo T. Valle, Jaakko Tuomilehto, Richard N. Bergman, Karen L. Mohlke, Michael Boehnke, and Francis S. Collins
Diabetes 2006 55: 2534 -2540. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q

Eleftheria Zeggini, Coleen M. Damcott, Robert L. Hanson, Mohammad A. Karim, N. William Rayner, Christopher J. Groves, Leslie J. Baier, Terri C. Hale, Andrew T. Hattersley, Graham A. Hitman, Sarah E. Hunt, William C. Knowler, Braxton D. Mitchell, Maggie C.Y. Ng, Jeffrey R. O’Connell, Toni I. Pollin, Martine Vaxillaire, Mark Walker, Xiaoqin Wang, Pamela Whittaker, Kunsan Xiang, Weiping Jia, Juliana C. N. Chan, Philippe Froguel, Panos Deloukas, Alan R. Shuldiner, Steven C. Elbein, Mark I. McCarthy for the International Type 2 Diabetes 1q Consortium
Diabetes 2006 55: 2541 -2548. [Abstract] [Full Text] [PDF] Online-Only Appendix  

New Polymorphism of ENPP1 (PC-1) Is Associated With Increased Risk of Type 2 Diabetes Among Obese Individuals

Jacek Bochenski, Grzegorz Placha, Krzysztof Wanic, Maciej Malecki, Jacek Sieradzki, James H. Warram, and Andrzej S. Krolewski
Diabetes 2006 55: 2626 -2630. [Abstract] [Full Text] [PDF]  

Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes

Swapan Kumar Das, Winston S. Chu, Terri C. Hale, Xiaoqin Wang, Rebekah L. Craig, Hua Wang, Alan R. Shuldiner, Philippe Froguel, Panos Deloukas, Mark I. McCarthy, Eleftheria Zeggini, Sandra J. Hasstedt, and Steven C. Elbein
Diabetes 2006 55: 2631 -2639. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Brief Genetics Reports:

Heterozygosity for a POMC-Null Mutation and Increased Obesity Risk in Humans

I. Sadaf Farooqi, Stenvert Drop, Agnes Clements, Julia M. Keogh, Joanna Biernacka, Sarah Lowenbein, Benjamin G. Challis, and Stephen O’Rahilly
Diabetes 2006 55: 2549 -2553. [Abstract] [Full Text] [PDF]  

Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk

Christopher J. Groves, Eleftheria Zeggini, Jayne Minton, Timothy M. Frayling, Michael N. Weedon, Nigel W. Rayner, Graham A. Hitman, Mark Walker, Steven Wiltshire, Andrew T. Hattersley, and Mark I. McCarthy
Diabetes 2006 55: 2640 -2644. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men

Cuilin Zhang, Lu Qi, David J. Hunter, James B. Meigs, JoAnn E. Manson, Rob M. van Dam, and Frank B. Hu
Diabetes 2006 55: 2645 -2648. [Abstract] [Full Text] [PDF]  

Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample

Laura J. Scott, Lori L. Bonnycastle, Cristen J. Willer, Andrew G. Sprau, Anne U. Jackson, Narisu Narisu, William L. Duren, Peter S. Chines, Heather M. Stringham, Michael R. Erdos, Timo T. Valle, Jaakko Tuomilehto, Richard N. Bergman, Karen L. Mohlke, Francis S. Collins, and Michael Boehnke
Diabetes 2006 55: 2649 -2653. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Polymorphisms in the Transcription Factor 7-Like 2 (TCF7L2) Gene Are Associated With Type 2 Diabetes in the Amish: Replication and Evidence for a Role in Both Insulin Secretion and Insulin Resistance

Coleen M. Damcott, Toni I. Pollin, Laurie J. Reinhart, Sandra H. Ott, Haiqing Shen, Kristi D. Silver, Braxton D. Mitchell, and Alan R. Shuldiner
Diabetes 2006 55: 2654 -2659. [Abstract] [Full Text] [PDF] Online-Only Appendix  

A Disease Haplotype for Advanced Nephropathy in Type 2 Diabetes at the ACE Locus

Daniel P.K. Ng, Grzegorz Placha, Serena Choo, Kee-seng Chia, James H. Warram, and Andrzej S. Krolewski
Diabetes 2006 55: 2660 -2663. [Abstract] [Full Text] [PDF]  

Metabolism:

Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats

Marcelo B.S. Flores, Maria Fernanda A. Fernandes, Eduardo R. Ropelle, Marcel C. Faria, Mirian Ueno, Lício A. Velloso, Mario J.A. Saad, and José B.C. Carvalheira
Diabetes 2006 55: 2554 -2561. [Abstract] [Full Text] [PDF]  

Signal Transduction:

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor

Myeong Jin Yoon, Gha Young Lee, Jun-Jae Chung, Young Ho Ahn, Seung Hwan Hong, and Jae Bum Kim
Diabetes 2006 55: 2562 -2570. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Obesity Studies:

Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes

Tamara Tchkonia, Nino Giorgadze, Tamar Pirtskhalava, Thomas Thomou, Matthew DePonte, Ada Koo, R. Armour Forse, Dharmaraj Chinnappan, Carmen Martin-Ruiz, Thomas von Zglinicki, and James L. Kirkland
Diabetes 2006 55: 2571 -2578. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Altered Adipose and Plasma Sphingolipid Metabolism in Obesity: A Potential Mechanism for Cardiovascular and Metabolic Risk

Fahumiya Samad, Kelly D. Hester, Guang Yang, Yusuf A. Hannun, and Jacek Bielawski
Diabetes 2006 55: 2579 -2587. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats

Juan M. Castellano, Victor M. Navarro, Rafael Fernández-Fernández, Juan Roa, Eva Vigo, Rafael Pineda, Carlos Dieguez, Enrique Aguilar, Leonor Pinilla, and Manuel Tena-Sempere
Diabetes 2006 55: 2602 -2610. [Abstract] [Full Text] [PDF]  

Retraction:

Retraction

Franz M. Matschinsky
Diabetes 2006 55: 2664 . [Extract] [Full Text] [PDF]  

Errata:

Errata

Diabetes 2006 55: 2665 . [Extract] [Full Text] [PDF]  

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